429 research outputs found
Utvecklingssamtal, en viktig del av den moderna undervisningen
En viktig del av skolans återkoppling till elever och vårdnadshavare sker genom obligatoriska
utvecklingssamtal. Då detta inte ingått i de obligatoriska kursmomenten har vi valt att fördjupa oss i
ämnet genom detta examensarbete. Vi anser att utvecklingssamtalet är en viktig del av läroprocessen både
för lärare och elever. Vi ville därför titta närmare på det eftersom det kommer att ingå i våra
arbetsuppgifter inom kort. Att utföra ett samtal på rätt sätt kan medföra stora vinster för den enskilde
eleven, detta bör tas på allvar. Ett illa genomfört samtal kan samtidigt medföra onödiga förluster och i
värsta fall leda till fördröjd inlärning. Vi har i detta arbete gjort kvalitativa intervjuer av lärare vi lärt
känna under vår studietid i syfte att få en djupare förståelse om utvecklingssamtalet. De frågeställningar
som vi har arbetat med är: Vad kännetecknar ett bra utvecklingssamtal? Hur användes det verbala och det
icke-verbala språket i samtalet på ett bra sätt? På vilket sätt spelar personliga relationer och
förtroende/tillit en stor roll? Intervjuerna spelades in och materialet transkriberades för att sedan
analyseras. Resultatet i detta examensarbete har vi redovisat under rubriker från vår intervjuguide. En
fråga som alla lärarna var eniga om var att utvecklingssamtalets syfte är att belysa var eleven ligger i sin
utveckling och hur eleven skall utvecklas. Att alla dessutom är överens om att det är viktigt och det leder
framåt stärker vår tro om att vi har valt ett betydelsefullt uppsatsämne. Vårt examensarbete har gett oss
insikter och värdefulla tankar när vi själva skall ha utvecklingssamtal i framtiden och vi bedömer att vi
kommit närmare vår ambition att kunna utföra ett bra samtal
Bridging Time Scales in Cellular Decision Making with a Stochastic Bistable Switch
Cellular transformations which involve a significant phenotypical change of
the cell's state use bistable biochemical switches as underlying decision
systems. In this work, we aim at linking cellular decisions taking place on a
time scale of years to decades with the biochemical dynamics in signal
transduction and gene regulation, occuring on a time scale of minutes to hours.
We show that a stochastic bistable switch forms a viable biochemical mechanism
to implement decision processes on long time scales. As a case study, the
mechanism is applied to model the initiation of follicle growth in mammalian
ovaries, where the physiological time scale of follicle pool depletion is on
the order of the organism's lifespan. We construct a simple mathematical model
for this process based on experimental evidence for the involved genetic
mechanisms. Despite the underlying stochasticity, the proposed mechanism turns
out to yield reliable behavior in large populations of cells subject to the
considered decision process. Our model explains how the physiological time
constant may emerge from the intrinsic stochasticity of the underlying gene
regulatory network. Apart from ovarian follicles, the proposed mechanism may
also be of relevance for other physiological systems where cells take binary
decisions over a long time scale.Comment: 14 pages, 4 figure
Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.
The ovaries of children with abdominal tumours were studied in 12 autopsy specimens. Ovaries from 25 children who died in accidents or after a short acute disease served as controls. All ovaries from normal children showed follicle growth, but follicle development was inhibited in 67% of the children with abdominal tumours. The effect of treatment with cytotoxic drugs and/or abdominal irradiation on ovarian morphology was investigated. Normal ovaries were found only in children who had received no chemotherapy or a short course. All patients who had been treated with radiation therapy either alone or in conjunction with chemotherapy had severely damaged ovaries: follicle growth was inhibited in all cases, and the number of small non-growing follicles was markedly reduced in most. It is argued that abdominal irradiation might impair follicle development as well as destroy small follicles
Integrating the Numerical Pain Rating Scale (NPRS) with an Eye Tracker: Feasibility and Initial Validation
This chapter details the integration of a Numerical Rating Scale (NPRSETI) with a portable eye tracker, enabling the assessment of pain in conditions in which verbal communication and use of hands are limited (e.g., advanced Amyotrophic lateral sclerosis, ALS). After detailing the construction of the NPRSETI, we describe its validation in an outpatient pain clinic. More specifically, thirty chronic pain patients performed the NPRSETI and filled a conventional NPRS (order was pseudo-randomized). Eye movements, including gaze direction and additional eye movement measures (e.g., saccade rate), were recorded, while participants rated their pain using the NPRSETI. The study’s findings indicated no significant differences in pain severity ratings of the NPRSETI and conventional NPRS. Notably, ratings using the two scales were highly correlated (r = 0.99). NPRSETI’s ratings were also strongly associated with participants’ currently experienced pain rating using the Brief Pain Inventory (BPI). The findings provide initial proof of concept for integrating conventional pain rating scales with an eye tracker and validate the NPRSETI compared with the well-validated and commonly used NPRS. Enhanced usability and decreasing costs of eye trackers will ease the additional research mandated to validate these preliminary findings and hopefully advance their integration into clinical practice
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