A System Design Approach for Unattended Solar Energy Harvesting Supply

Remote devices, such as sensors and communications devices, require continuously available power. In many applications, conventional approaches are too expensive, too large, or unreliable. For short-term needs, primary batteries may be used. However, they do not scale up well for long-term installations. Instead, energy harvesting methods must be used. Here, a system design approach is introduced that results in a highly reliable, highly available energy harvesting device for remote applications. First, a simulation method that uses climate data and target availability produces Pareto curves for energy storage and generation. This step determines the energy storage requirement in watt-hours and the energy generation requirement in watts. Cost, size, reliability, and longevity requirements are considered to choose particular storage and generation technologies, and then to specify particular components. The overall energy processing system is designed for modularity, fault tolerance, and energy flow control capability. Maximum power point tracking is used to optimize solar panel performance. The result is a highly reliable, highly available power source. Several prototypes have been constructed and tested. Experimental results are shown for one device that uses multicrystalline silicon solar cells and lithium-iron-phosphate batteries to achieve 100% availability. Future designers can use the same approach to design systems for a wide range of power requirements and installation locations

Synthesis of N-substituted 3,5-bis(arylidene)-4-piperidones with high antitumor and antioxidant activity

A series of 3,5-bis(arylidene)-4-piperidones (DAP compounds) are considered as synthetic analogs of curcumin for anticancer and anti-inflammatory properties. We performed structureactivity relationship studies by synthesizing a number of 3,5-bis(arylidene)-4-piperidones Nalkylated or acylated with nitroxides or their amine precursors as potent antioxidant moieties. Both subtituents on arylidene rings and on piperidone nitrogen (five- or six-membered, 2- or 3- or 3,4-disubstituted, isoindoline nitroxides) were varied. The anticancer efficacy of the new DAP compounds was tested by measuring their cytotoxicity to cancer cell lines A2780 (human epithelial ovarian cancer cell line) and MCF-7 (human breast cancer cell line) and to H9c2, a noncancerous (healthy) cardiac cell line. The results showed that all DAP compounds induced a significant loss of cell viability in both the human cancer cell lines tested, however only pyrroline appended nitroxides (5c,1 5e, 7, 9) showed limited toxicity toward noncancerous cell lines. Computer docking simulations support the biological activity tested. These results suggest that antioxidant-conjugated DAPs will be useful as a safe and effective anticancer agent for cancer therapy

Apparatus for Converting Direct Current to Alternating Current using Multiple Converters

An inverter for converting an input direct current (DC) waveform from a DC source to an output alternating current (AC) waveform for delivery to an AC grid includes an input converter, an output converter, and an active filter, each of which is electrically coupled to a bus. The bus may be a DC bus or an AC bus. The input converter is configured to convert the input DC waveform to a DC or AC bus waveform. The output converter is configured to convert the bus waveform to the output AC waveform at a grid frequency. The active filter is configured to reduce a double-frequency ripple power of the bus waveform by supplying power to and absorbing power from the power bus

Apparatus and Method for Controlling DC-AC Power Conversion

An apparatus and method for controlling the delivery of power from a DC source to an AC grid includes an inverter configured to deliver power from the unipolar input source to the AC grid and an inverter controller. The inverter includes an input converter, an active filter, and an output converter. The inverter controller includes an input converter controller, an active filter controller and an output converter controller. The input converter controller is configured to control a current delivered by the input converter to a galvanically isolated unipolar bus of the inverter. The output converter is configured to control the output converter to deliver power to the AC grid. Additionally, the active filter controller is configured to control the active filter to supply substantially all the power that is deliver by the output controller to the AC grid at a grid frequency

Apparatus for Converting Direct Current to Alternating Current using Multiple Converters

An inverter for converting an input direct current (DC) waveform from a DC source to an output alternating current (AC) waveform for delivery to an AC grid includes an input converter, an output converter, and an active filter, each of which is electrically coupled to a bus. The bus may be a DC bus or an AC bus. The input converter is configured to convert the input DC waveform to a DC or AC bus waveform. The output converter is configured to convert the bus waveform to the output AC waveform at a grid frequency. The active filter is configured to reduce a double-frequency ripple power of the bus waveform by supplying power to and absorbing power from the power bus

Genome-wide association study to identify potential genetic modifiers in a canine model for Duchenne muscular dystrophy

BACKGROUND: Duchenne muscular dystrophy (DMD) causes progressive muscle degeneration, cardiomyopathy and respiratory failure in approximately 1/5,000 boys. Golden Retriever muscular dystrophy (GRMD) resembles DMD both clinically and pathologically. Like DMD, GRMD exhibits remarkable phenotypic variation among affected dogs, suggesting the influence of modifiers. Understanding the role(s) of genetic modifiers of GRMD may identify genes and pathways that also modify phenotypes in DMD and reveal novel therapies. Therefore, our objective in this study was to identify genetic modifiers that affect discrete GRMD phenotypes. RESULTS: We performed a linear mixed-model (LMM) analysis using 16 variably-affected dogs from our GRMD colony (8 dystrophic, 8 non-dystrophic). All of these dogs were either full or half-siblings, and phenotyped for 19 objective, quantitative biomarkers at ages 6 and 12 months. Each biomarker was individually assessed. Gene expression profiles of 59 possible candidate genes were generated for two muscle types: the cranial tibialis and medial head of the gastrocnemius. SNPs significantly associated with GRMD biomarkers were identified on multiple chromosomes (including the X chromosome). Gene expression levels for candidate genes located near these SNPs correlated with biomarker values, suggesting possible roles as GRMD modifiers. CONCLUSIONS: The results of this study enhance our understanding of GRMD pathology and represent a first step toward the characterization of GRMD modifiers that may be relevant to DMD pathology. Such modifiers are likely to be useful for DMD treatment development based on their relationships to GRMD phenotypes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-016-2948-z) contains supplementary material, which is available to authorized users

UBVRI Light Curves of 44 Type Ia Supernovae

We present UBVRI photometry of 44 type-Ia supernovae (SN Ia) observed from 1997 to 2001 as part of a continuing monitoring campaign at the Fred Lawrence Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics. The data set comprises 2190 observations and is the largest homogeneously observed and reduced sample of SN Ia to date, nearly doubling the number of well-observed, nearby SN Ia with published multicolor CCD light curves. The large sample of U-band photometry is a unique addition, with important connections to SN Ia observed at high redshift. The decline rate of SN Ia U-band light curves correlates well with the decline rate in other bands, as does the U-B color at maximum light. However, the U-band peak magnitudes show an increased dispersion relative to other bands even after accounting for extinction and decline rate, amounting to an additional ~40% intrinsic scatter compared to B-band.Comment: 84 authors, 71 pages, 51 tables, 10 figures. Accepted for publication in the Astronomical Journal. Version with high-res figures and electronic data at http://astron.berkeley.edu/~saurabh/cfa2snIa

An Infrared Census of Star Formation in the Horsehead Nebula

At ~ 400 pc, the Horsehead Nebula (B33) is the closest radiatively-sculpted pillar to the Sun, but the state and extent of star formation in this structure is not well understood. We present deep near-infrared (IRSF/SIRIUS JHKs) and mid-infrared (Spitzer/IRAC) observations of the Horsehead Nebula in order to characterize the star forming properties of this region and to assess the likelihood of triggered star formation. Infrared color-color and color-magnitude diagrams are used to identify young stars based on infrared excess emission and positions to the right of the Zero-Age Main Sequence, respectively. Of the 45 sources detected at both near- and mid-infrared wavelengths, three bona fide and five candidate young stars are identified in this 7' by 7' region. Two bona fide young stars have flat infrared SEDs and are located at the western irradiated tip of the pillar. The spatial coincidence of the protostars at the leading edge of this elephant trunk is consistent with the Radiation-Driven Implosion (RDI) model of triggered star formation. There is no evidence, however, for sequential star formation within the immediate ~ 1.5' (0.17 pc) region from the cloud/H II region interface.Comment: 30 pages, 11 figures; accepted for publication in The Astronomical Journa

Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed a vast coordinated hypomethylation and overexpression effects in IFN-related genes, what is known as the IFN signature. Stratified and conditional analyses suggest a strong interaction between SS-associated HLA genetic variation and the presence of Anti-Ro/SSA autoantibodies in driving the IFN epigenetic signature and determining SS. We report a novel epigenetic signature characterized by increased DNA methylation levels in a large number of genes enriched in pathways such as collagen metabolism and extracellular matrix organization. We identified potential new genetic variants associated with SS that might mediate their risk by altering DNA methylation or gene expression patterns, as well as disease-interacting genetic variants that exhibit regulatory function only in the SS population. Our study sheds new light on the interaction between genetics, autoantibody profiles, DNA methylation and gene expression in SS, and contributes to elucidate the genetic architecture of gene regulation in an autoimmune population