578 research outputs found
Revenue Sharing in European Football: An Assessment of the Bundesliga’s New Four-Pillar Model
This thesis assesses the Bundesliga’s recently introduced TV revenue sharing system. Despite the prominent literature dis-cussing the relationship between revenue sharing in team sports and competitive balance, evaluations of specific distribution systems are limited. Hence, very little is known about the repercussions of different allocation keys on leagues and clubs. Contributing to the sports economics literature, this thesis examines the key decision factors that influence the effectiveness of revenue sharing systems, and analyses the feasibility of the Bundesliga’s reformed system.It starts with defining the new system, before introducing its background and a brief history of revenue sharing in the Bundesliga. Then this thesis sketches the most important concepts in sports economics, i.e. competitive balance and demand, before pointing out interdependencies between them. Afterwards, revenue sharing is introduced as a means to enhance competitive balance, including a brief description of alternative mechanisms. To compare the new model externally, revenue sharing models of other major sports leagues are presented. Finally, it evaluates the Bundesliga’s current situation in order to comprehend the league’s potential objectives. The thesis discusses possibilities on how revenue sharing can help the Bundesliga achieve those objectives, and ultimately assesses the new system’s feasibility in doing so. After modelling the league’s potential reaction to different revenue sharing models, its result is that the four-pillar model features several useful mechanisms, but does not give sufficient weight to them. The thesis’ assessment consequently is that the reformed system can be generally seen as positive, with room for further enhancements. It concludes with some starting points for potential future improvements, namely (1) increasing the equally-distributed share, (2) scaling up the new pillars’ relative importance and mitigating the danger of an overdominant team, and (3) implementing a top-to-bottom maximum payout cap.Keywords: TV Revenue Sharing, Four-Pillar Model, Bundesliga, Football, Soccer, DF
Comparative phyloinformatics of virus genes at micro and macro levels in a distributed computing environment
<p>Abstract</p> <p>Background</p> <p>Preparedness for a possible global pandemic caused by viruses such as the highly pathogenic influenza A subtype H5N1 has become a global priority. In particular, it is critical to monitor the appearance of any new emerging subtypes. Comparative phyloinformatics can be used to monitor, analyze, and possibly predict the evolution of viruses. However, in order to utilize the full functionality of available analysis packages for large-scale phyloinformatics studies, a team of computer scientists, biostatisticians and virologists is needed – a requirement which cannot be fulfilled in many cases. Furthermore, the time complexities of many algorithms involved leads to prohibitive runtimes on sequential computer platforms. This has so far hindered the use of comparative phyloinformatics as a commonly applied tool in this area.</p> <p>Results</p> <p>In this paper the graphical-oriented workflow design system called <it>Quascade </it>and its efficient usage for comparative phyloinformatics are presented. In particular, we focus on how this task can be effectively performed in a distributed computing environment. As a proof of concept, the designed workflows are used for the phylogenetic analysis of neuraminidase of H5N1 isolates (micro level) and influenza viruses (macro level). The results of this paper are hence twofold. Firstly, this paper demonstrates the usefulness of a graphical user interface system to design and execute complex distributed workflows for large-scale phyloinformatics studies of virus genes. Secondly, the analysis of neuraminidase on different levels of complexity provides valuable insights of this virus's tendency for geographical based clustering in the phylogenetic tree and also shows the importance of glycan sites in its molecular evolution.</p> <p>Conclusion</p> <p>The current study demonstrates the efficiency and utility of workflow systems providing a biologist friendly approach to complex biological dataset analysis using high performance computing. In particular, the utility of the platform Quascade for deploying distributed and parallelized versions of a variety of computationally intensive phylogenetic algorithms has been shown. Secondly, the analysis of the utilized H5N1 neuraminidase datasets at macro and micro levels has clearly indicated a pattern of spatial clustering of the H5N1 viral isolates based on geographical distribution rather than temporal or host range based clustering.</p
Prevalence of pelvic floor disorders in women with suspected gynecological malignancy: a survey-based study
Understanding of pelvic floor disorders among women with gynecological cancer is limited. The objective of this study was to describe the prevalence of pelvic floor disorders in women with suspected gynecological malignancy before surgery
Marketing madness or financial folly?: Implementing equity crowdfunding in the record industry
Purpose The purpose of this paper is to explore the implementation of equity crowdfunding (ECF) within the record industry in terms of challenges and opportunities, in addition to the marketing and financial implications for independent music artists and major record labels. Design/methodology/approach This study adopted a qualitative methodology consisting of two-stage interview-based research methods. A total of 44 semi-structured in-depth interviews were conducted with the CEOs of ECF platforms in the record industry, other related record industry informants, independent artist managers and senior executives from major record labels. Findings The loyalty aspect of ECF may have significant marketing potential in terms of inconspicuously using the equity platform as a “prosumer” identification mechanism. As this early career stage of artists is delicate in terms of establishing trust and patronage from their fans, these early marketing and ECF ventures should be implemented directly from the artist without external third-party involvement. Research limitations/implications The implications of this paper’s findings and theoretical model are not limited to the two studied stakeholder groups of the record industry. The insights in relation to the obstinate lack of understanding and clarity (particularly for independent artists) which surround ECF are likely to influence short-term strategic approaches by other players throughout the wider music industry. Practical implications The insights regarding negative approaches towards ECF by the labels may influence future “coopetition strategies” for independent labels, as they seek to navigate the changing industry dynamics. Originality/value This paper is the first study to empirically explore the predominantly under-researched area of ECF implementation in the record industry in terms of marketing and financial consequences for artists and labels. </jats:sec
How blebs and pseudopods cooperate during chemotaxis
Two motors can drive extension of the leading edge of motile cells: actin polymerization and myosin-driven contraction of the cortex, producing fluid pressure and the formation of blebs. Dictyostelium cells can move with both blebs and actin-driven pseudopods at the same time, and blebs, like pseudopods, can be orientated by chemotactic gradients. Here we ask how bleb sites are selected and how the two forms of projection cooperate. We show that membrane curvature is an important, yet overlooked, factor. Dictyostelium cells were observed moving under agarose, which efficiently induces blebbing, and the dynamics of membrane deformations were analyzed. Blebs preferentially originate from negatively curved regions, generated on the flanks of either extending pseudopods or blebs themselves. This is true of cells at different developmental stages, chemotaxing to either folate or cyclic AMP and moving with both blebs and pseudopods or with blebs only. A physical model of blebbing suggests that detachment of the cell membrane is facilitated in concave areas of the cell, where membrane tension produces an outward directed force, as opposed to pulling inward in convex regions. Our findings assign a role to membrane tension in spatially coupling blebs and pseudopods, thus contributing to clustering protrusions to the cell front
3D time series analysis of cell shape using Laplacian approaches
Background:
Fundamental cellular processes such as cell movement, division or food uptake critically depend on cells being able to change shape. Fast acquisition of three-dimensional image time series has now become possible, but we lack efficient tools for analysing shape deformations in order to understand the real three-dimensional nature of shape changes.
Results:
We present a framework for 3D+time cell shape analysis. The main contribution is three-fold: First, we develop a fast, automatic random walker method for cell segmentation. Second, a novel topology fixing method is proposed to fix segmented binary volumes without spherical topology. Third, we show that algorithms used for each individual step of the analysis pipeline (cell segmentation, topology fixing, spherical parameterization, and shape representation) are closely related to the Laplacian operator. The framework is applied to the shape analysis of neutrophil cells.
Conclusions:
The method we propose for cell segmentation is faster than the traditional random walker method or the level set method, and performs better on 3D time-series of neutrophil cells, which are comparatively noisy as stacks have to be acquired fast enough to account for cell motion. Our method for topology fixing outperforms the tools provided by SPHARM-MAT and SPHARM-PDM in terms of their successful fixing rates. The different tasks in the presented pipeline for 3D+time shape analysis of cells can be solved using Laplacian approaches, opening the possibility of eventually combining individual steps in order to speed up computations
Bistability in the actin cortex
Multi-color fluorescence imaging experiments of wave forming Dictyostelium cells have revealed that actin waves separate two domains of the cell cortex that differ in their actin structure and phosphoinositide composition. We propose a bistable model of actin dynamics to account for these experimental observation. The model is based on the simplifying assumption that the actin cytoskeleton is composed of two distinct network types, a dendritic and a bundled network. The two structurally different states that were observed in experiments correspond to the stable fixed points in the bistable regime of this model. Each fixed point is dominated by one of the two network types. The experimentally observed actin waves can be considered as trigger waves that propagate transitions between the two stable fixed points
Self-organizing actin waves that simulate phagocytic cup structures
This report deals with actin waves that are spontaneously generated on the planar, substrate-attached surface of Dictyostelium cells. These waves have the following characteristics. (1) They are circular structures of varying shape, capable of changing the direction of propagation. (2) The waves propagate by treadmilling with a recovery of actin incorporation after photobleaching of less than 10 seconds. (3) The waves are associated with actin-binding proteins in an ordered 3-dimensional organization: with myosin-IB at the front and close to the membrane, the Arp2/3 complex throughout the wave, and coronin at the cytoplasmic face and back of the wave. Coronin is a marker of disassembling actin structures. (4) The waves separate two areas of the cell cortex that differ in actin structure and phosphoinositide composition of the membrane. The waves arise at the border of membrane areas rich in phosphatidylinositol (3,4,5) trisphosphate (PIP3). The inhibition of PIP3 synthesis reversibly inhibits wave formation. (5) The actin wave and PIP3 patterns resemble 2-dimensional projections of phagocytic cups, suggesting that they are involved in the scanning of surfaces for particles to be taken up
No modern Irrawaddy River until the late Miocene-Pliocene
The deposits of large Asian rivers with unique drainage geometries have attracted considerable attention due to their explanatory power concerning tectonism, surface uplift and upstream drainage evolution. This study presents the first petrographic, heavy mineral, Nd and Sr isotope geochemistry, and detrital zircon geochronology results from the Holocene Irrawaddy megadelta alongside modern and ancient sedimentary provenance datasets to assess the late Neogene evolution of the Irrawaddy River. Contrary to models advocating a steady post-middle Miocene river, we reveal an evolution of the Irrawaddy River more compatible with regional evidence for kinematic reorganization in Myanmar during late-stage India-Asia collision. Quaternary sediments are remarkably consistent in terms of provenance but highlight significant decoupling amongst fine and coarse fraction 87Sr/86Sr and εNd due to hydraulic sorting. Only well after the late Miocene do petrographic, heavy mineral, isotope geochemistry, and detrital zircon U–Pb results from the trunk Irrawaddy and its tributaries achieve modern-day signatures. The primary driver giving rise to the geometry and provenance signature of the modern Irrawaddy River was regional late Miocene (≤10 Ma) basin inversion coupled with uplift and cumulative displacement along the Sagaing Fault. Middle to late Miocene provenance signatures cannot be reconciled with modern river geometries, and thus require significant loss of headwaters feeding the Chindwin subbasin after ∼14 Ma and the northern Shwebo subbasin after ∼11 Ma. Large-scale reworking after ∼7 Ma is evidenced by modern Irrawaddy River provenance, by entrenchment of the nascent drainage through Plio-Pleistocene inversion structures, and in the transfer of significant sediment volumes to the Andaman Sea
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