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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal

Herméneutiques du code dans les écritures numériques d’Abrüpt : perspectives critiques pour un champ littéraire en mutation

Ce mémoire a reçu la mention « exceptionnel » de la part du jury.Ce mémoire a pour objet d’étude la maison d’édition Abrüpt, dont la variété et l’hybridité des productions interrogent les frontières de la textualité. On retrouve chez Abrüpt un ensemble hétérogène d’objets numériques et imprimés qui ne se limitent guère au codex classique : espaces web dynamiques, feuillets pliables et imprimables à la demande, installations spatiales en réalité virtuelle, robots littéraires – pour ne nommer que ceux-ci. Si de nombreux choix éditoriaux témoignent d’une continuité marquée avec la tradition imprimée, la particularité d’Abrüpt consiste à investir les potentialités créatives des technologies numériques, notamment par l’écriture du code informatique. La singularité de ce projet de maîtrise repose en partie sur l’étude de l’envers technique, laquelle donne à voir le processus de création et le fonctionnement des productions littéraires que l’on peut étudier en accès libre via des archives (« dépôts ») facilement appropriables (« clonables ») sous des conditions permissives (grâce à des « licences libres »). Nous procédons d’abord à une analyse thématique d’un ensemble de manifestes choisis parmi le catalogue de la maison d’édition, ce qui permet d’en révéler les orientations économiques, politiques et idéologiques. Nous interrogeons ensuite l’« implémentation » de telles visions du monde dans deux études de cas, « Naufrages » et « enfer.txt ». Les études critiques du code examinant les régimes « extra-fonctionnels » du code informatique situé dans son contexte sociohistorique, c’est notamment par elle que nous entendons faire émerger un surcroît de sens au texte « numériquement conditionné » et à en actualiser le discours latent. Nous intégrons à notre démarche une approche conceptuelle, en particulier au détour d’un approfondissement de la notion de « programme », et recourons à des heuristiques issues des pratiques computationnelles et de l’interprétation modélisante.The subject of this dissertation is Abrüpt, a collective publisher whose diverse and hybrid productions question the boundaries of textuality. Its wide range of digital and printed objects are far from limited to the classic codex: dynamic web spaces, leaflets that can be folded and printed on demand, virtual reality installations, literary bots—to name but a few. While many of its editorial decisions remain in line with the printed tradition, the publisher’s particularity lies in its creative use of digital technologies, in particular through the writing of computer code. This master’s project examines the technical slope of Abrüpt’s works, attempting to reveal both the creative process and functioning of these literary productions which can be studied in open access via archives (“repositories”) that can be easily appropriated (“cloned”) under permissive conditions (thanks to “free licenses”). We begin with a thematic analysis of a set of manifestos selected from Abrüpt’s catalog, unveiling the economic, political and ideological orientations of the publisher. We then evaluate the “implementation” of such worldviews in two case studies, “Naufrages” and “enfer.txt”. The method of critical code studies examines the “extrafunctional” significance of computer source code situated in its sociohistorical context. It is through this method in particular that we intend to bring to the surface the additional meanings of these “digitally conditioned” texts, showing some possible actualizations of their latent discourse. We integrate a conceptual approach to our work, in particular through an in-depth examination of the notion of “program”, and draw on heuristics from computational practices and modeling interpretation

Centre d’anthropologie sociale – CAS

Jean-Pierre Albert, directeur d’étudesAnne Bouchy, directrice d’études à l’EFEO La part du rite dans les attitudes religieuses contemporaines. Orthopraxie, réinterprétations, adaptations, sécularisation Avec Marlène Albert-Llorca, Alain Ballabriga, Anny Bloch-Raymond, Marine Carrin, Patrizia Ciambelli, Jean-Louis Ormières, Valérie Robin, Guillaume Rozenberg, Harald Tambs-Lyche, Sébastien Tank-Storper, Claudine Vassas. Pour sa seconde année, le séminaire a continué d’explorer quelques-uns des ..

Centre d’anthropologie sociale – CAS

Jean-Pierre Albert, directeur d’étudesAnne Bouchy, directrice d’études à l’EFEO La part du rite dans les attitudes religieuses contemporaines. Orthopraxie, réinterprétations, adaptations, sécularisation Avec Marlène Albert-Llorca, Alain Ballabriga, Anny Bloch-Raymond, Marine Carrin, Patrizia Ciambelli, Jean-Louis Ormières, Valérie Robin, Guillaume Rozenberg, Harald Tambs-Lyche, Sébastien Tank-Storper, Claudine Vassas. Pour sa première année, le séminaire a été consacré à une réflexion de fond..

Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension

Background : Functional cerebrovascular regulatory mechanisms are important for maintaining constant cerebral blood flow and oxygen supply in heathy individuals and are altered in heart failure. We aim to examine whether pulmonary arterial hypertension (PAH) is associated with abnormal cerebrovascular regulation and lower cerebral oxygenation and their physiological and clinical consequences. Methods and Results : Resting mean flow velocity in the middle cerebral artery mean flow velocity in the middle cerebral artery (MCAvmean); transcranial Doppler), cerebral pressure‐flow relationship (assessed at rest and during squat‐stand maneuvers; analyzed using transfer function analysis), cerebrovascular reactivity to CO2, and central chemoreflex were assessed in 11 patients with PAH and 11 matched healthy controls. Both groups also completed an incremental ramp exercise protocol until exhaustion, during which MCAvmean, mean arterial pressure, cardiac output (photoplethysmography), end‐tidal partial pressure of CO2, and cerebral oxygenation (near‐infrared spectroscopy) were measured. Patients were characterized by a significant decrease in resting MCAvmean (P<0.01) and higher transfer function gain at rest and during squat‐stand maneuvers (both P<0.05). Cerebrovascular reactivity to CO2 was reduced (P=0.03), whereas central chemoreceptor sensitivity was increased in PAH (P<0.01), the latter correlating with increased resting ventilation (R2=0.47; P<0.05) and the exercise ventilation/CO2 production slope (Embedded Image slope; R2=0.62; P<0.05) during exercise for patients. Exercise‐induced increases in MCAvmean were limited in PAH (P<0.05). Reduced MCAvmean contributed to impaired cerebral oxygen delivery and oxygenation (both P<0.05), the latter correlating with exercise capacity in patients with PAH (R2=0.52; P=0.01). Conclusions : These findings provide comprehensive evidence for physiologically and clinically relevant impairments in cerebral hemodynamic regulation and oxygenation in PAH

A tale of two 'opens': intersections between Free and Open Source Software and Open Scholarship

There is no clear-cut boundary between Free and Open Source Software and Open Scholarship, and the histories, practices, and fundamental principles between the two remain complex. In this study, we critically appraise the intersections and differences between the two movements. Based on our thematic comparison here, we conclude several key things. First, there is substantial scope for new communities of practice to form within scholarly communities that place sharing and collaboration/open participation at their focus. Second, Both the principles and practices of FOSS can be more deeply ingrained within scholarship, asserting a balance between pragmatism and social ideology. Third, at the present, Open Scholarship risks being subverted and compromised by commercial players. Fourth, the shift and acceleration towards a system of Open Scholarship will be greatly enhanced by a concurrent shift in recognising a broader range of practices and outputs beyond traditional peer review and research articles. In order to achieve this, we propose the formulation of a new type of institutional mandate. We believe that there is substantial need for research funders to invest in sustainable open scholarly infrastructure, and the communities that support them, to avoid the capture and enclosure of key research services that would prevent optimal researcher behaviours. Such a shift could ultimately lead to a healthier scientific culture, and a system where competition is replaced by collaboration, resources (including time and people) are shared and acknowledged more efficiently, and the research becomes inherently more rigorous, verified, and reproducible

Asteroseismology and Interferometry

Asteroseismology provides us with a unique opportunity to improve our understanding of stellar structure and evolution. Recent developments, including the first systematic studies of solar-like pulsators, have boosted the impact of this field of research within Astrophysics and have led to a significant increase in the size of the research community. In the present paper we start by reviewing the basic observational and theoretical properties of classical and solar-like pulsators and present results from some of the most recent and outstanding studies of these stars. We centre our review on those classes of pulsators for which interferometric studies are expected to provide a significant input. We discuss current limitations to asteroseismic studies, including difficulties in mode identification and in the accurate determination of global parameters of pulsating stars, and, after a brief review of those aspects of interferometry that are most relevant in this context, anticipate how interferometric observations may contribute to overcome these limitations. Moreover, we present results of recent pilot studies of pulsating stars involving both asteroseismic and interferometric constraints and look into the future, summarizing ongoing efforts concerning the development of future instruments and satellite missions which are expected to have an impact in this field of research.Comment: Version as published in The Astronomy and Astrophysics Review, Volume 14, Issue 3-4, pp. 217-36

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe