Antisosyal Davranışları Önlemeye Yönelik “Başarıya İlk Adım Programı” Türkçe Versiyonu’nun Etkililiği

The purpose of this study was to examine the effectiveness of the Turkish version of the First Step to Success (TFSS) early intervention program on problem behaviors, social skills, and academic competence of at-risk students for antisocial behaviors in Turkey. Participants consisted of a total number of 102 students (53 students in experimental and 49 students in control group) and experimental group students’ teachers and mothers. Experimental group students were subjected to implementation of TFSS while control group students were not. Results revealed significant differences between the scores of two groups on problem behaviors and social skills. Moreover, significant decreases in experimental group students’ problem behavior scores and significant increases in their social skills and academic competence scores were observed. High levels of satisfaction were reported by experimental group students’ teachers and mothers. Results are being discussed.Bu çalışmanın amacı, Başarıya İlk Adım Programı Türkçe Versiyonu’nun (BİA-TV) antisosyal davranışlar açısından riskli olan öğrencilerin problem davranışları, sosyal becerileri ve akademik yeterlilikleri üzerindeki etkililiğini incelemektir. Çalışma 53’ü deney ve 49’u kontrol grubunda olmak üzere 31’i anasınıfından 37 birinci sınıf ve 34’ü ikinci sınıftan 102 öğrenciyle gerçekleştirilmiştir. Deney grubu öğrencileri ile BİA-AV programı uygulanırken, kontrol grubu ile herhangi bir uygulama gerçekleştirilmemiştir. Bulgular iki grubun problem davranışları ve sosyal beceri puanları arasında anlamlı farklılıklar olduğunu göstermiştir. Programın deney grubu öğrencilerinin problem davranışlarında anlamlı düşüşe, sosyal beceri ve akademik yeterlilik puanlarında anlamlı artışa yol açtığı gözlenmiştir. Katılımcıların öğretmenleri ve annelerinin memnuniyet düzeyleri yüksek bulunmuştur. Bulgular tartışılmıştır

Infection prevention and control practice for Crimean-Congo hemorrhagic fever - A multicenter cross-sectional survey in Eurasia

<div><p>Background</p><p>Crimean Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection that presents significant risk of nosocomial transmission to healthcare workers.</p><p>Aim</p><p>Evaluation of CCHF infection prevention and control (IP&C) practices in healthcare facilities that routinely manage CCHF cases in Eurasia.</p><p>Methods</p><p>A cross-sectional CCHF IP&C survey was designed and distributed to CCHF centers in 10 endemic Eurasian countries in 2016.</p><p>Results</p><p>Twenty-three responses were received from centers in Turkey, Pakistan, Russia, Georgia, Kosovo, Bulgaria, Oman, Iran, India and Kazakhstan. All units had dedicated isolation rooms for CCHF, with cohorting of confirmed cases in 15/23 centers and cohorting of suspect and confirmed cases in 9/23 centers. There was adequate personal protective equipment (PPE) in 22/23 facilities, with 21/23 facilities reporting routine use of PPE for CCHF patients. Adequate staffing levels to provide care reported in 14/23 locations. All centers reported having a high risk CCHFV nosocomial exposure in last five years, with 5 centers reporting more than 5 exposures. Education was provided annually in most centers (13/23), with additional training requested in PPE use (11/23), PPE donning/doffing (12/23), environmental disinfection (12/23) and waste management (14/23).</p><p>Conclusions</p><p>Staff and patient safety must be improved and healthcare associated CCHF exposure and transmission eliminated. Improvements are recommended in isolation capacity in healthcare facilities, use of PPE and maintenance of adequate staffing levels. We recommend further audit of IP&C practice at individual units in endemic areas, as part of national quality assurance programs.</p></div

A study on performance based logistics/performance based service acquisitions and their applicability to Turkish Navy service acquisition activities

MBA Professional ReportThe purpose of this MBA professional report is to investigate and analyze Performance Based Logistics (PBL)/Performance Based Service Acquisitions (PBSA) and provide implementation alternatives for Turkish Navy service acquisitions. This Professional MBA Report includes a literature review and background information about PBL and PBSA; current PBL and PBSA implementations in the U.S.A.; current Turkish acquisition rules and regulations, along with the legal constraints as to the applicability of PBSA; Turkish Navy service acquisition activities and associated problematic areas; problems with the implementation of PBL and PBSA in the U.S.A. and recommendations for alternative implementation solutions based on the findings.http://archive.org/details/astudyonperforma1094510026Turkish Navy authorApproved for public release; distribution is unlimited

The effect of CYP2C9 gene polymorphisms on blood pressure lowering response to losartan in patients with essential hypertension

Purpose: In this study, the possible effects of CYP2C9 polymorphisms on the clinical response to losartan were investigated in a group of hypertensive patients. Materials and Methods: Seventy-four patients, newly diagnosed to have essential hypertension, and were subsequently prescribed losartan by attending physicians, were prospectively recruited for the study. Blood pressure measurements at the initiation of losartan treatment and six weeks after were completed for all participants. Genetic analysis for CYP2C9 polymorphisms was performed in blood samples collected at baseline. CYP2C9 *2 and *3 variant alleles were genotyped, and polymorphic patients' treatment responses were compared with the patients' who were carrying the wild type genotype. Results: Analysis comparing the wild type genotype and CYP2C9*1*2 genotype revealed a trend toward more systolic blood pressure reduction in favor of wild-type genotype. However, there was no statistically significant difference between these two groups considering the change in diastolic blood pressure levels. Regarding the CYP2C9*1*3 genotype, there were no significant differences in systolic or diastolic blood pressure changes. Conclusion: CYP2C9*1*2 polymorphism affects the systolic blood pressure response to losartan in hypertensive patients, while the CYP2C9*1*3 genotype was not shown in associated with systolic or diastolic blood pressure responses.Hacettepe University Scientific Projects Coordination Unit [0801101009]This study was financially supported by Hacettepe University Scientific Projects Coordination Unit (Number: 0801101009)

Lens Concentration of Ofloxacin and Lomefloxacin in an Experimental Endophthalmitis Model

Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes. Objective: The aim of this study was to determine the penetration of topical ofloxacin and lomefloxacin into the lens in a rabbit endophthalmitis model. Methods: New Zealand white rabbits were randomly divided into 2 groups. The left eyes were infected with an intravitreal inoculation of S aureus. The right eyes were used as a noninoculated control. Groups 1 and 2 received topical ofloxacin and lomefloxacin treatment, respectively, 24 hours after the inoculation. Two drops of the study drugs were instilled in the eyes every 30 minutes for 3 hours and then every 60 minutes for 3 hours. Lens samples were obtained 30 minutes after the last ofloxacin or lomefloxacin drops were administered. High-performance liquid chromatography was used to determine the fluoroquinolone concentration. Results: Ten rabbits were equally divided into the 2 treatment groups. There was no significant difference in mean (SD) lens concentrations between the control and inoculated eyes in either treatment group-ofloxacin (0.26 [0.32] mu g/mL vs 0.11 [0.05] mu g/mL, respectively) and lomefloxacin (0.50 [0.87] mu g/mL vs 0.12 [0.08] mu g/mL, respectively). Conclusions: The results of this small experimental study found that topical ofloxacin and lomefloxacin can accumulate in the crystalline lens after installation. Inflammation did not affect the penetration of ofloxacin or lomefloxacin into the lens.WoSScopu