Ideal Bose gas in fractal dimensions and superfluid 4^4He in porous media

Physical properties of ideal Bose gas with the fractal dimensionality between D=2 and D=3 are theoretically investigated. Calculation shows that the characteristic features of the specific heat and the superfluid density of ideal Bose gas in fractal dimensions are strikingly similar to those of superfluid Helium-4 in porous media. This result indicates that the geometrical factor is dominant over mutual interactions in determining physical properties of Helium-4 in porous media.Comment: 13 pages, 6 figure

Spontaneous orbiting of two spheres levitated in a vibrated liquid

In the absence of gravity, particles can form a suspension in a liquid irrespective of the difference in density between the solid and the liquid. If such a suspension is subjected to vibration there is relative motion between the particles and the fluid which can lead to self-organization and pattern formation. Here we describe experiments carried out to investigate the behavior of two identical spheres suspended magnetically in a fluid, mimicking weightless conditions. Under vibration the spheres mutually attract and, for sufficiently large vibration amplitudes, the spheres are observed to spontaneously orbit each other. The collapse of the experimental data onto a single curve indicates that the instability occurs at a critical value of the streaming Reynolds number. Simulations repro- duce the observed behaviour qualitatively and quantitatively, and are used to identify the features of the flow that are responsible for this instability

Hidden spin-current conservation in 2d Fermi liquids

We report the existence of regimes of the two dimensional Fermi liquid that show unusual conservation of the spin current and may be tuned by varying some parameter like the density of fermions. We show that for reasonable models of the effective interaction the spin current may be conserved in general in 2d, not only for a particular regime. Low temperature spin waves propagate distinctively in these regimes and entirely new ``spin-acoustic'' modes are predicted for scattering-dominated temperature ranges. These new high-temperature propagating spin waves provide a clear signature for the experimental search of such regimes.Comment: 4 pages, no figures, revised version, accepted for pub. in the PR

XY models with disorder and symmetry-breaking fields in two dimensions

The combined effect of disorder and symmetry-breaking fields on the two-dimensional XY model is examined. The study includes disorder in the interaction among spins in the form of random phase shifts as well as disorder in the local orientation of the field. The phase diagrams are determined and the properties of the various phases and phase transitions are calculated. We use a renormalization group approach in the Coulomb gas representation of the model. Our results differ from those obtained for special cases in previous works. In particular, we find a changed topology of the phase diagram that is composed of phases with long-range order, quasi-long-range order, and short-range order. The discrepancies can be ascribed to a breakdown of the fugacity expansion in the Coulomb gas representation. Implications for physical systems such as planar Josephson junctions and the faceting of crystal surfaces are discussed.Comment: 17 pages Latex with 5 eps figures, change: acknowledgment extende

Surface Region of Superfluid Helium as an Inhomogeneous Bose-Condensed Gas

We present arguments that the low density surface region of self-bounded superfluid $^4$He systems is an inhomogeneous dilute Bose gas, with almost all of the atoms occupying the same single-particle state at $T = 0$. Numerical evidence for this complete Bose-Einstein condensation was first given by the many-body variational calculations of $^4$He droplets by Lewart, Pandharipande and Pieper in 1988. We show that the low density surface region can be treated rigorously using a generalized Gross-Pitaevskii equation for the Bose order parameter.Comment: 4 pages, 1 Postscript figur

Nonequilibrium effective field theory for absorbing state phase transitions in driven open quantum spin systems

Phase transitions to absorbing states are among the simplest examples of critical phenomena out of equilibrium. The characteristic feature of these models is the presence of a fluctuationless configuration which the dynamics cannot leave, which has proved a rather stringent requirement in experiments. Recently, a proposal to seek such transitions in highly tuneable systems of cold atomic gases offers to probe this physics and, at the same time, to investigate the robustness of these transitions to quantum coherent effects. Here we specifically focus on the interplay between classical and quantum fluctuations in a simple driven open quantum model which, in the classical limit, reproduces a contact process, which is known to undergo a continuous transition in the "directed percolation" universality class. We derive an effective long-wavelength field theory for the present class of open spin systems and show that, due to quantum fluctuations, the nature of the transition changes from second to first order, passing through a bicritical point which appears to belong instead to the "tricritical directed percolation" class

Transcriptional Evidence for the Role of Chronic Venlafaxine Treatment in Neurotrophic Signaling and Neuroplasticity Including also Glutatmatergic- and Insulin-Mediated Neuronal Processes.

OBJECTIVES: Venlafaxine (VLX), a serotonine-noradrenaline reuptake inhibitor, is one of the most commonly used antidepressant drugs in clinical practice for the treatment of major depressive disorder (MDD). Despite being more potent than its predecessors, similarly to them, the therapeutical effect of VLX is visible only 3-4 weeks after the beginning of treatment. Furthermore, recent papers show that antidepressants, including also VLX, enhance the motor recovery after stroke even in non depressed persons. In the present, transcriptomic-based study we looked for changes in gene expressions after a long-term VLX administration. METHODS: Osmotic minipumps were implanted subcutaneously into Dark Agouti rats providing a continuous (40 mg/kg/day) VLX delivery for three weeks. Frontal regions of the cerebral cortex were isolated and analyzed using Illumina bead arrays to detect genes showing significant chances in expression. Gene set enrichment analysis was performed to identify specific regulatory networks significantly affected by long term VLX treatment. RESULTS: Chronic VLX administration may have an effect on neurotransmitter release via the regulation of genes involved in vesicular exocytosis and receptor endocytosis (such as Kif proteins, Myo5a, Sv2b, Syn2 or Synj2). Simultaneously, VLX activated the expression of genes involved in neurotrophic signaling (Ntrk2, Ntrk3), glutamatergic transmission (Gria3, Grin2b and Grin2a), neuroplasticity (Camk2g/b, Cd47), synaptogenesis (Epha5a, Gad2) and cognitive processes (Clstn2). Interestingly, VLX increased the expression of genes involved in mitochondrial antioxidant activity (Bcl2 and Prdx1). Additionally, VLX administration also modulated genes related to insulin signaling pathway (Negr1, Ppp3r1, Slc2a4 and Enpp1), a mechanism that has recently been linked to neuroprotection, learning and memory. CONCLUSIONS: Our results strongly suggest that chronic VLX treatment improves functional reorganization and brain plasticity by influencing gene expression in regulatory networks of motor cortical areas. These results are consonant with the synaptic (network) hypothesis of depression and antidepressant-induced motor recovery after stroke

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112