“Long have I wished to see the king:” Indigenous Transatlantic Diplomacy in the 18th Century North American Southeast

This thesis situates three examples of transatlantic diplomacy practiced by Cherokee and Yamacraw diplomats in the eighteenth century within their Indigenous contexts. Utilizing treaty negotiations, transcripts from diplomatic summits, official correspondence, published journals, and newspapers, this study aims to situate these delegations within an Indigenous and transatlantic sociopolitical context. The aim of this work is to address questions regarding the objectives of the people involved, and to trace the outcomes of their policies. The answers to these questions explain one of many southeastern Indigenous political strategies of the eighteenth century, one that highlights the imperial center as a crucial setting in which Indigenous diplomatic policy was directed. The primary focus of this study, however, remains the North American interior, for the transatlantic diplomats prioritized their homes above all else. This thesis finds that the Cherokee and Yamacraw diplomats both effectuated several of their desired outcomes in the short term, as well as influenced the course taken by successive generations of Indigenous leaders who learned from their triumphs and their failures

Efficacy of clip-wrapping in treatment of complex pediatric aneurysms

pre-printPurpose: Pediatric aneurysms (PAs) are distinct from their adult counterparts with respect to typical location, aneurysm type, and known predisposing risk factors. Many strategies have been employed to treat PAs, but, although it has been used frequently in adults, clip-wrapping in pediatric patients has only been reported once. We present a series of pediatric patients that underwent clip-wrapping and discuss this strategy as an effective means of treating unclippable PAs. Methods: Pediatric patients with clip-wrapped aneurysms over a 5-year period were retrospectively identified. Clinical presentation, surgical management, and clinical and radiological outcome of the patients were evaluated. Results: Five pediatric patients with aneurysms were treated with clip-wrapping during the specified period. Three had traumatic pseudoaneurysms, with two subarachnoid hemorrhages from aneurysm rupture. One patient presented with mycotic pseudoaneurysm rupture causing a large intraparenchymal and subarachnoid hemorrhage. Another patient had a dissecting complex saccular lenticulostriate aneurysm with 4 perforating vessels arising from the dome. Four patients had good clinical results, with Glasgow Outcome Scale (GOS) scores of 5 after at least 1-year follow-up (mean 24.2); one patient had a GOS score of 5 at discharge but no additional follow-up. Post-operative neuroimaging demonstrated vessel patency after clip-wrapping with no recurrent hemorrhages or increase in aneurysm size; however, one had progressive occlusion of the UU IR Author Manuscript UU IR Author Manuscript University of Utah Institutional Repository Author Manuscript Bowers et al. 3 artery in a delayed fashion and had a small clinical ischemic event from which she fully recovered. Conclusions: Clip-wrapping appears to be an effective underutilized technique for treatment of pediatric complex aneurysms that cannot be treated with conventional methods. Keywords: Complex aneurysms; pediatric; clip-wrapping Running Title: Clip-wrapping pediatric aneurysms UU IR Author Manuscript UU IR Author Manuscript University of Utah Institutional Repository Author Manuscript

Surgical treatment of craniofacial fibrous dysplasia in adults

pre-printCraniofacial fibrous dysplasia is a rare disorder that may require neurosurgical expertise for definitive management; however, surgical management of FD in adult patients is uncommon. Although other therapies have been shown to slow progression, the only definitive cure for adult craniofacial FD is complete resection with subsequent reconstruction. The authors review the biological, epidemiologic, clinical, genetic, and radiographic characteristics of adult FD, with an emphasis on surgical management of FD. They present a small series of three adult patients with complex FD that highlights the surgical complexity required in some adult patients with FD. Because of the complex nature of these adult polyostotic craniofacial cases, the authors used neurosurgical techniques specific to the different surgical indications, including a transsphenoidal approach for resection of sphenoidal sinus FD, a transmaxillary approach to decompress the maxillary branch of the trigeminal nerve with widening of the foramen rotundum, and complete calvarial craniectomy with cranioplasty reconstruction. These cases exemplify the diverse range of skull-base techniques required in the spectrum of surgical management of adult FD and demonstrate that novel variations on standard neurosurgical approaches to the skull base can provide successful outcomes with minimal complications in adults with complex craniofacial FD

Low Risk Monitoring in Neurocritical Care

Background/Rationale: Patients are admitted to Intensive care units (ICUs) either because they need close monitoring despite a low risk of hospital mortality (LRM group) or to receive ICU specific active treatments (AT group). The characteristics and differential outcomes of LRM patients vs. AT patients in Neurocritical Care Units are poorly understood. Methods: We classified 1,702 patients admitted to our tertiary and quaternary care center Neuroscience-ICU in 2016 and 2017 into LRM vs. AT groups. We compared demographics, admission diagnosis, goal of care status, readmission rates and managing attending specialty extracted from the medical record between groups. Acute Physiology, Age and Chronic Health Evaluation (APACHE) IVa risk predictive modeling was used to assess comparative risks for ICU and hospital mortality and length of stay between groups. Results: 56.9% of patients admitted to our Neuroscience-ICU in 2016 and 2017 were classified as LRM, whereas 43.1% of patients were classified as AT. While demographically similar, the groups differed significantly in all risk predictive outcome measures [APACHE IVa scores, actual and predicted ICU and hospital mortality (p \u3c 0.0001 for all metrics)]. The most common admitting diagnosis overall, cerebrovascular accident/stroke, was represented in the LRM and AT groups with similar frequency [24.3 vs. 21.3%, respectively (p = 0.15)], illustrating that further differentiating factors like symptom duration, neurologic status and its dynamic changes and neuro-imaging characteristics determine the indication for active treatment vs. observation. Patients with intracranial hemorrhage/hematoma were significantly more likely to receive active treatments as opposed to having a primary focus on monitoring [13.6 vs. 9.8%, respectively (p = 0.017)]. Conclusion: The majority of patients admitted to our Neuroscience ICU (56.9%) had \u3c10% hospital mortality risk and a focus on monitoring, whereas the remaining 43.1% of patients received active treatments in their first ICU day. LRM Patients exhibited significantly lower APACHE IVa scores, ICU and hospital mortality rates compared to AT patients. Observed-over-expected ICU and hospital mortality ratios were better than predicted by APACHE IVa for low risk monitored patients and close to prediction for actively treated patients, suggesting that at least a subset of LRM patients may safely and more cost effectively be cared for in intermediate level care settings

MICROGRID MODELING ASSESSMENT FOR CLIMATE TRENDS AND WEATHER EVENTS

This report performs a gap analysis on microgrid models with respect to climate change risks at Naval installations. Six climate change risks are identified for the model analysis including drought, flooding, heat, cold, wildfires, and weather extremes. Each climate change risk is decomposed into ordered effects that inform the impacts that the climate risks may have on microgrids. The climate change risks, ordered effects, and the impacts on microgrids are used to analyze three microgrid models to determine if they adequately incorporate the six climate risks. A model analysis framework is developed to identify gaps in the approach of the models, the input parameters of the models, and the assumptions made in the models. The analysis demonstrates that gaps exist in each model when considering the climate change risks, the ordered effects, and the impacts to the microgrid. These gaps exist in all three models analyzed using the model analysis framework. The identified gaps are used to develop recommendations for ways to improve the incorporation of the climate change risks into microgrid models and the necessary research required to inform that data used in microgrid models.Naval Facilities Engineering CommandCivilian, Department of the NavyCivilian, Department of the NavyCivilian, Department of the NavyCivilian, Department of the NavyApproved for public release. Distribution is unlimited

Recommendations for reporting ion mobility Mass Spectrometry measurements

Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N; (ii) ion mobility does not measure molecular surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model; (iii) methods relying on calibration are empirical (and thus may provide method‐dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort toward establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. © 2019 The Authors. Mass Spectrometry Reviews Published by Wiley Periodicals, Inc

On Wings of the Minimum Induced Drag: Spanload Implications for Aircraft and Birds

For nearly a century Ludwig Prandtl's lifting-line theory remains a standard tool for understanding and analyzing aircraft wings. The tool, said Prandtl, initially points to the elliptical spanload as the most efficient wing choice, and it, too, has become the standard in aviation. Having no other model, avian researchers have used the elliptical spanload virtually since its introduction. Yet over the last half-century, research in bird flight has generated increasing data incongruous with the elliptical spanload. In 1933 Prandtl published a little-known paper presenting a superior spanload: any other solution produces greater drag. We argue that this second spanload is the correct model for bird flight data. Based on research we present a unifying theory for superior efficiency and coordinated control in a single solution. Specifically, Prandtl's second spanload offers the only solution to three aspects of bird flight: how birds are able to turn and maneuver without a vertical tail; why birds fly in formation with their wingtips overlapped; and why narrow wingtips do not result in wingtip stall. We performed research using two experimental aircraft designed in accordance with the fundamentals of Prandtl's second paper, but applying recent developments, to validate the various potentials of the new spanload, to wit: as an alternative for avian researchers, to demonstrate the concept of proverse yaw, and to offer a new method of aircraft control and efficiency