Advances in the design and development of oncolytic measles viruses.

A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has rapidly emerged as a potentially useful anticancer modality. Derivatives of the Edmonston MV vaccine strain possess a remarkable safety record in humans. Promising results in preclinical animal models and evidence of biological activity in early phase trials contribute to the enthusiasm. Genetic modifications have enabled MV to evolve from a vaccine agent to a potential anticancer therapy. Specifically, alterations of the MV genome have led to improved tumor selectivity and delivery, therapeutic potency, and immune system modulation. In this article, we will review the advancements that have been made in the design and development of MV that have led to its use as a cancer therapy. In addition, we will discuss the evidence supporting its use, as well as the challenges associated with MV as a potential cancer therapeutic

Differences Between VLBI2010 and S/X Hardware

While the overall architecture is similar for the station hardware in current S/X systems and in the VLBI2010 systems under development, various functions are implemented differently. Some of these differences, and the reasons behind them, are described here

Continuity properties of vectors realizing points in the classical field of values

For an $n$-by-$n$ matrix $A$, let $f_A$ be its "field of values generating function" defined as $f_A\colon x\mapsto x^*Ax$. We consider two natural versions of the continuity, which we call strong and weak, of $f_A^{-1}$ (which is of course multi-valued) on the field of values $F(A)$. The strong continuity holds, in particular, on the interior of $F(A)$, and at such points $z \in \partial F(A)$ which are either corner points, belong to the relative interior of flat portions of $\partial F(A)$, or whose preimage under $f_A$ is contained in a one-dimensional set. Consequently, $f_A^{-1}$ is continuous in this sense on the whole $F(A)$ for all normal, 2-by-2, and unitarily irreducible 3-by-3 matrices. Nevertheless, we show by example that the strong continuity of $f_A^{-1}$ fails at certain points of $\partial F(A)$ for some (unitarily reducible) 3-by-3 and (unitarily irreducible) 4-by-4 matrices. The weak continuity, in its turn, fails for some unitarily reducible 4-by-4 and untiarily irreducible 6-by-6 matrices.Comment: 9 pages, 2 figures. Linear and Multilinear Algebra 201

How to register a VGOS radio telescope at ITU and why it is important

VGOS radio telescopes enable observations in the range of 2-14 GHz and are much more receptive for unwanted radio frequency interference. Some space-borne transmitters may cause detrimental radiation to VGOS receivers. The registration of new VGOS sites at ITU is important to obtain administrative protection. This may help to avoid direct illumination by strong radars, as well as provide protection in the dedicated RAS bands from lower-level interference that degrades system sensitivity. This article introduces the risk of damage and explains the registration procedur

Haystack Analysis Center

Analysis activities at Haystack Observatory are directed towards improving the accuracy of geodetic measurements, whether these are from VLBI, GNSS, SLR, or any other technique. Those analysis activities that are related to technology development are reported elsewhere in this volume. In this report, a preliminary analysis of the first geodetic sessions with the new broadband geodetic VLBI system is reported

Aerobic Capacity is Related to Repeated Sprint Ability with Sprint Distances Less Than 40 Meters.

International Journal of Exercise Science 10(2): 197-204, 2017 Research is inconclusive regarding the association between aerobic fitness (objectively measured VO2max) and repeated sprint performance when the sprints are less than 40 meters. Soccer athletes must be able to repeat sprints without significant decreases in speed and strength and conditioning coaches need to better understand if aerobic fitness is related to repeated sprint ability (RSA). Twenty (10 male, 10 female) Division I soccer athletes first completed a graded maximal treadmill test to measure VO2max. Then on a separate day, athletes completed the RSA test. The RSA test consisted of 10, 30-meter sprints which athletes repeated every 30 seconds. There were significant negative correlations (r ≤ -0.69, P \u3c 0.001) between VO2max and all 10-sprint times and average sprint time. More aerobically fit Division I soccer athletes were faster at all time points during the RSA test. Aerobic fitness is associated with faster sprint times during a more anaerobic RSA test when sprint distances are less than 40 meters

Enantioselective Construction of α-Quaternary Cyclobutanones by Catalytic Asymmetric Allylic Alkylation

No strain, no gain! The first transition metal-catalyzed enantioselective α-alkylation of cyclobutanones is reported. This method employs palladium catalysis and an electron-deficient PHOX-type ligand to afford all-carbon α-quaternary cyclobutanones in good to excellent yields and enantioselectivities (see scheme)

Haystack Observatory VLBI Correlator

This report summarizes the activities of the Haystack Correlator during 2012. Highlights include finding a solution to the DiFX InfiniBand timeout problem and other DiFX software development, conducting a DBE comparison test following the First International VLBI Technology Workshop, conducting a Mark IV and DiFX correlator comparison, more broadband delay experiments, more u- VLBI Galactic Center observations, and conversion of RDV session processing to the Mark IV/HOPS path. Non-real-time e-VLBI transfers and engineering support of other correlators continued

Pulmonary Tumor Thrombotic Microangiopathy : A New Paraneoplastic Syndrome

This report, based on data from a clinical case, proposes that pulmonary tumor thrombotic microangiopathy, an underdiagnosed cause of pulmonary hypertension and death in patients with adenocarcinoma, is a paraneoplastic syndrome (PNS). Clinicians in general must be alert to the presence or development of PNS that may precede, coincide with, follow, or herald the recurrence or the primary diagnosis of malignancy since early recognition facilitates prompt diagnosis and treatment.Peer reviewe