Superradiant axion clouds around asteroid-mass primordial black holes

We analyze the dynamics and observational signatures of axion clouds formed via the superradiant instability around primordial black holes, focusing on the mass range $10^{14}-10^{18}$ kg where the latter may account for all the dark matter. We take into account the leading effects of axion self-interactions, showing that, even though these limit the number of axions produced within each cloud, a large number of superradiant axions become free of the black hole's gravitational potential and accumulate in the intergalactic medium or even in the host galaxy, depending on their escape velocity. This means that primordial black hole dark matter may lead to a sizeable astrophysical population of non-relativistic axions, with masses ranging from 0.1 eV to 1 MeV, depending on the primordial black hole mass and spin. We then show that if such axions couple to photons their contribution to the galactic and extragalactic background flux, mainly in the X-ray and gamma-ray band of the spectrum, is already beyond current observational limits for a large range of parameters that are, therefore, excluded. We finish by showing the prospects of the Athena X-ray telescope to further probe this co-existence of primordial black holes and axions.Comment: 21 pages, 5 figure

Quality and durability properties and life-cycle assessment of high volume biomass fly ash mortar

The effect of using biomass fly ash (BFA) on the quality, durability and sustainability of mortars was studied. Using high amounts of BFA does not lead to a production of mortars with better performance than a plain cement mortar. However, when BFA is used in small amounts mixed with coal fly ash, mortars with similar compressive strength, to that of a cement mortar, but with less carbonation and with better environmental performance are obtained. Using BFA in the concrete industry can lead to a minimisationof issues related to the high volume fly ash concrete.The authors wish to thank the Portuguese Foundation for Science and Technology (FCT) and the Eco-Construction and Rehabilitation Doctoral Program for supporting the PhD scholarship (reference PD/BD/52661/2014). This work was also financed by FEDER funds through the Competitivity Factors Operational Programme – COMPETE and by national funds through FCT – Foundation for Science and Technology within the scope of the project POCI-01- 0145-FEDER- 007633 and through the Regional Operational Programme CENTRO2020 within the scope of the project CENTRO-01- 0145-FEDER- 000006.info:eu-repo/semantics/publishedVersio

Comparative environmental life-cycle analysis of concretes using biomass and coal fly ashes as partial cement replacement material

Nowadays, the concrete production sector is challenged by attempts to minimize the usage of raw materials and energy consumption, as well as by environmental concerns. Therefore, it is necessary to choose better options, e.g. new technologies or materials with improved life-cycle performance. One solution for using resources in an efficient manner is to close the materials' loop through the recycling of materials that result either from the end-of-life of products or from being the by-product of an industrial process. It is well known that the production of Portland cement, one of the materials most used in the construction sector, has a significant contribution to the environmental impacts, mainly related with carbon dioxide emission. Therefore, the study and utilization of by-products or wastes usable as cement replacement in concrete can supply more sustainable options, provided that these type of concrete produced has same durability and equivalent quality properties as standard concrete. This work studied the environmental benefits of incorporating different percentages of two types of fly ashes that can be used in concrete as cement replacement. These ashes are waste products of power and heat production sectors using coal or biomass as fuels. The results showed that both ashes provide a benefit for the concrete production both in terms of environmental impact minimization and a better environmental performance through an increase in cement replacement. It is possible to verify that the incorporation of fly ashes is a sustainable option for cement substitution and a possible path to improve the environmental performance of the concrete industry.The authors wish to thank to FCT (Fundação para a Ciência e Tecnologia – Portugal) and to the Doctoral Program Eco-Construction and Rehabilitation (EcoCoRe) for supporting the PhD scholarship (with the grant-number PD/BD/52661/2014)

Environmental life cycle assessment of concrete containing biomass fly ash

Concrete production sector is challenged by attempts to minimize the consumption of raw materials and energy and to reduce environmental impact. The use of end-of-life products as cement replacement can allow the production of concrete with the same durability, similar quality properties and with improved environmental performance. This work studies the environmental benefits of incorporating different percentages of two types of fly ashes that can be used in concrete as cement replacement, according to the Portuguese context. The results showed that both ashes provide a benefit for the concrete production because it is possible to produce concrete with low Portland cement content and with a better environmental performance while achieving satisfactory mechanical resistance. As already demonstrated for coal fly ash, the use of biomass fly ash seems to be a promising alternative for the replacement of Portland cement.FCT (Fundação para a Ciência e Tecnologia – Portugal) and to the Doctoral Program Eco-Construction and Rehabilitation for supporting the PhD scholarship (with the reference PD/BD/52661/2014

An Application of Simple and Compact Genetic Algorithms for Estimating Harmonic Components

This work presents an approach for the harmonic components estimation problem present in electrical power systems by making use of evolutionary algorithms. The referential data were obtained by the ATP (Alternative Transients Program) software. Compact and simple genetic algorithms were applied to estimate the parameters of non-linear function to generate a waveform as similar as possible to the one provided by the ATP software. The results yielded by the aforementioned evolutionary algorithms were then compared with one another in a number of scenarios, using the values obtained by the waveform of reference generated by the ATP software. The comparisons were used to seek evidence of which algorithm solved the problem in a setting with limited availability of computational resources. Based on the generated results, it has been found that compact genetic algorithm satisfactorily solves the proposed problem and it is the most indicated method, when less computational effort is required

Multi-compartment profiling of cacterial and host metabolites identifies intestinal dysbiosis and its functional consequences in the critically ill child

Adverse physiology and antibiotic exposure devastate the intestinal microbiome in critical illness. Time and cost implications limit the immediate clinical potential of microbial sequencing to identify or treat intestinal dysbiosis. Here, we examined whether metabolic profiling is a feasible method of monitoring intestinal dysbiosis in critically ill children. Prospective multicenter cohort study. Three U.K.-based PICUs. Mechanically ventilated critically ill (n = 60) and age-matched healthy children (n = 55). Collection of urine and fecal samples in children admitted to the PICU. A single fecal and urine sample was collected in healthy controls. Untargeted and targeted metabolic profiling using 1H-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry or urine and fecal samples. This was integrated with analysis of fecal bacterial 16S ribosomal RNA profiles and clinical disease severity indicators. We observed separation of global urinary and fecal metabolic profiles in critically ill compared with healthy children. Urinary excretion of mammalian-microbial co-metabolites hippurate, 4-cresol sulphate, and formate were reduced in critical illness compared with healthy children. Reduced fecal excretion of short-chain fatty acids (including butyrate, propionate, and acetate) were observed in the patient cohort, demonstrating that these metabolites also distinguished between critical illness and health. Dysregulation of intestinal bile metabolism was evidenced by increased primary and reduced secondary fecal bile acid excretion. Fecal butyrate correlated with days free of intensive care at 30 days (r = 0.38; p = 0.03), while urinary formate correlated inversely with vasopressor requirement (r = -0.2; p = 0.037). Disruption to the functional activity of the intestinal microbiome may result in worsening organ failure in the critically ill child. Profiling of bacterial metabolites in fecal and urine samples may support identification and treatment of intestinal dysbiosis in critical illness.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Baryogenesis through split Higgsogenesis

We study the cosmological evolution of asymmetries in the two-Higgs doublet extension of the Standard Model, prior to the electroweak phase transition. If Higgs flavour-exchanging interactions are sufficiently slow, then a relative asymmetry among the Higgs doublets corresponds to an effectively conserved quantum number. Since the magnitude of the Higgs couplings depends on the choice of basis in the :Higgs doublet space, we attempt to formulate basis-independent out-of-equilibrium conditions. We show that an initial asymmetry between the fliggs scalars, which could be generated by GP violation in the :Higgs sector, will be transformed into a baryon asymmetry by the sphalerons, without the need of B ¿ L violation. This novel mechanism of baryogenesis through (split) Higgsogenesis is exemplified with simple scenarios based on the out-of-equilibrium decay of heavy singlet scalar fields into the illiggs doublets

Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children.

PURPOSE: With growing evidence that rare single gene disorders present in the neonatal period, there is a need for rapid, systematic, and comprehensive genomic diagnoses in ICUs to assist acute and long-term clinical decisions. This study aimed to identify genetic conditions in neonatal (NICU) and paediatric (PICU) intensive care populations. METHODS: We performed trio whole genome sequence (WGS) analysis on a prospective cohort of families recruited in NICU and PICU at a single site in the UK. We developed a research pipeline in collaboration with the National Health Service to deliver validated pertinent pathogenic findings within 2-3 weeks of recruitment. RESULTS: A total of 195 families had whole genome analysis performed (567 samples) and 21% received a molecular diagnosis for the underlying genetic condition in the child. The phenotypic description of the child was a poor predictor of the gene identified in 90% of cases, arguing for gene agnostic testing in NICU/PICU. The diagnosis affected clinical management in more than 65% of cases (83% in neonates) including modification of treatments and care pathways and/or informing palliative care decisions. A 2-3 week turnaround was sufficient to impact most clinical decision-making. CONCLUSIONS: The use of WGS in intensively ill children is acceptable and trio analysis facilitates diagnoses. A gene agnostic approach was effective in identifying an underlying genetic condition, with phenotypes and symptomatology being primarily used for data interpretation rather than gene selection. WGS analysis has the potential to be a first-line diagnostic tool for a subset of intensively ill children

Phlebotomine sand fly survey in the focus of leishmaniasis in Madrid, Spain (2012-2014): seasonal dynamics, Leishmania infantum infection rates and blood meal preferences

BACKGROUND: An unusual increase of human leishmaniasis cases due to Leishmania infantum is occurring in an urban area of southwestern Madrid, Spain, since 2010. Entomological surveys have shown that Phlebotomus perniciosus is the only potential vector. Direct xenodiagnosis in hares (Lepus granatensis) and rabbits (Oryctolagus cuniculus) collected in the focus area proved that they can transmit parasites to colonized P. perniciosus. Isolates were characterized as L. infantum. The aim of the present work was to conduct a comprehensive study of sand flies in the outbreak area, with special emphasis on P. perniciosus. METHODS: Entomological surveys were done from June to October 2012-2014 in 4 stations located close to the affected area. Twenty sticky traps (ST) and two CDC light traps (LT) were monthly placed during two consecutive days in every station. LT were replaced every morning. Sand fly infection rates were determined by dissecting females collected with LT. Molecular procedures applied to study blood meal preferences and to detect L. infantum were performed for a better understanding of the epidemiology of the outbreak. RESULTS: A total of 45,127 specimens belonging to 4 sand fly species were collected: P. perniciosus (75.34%), Sergentomyia minuta (24.65%), Phlebotomus sergenti (0.005%) and Phlebotomus papatasi (0.005%). No Phlebotomus ariasi were captured. From 3203 P. perniciosus female dissected, 117 were infected with flagellates (3.7%). Furthermore, 13.31% and 7.78% of blood-fed and unfed female sand flies, respectively, were found infected with L. infantum by PCR. The highest rates of infected P. perniciosus were detected at the end of the transmission periods. Regarding to blood meal preferences, hares and rabbits were preferred, although human, cat and dog blood were also found. CONCLUSIONS: This entomological study highlights the exceptional nature of the Leishmania outbreak occurring in southwestern Madrid, Spain. It is confirmed that P. perniciosus is the only vector in the affected area, with high densities and infection rates. Rabbits and hares were the main blood meal sources of this species. These results reinforce the need for an extensive and permanent surveillance in this region, and others of similar characteristics, in order to control the vector and regulate the populations of wild reservoirs.This study was partially sponsored and funded by: Dirección General de Salud Pública, Consejería de Sanidad, Comunidad de Madrid; Colegio de Veterinarios de Madrid; Colegio de Biólogos de Madrid and EU grant FP7-261504 EDENext (http://www.edenext.eu).S