Leprosy Post-Exposure Prophylaxis (LPEP) programme: Study protocol for evaluating the feasibility and impact on case detection rates of contact tracing and single dose rifampicin

Introduction: The reported number of new leprosy patients has barely changed in recent years. Thus, additional approaches or modifications to the current standard of passive case detection are needed to interrupt leprosy transmission. Large-scale clinical trials with single dose rifampicin (SDR) given as post-exposure prophylaxis (PEP) to contacts of newly diagnosed patients with leprosy have shown a 50-60% reduction of the risk of developing leprosy over the following 2 years. To accelerate the uptake of this evidence and introduction of PEP into national leprosy programmes, data on the effectiveness, impact and feasibility of contact tracing and PE

Cross-border outbreak of Salmonella enterica ssp. enterica serovar Bovismorbificans : multiple approaches for an outbreak investigation in Germany and Switzerland

In July 2014, an outbreak of Salmonella enterica ssp. enterica serovar Bovismorbificans was detected in Switzerland. The goal of the outbreak investigation was to rapidly identify and eliminate the contamination source in order to prevent new cases.; A case-case study design was applied comprising reported cases of S. Bovismorbificans and cases of other serovars. A trawling questionnaire was administered by telephone interview. Data were collected for 34 cases (20 S. Bovismorbificans and 14 Salmonella spp.) pertaining to food consumption during the 72 hours prior to symptom onset.; A statistically significant association between an S. Bovismorbificans infection and the consumption of 'salads' (odds ratio [OR] 14.3, 95% confidence interval [CI] 1.47-138.27) as well as the consumption of 'sprouts' (OR 10.6, 95% CI 1.16-97.59) was found. Principal places of consumption of 'salads' and 'sprouts' in outbreak cases were restaurants in southern Germany (80.0%, 95% CI 56.3%-94.3%). Microbiological analysis in Germany identified S. Bovismorbificans on sprouts, and genotype analysis confirmed that Swiss and German cases shared the same outbreak strain. The contaminated products were removed from the market in Germany, preventing an on-going outbreak.; The combination of the applied methods and the collaboration between the two countries proved to be crucial elements of this investigation. A series of sprouts-associated salmonellosis outbreaks underpin the importance of this vegetable as a potential food-borne pathogen carrier

The CORALIE survey for southern extrasolar planets: XVIII. Three new massive planets and two low-mass brown dwarfs at greater than 5 AU separation

Context. Since 1998, a planet-search around main sequence stars within 50~pc in the southern hemisphere has been carried out with the CORALIE spectrograph at La Silla Observatory. Aims. With an observing time span of more than 20 years, the CORALIE survey is able to detect long term trends in data with masses and separations large enough to select ideal targets for direct imaging. Detecting these giant companion candidates will allow us to start bridging the gap between radial velocity detected exoplanets and directly imaged planets and brown dwarfs. Methods. Long-term precise Doppler measurements with the CORALIE spectrograph reveal radial velocity signatures of massive planetary companions and brown dwarfs on long-period orbits. Results. In this paper we report the discovery of new companions orbiting HD~181234, HD~13724, HD~25015, HD~92987 and HD~50499. We also report updated orbital parameters for HD~50499b, HD~92788b and HD~98649b. In addition, we confirm the recent detection of HD~92788c. The newly reported companions span a period range of 15.6 to 40.4 years and a mass domain of 2.93 to 26.77 $M_{\mathrm{Jup}}$, the latter of which straddles the nominal boundary between planets and brown dwarfs. Conclusion. We have reported the detection of five new companions and updated parameters of four known extrasolar planets. We identify at least some of these companions to be promising candidates for imaging and further characterisation

The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p

The glycerol-3-phosphate acyltransferase Sct1p/Gat2p is shown to regulate fatty acyl chain desaturation by competing with the fatty acid desaturase Ole1p for C16:0-CoA. The activity of Sct1p depends on the level of expression and the phosphorylation state. The acyltransferase Cst26p regulates the phosphorylation of Sct1p