The Lark's Lonely Twittering: An Analysis of the Monologues in A Doll's House

In this article we examine Ibsen’s use of monologues in A Doll’s House. The use of monologues in this play has been criticized, and by some characterized as old and conventional, while others have considered this a futile device. However, previous scholars and critics have neither agreed on the number of monologues, nor about where in the play these monologues appear. Our close reading shows that there are as many as nineteen monologues in the play, several in each act, and that three of the characters express themselves in monologues. We find surprising dramaturgic patterns in the use of this device, and this indicates that Ibsen’s use of monologues in A Doll’s House has a more important function than the literature about A Doll’s House until now has found. Our intention in this article is not to give a new interpretation of A Doll’s House, but to examine Ibsen’s use of monologues in the play, to reflect on the questions of why Ibsen made use of this device, and to consider what aesthetic functions this device might have.acceptedVersio

Being in the moment - an investigation of the aesthetic learning processes in a Storyline

Chapter 13. This chapter describes a qualitative study that illustrates the aesthetic learning processes facilitated by a specific Storyline conducted in a Teacher Education Programme in Eastern Norway. The purpose is to uncover the types of aesthetic competences that are developed through aesthetic working methods in interdisciplinary projects, and which competences must be strengthened within the aesthetic subjects’ own context. Despite Norway’s new national curriculum emphasising creative and explorative learning methods, the aesthetic subjects are under pressure. There is no requirement for teacher competence in the subjects, while they are demanded as methods in interdisciplinary projects and for in-depth learning. Our theoretical framework in this study is the four aspects of aesthetic learning processes, learning IN, WITH, ABOUT and THROUGH aesthetic activity, as explained by Lindström (2012), supported by Dewey’s (1980) view on aesthetic experiences. The study consists of group interviews with the students after completion of a cross-curricular Storyline.publishedVersio

Frå DesignDialog til Design Literacy

Artikkelen gjev ei historisk framstilling av korleis forskingsfeltet designdidaktikk er utvikla dei siste 20 åra, med vekt på kva rolle professor Liv Merete Nielsen har spelt i arbeidet med å styrke fagfeltet sin intellektuelle identitet. Konseptet «the making disciplines» om korleis akademiske fellesskap blir utvikla gjev eit av dei teoretiske perspektiva til framstillinga. Studiet fortel korleis Nielsen bevegar seg mellom mange roller i dette. Ho er forskar, forskingsentreprenør og forskingsleiar, og bygger ny kunnskap gjennom å integrere «making», «making-knowledge», det akademiske og det fagdidaktiske. Artikkelen har Nielsen sine publikasjonar samt intervju med kollegaer og stipendiatar som kjelde­grunnlag

Boligsosialt arbeid som helhet, samarbeid og individuell oppfølging. Evaluering av prosjekt Bolig med nogo attåt

Prosjektet ”Bolig med nogo attåt” er ledd i Kirkens Sosialtjenestes arbeid for å utvikle nye perspektiver, nye tiltak og nye metoder i innsatsen mot bekjempelse av bostedsløshet. En overordnet intensjon har vært å se boligsosialt arbeid i sammenheng med øvrig oppfølgingsarbeid. Målet har slik ikke bare vært å kvantitativt redusere antallet bostedsløse, men også å bidra til økt livskvalitet for mennesker med problemer knyttet til både bolig og rus, som tradisjonelt har lidd under manglende sammenheng i tiltaksapparatet. Målgruppa for prosjektet er i første rekke voksne mennesker som har bakgrunn med enten rusproblemer eller kriminalitet. Man har også i det siste satt søkelys på unge voksne i overgangen mellom barnevern og voksenliv, men dette arbeidet er på et relativt tidlig stadium. Prosjektet har praktisk nedslagsfelt gjennom fem tiltak rettet mot syv ulike kommuner på landsbasis. I tillegg er det opprettet en egen prosjektmedarbeiderstilling ved Kirkens Sosialtjenestes hovedkontor. Prosjektperioden løper ut 2007, og Kirkens sosialtjeneste har nå gitt Diakonhjemmets Høgskole i oppdrag å evaluere prosjektet. Evalueringen har fokusert på følgende problemstilling: Hvilke positive og kritiske faktorer kan beskrives i det boligsosiale arbeidet i prosjekt ”Bolig med nogo attåt”, og hvilke forbedringspotensialer kan man peke på

Kunnskapsoppsummering. NAV-kontoret og den kommunale barneverntjenestens oppfølging av unge med barnevernserfaring

Vi har i denne litteraturgjennomgangen beskrevet eksisterende kunnskap om NAV-kontorets og det kommunale barnevernets oppfølging av unge med barnevernserfaring i alderen 18-23 år. Grunnlaget for studien er relevant norsk litteratur, publisert i vitenskaplige databaser, nettressursene til NAV og Bufdir, samt publikasjonslistene til forskningsmiljøene FAFO, AFI, og NOVA. Publikasjonene stammer fra tidsrommet mellom 2006 og 2016. Totalt fant vi 31 publikasjoner med relevans for problem-stillingen. I tillegg har vi funnet støtte i praktisk kunnskap fra feltet, samla i et erfaringsseminar for fem kommuner/bydeler i juni 2016.K

Kunnskapsoppsummering. NAV-kontoret og den kommunale barneverntenesta si oppfølging av unge med barnevernserfaring

Vi har i denne litteraturgjennomgangen skildra eksisterande kunnskap om NAV-kontoret og det kommunale barnevernet si oppfølging av unge med barnevernserfaring, i alderen 18-23 år. Grunnlaget for studien er relevant norsk litteratur, publisert i vitskaplege databasar, nettressursane til NAV og Bufdir, samt publikasjonslistene til forskingsmiljøa FAFO, AFI, og NOVA. Publikasjonane stammar frå tidsromet mellom 2006 og 2016. Totalt fann vi 31 publikasjonar med relevans for vår problemstilling. I tillegg har vi funne støtte i praktisk kunnskap frå feltet, samla i eit erfaringsseminar for fem kommunar/bydelar i juni 2016.K

“…but, it’s really grown on me, Storyline, as practical as it has been’: A critical inquiry of student teachers’ experiences of The Scottish Storyline Approach in teacher education

Through qualitative interviews and self-administrated online surveys, this study critically examines how 104 first-year student teachers experience The Scottish Storyline Approach, a cross-curricular approach to teaching and learning. Framed by Dewey's (2005) concept of experience, The Storyline Approach is discussed as a possible didactic tool for making teaching and learning meaningful. Although not all students experience Storyline as positive, this study finds that the majority of the students report Storyline as relevant for their future profession.publishedVersio

Hvordan sikre best mulig tilbud for barnevernsungdom i overgangen til voksenlivet?

Hovedproblemstillingen i dette prosjektet har vært: Hvordan sikre et best mulig tilbud for barnevernsungdom i overgangen til voksenlivet? Overordnede problemstillinger var: - Hvilken betydning har organisasjonstilhørighet for utformingen av tjenestene ungdommene får? - Hvordan bør samarbeidet mellom NAV-kontoret og barneverntjenesten være? Et hovedformål fra prosjektet har vært utviklingen av et arbeidsverktøy til bruk for ansatte i barneverntjenesten og på NAV-kontoret knyttet til arbeid med denne målgruppen. For å få svar på problemstillingen og lage et best mulig arbeidsverktøy ble prosjektet utformet som flere delprosjekter.Prosjektet er finansiert av K

Functional Characterization of Rare RAB12 Variants and Their Role in Musician's and Other Dystonias

Mutations in RAB (member of the Ras superfamily) genes are increasingly recognized as cause of a variety of disorders including neurological conditions. While musician's dystonia (MD) and writer's dystonia (WD) are task-specific movement disorders, other dystonias persistently affect postures as in cervical dystonia. Little is known about the underlying etiology. Next-generation sequencing revealed a rare missense variant (c.586A> G; p.Ile196Val) in RAB12 in two of three MD/WD families. Next, we tested 916 additional dystonia patients; 512 Parkinson's disease patients; and 461 healthy controls for RAB12 variants and identified 10 additional carriers of rare missense changes among dystonia patients (1.1%) but only one carrier in non-dystonic individuals (0.1%; p = 0.005). The detected variants among index patients comprised p.Ile196Val (n = 6); p.Ala174Thr (n = 3); p.Gly13Asp; p.Ala148Thr; and p.Arg181Gln in patients with MD; cervical dystonia; or WD. Two relatives of MD patients with WD also carried p.Ile196Val. The two variants identified in MD patients (p.Ile196Val; p.Gly13Asp) were characterized on endogenous levels in patient-derived fibroblasts and in two RAB12-overexpressing cell models. The ability to hydrolyze guanosine triphosphate (GTP), so called GTPase activity, was increased in mutants compared to wildtype. Furthermore, subcellular distribution of RAB12 in mutants was altered in fibroblasts. Soluble Transferrin receptor 1 levels were reduced in the blood of all three tested p.Ile196Val carriers. In conclusion, we demonstrate an enrichment of missense changes among dystonia patients. Functional characterization revealed altered enzyme activity and lysosomal distribution in mutants suggesting a contribution of RAB12 variants to MD and other dystonias

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

Coronary artery disease (CAD) is the underlying cause of myocardial infarction and stroke that together are responsible for nearly 30% of all global deaths. CAD is a common complex disease caused by the interactions of multiple genetic and environmental risk factors acting across several metabolic and vascular tissues. Owing to the complexity of these interactions, systems genetics is an increasingly recognized path to a better understanding of complex diseases. In this thesis, we applied systems genetics by integrating the analysis of genotype (DNA) and global gene expression (RNA) data from metabolic and vascular tissues with phenotype data from the clinically well-characterized subjects in the Stockholm Atherosclerosis Gene Expression (STAGE) study. We validated the initial findings using genome-wide association studies (GWAS) and several gene expression datasets from mice and cell models. As a result, we for the first time inferred regulatory gene networks (RGNs) with key drivers of CAD, several of its main risk factors and atherosclerosis regression. In paper I, we designed a computational pipeline to reconstruct RGNs with key drivers in CAD using the STAGE study. Then, by integrating expression quantitative traits (eQTLs) of these RGNs with genotype data from several GWAS, 30 CAD-causal RGNs interconnected in blood, vascular and metabolic tissues were identified. Twelve of these RGNs were further validated in gene expression and phenotype data from the Hybrid Mouse Diversity Panel. As proof of concept, by targeting the key drivers AIP, DRAP1, POLR2I, and PQBP1 in a cross-species-validated, arterial-wall RGN involving RNA-processing genes, we re-identified this RGN in THP-1 foam cells and independent gene expression data from CAD macrophages and carotid lesions. In paper II, we developed a cross-tissue weighted gene co-expression network analysis (X-WGCNA) method (used in Paper I) that reliably captures gene activities both within and across tissues. X-WGCNA is implemented as a package in R and is available online. In paper III, we inferred transcription factor (TF) RGNs from three plasma cholesterol lowering (PCL)-responsive gene sets causally related to regression of early, mature, and advanced mouse atherosclerosis. We then used THP-1 cells in an in vitro atherosclerosis regression model to successfully validate 3 key drivers in these RGNs driving regression in early (PPARG), mature (MLL5), and advanced (SRSF10/XRN2) atherosclerosis. In paper IV, we inferred the STAGE eQTLs (used in papers I and II) and identified subsets with gene regulatory effects across multiple tissues that according to GWAS were highly enriched in association with CAD. To better understand the pathophysiological role of these multi-tissue eQTLs, we identified and analyzed a number of associated gene sets. A key result of this thesis is a repository of RGNs with key drivers for CAD, CAD risk factors, and atherosclerosis regression. This repository together with the computational pipeline including X-WGCNA should be useful in future studies that aim to go beyond genetic loci identified by GWAS and provide opportunities for novel diagnostics and therapies