Rates for the reactions antiproton-proton --> pi phi and gamma phi

We study antiproton-proton annihilation at rest into $\pi\phi$ and $\gamma\phi$. Rescattering by $\overline{K^*}K+K^*\overline{K}$ and $\rho^{+}\rho^{-}$ for $\overline{p}p\rightarrow\pi\phi$ states is sizable, of order $(0.90\, {\rm to}\,2.6)\times 10^{-4}$ in the branching ratio, but smaller than experiment. For $\overline{p}p\rightarrow\gamma\phi$ the rescattering contributions are negligible, but the $\gamma\phi$ channel is well explained by a $\rho\phi$ intermediate state combined with vector meson dominance.Comment: 12 pages, plain latex, 2 postscript figures available upon request, PSI-PR-93-2

Involvement of GPR17 in neuronal fibre outgrowth

Characterization of new pharmacological targets is a promising approach in research of neurorepair mechanisms. The G protein-coupled receptor 17 (GPR17) has recently been proposed as an interesting pharmacological target, e.g., in neuroregenerative processes. Using the well-established ex vivo model of organotypic slice co-cultures of the mesocortical dopaminergic system (prefrontal cortex (PFC) and substantia nigra/ventral tegmental area (SN/VTA) complex), the influence of GPR17 ligands on neurite outgrowth from SN/VTA to the PFC was investigated. The growth-promoting effects of Montelukast (MTK; GPR17- and cysteinyl-leukotriene receptor antagonist), the glial cell line-derived neurotrophic factor (GDNF) and of two potent, selective GPR17 agonists (PSB-16484 and PSB-16282) were characterized. Treatment with MTK resulted in a significant increase in mean neurite density, comparable with the effects of GDNF. The combination of MTK and GPR17 agonist PSB-16484 significantly inhibited neuronal growth. qPCR studies revealed an MTK-induced elevated mRNA-expression of genes relevant for neuronal growth. Immunofluorescence labelling showed a marked expression of GPR17 on NG2-positive glia. Western blot and RT-qPCR analysis of untreated cultures suggest a time-dependent, injury-induced stimulation of GPR17. In conclusion, MTK was identified as a stimulator of neurite fibre outgrowth, mediating its effects through GPR17, highlighting GPR17 as an interesting therapeutic target in neuronal regeneration

A Critical Success Factor Framework for Implementing Sustainable Innovative and Affordable Housing: A Systematic Review and Bibliometric Analysis

The actualization of affordable housing remains a challenge. This challenge is exacerbated by the increasing societal demand for the incorporation of sustainability principles into such housing types to improve levels of occupant health and well-being whilst avouching the desired levels of affordability. Innovative technologies and practices have been described as beneficial to the effectuation of sustainable affordable housing. However, knowledge concerning the deployment of innovative technologies and practices in sustainable affordable housing (sustainable, innovative, affordable housing—SIAH) delivery remains nascent. Consequently, there is a lack of a common ontology among stakeholders concerning how to realize SIAH. This study aims to contribute toward the development of this body of knowledge through the establishment of the critical success factors (CSFs) for effective SIAH implementation. To achieve this objective, a systematic review and bibliometric analysis focusing on a juxtaposition of sustainable, innovative and affordable housing concepts was carried out based on the relevant literature. This led to the identification and clustering of CSFs for these housing concepts at individual levels and as a collective (SIAH). The findings of the study consisted of the establishment of four distinct yet interrelated facets through which SIAH can be achieved holistically, namely, housing design, house element, housing production method and housing technology. A total of 127 CSFs were found to be aligned to these facets, subsequently clustered, and conclusively used for the development of a SIAH CSF framework. The most frequently occurring CSFs with predominant interconnections were the utilization of energy-efficient systems/fittings, tenure security, a comfortable and healthy indoor environment, affordable housing price in relation to income and using water-efficient systems/fittings CSFs, and establishing the emergent SIAH CSF framework. The framework in this study is useful in the documentation of SIAH features for construction projects and further studies into SIAH CSFs

Multiple Auger cycle photoionisation of manganese atoms by short soft x-ray pulses

The multiple ionisation of atomic Mn, excited at (photon energy: 52.1 eV) and above (photon energy: 61.1 eV) the discrete giant 3p–3d resonance, was studied using high irradiation free-electron-laser soft x-ray pulses from the BL2 beamline of FLASH, DESY, Hamburg. In particular, the impact of the giant resonance on the ionisation mechanism was investigated. Ion mass-over-charge spectra were obtained by means of ion time-of-flight spectrometry. For the two photon energies, the yield of the different ionic charge states Mnq+ (q = 0–7) was determined as a function of the irradiance of the soft x-ray pulses. The maximum charge state observed was Mn6+ for resonant excitation at 52.1 eV and Mn7+ for non-resonant excitation at 61.1 eV at a maximum irradiation of 3×10 13Wcm−2. .DFG, 170620586, SFB 925: Licht-induzierte Dynamik und Kontrolle korrelierter QuantensystemeBMBF, 05KS7GU2, Verbundprojekt: PIPE - Photon-Ion-Spektrometer an PETRA III. Teilprojekt 2: Entwicklung und Aufbau eines flexiblen Zwei-Strahl Experiments zur Erforschung elektrisch geladener, massenselektierter und zustandspräparierter Ionen (Atome, Cluster und Nanopartikel).BMBF, 05K10GUB, Verbundprojekt PIPE - Photon-Ion-Spektrometer an PETRA III: Photoion-, Photoelektron- und Fluoreszenz-Experimente mit massenselektierten Nanoteilchen. Teilprojekt 2: Ionenfalle und Hochfeldmagnet.BMBF, 05K13GUA, Verbundprojekt 05K2013 - IONSYS: Quellen und Nachweissysteme für innovative Untersuchungen zusammengesetzter ionischer Systeme mit Photonen. Teilprojekt 2.EC/H2020/654220/EU/European Cluster of Advanced Laser Light Sources/EUCAL

Inclusive production of charged pions in p+C collisions at 158 GeV/c beam momentum

The production of charged pions in minimum bias p+C interactions is studied using a sample of 377000 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The data cover a phase space area ranging from 0 to 1.8 GeV/c in transverse momentum and from -0.1 to 0.5 in Feynman x. Inclusive invariant cross sections are given on a grid of 270 bins per charge thus offering for the first time a dense coverage of the projectile hemisphere and of the cross-over region into the target fragmentation zone.Comment: 31 pages, 30 figures, submitted to European Journal of Physic

The impacts of environmental warming on Odonata: a review

Climate change brings with it unprecedented rates of increase in environmental temperature, which will have major consequences for the earth's flora and fauna. The Odonata represent a taxon that has many strong links to this abiotic factor due to its tropical evolutionary history and adaptations to temperate climates. Temperature is known to affect odonate physiology including life-history traits such as developmental rate, phenology and seasonal regulation as well as immune function and the production of pigment for thermoregulation. A range of behaviours are likely to be affected which will, in turn, influence other parts of the aquatic ecosystem, primarily through trophic interactions. Temperature may influence changes in geographical distributions, through a shifting of species' fundamental niches, changes in the distribution of suitable habitat and variation in the dispersal ability of species. Finally, such a rapid change in the environment results in a strong selective pressure towards adaptation to cope and the inevitable loss of some populations and, potentially, species. Where data are lacking for odonates, studies on other invertebrate groups will be considered. Finally, directions for research are suggested, particularly laboratory studies that investigate underlying causes of climate-driven macroecological patterns

Water

Meta-analysis can be a powerful tool for demonstrating the applicability of a concept beyond the context of individual clinical trials and observational studies, including exploration of effects across different subgroups. Meta-analysis avoids Simpson's paradox, in which a consistent effect in constituent trials is reversed when results are simply pooled. Meta-analysis in critical care medicine is made more complicated, however, by the heterogeneous nature of critically ill patients and the contexts within which they are treated. Failure to properly adjust for this heterogeneity risks missing important subgroup effects in, for example, the interaction of treatment with varying levels of baseline risk. When subgroups are defined by characteristics that vary within constituent trials (such as age) rather than features constant within each trial (such as drug dose), there is the additional risk of incorrect conclusions due to the ecological fallacy. The present review explains these problems and the strategies by which they are overcome

Large Scale CW ECRH Systems : Some considerations

Electron Cyclotron Resonance Heating (ECRH) is a key component in the heating arsenal for the next step fusion devices like W7-X and ITER. These devices are equipped with superconducting coils and are designed to operate steady state. ECRH must thus operate in CW-mode with a large flexibility to comply with various physics demands such as plasma start-up, heating and current drive, as well as configurationand MHD - control. The request for many different sophisticated applications results in a growing complexity, which is in conflict with the request for high availability, reliability, and maintainability. ‘Advanced’ ECRH-systems must, therefore, comply with both the complex physics demands and operational robustness and reliability. The W7-X ECRH system is the first CW- facility of an ITER relevant size and is used as a test bed for advanced components. Proposals for future developments are presented together with improvements of gyrotrons, transmission components and launchers

Development of the 174 GHz collective Thomson scattering diagnostics at Wendelstein 7-X

In this paper, we present the design and commissioning results of the upgraded collective Thomson scattering diagnostic at the Wendelstein 7-X stellarator. The diagnostic has a new radiometer designed to operate between the second and third harmonics of the electron cyclotron emission from the plasma at 171–177 GHz, where the emission background has a minimum and is of order 10–100 eV. It allows us to receive the scattered electromagnetic field with a significantly improved signal-to-noise ratio and extends the set of possible scattering geometries compared to the case of the original instrument operated at 140 GHz. The elements of the diagnostic are a narrowband notch filter and a frequency stabilized probing gyrotron that will allow measuring scattered radiation spectra very close to the probing frequency. Here, we characterize the microwave components applied to the radiometer and demonstrate the performance of the complete system that was achieved during the latest experimental campaign, OP2.1