8,259 research outputs found
Thermal rectification in asymmetric U-shaped graphene flakes
In this paper, we study the thermal rectification in asymmetric U-shaped
graphene flakes by using nonequilibrium molecular dynamics simulations. The
graphene flakes are composed by a beam and two arms. It is found that the heat
flux runs preferentially from the wide arm to the narrow arm which indicates a
strong rectification effect. The dependence of the rectification ratio upon the
heat flux, the length and the width of the beam, the length and width of the
two arms are studied. The result suggests a possible route to manage heat
dissipation in U-shaped graphene based nanoelectronic devices.Comment: 3 pages, 4 figure
Liquidity and Efficiency in Three Related Foreign Exchange Options Markets
The foreign currency market in a small open economy, like Israel, plays a major role in
fiscal and monetary policy decisions, through its effects on the financial markets and the
real economy. In this paper we explore the liquidity and efficiency in three related
foreign exchange options markets and the information content of the instruments traded
in these markets. The unique data set on OTC trading and the central bank auctions, in
addition to the exchange traded options provide us with insights about the operation of these markets, their relative efficiency, their information content and their
interrelationship. An important aspect is the effect of liquidity on the pricing of options in these markets. As expected, we find that, except for extreme cases, liquidity does not
affect options prices
Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity
The receptor tyrosine kinase Met and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas the deregulation of Met signaling is associated with tumorigenesis. While ligand-activated Met promotes survival, caspase-dependent generation of the p40 Met fragment leads to apoptosis induction â hallmark of the dependence receptor. Although the survival signaling pathways induced by Met are well described, the pro-apoptotic signaling pathways are unknown. We show that, although p40 Met contains the entire kinase domain, it accelerates apoptosis independently of kinase activity. In cell cultures undergoing apoptosis, the fragment shows a mitochondrial localization, required for p40 Met-induced cell death. Fulminant hepatic failure induced in mice leads to the generation of p40 Met localized also in the mitochondria, demonstrating caspase cleavage of Met in vivo. According to its localization, the fragment induces mitochondrial permeabilization, which is inhibited by Bak silencing and Bcl-xL overexpression. Moreover, Met silencing delays mitochondrial permeabilization induced by an apoptotic treatment. Thus, the Met-dependence receptor in addition to its well-known role in survival signaling mediated by its kinase activity, also participates in the intrinsic apoptosis pathway through the generation of p40 Met â a caspase-dependent fragment of Met implicated in the mitochondrial permeabilization process
Shock waves in ultracold Fermi (Tonks) gases
It is shown that a broad density perturbation in a Fermi (Tonks) cloud takes
a shock wave form in the course of time evolution. A very accurate analytical
description of shock formation is provided. A simple experimental setup for the
observation of shocks is discussed.Comment: approx. 4 pages&figures, minor corrections^2, to be published as a
Letter in Journal of Physics
Heat conduction in graphene flakes with inhomogeneous mass interface
Using nonequilibrium molecular dynamics simulations, we study the heat
conduction in graphene flakes composed by two regions. One region is
mass-loaded and the other one is intact. It is found that the mass interface
between the two regions greatly decreases the thermal conductivity, but it
would not bring thermal rectification effect. The dependence of thermal
conductivity upon the heat flux and the mass difference ratio are studied to
confirm the generality of the result. The interfacial scattering of solitons is
studied to explain the absence of rectification effect.Comment: 5 pages, 4 figure
Genes for extracellular matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development
Extracellular matrix (ECM) remodeling accompanies cell migration, cell-cell interactions, embryo expansion, uterine implantation, and tissue invasion during mammalian embryogenesis. We have found that mouse embryos secrete functional ECM-degrading metalloproteinases, including collagenase and stromelysin, that are inhibitable by the tissue inhibitor of metalloproteinases (TIMP) and that are regulated during peri-implantation development and endoderm differentiation. mRNA transcripts for collagenase, stromelysin, and TIMP were detected as maternal transcripts in the unfertilized egg, were present at the zygote and cleavage stages, and increased at the blastocyst stage and with endoderm differentiation. These data suggest that metalloproteinases function in cell-ECM interactions during growth, development, and implantation of mammalian embryos
Idea-caution before exploitation:the use of cybersecurity domain knowledge to educate software engineers against software vulnerabilities
The transfer of cybersecurity domain knowledge from security experts (âEthical Hackersâ) to software engineers is discussed in terms of desirability and feasibility. Possible mechanisms for the transfer are critically examined. Software engineering methodologies do not make use of security domain knowledge in its form of vulnerability databases (e.g. CWE, CVE, Exploit DB), which are therefore not appropriate for this purpose. An approach based upon the improved use of pattern languages that encompasses security domain knowledge is proposed
Finite Element Methods for Elliptic Distributed Optimal Control Problems with Pointwise State Constraints
Finite element methods for a model elliptic distributed optimal control
problem with pointwise state constraints are considered from the perspective of
fourth order boundary value problems
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