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Memory in autism spectrum disorder: a meta-analysis of experimental studies
To address inconsistencies in the literature on memory in Autism Spectrum Disorder (ASD), we report the first ever meta-analysis of short-term (STM) and episodic long-term (LTM) memory in ASD, evaluating the effects of type of material, type of retrieval and the role of inter-item relations. Analysis of 64 studies comparing individuals with ASD and typical development (TD) showed greater difficulties in ASD compared to TD individuals in STM (Hedges’ g=-0.53 [95%CI -0.90; -0.16], p=.005, I²=96%) compared to LTM (g=-0.30 [95%CI -0.42; -0.17], p<.00001, I²=24%), a small difficulty in verbal LTM (g=-0.21, p=.01), contrasting with a medium difficulty for visual LTM (g= -0.41, p=.0002) in ASD compared to TD individuals. We also found a general diminution in free recall compared to cued recall and recognition (LTM, free recall: g=-0.38, p<.00001, cued recall: g=-0.08, p=.58, recognition: g=-0.15, p=.16; STM, free recall: g=-0.59, p=.004, recognition: g=-0.33, p=.07). We discuss these results in terms of their relation to semantic memory. The limited diminution in verbal LTM and preserved overall recognition and cued recall (supported retrieval) may result from a greater overlap of these tasks with semantic long-term representations which are overall preserved in ASD. By contrast, difficulties in STM or free recall may result from less overlap with the semantic system or may involve additional cognitive operations and executive demands. These findings highlight the need to support STM functioning in ASD and acknowledge the potential benefit of using verbal materials at encoding and broader forms of memory support at retrieval to enhance performance
Terrace reconstruction and long profile projection: a case study from the Solent river system near Southampton, England
River terrace sequences are important frameworks for archaeological evidence and as
such it is important to produce robust correlations between what are often fragmentary
remnants of ancient terraces. This paper examines both conceptual and practical issues
related to such correlations, using a case study from the eastern part of the former Solent
River system near Southampton, England. In this region two recent terrace schemes
have been constructed using different data to describe the terrace deposits: one based
mainly on terrace surfaces; the other on gravel thicknesses, often not recording the
terrace surface itself. The utility of each of these types of data in terrace correlation is
discussed in relation to the complexity of the record, the probability of post-depositional
alteration of surface sediments and comparison of straight-line projections with modern
river long profiles. Correlation using age estimates is also discussed, in relation to
optically-stimulated luminescence dating of sand lenses within terrace gravels in this
region during the PASHCC project. It is concluded that the need for replication at single
sites means that this approach has limited use for correlative purposes, although dating
of sediments is important for understanding wider landscape evolution and patterns of
human occupation
A micropillar for cavity optomechanics
We present a new micromechanical resonator designed for cavity optomechanics.
We have used a micropillar geometry to obtain a high-frequency mechanical
resonance with a low effective mass and a very high quality factor. We have
coated a 60-m diameter low-loss dielectric mirror on top of the pillar and
are planning to use this micromirror as part of a high-finesse Fabry-Perot
cavity, to laser cool the resonator down to its quantum ground state and to
monitor its quantum position fluctuations by quantum-limited optical
interferometry
Quantifying the Energetics and Length Scales of Carbon Segregation to Fe Symmetric Tilt Grain Boundaries Using Atomistic Simulations
Segregation of impurities to grain boundaries plays an important role in both
the stability and macroscopic behavior of polycrystalline materials. The
research objective in this work is to better characterize the energetics and
length scales involved with the process of solute and impurity segregation to
grain boundaries. Molecular dynamics simulations are used to calculate the
segregation energies for carbon within multiple grain boundary sites over a
database of 125 symmetric tilt grain boundaries in Fe. The simulation results
show that the majority of atomic sites near the grain boundary have segregation
energies lower than in the bulk. Moreover, depending on the boundary, the
segregation energies approach the bulk value approximately 5-12 \AA\ away from
the center of the grain boundary, providing an energetic length scale for
carbon segregation. A subsequent data reduction and statistical representation
of this dataset provides critical information such as about the mean
segregation energy and the associated energy distributions for carbon atoms as
a function of distance from the grain boundary, which quantitatively informs
higher scale models with energetics and length scales necessary for capturing
the segregation behavior of impurities in Fe. The significance of this research
is the development of a methodology capable of ascertaining segregation
energies over a wide range of grain boundary character (typical of that
observed in polycrystalline materials), which herein has been applied to carbon
segregation in a specific class of grain boundaries in iron
Navigating the stigmatised identities of poverty in austere times: Resisting and responding to narratives of personal failure
© 2015, © The Author(s) 2015. Behavioural explanations of poverty and disadvantage have figured heavily in political rhetoric in the era of austerity, as a means to understand trajectories into poverty and subsequent relationships between benefit claimants and the state. These discourses are not restricted to political debate, as previous studies demonstrate they impact upon public consciousness and structure the ways that the general public think about poverty, as well as shaping the ways in which people living on low incomes are treated. Drawing upon the testimonies of 62 people in England and Scotland experiencing poverty, this article seeks to understand our participants’ responses to these discourses, in particular: how these behavioural explanations impact upon their understanding of their own situations, as well as their self perceptions; how these discourses shape their relationships with others, in terms of their experience of disrespect; and how participants seek to dissociate themselves from their stigmatising implications
Breakdown of Scaling in the Nonequilibrium Critical Dynamics of the Two-Dimensional XY Model
The approach to equilibrium, from a nonequilibrium initial state, in a system
at its critical point is usually described by a scaling theory with a single
growing length scale, , where z is the dynamic exponent
that governs the equilibrium dynamics. We show that, for the 2D XY model, the
rate of approach to equilibrium depends on the initial condition. In
particular, if no free vortices are present in the
initial state, while if free vortices are
present.Comment: 4 pages, 3 figure
Dynamics of gravity driven three-dimensional thin films on hydrophilic-hydrophobic patterned substrates
We investigate numerically the dynamics of unstable gravity driven
three-dimensional thin liquid films on hydrophilic-hydrophobic patterned
substrates of longitudinal stripes and checkerboard arrangements. The thin film
can be guided preferentially on hydrophilic longitudinal stripes, while fingers
develop on adjacent hydrophobic stripes if their width is large enough. On
checkerboard patterns, the film fingering occurs on hydrophobic domains, while
lateral spreading is favoured on hydrophilic domains, providing a mechanism to
tune the growth rate of the film. By means of kinematical arguments, we
quantitatively predict the growth rate of the contact line on checkerboard
arrangements, providing a first step towards potential techniques that control
thin film growth in experimental setups.Comment: 30 pages, 12 figure
A systematic literature review and meta-analysis of community pharmacist-led interventions to optimise the use of antibiotics.
AIMS: The aim of this systematic review is to assess the effects of community pharmacist-led interventions to optimise the use of antibiotics and identify which interventions are most effective. METHODS: This review was conducted according to the PRISMA guidelines (PROSPERO: CRD42020188552). PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched for (randomised) controlled trials. Included interventions were required to target antibiotic use, be set in the community pharmacy context, and be pharmacist-led. Primary outcomes were quality of antibiotic supply and adverse effects while secondary outcomes included patient-reported outcomes. Risk of bias was assessed using the 'Cochrane suggested risk of bias criteria' and narrative synthesis of primary outcomes conducted. RESULTS: Seventeen studies were included covering in total 3822 patients (mean age 45.6 years, 61.9% female). Most studies used educational interventions. Three studies reported on primary outcomes, 12 on secondary outcomes and two on both. Three studies reported improvements in quality of dispensing, interventions led to more intensive symptom assessment (up to 30% more advice given) and a reduction of over-the-counter supply up to 53%. Three studies led to higher consumer satisfaction, effects on adherence from nine studies were mixed (risk difference 0.04 [-0.02, 0.10]). All studies had unclear or high risks of bias across at least one domain, with large heterogeneity between studies. CONCLUSIONS: Our review suggests some positive results from pharmacist-led interventions, but the interventions do not seem sufficiently effective as currently implemented. This review should be interpreted as exploratory research, as more high-quality research is needed
Multiscale correlative tomography: an investigation of creep cavitation in 316 stainless steel
Creep cavitation in an ex-service nuclear steam header Type 316 stainless steel sample is investigated through a multiscale tomography workflow spanning eight orders of magnitude, combining X-ray computed tomography (CT), plasma focused ion beam (FIB) scanning electron microscope (SEM) imaging and scanning transmission electron microscope (STEM) tomography. Guided by microscale X-ray CT, nanoscale X-ray CT is used to investigate the size and morphology of cavities at a triple point of grain boundaries. In order to understand the factors affecting the extent of cavitation, the orientation and crystallographic misorientation of each boundary is characterised using electron backscatter diffraction (EBSD). Additionally, in order to better understand boundary phase growth, the chemistry of a single boundary and its associated secondary phase precipitates is probed through STEM energy dispersive X-ray (EDX) tomography. The difference in cavitation of the three grain boundaries investigated suggests that the orientation of grain boundaries with respect to the direction of principal stress is important in the promotion of cavity formation
Radiation-pressure cooling and optomechanical instability of a micro-mirror
Recent experimental progress in table-top experiments or gravitational-wave
interferometers has enlightened the unique displacement sensitivity offered by
optical interferometry. As the mirrors move in response to radiation pressure,
higher power operation, though crucial for further sensitivity enhancement,
will however increase quantum effects of radiation pressure, or even jeopardize
the stable operation of the detuned cavities proposed for next-generation
interferometers. The appearance of such optomechanical instabilities is the
result of the nonlinear interplay between the motion of the mirrors and the
optical field dynamics. In a detuned cavity indeed, the displacements of the
mirror are coupled to intensity fluctuations, which modifies the effective
dynamics of the mirror. Such "optical spring" effects have already been
demonstrated on the mechanical damping of an electromagnetic waveguide with a
moving wall, on the resonance frequency of a specially designed flexure
oscillator, and through the optomechanical instability of a silica
micro-toroidal resonator. We present here an experiment where a
micro-mechanical resonator is used as a mirror in a very high-finesse optical
cavity and its displacements monitored with an unprecedented sensitivity. By
detuning the cavity, we have observed a drastic cooling of the micro-resonator
by intracavity radiation pressure, down to an effective temperature of 10 K. We
have also obtained an efficient heating for an opposite detuning, up to the
observation of a radiation-pressure induced instability of the resonator.
Further experimental progress and cryogenic operation may lead to the
experimental observation of the quantum ground state of a mechanical resonator,
either by passive or active cooling techniques
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