Cистемна організація уваги та загальні принципи її корекції як засіб оптимізації учбової та професійної діяльності

У статті викладено результати літературних та експериментальних досліджень, у яких розкриваються основні напрямки, котрі стосуються феномени уваги:механізми її виникнення, типи уваги, функції контролю та управління. Розглянуто ряд методів, котрі можуть бути використані для тренінгів, з метою збільшення об’єму уваги, ступеня її концентрації, швидкості, ступеня зосередження, переключення і розподілу

Utilisation de l'antigène urinaire à légionelle à l'hôpital de Lourdes

Nous avons mené à l'hôpital de Lourdes sur l'année 2008 une étude rétrospective sur l'utilisation de l'antigène urinaire à légionelle. Nous avons étudié les dossiers des 117 demandes d'antigène urinaire afin de comprendre pourquoi une telle demande avait été faite et de voir si elle était justifiée. Ce test, rapide, sensible, spécifique et facilement réalisable a permis d'augmenter le nombre de diagnostic de pneumopathies à légionelle en France depuis 1997. Nous nous sommes basés sur des critères cliniques, biologiques et radiographiques pour juger l'utilisation de ce test. Nous avons remarqué qu'il était utilisé de façon trop importante, même s'il ne faut pas oublier que la légionellose est une maladie qui est difficile à diagnostiquer par son manque de spécificité et qui est potentiellement grave par son retard de prise en charge. Il nous paraît donc nécessaire de sensibiliser les médecins sur ce sujet pour améliorer leur pratique médicale quotidienne.TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Growth and characterization of ferroelectric thin films for high frequency agile devices

International audienc

Perovskite and tetragonal tungsten bronze phase thin films in the K-Na-Nb-O system: structural and dielectric characterizations

International audienc

Niobates ferroelectric thin films: i/ growth and characterization of perovskite and TTB phases in the K-Na-Nb-O system; ii/ potential of application in high frequency miniature tunable devices

International audienc

Niobates ferroelectric thin films: i/ growth and characterization of perovskite and TTB phases in the K-Na-Nb-O system; ii/ potential of application in high frequency miniature tunable devices

International audienc

Perovskite and tetragonal tungsten bronze phase thin films in the K-Na-Nb-O system: structural and dielectric characterizations

International audienc

Tetragonal tungsten bronze phase thin films in the K–Na–Nb–O system: Pulsed laser deposition, structural and dielectric characterizations

International audiencePulsed laser deposition parameters have been determined to synthesize pure Tetragonal Tungsten Bronze (TTB) phase thin films in the (K,Na)–Nb–O system (KNN). In relation to the high volatility of alkaline elements, it was found that the target composition and the target-substrate distance are of first importance. The TTB phase was identified by X-ray and electron diffraction and the surface microstructure consisting mainly of nanorods supports the formation of hallmark of the TTB phase. Poly-oriented nanorods have been obtained on both C-plane sapphire and (111)Pt/TiO2/SiO2/(001)Si substrates whereas horizontal nanorods oriented along the (hk0) planes have been grown on (100) and (110) SrTiO3. All the nanorods are parallel together when grown on (110) SrTiO3 and they present two in-plane orientations rotated of 90° from each other on (100) SrTiO3. Dielectric characteristics (dielectric permittivity εr, and loss tangent tanδ) have been measured at low (1 kHz - 1 MHz) and high (1 GHz–40 GHz) frequencies, on films deposited on Pt coated silicon and sapphire, respectively. A value of εr = 200 at 1 kHz with tanδ = 0.015 were measured in a parallel plate capacitor configuration, whereas εr = 130 and tanδ = 0.20 at 10 GHz were retrieved from transmission lines printed on the KNN TTB thin film grown on C-plane sapphire. Raman investigations of the TTB films were performed in the temperature range 77–873 K, confirming the TTB phase formation and the absence of structural transition. Piezoelectric Force Microscopy measurements evidenced a piezoelectric signal although no switching could be performed. However the dielectric measurements, complicated by high leakage currents when a DC voltage was applied, did not evidence any proof of ferroelectricity for the undoped KNN TTB films whereas results reported on other niobates (A,A′)6Nb10O30 (with A: K, Na and A’: Sr, Ba, Ca) have shown Curie temperatures, lying between 156 °C and 560 °C, separating the paraelectric phase (space group: P4/mbm N°127) and the ferroelectric one (space group: P4bm N°100)

Isatuximab plus pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma in real-world: The retrospective IMAGE study

International audienceBACKGROUND: IMAGE is a retrospective cohort study of patients enrolled in early access programs (EAPs) in France with relapsed/refractory multiple myeloma (RRMM) receiving isatuximab with pomalidomide and dexamethasone (Isa-Pd).METHODS: Patients aged ≥18 years with RRMM who received ≥1 dose of Isa under the EAPs between July 29, 2019 and August 30, 2020 were included. Effectiveness endpoints included progression-free survival (PFS) and response rates. Verbatim terms for adverse events (AEs) were coded using the Medical Dictionary for Regulatory Activities and not graded for severity.RESULTS: A total of 294 and 299 patients were included in the effectiveness and safety populations, respectively. IMAGE included patients who received one prior line of treatment (10.2%) and were daratumumab-refractory (19.1%). At median follow-up of 14.2 months, median PFS in the effectiveness population was 12.4 months (95% CI 9.0-15.0). Overall response and very good partial response rates were 46.3% and 27.9%, respectively. Subgroup analyses reflected similar results. In the safety population, 26.4% of patients reported at least one AE; the most common any-grade AE was neutropenia (9.4%).CONCLUSION: IMAGE demonstrated Isa-Pd had meaningful effectiveness in median PFS and depth of response and no new safety signals in a real-world context, consistent with clinical trial results