235 research outputs found
Cross-correlating Carbon Monoxide Line-intensity Maps with Spectroscopic and Photometric Galaxy Surveys
Line-intensity mapping (LIM or IM) is an emerging field of observational
work, with strong potential to fit into a larger effort to probe large-scale
structure and small-scale astrophysical phenomena using multiple complementary
tracers. Taking full advantage of such complementarity means, in part,
undertaking line-intensity surveys with galaxy surveys in mind. We consider the
potential for detection of a cross-correlation signal between COMAP and blind
surveys based on photometric redshifts (as in COSMOS) or based on spectroscopic
data (as with the HETDEX survey of Lyman- emitters). We find that
obtaining accuracy in redshifts and
sources per Mpc with spectroscopic redshift determination
should enable a CO-galaxy cross spectrum detection significance at least twice
that of the CO auto spectrum. Either a future targeted spectroscopic survey or
a blind survey like HETDEX may be able to meet both of these requirements.Comment: 19 pages + appendix (31 pages total), 16 figures, 6 tables; accepted
for publication in Ap
CCAT-prime: Science with an Ultra-widefield Submillimeter Observatory at Cerro Chajnantor
We present the detailed science case, and brief descriptions of the telescope
design, site, and first light instrument plans for a new ultra-wide field
submillimeter observatory, CCAT-prime, that we are constructing at a 5600 m
elevation site on Cerro Chajnantor in northern Chile. Our science goals are to
study star and galaxy formation from the epoch of reionization to the present,
investigate the growth of structure in the Universe, improve the precision of
B-mode CMB measurements, and investigate the interstellar medium and star
formation in the Galaxy and nearby galaxies through spectroscopic,
polarimetric, and broadband surveys at wavelengths from 200 um to 2 mm. These
goals are realized with our two first light instruments, a large field-of-view
(FoV) bolometer-based imager called Prime-Cam (that has both camera and an
imaging spectrometer modules), and a multi-beam submillimeter heterodyne
spectrometer, CHAI. CCAT-prime will have very high surface accuracy and very
low system emissivity, so that combined with its wide FoV at the unsurpassed
CCAT site our telescope/instrumentation combination is ideally suited to pursue
this science. The CCAT-prime telescope is being designed and built by Vertex
Antennentechnik GmbH. We expect to achieve first light in the spring of 2021.Comment: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared
Detectors and Instrumentation for Astronomy IX, June 14th, 201
The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease
Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson’s disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ventral tegmental area. However, the relative importance of these subtypes for functional repair of the brain affected by Parkinson’s disease has not been studied thoroughly. Here, we report results from a series of grafting experiments where the anatomical and functional properties of grafts either selectively lacking in A9 neurons, or with a typical A9/A10 composition were compared. The results show that the A9 component of intrastriatal grafts is of critical importance for recovery in tests on motor performance, in a rodent model of Parkinson’s disease. Analysis at the histological level indicates that this is likely to be due to the unique ability of A9 neurons to innervate and functionally activate their target structure, the dorsolateral region of the host striatum. The findings highlight dopamine neuronal subtype composition as a potentially important parameter to monitor in order to understand the variable nature of functional outcome better in transplantation studies. Furthermore, the results have interesting implications for current efforts in this field to generate well-characterized and standardized preparations of transplantable dopamine neuronal progenitors from stem cells
Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review
Fine particulate air pollution <2.5 μm in diameter (PM(2.5)) is a major environmental threat to global public health. Multiple national and international medical and governmental organizations have recognized PM(2.5) as a risk factor for cardiopulmonary diseases. A growing body of evidence indicates that several personal-level approaches that reduce exposures to PM(2.5) can lead to improvements in health endpoints. Novel and forward-thinking strategies including randomized clinical trials are important to validate key aspects (e.g., feasibility, efficacy, health benefits, risks, burden, costs) of the various protective interventions, in particular among real-world susceptible and vulnerable populations. This paper summarizes the discussions and conclusions from an expert workshop, Reducing the Cardiopulmonary Impact of Particulate Matter Air Pollution in High Risk Populations, held on May 29 to 30, 2019, and convened by the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Centers for Disease Control and Prevention
COMAP Early Science: VIII. A Joint Stacking Analysis with eBOSS Quasars
We present a new upper limit on the cosmic molecular gas density at z = 2.4 − 3.4 obtained using the first year of observations from the CO Mapping Array Project (COMAP). COMAP data cubes are stacked on the 3D positions of 243 quasars selected from the Extended Baryon Oscillation SpectroscopicSurvey (eBOSS) catalog, yielding a 95% upper limit for flux from CO(1-0) line emission of 0.129 Jykm/s. Depending on the balance of the emission between the quasar host and its environment, this value can be interpreted as an average CO line luminosity L′CO of eBOSS quasars of ≤ 1.26 × 1011 K km pc2s−1, or an average molecular gas density ρH2 in regions of the universe containing a quasar of ≤ 1.52 × 108 M⊙ cMpc−3. The L′ CO upper limit falls among CO line luminosities obtained fromindividually-targeted quasars in the COMAP redshift range, and the ρH2 value is comparable to upper limits obtained from other Line Intensity Mapping (LIM) surveys and their joint analyses. Further, we forecast the values obtainable with the COMAP/eBOSS stack after the full 5-year COMAP Pathfinder survey. We predict that a detection is probable with this method, depending on the CO properties of the quasar sample. Based on the achieved sensitivity, we believe that this technique of stacking LIM data on the positions of traditional galaxy or quasar catalogs is extremely promising, both asa technique for investigating large galaxy catalogs efficiently at high redshift and as a technique for bolstering the sensitivity of LIM experiments, even with a fraction of their total expected survey data
COMAP Early Science: VIII. A Joint Stacking Analysis with eBOSS Quasars
We present a new upper limit on the cosmic molecular gas density at
obtained using the first year of observations from the CO Mapping
Array Project (COMAP). COMAP data cubes are stacked on the 3D positions of 282
quasars selected from the Extended Baryon Oscillation Spectroscopic Survey
(eBOSS) catalog, yielding a 95% upper limit for flux from CO(1-0) line emission
of 0.210 Jy km/s. Depending on the assumptions made, this value can be
interpreted as either an average CO line luminosity of eBOSS
quasars of K km pc s, or an average
molecular gas density in regions of the universe containing
a quasar of M cMpc. The
upper limit falls among CO line luminosities obtained from
individually-targeted quasars in the COMAP redshift range, and the
value is comparable to upper limits obtained from other
Line Intensity Mapping (LIM) surveys and their joint analyses. Further, we
forecast the values obtainable with the COMAP/eBOSS stack after the full 5-year
COMAP Pathfinder survey. We predict that a detection is probable with this
method, depending on the CO properties of the quasar sample. Based on these
achieved sensitivities, we believe that this technique of stacking LIM data on
the positions of traditional galaxy or quasar catalogs is extremely promising,
both as a technique for investigating large galaxy catalogs efficiently at high
redshift and as a technique for bolstering the sensitivity of LIM experiments,
even with a fraction of their total expected survey data.Comment: 15 pages, 8 figures. To be submitted to Ap
COMAP Early Science: III. CO Data Processing
We describe the first season COMAP analysis pipeline that converts raw
detector readouts to calibrated sky maps. This pipeline implements four main
steps: gain calibration, filtering, data selection, and map-making. Absolute
gain calibration relies on a combination of instrumental and astrophysical
sources, while relative gain calibration exploits real-time total-power
variations. High efficiency filtering is achieved through spectroscopic
common-mode rejection within and across receivers, resulting in nearly
uncorrelated white noise within single-frequency channels. Consequently,
near-optimal but biased maps are produced by binning the filtered time stream
into pixelized maps; the corresponding signal bias transfer function is
estimated through simulations. Data selection is performed automatically
through a series of goodness-of-fit statistics, including and
multi-scale correlation tests. Applying this pipeline to the first-season COMAP
data, we produce a dataset with very low levels of correlated noise. We find
that one of our two scanning strategies (the Lissajous type) is sensitive to
residual instrumental systematics. As a result, we no longer use this type of
scan and exclude data taken this way from our Season 1 power spectrum
estimates. We perform a careful analysis of our data processing and observing
efficiencies and take account of planned improvements to estimate our future
performance. Power spectrum results derived from the first-season COMAP maps
are presented and discussed in companion papers.Comment: Paper 3 of 7 in series. 26 pages, 23 figures, submitted to Ap
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