6 research outputs found
Osteosarcomagenesis: Biology, Development, Metastasis, and Mechanisms of Pain
Osteosarcoma is the most common primary cancer of the bone and third most common cancer in children and adolescents with approximately 900 new cases annually in the United States. A major facet of osteosarcoma is its high level of genomic instability, in particular chromosomal instability, which is the result of increased or decreased chromosome number in a cell. Furthermore, pain is the most common symptomatic feature of osteosarcoma that lacks effective therapy. Pain in osteosarcoma is relatively more complicated than many other painful conditions requiring a more thorough understanding of its etiology, pathobiology, and neurobiology to allow the development of better therapies for reducing pain in osteosarcoma patients. Studies are underway to define the diverse modalities of presentation, growth, development, metastases, and nociception in osteosarcoma. New data from human studies in combination with data from studies incorporating transgenic mouse models of osteosarcoma are providing valuable insights into the mechanisms underlying the development of both the tumor and the tumor-induced pain. These new data will undoubtedly lead to improved prognoses, as well as the development of novel therapeutics that will significantly decrease bone cancer pain
Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model
Este proyecto se redacta como definiciĂłn de la reforma del local mencionado con anterioridad, para su explotaciĂłn comercial como tienda de conveniencia. El acceso principal se realiza desde la calle Felip II. Se plantea una separaciĂłn funcional del local. En la planta baja se sitĂşan la zona de venta con las cajas de cobro, dos aseos aseo para el pĂşblico y el oficio de panaderĂa con su mostrador correspondiente. La planta baja comunica a travĂ©s de una escalera y una plataforma montacargas con una entreplanta, denominada “altillo” en los planos.
AquĂ se ubican los espacios de acceso restringido: los vestuarios y aseos del personal, almacĂ©n, cuarto de control del almacĂ©n, cuarto de mercancĂa valiosa, cuarto de informática, cuarto de limpieza y cuarto de basuras. El almacĂ©n comunica directamente con la planta baja mediante una plataforma montacargas, situada cerca del acceso al local
The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens
Osteosarcoma is the most common malignant bone tumor found in children and adolescents and is associated with many complications including cancer pain and metastasis. While cancer patients often seek complementary and alternative medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of chemotherapy and treatment, there is little known about the effect of acupuncture treatment on tumor growth and metastasis. Here we evaluate the effects of six different electroacupuncture (EA) regimens on osteosarcoma tumor growth and metastasis in both male and female mice. The most significant positive effects were observed when EA was applied to the ST-36 acupoint twice weekly (EA-2X/3) beginning at postimplantation day 3 (PID 3). Twice weekly treatment produced robust reductions in tumor growth. Conversely, when EA was applied twice weekly (EA-2X/7), starting at PID 7, there was a significant increase in tumor growth. We further demonstrate that EA-2X/3 treatment elicits significant reductions in tumor lymphatics, vasculature, and innervation. Lastly, EA-2X/3 treatment produced a marked reduction in pulmonary metastasis, thus providing evidence for EA’s potential antimetastatic capabilities. Collectively, EA-2X/3 treatment was found to reduce both bone tumor growth and lung metastasis, which may be mediated in part through reductions in tumor-associated vasculature, lymphatics, and innervation
Human β‑Defensin 1 and β‑Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors
β-Defensin 3 (BD3) was identified
as a ligand for the melanocortin
receptors (MCRs) in 2007, although the pharmacology activity of BD3
has not been clearly elucidated. Herein, it is demonstrated that human
BD3 and mouse BD3 are full micromolar agonists at the MCRs. Furthermore,
mouse β-defensin 1 (BD1) and human BD1 are also MCR micromolar
agonists. This work identifies BD1 as an endogenous MCR ligand and
clarifies the controversial role of BD3 as a micromolar agonist