Prospecting in late-type dwarfs: A calibration of infrared and visible spectroscopic metallicities of late K and M dwarfs spanning 1.5 dex

Knowledge of late K and M dwarf metallicities can be used to guide planet searches and constrain planet formation models. However, the determination of metallicities of late-type stars is difficult because visible wavelength spectra of their cool atmospheres contain many overlapping absorption lines, preventing the measurement of equivalent widths. We present new methods, and improved calibrations of existing methods, to determine metallicities of late K and M dwarfs from moderate resolution (1300 -0.5, but are less useful for more metal-poor stars

Universality of the Lyapunov regime for the Loschmidt echo

The Loschmidt echo (LE) is a magnitude that measures the sensitivity of quantum dynamics to perturbations in the Hamiltonian. For a certain regime of the parameters, the LE decays exponentially with a rate given by the Lyapunov exponent of the underlying classically chaotic system. We develop a semiclassical theory, supported by numerical results in a Lorentz gas model, which allows us to establish and characterize the universality of this Lyapunov regime. In particular, the universality is evidenced by the semiclassical limit of the Fermi wavelength going to zero, the behavior for times longer than Ehrenfest time, the insensitivity with respect to the form of the perturbation and the behavior of individual (non-averaged) initial conditions. Finally, by elaborating a semiclassical approximation to the Wigner function, we are able to distinguish between classical and quantum origin for the different terms of the LE. This approach renders an understanding for the persistence of the Lyapunov regime after the Ehrenfest time, as well as a reinterpretation of our results in terms of the quantum--classical transition.Comment: 33 pages, 17 figures, uses Revtex

Effects of genotype on the response of Populus tremuloides michx. To ozone and nitrogen deposition

Elevated O 3 concentrations and N deposition levels co -occur in much of eastern United States. However, very little is known about their combined effects on tree growth. The effects of three O 3 treatments: charcoal-filtered air, non-filtered air and O 3 , added at the rate of 80 ppb for 6 hr d −1 3 d per week), four N deposition levels (0, 10, 20 and 40 kg ha −1 yr −1 ), and their interactions on growth of two Populus tremuloides clones in open-top chambers at two sites 600 km apart in Michigan were examined. Our results revealed a highly significant fertilization effect of the N treatments, even at the 10 kg ha −1 yr −1 rate. Ozone alone induced foliar injury, but not significant growth reductions. There was an indication that O 3 decreased growth at the O N level, but this decrease was reversed in all N treatments by the N fertilization effect. Further study is needed to more fully understand the combined effects of N deposition and O 3 .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43906/1/11270_2004_Article_BF00480254.pd

The TESS-Keck Survey. II. An Ultra-Short-Period Rocky Planet And Its Siblings Transiting The Galactic Thick-Disk Star TOI-561

We report the discovery of TOI-561, a multiplanet system in the galactic thick disk that contains a rocky, ultra-short-period planet. This bright (V = 10.2) star hosts three small transiting planets identified in photometry from the NASA TESS mission: TOI-561 b (TOI-561.02, P = 0.44 days, Rp = 1.45 ± 0.11 R⊕), c (TOI-561.01, P = 10.8 days, Rp = 2.90 ± 0.13 R⊕), and d (TOI-561.03, P = 16.3 days, Rp = 2.32 ± 0.16 R⊕). The star is chemically ([Fe/H] = −0.41 ± 0.05, [α/Fe] = +0.23 ± 0.05) and kinematically consistent with the galactic thick-disk population, making TOI-561 one of the oldest (10 ± 3 Gyr) and most metal-poor planetary systems discovered yet. We dynamically confirm planets b and c with radial velocities from the W. M. Keck Observatory High Resolution Echelle Spectrometer. Planet b has a mass and density of 3.2 ± 0.8 M⊕ and ${5.5}_{-1.6}^{+2.0}$g cm−3, consistent with a rocky composition. Its lower-than-average density is consistent with an iron-poor composition, although an Earth-like iron-to-silicates ratio is not ruled out. Planet c is 7.0 ± 2.3 M⊕ and 1.6 ± 0.6 g cm−3, consistent with an interior rocky core overlaid with a low-mass volatile envelope. Several attributes of the photometry for planet d (which we did not detect dynamically) complicate the analysis, but we vet the planet with high-contrast imaging, ground-based photometric follow-up, and radial velocities. TOI-561 b is the first rocky world around a galactic thick-disk star confirmed with radial velocities and one of the best rocky planets for thermal emission studies

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Introduction: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods: We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement. Results: The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive as

Cerium neodymium oxide solid solution synthesis as a potential analogue for substoichiometric AmO 2 for radioisotope power systems

The European Space Agency (ESA) is sponsoring a research programme on the development of americium oxides for radioisotope generators and heater units. Cubic AmO2-(x/2) with an O/Am ratio between 1.65 and 1.75 is a potentially suitable compound for pellet sintering. C-type (Ia-3) Ce1-xNdxO2-(x/2) oxides with 0.5 &lt; x &lt; 0.7 could be used as a surrogate for some Ia-3 AmO2-(x/2). A new Ce1-xNdxO2-(x/2) production process has been investigated where a nominally selected x value of 0.6 was targeted: Ce and Nd nitrates and oxalic acid were added drop-wise into a vessel, where they continuously reacted to create oxalate precipitates. The effect of temperature (25 °C, 60 °C) of the reactants (mixed at 250 revolutions per minute) on oxalate particle shape and size were investigated. Oxalates were calcined at 900 °C to produce oxide particles. Oxalate particle properties were characterised as these are expected to influence oxides particle properties and fuel pellet sintering.</p

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

The TESS-Keck survey. II. An ultra-short-period rocky planet and its siblings transiting the galactic thick-disk star TOI-561

We report the discovery of TOI-561, a multiplanet system in the galactic thick disk that contains a rocky, ultrashort- period planet. This bright (V = 10.2) star hosts three small transiting planets identified in photometry from the NASA TESS mission: TOI-561 b (TOI-561.02, P = 0.44 days, Rp = 1.45 ± 0.11 R⊕), c (TOI-561.01, P = 10.8 days, Rp = 2.90 ± 0.13 R⊕), and d (TOI-561.03, P = 16.3 days, Rp = 2.32 ± 0.16 R⊕). The star is chemically ([Fe/ H] = -0.41 ± 0.05, [a/Fe]=+0.23 ± 0.05) and kinematically consistent with the galactic thick-disk population, making TOI-561 one of the oldest (10 ± 3 Gyr) and most metal-poor planetary systems discovered yet. We dynamically confirm planets b and c with radial velocities from the W. M. Keck Observatory High Resolution Echelle Spectrometer. Planet b has a mass and density of 3.2 ± 0.8M⊕ and 5.5+2.0-1.6g cm-3, consistent with a rocky composition. Its lower-than-average density is consistent with an iron-poor composition, although an Earth-like iron-to-silicates ratio is not ruled out. Planet c is 7.0 ± 2.3M⊕ and 1.6 ± 0.6 g cm-3, consistent with an interior rocky core overlaid with a low-mass volatile envelope. Several attributes of the photometry for planet d (which we did not detect dynamically) complicate the analysis, but we vet the planet with high-contrast imaging, groundbased photometric follow-up, and radial velocities. TOI-561 b is the first rocky world around a galactic thick-disk star confirmed with radial velocities and one of the best rocky planets for thermal emission studies