Una mirada al pasado nos proyecta al futuro : innovación y diseño en la industria argentina

La industria argentina ha sufrido avatares por influencia del contexto social, económico y político. En estas circunstancias se desenvuelve el diseño, desempeñando un rol orientado a producir cambios e innovaciones en la industria. A partir de la mirada de objetos que ya son historia, se evidencia que la innovación es un aspecto poco considerado en el ámbito industrial que, sin embargo, puede alcanzarse con la determinación del capital humano, con el rol de Estado y con la voluntad de las empresas. Por todo ello, la innovación es un proceso complejo e interactivo en el que se pone de manifiesto su carácter social.Fil: Braconi, Laura Viviana. Universidad Nacional de Cuyo. Facultad de Artes y Diseñ

Design and innovation : a vision about furniture industries at Mendoza

Se analizaron los procesos de cambio tecnológico en la industria del mueble en Mendoza, considerando el rol del diseño industrial. Ésta partió del supuesto que el diseño, la innovación y la tecnología se vinculan en este proceso. Sin embargo, el diseño ocupa un papel de escasa relevancia. El objetivo fue analizar el proceso de cambio tecnológico, teniendo en cuenta la incidencia de la innovación y en particular del diseño; analizar las políticas públicas provinciales dirigidas hacia este subsector. Metodológicamente se combinaron los paradigmas cuantitativo y cualitativo. Se pudo caracterizar el subsector y los empresarios de las empresas. Se espera que con los resultados puedan verse beneficiados organismos públicos y privados e instituciones académicas (UNCuyo), especialmente los dedicados a la vinculación con el medio productivo.We analyzed the process of technological changes at Mendoza’s furniture industry, considering the role of design in that process. We started supposing that Design, Innovation and Technology are part of the process. However the analysis showed that the role of industrial design takes part in the process in a small way. The purpose of this investigation is to analyze how design and innovation contribute to the process of technological changes at furniture industry, also analyze local public politics towards this industrial sector. Quantitative and qualitative paradigms had been methodologically combined. The furniture sector and enterprise owners had been characterized. We hope that results of these investigation benefits public and private organizations, like UNCuyo, especially those who promote connection between professional and Industry.Fil: Braconi, Laura Viviana. Universidad Nacional de Cuyo. Facultad de Artes y Diseñ

Proyectos bienales 2009-2011

El propósito de este trabajo es conocer el proceso de cambio tecnológico, especialmente la innovación y el diseño, a través de la lectura de objetos relevantes de las décadas de 1930 a 1950 en la provincia de Mendoza pertenecientes a la industria. Asimismo analizar la incidencia de la innovación y en particular del diseño, en objetos de uso cotidiano producidos por la industria metalmecánica. También observar e indagar aspectos socioculturales que pueden haber influido en la generación de nuevos objetos de uso. Se parte del supuesto que el diseño, la tecnología y la innovación se vinculan en el proceso de cambio tecnológico. En particular la innovación y el diseño desempeñan un rol de importancia en este proceso. Los resultados pretendidos permitirán contribuir al avance del conocimiento de la problemática de la innovación y su relación con el cambio tecnológico. Se podría conocer la influencia del diseño industrial en el proceso de cambio tecnológico. Asimismo se contribuirá a aportar conocimiento sobre la industria local, pero en su relación directa con la innovación y el diseño. Se trabajaría con la combinación de los paradigmas cuantitativo y cualitativo, mediante el empleo de fuentes documentales y entrevistas profundas, en particular historia de vida como estudio de caso. Los resultados obtenidos podrán transferirse a otras carreras de Diseño de otras Instituciones de Educación Superior y eventualmente a otras carreras de la U.N. Cuyo.The intention of this work is know the process of technological change, especially the innovation and the design, through the reading of notables objects of decades from 1930 to 1950 in the province of Mendoza to belong to the industry. Also to analyze the incidence of the innovation and in particular of the design, in objects of daily use produced by the industry metallurgical. Also to observe and to make inquiries sociocultural aspects that can have influenced in the generation of new objects of use. Part of supposing if the design, the technology and the innovation are in the process of technological change. In particular the innovation and the design carry out a roll of importance in this process. The tried results will allow to contribute to the advance of the knowledge of problematic of the innovation and their relation with the technological change. The influence could be known the industrial design in the process of technological change. Also it will be contributed to contribute knowledge on the local industry, but in the direct relation with the innovation and the design. It will work with the combination of the paradigms quantitative and qualitative, by means of the use of documentary sources and deep interviews, in particular life history as case study. The obtained results will be able to possibly transfer to other degrees of Design of other Institutions of Higher Education and possibly to other degrees of the U.N. Cuy

Connections among stakeholders of the socio-productive system and the strategic intervention of design as a facilitation and differentiation model : second stage

El propósito de este trabajo es continuar la línea de trabajo iniciada con el Proyecto de Investigación (2016-2018). Para ello, se propone analizar estrategias dentro del proceso de innovación que generan cambios en emprendimientos locales (2015-2018). Casos: Ruta de Artesanos y productores agrícolas del Valle de Uco. También profundizar en el análisis de las capacidades tecnológicas, y en especial, las formas de generación de innovaciones de los casos seleccionados. Analizar la articulación entre casos de estudio y la FAD como parte del sistema científico- tecnológico. Y finalmente observar e indagar el rol estatal y su influencia por políticas públicas en la promoción de emprendimientos socio-productivos.En este proyecto se parte del supuesto que la falta de procesos de innovación en los emprendimientos locales, existe por la carencia de cultura en diseño sistematizada. Entendiendo al "diseño" como un intangible que aporta "diferenciación con agregado de valor" de lo que ofrecen, ya sea productos o servicios, como clave competitiva a través de la incorporación de ciertas herramientas como el diseño y "sistematizada" por una falta de integración de los diferentes actores del territorio. Metodológicamente se centrará en emprendimientos locales del Gran Mendoza y del Valle de Uco, considerando sectores que se vieran favorecidos por la innovación y los aportes del diseño comprendiendo rubros como: calzados, textiles, agrícola, entre otros. Se trabajará sobre el modelo cualitativo con el empleo de fuentes documentales y distintos instrumentos para obtener información (entrevistas y fotografía). Los resultados pretendidos permitirán contribuir al avance del conocimiento de la problemática de la innovación y su relación con la industria local, especialmente en el desempeño de mipymes locales que tienen vinculación con acciones de innovación y diseño. Esto implica que se contribuirá a aportar conocimiento sobre parte de la producción local, sobre cómo se generan las diferentes actividades de innovación en los diversos emprendimientos locales. Los resultados obtenidos podrán transferirse a otras carreras de Diseño de otras Instituciones de Educación Superior y eventualmente a otras carreras de la UNCuyo.The purpose of this project is to continue the line of work initiated with the Research Project 2016-2018. For this reason, it is proposed to analyze strategies within the innovation process that generate changes in local enterprises (2015-2018). Cases: Route of Artisans and agricultural producers in Uco Valley. It is also diced to study the technological capabilities and the ways of generating innovations of selected cases. Furthermore, it is included the analyze of the articulation between the studied cases and the Facultad de Artes y Diseño (FAD) as part of the scientific-technological system. Is important to mention that this project research aboard the observation and investigation of public policies which have influenced in the promotion of socio-productive entrepreneurships.It is assumed that the absence of innovation processes in local enterprises occurs due to the lack of a systematized design culture. The 'design' is an intangible discipline that provides 'differentiation with added value' to products or services. This conception makes this activity as certain tools which offer a competitive key, especially if there is a low integration of stakeholders in the system of the territory. The methodology will be applied to local entrepreneurship situated in Greater Mendoza and Uco Valley. In this way, it will be considered those areas that were favored by innovation and the contributions of design. This includes items such as footwear, textiles, agriculture, among others. The research will be based on a qualitative model with the use of documentary sources and different instruments to get information like interviews and photography

Innovación y diseño en la industria de Mendoza : Análisis de casos

Este trabajo se enmarca en el Proyecto de Investigación “Innovación y Diseño en la Industria Mendocina. Análisis de casos de objetos de uso cotidiano (1930-1950)”. El mismo tiene como propósito general conocer y analizar el proceso de cambio tecnológico, en particular en la innovación y el diseño, en el período comprendido entre las décadas de 1930 y 1950. Asimismo observar e indagar aspectos socioculturales que pueden haber influido en la generación de nuevos objetos de uso. En particular, la propuesta de este trabajo es revisar algunos ejemplos importantes de la industria a lo largo de la historia, desde la mirada del diseño industrial e intentando ver cuando aparece el diseño industrial en el país. (Párrafo extraído del texto a modo de resumen) Mesa: Artes proyectuales: identidad, innovación e investigaciónFacultad de Bellas Arte

Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry

Background: Lymph node metastasis and positive resection margins have been reported to be major determinants of overall survival (OS) and poor recurrence-free survival (RFS) for patients who underwent resection for perihilar cholangiocarcinoma (pCCA). However, the prognostic value of positive lymph nodes independently from resection margin status on OS has not been evaluated. Methods: From the European Cholangiocarcinoma (ENSCCA) registry, patients who underwent resection for pCCA between 1994 and 2021 were included in this retrospective cohort study. The primary outcome was OS stratified for resection margin and lymph node status. The secondary outcome was recurrence-free survival. Results: A total of 325 patients from 11 different centers and six European countries were included. Of these, 194 (59.7%) patients had negative resection margins. In 113 (34.8%) patients, positive lymph nodes were found. Lymph node status, histological grade, and ECOG performance status were independent prognostic factors for survival. The median OS for N0R0, N0R1, N+R0, and N+R1 was 38, 30, 18, and 12 months, respectively (p < 0.001). Conclusion: These data indicate that in the presence of positive regional lymph nodes, resection margin status does not determine OS or RFS in patients with pCCA. Achieving negative margins in patients with positive nodes should not come at the expense of more extensive surgery and associated higher mortality.The ENSCCA Registry is completely funded by the European Association for the Study of the Liver (EASL; Registry grant awards 2016 and 2019 to J.M.B.), Incyte Bioscience International Sàrl (grant award 2020 to J.M.B.) and European Union’s Horizon 2020 Research and Innovation Program (grant number 825510, ESCALON: to J.M.B. and A.L.)

Criteria for preclinical models of cholangiocarcinoma:scientific and medical relevance

Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

[EN] Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies. The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly. The current diagnosis of CCA by non- invasive approaches is not accurate enough, and histological confirmation is necessary. Furthermore, the high heterogeneity of CCAs at the genomic, epigenetic and molecular levels severely compromises the efficacy of the available therapies. In the past decade, increasing efforts have been made to understand the complexity of these tumours and to develop new diagnostic tools and therapies that might help to improve patient outcomes. In this expert Consensus Statement, which is endorsed by the European Network for the Study of Cholangiocarcinoma, we aim to summarize and critically discuss the latest advances in CCA, mostly focusing on classification, cells of origin, genetic and epigenetic abnormalities, molecular alterations, biomarker discovery and treatments. Furthermore, the horizon of CCA for the next decade from 2020 onwards is highlightedJ.M.B. received EASL Registry Awards 2016 and 2019 (European CCA Registry, ENS-CCA). J.M.B. and M.J.P. were supported by: the Spanish Ministry of Economy and Competitiveness (J.M.B.: FIS PI12/00380, FIS PI15/01132, FIS PI18/01075 and Miguel Servet Programme CON14/00129; M.J.P.: FIS PI14/00399, FIS PI17/00022 and Ramon y Cajal Programme RYC-2015-17755, co-financed by “Fondo Europeo de Desarrollo Regional” (FEDER)); ISCIII CIBERehd; “Diputación Foral de Gipuzkoa” (J.M.B: DFG15/010, DFG16/004), and BIOEF (Basque Foundation for Innovation and Health Research: EiTB Maratoia BIO15/CA/016/BD); the Department of Health of the Basque Country (M.J.P.: 2015111100; J.M.B.: 2017111010), and “Fundación Científica de la Asociación Española Contra el Cancer” (AECC Scientific Foundation) (J.M.B.). J.M.B. and J.W.V. were supported by the European Commission Horizon 2020 programme (ESCALON project 825510). The laboratory of J.B.A. is supported by competitive grants from the Danish Medical Research Council, the Danish Cancer Society, and the Novo Nordisk and A.P. Møller Foundations. J.J.G.M. and R.I.R.M. were supported by the Carlos III Institute of Health, Spain (PI16/00598 and PI18/00428) and were co-financed by the European Regional Development Fund. J.M.B. and J.J.G.M. were supported by the Ministry of Science and Innovation, Spain (SAF2016-75197-R), and the “Asociación Española Contra el Cancer”, Spain (AECC-2017). R.I.R.M. was supported by the “Centro Internacional sobre el Envejecimiento”, Spain (OLD-HEPAMARKER, 0348-CIE-6-E). A.L. received funding from the Christie Charity. M.M. was supported by the Università Politecnica delle Marche, Ancona, Italy (040020_R.SCIENT.A_2018_MARZIONI_M_STRATEGICO_2017). M.S. was supported by the Yale Liver Center Clinical and Translational Core and the Cellular and Molecular Core (DK034989 Silvio O. Conte Digestive Diseases Research Center). C.C. is supported by grants from INSERM, Université de Rennes, INCa, and ITMO Cancer AVIESAN dans le cadre du Plan Cancer (Non-coding RNA in Cancerology: Fundamental to Translational), Ligue Contre le Cancer and Région Bretagne. J.Bruix was supported by grants from Instituto de Salud Carlos III (PI18/00763), AECC (PI044031) and WCR (AICR) 16-0026. A.F. was supported by grants from ISCIII (PI13/01229 and PI18/00542). CIBERehd is funded by the Instituto de Salud Carlos III. V.C., D.M., J. Bridgewater and P.I. are members of the European Reference Network - Hepatological Diseases (ERN RARE-LIVER). J.M.B. is a collaborator of the ERN RARE-LIVER