COVID-19 Vaccine Distribution for the Homeless Population in Virginia

Due to the lack of proper personal hygiene, clean water and housing, the homeless population is more susceptible to infections. In addition, the homeless are more likely to have compromised immune systems (i.e., HIV/AIDS) due to illicit drug use and sex work. Furthermore, there is not a current systematic state program that allows feasible access to the COVID-19 vaccine due to limited internet access and/or phone access. We are proposing that the Virginia House of Delegates provide state funding for vaccination drives in areas with high poverty rates. Locations can be at soup kitchens, food banks, domestic abuse shelters, and homeless shelters

Prolonged acute kidney injury exacerbates lung inflammation at 7 days post‐acute kidney injury

Patients with acute kidney injury (AKI) have increased mortality; data suggest that the duration, not just severity, of AKI predicts increased mortality. Animal models suggest that AKI is a multisystem disease that deleteriously affects the lungs, heart, brain, intestine, and liver; notably, these effects have only been examined within 48 h, and longer term effects are unknown. In this study, we examined the longer term systemic effects of AKI, with a focus on lung injury. Mice were studied 7 days after an episode of ischemic AKI (22 min of renal pedicle clamping and then reperfusion) and numerous derangements were present including (1) lung inflammation; (2) increased serum proinflammatory cytokines; (3) liver injury; and (4) increased muscle catabolism. Since fluid overload may cause respiratory complications post-AKI and fluid management is a critical component of post-AKI care, we investigated various fluid administration strategies in the development of lung inflammation post-AKI. Four different fluid strategies were tested - 100, 500, 1000, or 2000 μL of saline administered subcutaneously daily for 7 days. Interestingly, at 7 days post-AKI, the 1000 and 2000 μL fluid groups had less severe AKI and less severe lung inflammation versus the 100 and 500 μL groups. In summary, our data demonstrate that appropriate fluid management after an episode of ischemic AKI led to both (1) faster recovery of kidney function and (2) significantly reduced lung inflammation, consistent with the notion that interventions to shorten AKI duration have the potential to reduce complications and improve patient outcomes

The Vehicle, Spring 1999

Vol. 40, No. 2 Table of Contents Poetry Eve\u27s DaughterSylvia Whippopage 1 When We Wore Canoes On Our ShouldersMandy Watsonpage 2 This Is Not A Poem About GrandpaJake Tolbertpage 3 Old relationshipsBrandi Kinneypage 5 UntitledErin Winnerpage 6 BraverySylvia Whippopage 6 deep dark closetNicole Smithpage 7 Belly EarthTara Coburnpage 9 The River and FireJake Tolbertpage 10 UntitledAutumn Williamspage 12 Action PotentialKim Evanspage 13 Chimerical (a song for children)D.M. Attrapepage 14 UntitledAutumn Williamspage 16 UntitledMatthew Armstrongpage 18 Building YouSylvia Whippopage 19 RunningKim Evanspage 20 Walking Jenn to WorkJake Tolbertpage 22 Looking InKim Hunterpage 23 Void Between Me and WisconsinMandy Watsonpage 24 Artwork UntitledWendy Finchpage 4 MeditationJennifer Lundpage 8 UntitledSteve Drakepage 15 MemoriesJennifer Lundpage 21 UntitledKathryn Kolasinskipage 25 Prose FoundKim Hunterpage 26 A Day in the Life of William Baxter, DriverDaniel Fitzgeraldpage 32https://thekeep.eiu.edu/vehicle/1072/thumbnail.jp

The Vehicle, Spring 1999

Vol. 40, No. 2 Table of Contents Poetry Eve\u27s DaughterSylvia Whippopage 1 When We Wore Canoes On Our ShouldersMandy Watsonpage 2 This Is Not A Poem About GrandpaJake Tolbertpage 3 Old relationshipsBrandi Kinneypage 5 UntitledErin Winnerpage 6 BraverySylvia Whippopage 6 deep dark closetNicole Smithpage 7 Belly EarthTara Coburnpage 9 The River and FireJake Tolbertpage 10 UntitledAutumn Williamspage 12 Action PotentialKim Evanspage 13 Chimerical (a song for children)D.M. Attrapepage 14 UntitledAutumn Williamspage 16 UntitledMatthew Armstrongpage 18 Building YouSylvia Whippopage 19 RunningKim Evanspage 20 Walking Jenn to WorkJake Tolbertpage 22 Looking InKim Hunterpage 23 Void Between Me and WisconsinMandy Watsonpage 24 Artwork UntitledWendy Finchpage 4 MeditationJennifer Lundpage 8 UntitledSteve Drakepage 15 MemoriesJennifer Lundpage 21 UntitledKathryn Kolasinskipage 25 Prose FoundKim Hunterpage 26 A Day in the Life of William Baxter, DriverDaniel Fitzgeraldpage 32https://thekeep.eiu.edu/vehicle/1072/thumbnail.jp

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4

Thiostrepton, a macrocyclic thiopeptide antibiotic, inhibits prokaryotic translation by interfering with the function of elongation factor G (EF-G). Here, we have used 70S ribosome binding and GTP hydrolysis assays to study the effects of thiostrepton on EF-G and a newly described translation factor, elongation factor 4 (EF4). In the presence of thiostrepton, ribosome-dependent GTP hydrolysis is inhibited for both EF-G and EF4, with IC(50) values equivalent to the 70S ribosome concentration (0.15 µM). Further studies indicate the mode of thiostrepton inhibition is to abrogate the stable binding of EF-G and EF4 to the 70S ribosome. In support of this model, an EF-G truncation variant that does not possess domains IV and V was shown to possess ribosome-dependent GTP hydrolysis activity that was not affected by the presence of thiostrepton (>100 µM). Lastly, chemical footprinting was employed to examine the nature of ribosome interaction and tRNA movements associated with EF4. In the presence of non-hydrolyzable GTP, EF4 showed chemical protections similar to EF-G and stabilized a ratcheted state of the 70S ribosome. These data support the model that thiostrepton inhibits stable GTPase binding to 70S ribosomal complexes, and a model for the first step of EF4-catalyzed reverse-translocation is presented

Hypersensitivity reactions related to oxaliplatin (OHP)

Patients treated with platinum compounds are subject to hypersensitivity reactions. Our study has highlighted the reactions related to oxaliplatin (OHP) infusion. One hundred and twenty-four patients affected by advanced colorectal cancer were treated with different schedules containing OHP, at the Institute of Haematology and Medical Oncology 'L. and A. Seragnoli' of Bologna and at the Medical Oncology Division of Livorno Hospital. Seventeen patients (13%) showed hypersensitivity reactions after a few minutes from the start of the OHP infusion. Usually, these reactions were seen after 2-17 exposures to OHP (Mean\ub1s.e.: 9.4\ub11.07). No patient experienced allergic reactions at his/her first OHP infusion. Eight patients developed a mild reaction consisting of flushing and swelling of the face and hands, itching, sweating and lachrymation. The remaining nine patients showed a moderate-severe reaction with dyspnoea, wheezing, laryngospasm, psycho-motor agitation, tachycardia, precordial pain, diffuse erythema, itching and sweating. Six patients out of 17 were re-exposed to the drug with premedication of steroids and all except one developed the hypersensitivity reaction again. The cumulative dose, the time of exposure to OHP and the clinical features are variable and unpredictable. The risk of developing hypersensitivity reactions in patients treated with a short infusion of OHP cannot be underestimated. \ua9 2003 Cancer Research UK

Girls and Boys Born before 28 Weeks Gestation: Risks of Cognitive, Behavioral, and Neurologic Outcomes at Age 10 Years

To compare the prevalence of cognitive, neurological, and behavioral outcomes at 10 years of age in 428 girls and 446 boys who were born extremely preterm (EP)

The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm

OBJECTIVE: To assess the association between maternal prepregnancy body mass index and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm. STUDY DESIGN: Study participants were 535 ten-year-old children enrolled previously in the prospective multicenter Extremely Low Gestational Age Newborns cohort study who were products of singleton pregnancies. Soon after delivery, mothers provided information about prepregnancy weight. Prepregnancy body mass index and adequacy of weight gain were characterized based on this information. Children underwent a neurocognitive evaluation at 10 years of age. RESULTS: Maternal prepregnancy obesity was associated with increased odds of a lower score for Differential Ability Scales-II Verbal IQ, for Developmental Neuropsychological Assessment-II measures of processing speed and visual fine motor control, and for Wechsler Individual Achievement Test-III Spelling. Children born to mothers who gained an excessive amount of weight were at increased odds of a low score on the Oral and Written Language Scales Oral Expression assessment. Conversely, children whose mother did not gain an adequate amount of weight were at increased odds of a lower score on the Oral and Written Language Scales Oral Expression and Wechsler Individual Achievement Test-III Word Reading assessments. CONCLUSION: In this cohort of infants born extremely preterm, maternal obesity was associated with poorer performance on some assessments of neurocognitive function. Our findings are consistent with the observational and experimental literature and suggest that opportunities may exist to mitigate risk through education and behavioral intervention before pregnancy