NERVA irradiation program. GTR 23, volume 1: Combined effects of reactor radiation and cryogenic temperature on NERVA structural materials

Specimens fabricated from structural materials that were candidates for certain NERVA applications were irradiated in liquid nitrogen (LN2), liquid hydrogen (LH2), water, and air. The specimens irradiated in LN2 were stored in LN2 and finally tested in LN2, or at some higher temperature in a few instances. The specimens irradiated in LH2 underwent an unplanned warmup while in storage so this portion of the test was lost; some specimens were tested in LN2 but none were tested in LH2. The Ground Test Reactor was the radiation source. The test specimens consisted mainly of tensile and fracture toughness specimens of several different materials, but other types of specimens such as tear, flexure, springs, and lubricant were also irradiated. Materials tested include Hastelloy X, Al, Ni steel, steel, Be, ZrC, Ti-6Al-4V, CuB, and Ti-5Al-2.5Sn

Functional design for operational earth resources ground data processing

The author has identified the following significant results. Study emphasis was on developing a unified concept for the required ground system, capable of handling data from all viable acquisition platforms and sensor groupings envisaged as supporting operational earth survey programs. The platforms considered include both manned and unmanned spacecraft in near earth orbit, and continued use of low and high altitude aircraft. The sensor systems include both imaging and nonimaging devices, operated both passively and actively, from the ultraviolet to the microwave regions of the electromagnetic spectrum

Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC

Human and simian immunodeficiency-associated retroviruses are extraordinarily complex, containing at least five genes, tat, art, sor, R, and 3' orf, in addition to the structural genes gag, pol, and env. Recently, nucleotide sequence analysis of human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency virus SIVMAC revealed the existence of still another open reading frame, termed X, which is highly conserved between these two viruses but absent from HIV-1. In this report, we demonstrate for the first time that the X open reading frame represents a functional retroviral gene in both HIV-2 and SIVMAC and that it encodes a virion-associated protein of 14 and 12 kilodaltons, respectively. We also describe the production of recombinant TrpE/X fusion proteins in Escherichia coli and show that sera from some HIV-2-infected individuals specifically recognize these proteins

Influence of Nonbonded Interactions on Molecular Geometry and Energy: Calculations for Hydrocarbons Based on Urey—Bradley Field

A modified Urey—Bradley potential energy function comprised of quadratic terms for bond stretches, bond‐angle bends, and torsional displacements together with analytical expressions for pairwise nonbonded interactions was chosen to represent the force field for hydrocarbon molecules. Quadratic constants were taken from the spectroscopic U☒B analyses of Schachtschneider and Snyder [Spectrochim. Acta 19, 117 (1963)], while the nonbonded functions adopted were those proposed by Bartell [J. Chem. Phys. 32, 827 (1960)]. Reference bond angles for the quadratic terms were taken to be 109.5° or 120° for tetrahedral or trigonal coordination, respectively. Reference single‐bond lengths and the torsional constant were adjusted to fit the experimental data for CH4 and C2H6. Double bonds and ring bonds in cyclopropyl compounds were considered to be rigid. The above selections served to establish a universal model force field for hydrocarbons with no remaining adjustable parameters. The potential energy functions for a variety of saturated hydrocarbons and several olefins and cyclopropyl derivatives were minimized with respect to independent structure parameters (i.e., bond stretches, bends, and internal rotations). Even though all C☒H (and C☒C) bonds were input to be identical to those in CH4 (and C2H6) except for nonbonded environment, the bond lengths and angles corresponding to the minimum potential energy exhibited an appreciable variation from molecule to molecule, as did also the strain energies of geometric and rotational isomers. Calculated trends in structures, isomerization energies, and barriers to rotation agreed quite well with experimentally observed trends, provided that experimental isomerization energies were corrected to 0°K and zero‐point energies were taken into account. Some novel features of the results and applications of the model for predicting deformations in strained systems are discussed. The present study differs from previous work in the area of ``molecular mechanics'' in the use of a more general force field, in allowing the strained molecules to relax in all degrees of freedom (except for unsaturated groups and cyclopropyl rings), in the selection of molecular systems, and in a detailed comparison with experiment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70433/2/JCPSA6-47-10-3736-1.pd

S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis

Suspension cultures of Berberis species are useful sources for the detection and isolation of a new enzyme which transfers the methyl group from S-adenosyl-L-methionine specifically to the 9-position of the (S)-enantiomer of scoulerine, producing (S)-tetrahydrocolumbamine. The enzyme was enriched 27-fold; it is not particle bound, has a pH optimum of 8.9, a molecular weight of 63 000 and shows a high degree of substrate specificity

The Warm Molecular Gas Around the Cloverleaf Quasar

We present the first broadband lambda = 1 mm spectrum toward the z=2.56 Cloverleaf Quasar, obtained with Z-Spec, a 1-mm grating spectrograph on the 10.4-meter Caltech Submillimeter Observatory. The 190-305 GHz observation band corresponds to rest-frame 272 to 444 microns, and we measure the dust continuum as well as all four transitions of carbon monoxide (CO) lying in this range. The power-law dust emission, F_nu = 14 mJy (nu/240GHz)^3.9 is consistent with the published continuum measurements. The CO J=6->5, J=8->7, and J=9->8 measurements are the first, and now provide the highest-J CO information in this source. Our measured CO intensities are very close to the previously-published interferometric measurements of J=7->6, and we use all available transitions and our 13CO upper limits to constrain the physical conditions in the Cloverleaf molecular gas disk. We find a large mass (2-50x10^9 Msun) of highly-excited gas with thermal pressure nT > 10^6 Kcm^-3. The ratio of the total CO cooling to the far-IR dust emission exceeds that in the local dusty galaxies, and we investigate the potential heating sources for this bulk of warm molecular gas. We conclude that both UV photons and X-rays likely contribute, and discuss implications for a top-heavy stellar initial mass function arising in the X-ray-irradiated starburst. Finally we present tentative identifications of other species in the spectrum, including a possible detection of the H20 2_0,2->1_1,1 transition at lambda_rest = 303 microns.Comment: ApJ in press, 12 pages in emulateAp

GPS survey of the western Tien Shan

There were two major developments in 1994 in our collaborative GPS experiment in the Tien Shan of the Former Soviet Union (FSU). Both were motivated by our expectation that we will ultimately obtain better science at lower cost if we involve our colleagues in the FSU more deeply in (1) the collection and (2) the analysis of data. As an experimental test of the concept of having our local collaborators carry out the field work semi-autonomously, we sent 6 MIT receivers to the Tien Shan for a period of 3 months. To enable our collaborators to have the capability for data analysis, we provided computers for two data analysis centers and organized a two-week training session. This report emphasizes the rationale for deeper involvement of FSU scientists, describes the training sessions, discusses the data collection, and presents the results. We also discuss future plans. More detailed discussion of background, general scientific objectives, discussions with collaborators, and results for the campaigns in 1992 and 1993 have been given in previous reports

A Census of the High-Density Molecular Gas in M82

We present a three-pointing study of the molecular gas in the starburst nucleus of M82 based on 190 - 307 GHz spectra obtained with Z-Spec at the Caltech Submillimeter Observatory. We present intensity measurements, detections and upper limits, for 20 transitions, including several new detections of CS, HNC, C2H, H2CO, and CH3CCH lines. We combine our measurements with previously-published measurements at other frequencies for HCN, HNC, CS, C34S, and HCO+ in a multi-species likelihood analysis constraining gas mass, density and temperature, and the species' relative abundances. We find some 1.7 - 2.7 x 10^8 M_sun of gas with n_H2 between 1 - 6 x 10^4 cm^-3 and T > 50 K. While the mass and temperature are comparable to values inferred from mid-J CO transitions, the thermal pressure is a factor of 10 - 20 greater. The molecular interstellar medium is largely fragmented and is subject to ultraviolet irradiation from the star clusters. It is also likely subject to cosmic rays and mechanical energy input from the supernovae, and is warmer on average than the molecular gas in the massive star formation regions in the Milky Way. The typical conditions in the dense gas in M82's central kpc appear unfavorable for further star formation; if any appreciable stellar populations are currently forming, they are likely biased against low mass stars, producing a top-heavy initial mass function.Comment: 15 pages (using emulateapj.cls), 6 figures, Astrophysical Journal, in pres

Redshift Determination and CO Line Excitation Modeling for the Multiply Lensed Galaxy HLSW-01

We report on the redshift measurement and CO line excitation of HERMES J105751.1+573027 (HLSW-01), a strongly lensed submillimeter galaxy discovered in Herschel/SPIRE observations as part of the Herschel Multi-tiered Extragalactic Survey (HerMES). HLSW-01 is an ultra-luminous galaxy with an intrinsic far-infrared luminosity of L _(FIR) = 1.4 × 10^(13) L _⊙, and is lensed by a massive group of galaxies into at least four images with a total magnification of μ = 10.9 ± 0.7. With the 100 GHz instantaneous bandwidth of the Z-Spec instrument on the Caltech Submillimeter Observatory, we robustly identify a redshift of z = 2.958 ± 0.007 for this source, using the simultaneous detection of four CO emission lines (J = 7 → 6, J = 8 → 7, J = 9 → 8, and J = 10 → 9). Combining the measured line fluxes for these high-J transitions with the J = 1 → 0, J = 3 → 2, and J = 5 → 4 line fluxes measured with the Green Bank Telescope, the Combined Array for Research in Millimeter Astronomy, and the Plateau de Bure Interferometer, respectively, we model the physical properties of the molecular gas in this galaxy. We find that the full CO spectral line energy distribution is described well by warm, moderate-density gas with T _(kin) = 86-235 K and n_H_2 = (1.1-3.5)x10^3 cm^(–3). However, it is possible that the highest-J transitions are tracing a small fraction of very dense gas in molecular cloud cores, and two-component models that include a warm/dense molecular gas phase with T _(kin) ~ 200 K, n_H_2 ~ 10^5 cm^(–3) are also consistent with these data. Higher signal-to-noise measurements of the J _(up) ≥ 7 transitions with high spectral resolution, combined with high spatial resolution CO maps, are needed to improve our understanding of the gas excitation, morphology, and dynamics of this interesting high-redshift galaxy