17 research outputs found
Individual learning on environmental vocational education and training courses does not always lead to the workplace application of knowledge and skills
YesEmpirical research on three commercial environmental vocational education and training programmes revealed distinct personal, teaching and work-based presage factors, which influenced individual learning and learning transfer to the workplace. The extent to which behaviour change and learning transfer occurred depended on a diverse range of factors, notably the workplace utility of the course; student’s level of personal commitment and position within the employing organisation; strength of the organisation’s environmental culture; level of post-course managerial/supervisory support available within the workplace; and changing workplace circumstances/priorities
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The Use of Computerized Thermodynamics Databases for Solidification Modeling of Fusion Welds in Multi-Component Alloys
Most engineering alloys contain numerous alloying elements and their solidification behavior can not typically be modeled with existing binary and ternary phase diagrams. There has recently been considerable progress in the development of thermodynamic software programs for calculating solidification parameters and phase diagrams of multi-component systems. These routines can potentially provide useful input data that are needed in multi-component solidification models. However, these thermodynamic routines require validation before they can be confidently applied to simulations of alloys over a wide range of composition. In this article, a preliminary assessment of the accuracy of the Thermo-Calc NiFe Superalloy database is presented. The database validation is conducted by comparing calculated phase diagram quantities to experimental measurements available in the literature. Comparisons are provided in terms of calculated and measured liquidus and solidus temperatures and slopes, equilibrium distribution coefficients, and multi-component phase diagrams. Reasonable agreement is observed among the comparisons made to date. Examples are provided which illustrate how the database can be used to approximate the solidification sequence and final segregation patterns in multi-component alloys. An additional example of the coupling of calculated phase diagrams to solute redistribution computations in a commercial eight component Ni base superalloy is also presented
The effects of acetosyringone and pH on Agrobacterium-mediated transformation vary according to plant species
Explants of five plant species (Allium cepa, Antirrhinum majus, Brassica campestris, Glycine max, and Nicotiana tabacum) were co-cultivated with three Agrobacterium tumefaciens stains under different conditions to assess the effects of acetosyringone and medium pH on strain virulence. Tumours were incited on all dicotyledonous species by strains N2/73 and A281. The presence of acetosyringone during co-cultivation generally enhanced the virulence of these strains, most markedly N2/73 on A. majus and G. max, and A281 on G. max. Strain Ach5 was virulent only on N. tabacum in the absence of acetosyringone, which, when present, extended the host range to include A. majus. There was evidence to suggest that acetosyringone may suppress virulence in some strain/plant species interactions. Virulence was affected in some cases by medium pH, but there was no general effect across plant species
CLIMATIC VARIABILITY, CLIMATIC CHANGE, RUNOFF, AND SUSPENDED SEDIMENT REGIMES IN NORTHERN CANADA
Genetic Analysis of \u27PAX6-Negative\u27 Individuals with Aniridia or Gillespie Syndrome.
We report molecular genetic analysis of 42 affected individuals referred with a diagnosis of aniridia who previously screened as negative for intragenic PAX6 mutations. Of these 42, the diagnoses were 31 individuals with aniridia and 11 individuals referred with a diagnosis of Gillespie syndrome (iris hypoplasia, ataxia and mild to moderate developmental delay). Array-based comparative genomic hybridization identified six whole gene deletions: four encompassing PAX6 and two encompassing FOXC1. Six deletions with plausible cis-regulatory effects were identified: five that were 3\u27 (telomeric) to PAX6 and one within a gene desert 5\u27 (telomeric) to PITX2. Sequence analysis of the FOXC1 and PITX2 coding regions identified two plausibly pathogenic de novo FOXC1 missense mutations (p.Pro79Thr and p.Leu101Pro). No intragenic mutations were detected in PITX2. FISH mapping in an individual with Gillespie-like syndrome with an apparently balanced X;11 reciprocal translocation revealed disruption of a gene at each breakpoint: ARHGAP6 on the X chromosome and PHF21A on chromosome 11. In the other individuals with Gillespie syndrome no mutations were identified in either of these genes, or in HCCS which lies close to the Xp breakpoint. Disruption of PHF21A has previously been implicated in the causation of intellectual disability (but not aniridia). Plausibly causative mutations were identified in 15 out of 42 individuals (12/32 aniridia; 3/11 Gillespie syndrome). Fourteen of these mutations presented in the known aniridia genes; PAX6, FOXC1 and PITX2. The large number of individuals in the cohort with no mutation identified suggests greater locus heterogeneity may exist in both isolated and syndromic aniridia than was previously appreciated
Proceedings on the repeal of an Act before the Constitutional Court, with focus on the review of whether the Act was adopted in the constitutionally prescribed procedure
Proceedings on the repeal of an Act before the Constitutional Court, with focus on the review of whether the Act was adopted in the constitutionally prescribed procedure Abstract The thesis deals with the judicial control of constitutionality with a specific focus on the review of the constitutionality of the legislative procedure. The first part of the thesis deals with the general definition of the constitutional judiciary, the position of the Constitutional Court in constitutional system of the Czech Republic and the definition of basic concepts that must be unconditionally known for the next parts of the thesis. The first part of the thesis concludes with a reflection on the topic whether the Constitutional Court really maintains its role as a predominantly negative legislator. In the second part, the thesis focuses on the description of the current legislation on court proceedings of the repeal of an Act or its individual provisions. The main topic of the second part of the thesis deals are the special effects of the decisions of the Constitutional Court in this type of proceedings and the question about binding nature of its reasoning. The author describes, for example, the specific effects of these decisions in horizontal relations or their effects on the specific proceedings from which the proposal..
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children
Identification of regulatory deletions telomeric to <i>PAX6</i>.
<p>Regulatory deletions telomeric to <i>PAX6</i> were identified in individual 1514 (chr11:30,874,642–31,654,833), individual 753 (chr11:30,967,000–31,704,000), individual 555 (chr11:31,108,579–31,649–842), individual 2014 (chr11:31,234,395–31,751,815) and individual 659 (chr11:31,379,000–31,708,000). The schematic diagram shows how the ‘critical region’ (delimited by grey dotted lines) required for <i>PAX6</i> transcriptional activation was delineated by combining our data with published deletions with known coordinates [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153757#pone.0153757.ref055" target="_blank">55</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153757#pone.0153757.ref067" target="_blank">67</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153757#pone.0153757.ref068" target="_blank">68</a>]. <i>PAX6</i> regulatory deletions from the present study are shown by red blocks. Genes transcribed on the forward strand are in blue and those transcribed on the reverse strand are in green, also indicated by arrows. Genomic coordinates are based on the Human Genome Assembly hg18.</p