93 research outputs found
A quantum trampoline for ultra-cold atoms
We have observed the interferometric suspension of a free-falling
Bose-Einstein condensate periodically submitted to multiple-order diffraction
by a vertical 1D standing wave. The various diffracted matter waves recombine
coherently, resulting in high contrast interference in the number of atoms
detected at constant height. For long suspension times, multiple-wave
interference is revealed through a sharpening of the fringes. We use this
scheme to measure the acceleration of gravity
Two-Dimensional Patterning by a Trapping/Depletion Mechanism: The Role of TTG1 and GL3 in Arabidopsis Trichome Formation
Trichome patterning in Arabidopsis serves as a model system to study how single cells are selected within a field of initially equivalent cells. Current models explain this pattern by an activator–inhibitor feedback loop. Here, we report that also a newly discovered mechanism is involved by which patterning is governed by the removal of the trichome-promoting factor TRANSPARENT TESTA GLABRA1 (TTG1) from non-trichome cells. We demonstrate by clonal analysis and misexpression studies that Arabidopsis TTG1 can act non-cell-autonomously and by microinjection experiments that TTG1 protein moves between cells. While TTG1 is expressed ubiquitously, TTG1–YFP protein accumulates in trichomes and is depleted in the surrounding cells. TTG1–YFP depletion depends on GLABRA3 (GL3), suggesting that the depletion is governed by a trapping mechanism. To study the potential of the observed trapping/depletion mechanism, we formulated a mathematical model enabling us to evaluate the relevance of each parameter and to identify parameters explaining the paradoxical genetic finding that strong ttg1 alleles are glabrous, while weak alleles exhibit trichome clusters
Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance
Malaria symptoms occur during Plasmodium falciparum development into red blood cells. During this process, the parasites make substantial modifications to the host cell in order to facilitate nutrient uptake and aid in parasite metabolism. One significant alteration that is required for parasite development is the establishment of an anion channel, as part of the establishment of New Permeation Pathways (NPPs) in the red blood cell plasma membrane, and we have shown previously that one channel can be activated in uninfected cells by exogenous protein kinase A. Here, we present evidence that in P. falciparum-infected red blood cells, a cAMP pathway modulates anion conductance of the erythrocyte membrane. In patch-clamp experiments on infected erythrocytes, addition of recombinant PfPKA-R to the pipette in vitro, or overexpression of PfPKA-R in transgenic parasites lead to down-regulation of anion conductance. Moreover, this overexpressing PfPKA-R strain has a growth defect that can be restored by increasing the levels of intracellular cAMP. Our data demonstrate that the anion channel is indeed regulated by a cAMP-dependent pathway in P. falciparum-infected red blood cells. The discovery of a parasite regulatory pathway responsible for modulating anion channel activity in the membranes of P. falciparum-infected red blood cells represents an important insight into how parasites modify host cell permeation pathways. These findings may also provide an avenue for the development of new intervention strategies targeting this important anion channel and its regulation
Cold atoms in space: community workshop summary and proposed road-map
We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies
Sensorimotor Experience Influences Recovery of Forelimb Abilities but Not Tissue Loss after Focal Cortical Compression in Adult Rats
Sensorimotor activity has been shown to play a key role in functional outcome after extensive brain damage. This study was aimed at assessing the influence of sensorimotor experience through subject-environment interactions on the time course of both lesion and gliosis volumes as well as on the recovery of forelimb sensorimotor abilities following focal cortical injury. The lesion consisted of a cortical compression targeting the forepaw representational area within the primary somatosensory cortex of adult rats. After the cortical lesion, rats were randomly subjected to various postlesion conditions: unilateral C5–C6 dorsal root transection depriving the contralateral cortex from forepaw somatosensory inputs, standard housing or an enriched environment promoting sensorimotor experience and social interactions. Behavioral tests were used to assess forelimb placement during locomotion, forelimb-use asymmetry, and forepaw tactile sensitivity. For each group, the time course of tissue loss was described and the gliosis volume over the first postoperative month was evaluated using an unbiased stereological method. Consistent with previous studies, recovery of behavioral abilities was found to depend on post-injury experience. Indeed, increased sensorimotor activity initiated early in an enriched environment induced a rapid and more complete behavioral recovery compared with standard housing. In contrast, severe deprivation of peripheral sensory inputs led to a delayed and only partial sensorimotor recovery. The dorsal rhizotomy was found to increase the perilesional gliosis in comparison to standard or enriched environments. These findings provide further evidence that early sensory experience has a beneficial influence on the onset and time course of functional recovery after focal brain injury
iSense: a technology platform for cold atom based quantum technologies
A breakthrough in cold atom quantum technology is hindered by a bottleneck in the supporting technologies. We discuss a cold atom technology platform developed within the European iSense project, aiming at a gravimeter as demonstrator
Design of a dual species atom interferometer for space
Atom interferometers have a multitude of proposed applications in space
including precise measurements of the Earth's gravitational field, in
navigation & ranging, and in fundamental physics such as tests of the weak
equivalence principle (WEP) and gravitational wave detection. While atom
interferometers are realized routinely in ground-based laboratories, current
efforts aim at the development of a space compatible design optimized with
respect to dimensions, weight, power consumption, mechanical robustness and
radiation hardness. In this paper, we present a design of a high-sensitivity
differential dual species Rb/Rb atom interferometer for space,
including physics package, laser system, electronics and software. The physics
package comprises the atom source consisting of dispensers and a 2D
magneto-optical trap (MOT), the science chamber with a 3D-MOT, a magnetic trap
based on an atom chip and an optical dipole trap (ODT) used for Bose-Einstein
condensate (BEC) creation and interferometry, the detection unit, the vacuum
system for mbar ultra-high vacuum generation, and the
high-suppression factor magnetic shielding as well as the thermal control
system. The laser system is based on a hybrid approach using fiber-based
telecom components and high-power laser diode technology and includes all laser
sources for 2D-MOT, 3D-MOT, ODT, interferometry and detection. Manipulation and
switching of the laser beams is carried out on an optical bench using Zerodur
bonding technology. The instrument consists of 9 units with an overall mass of
221 kg, an average power consumption of 608 W (819 W peak), and a volume of 470
liters which would well fit on a satellite to be launched with a Soyuz rocket,
as system studies have shown.Comment: 30 pages, 23 figures, accepted for publication in Experimental
Astronom
STE-QUEST - Test of the Universality of Free Fall Using Cold Atom Interferometry
In this paper, we report about the results of the phase A mission study of the atom
interferometer instrument covering the description of the main payload elements, the
atomic source concept, and the systematic error sources
Technology roadmap for cold-atoms based quantum inertial sensor in space
Recent developments in quantum technology have resulted in a new generation of sensors for measuring inertial quantities, such as acceleration and rotation. These sensors can exhibit unprecedented sensitivity and accuracy when operated in space, where the free-fall interrogation time can be extended at will and where the environment noise is minimal. European laboratories have played a leading role in this field by developing concepts and tools to operate these quantum sensors in relevant environment, such as parabolic flights, free-fall towers, or sounding rockets. With the recent achievement of Bose-Einstein condensation on the International Space Station, the challenge is now to reach a technology readiness level sufficiently high at both component and system levels to provide "off the shelf"payload for future generations of space missions in geodesy or fundamental physics. In this roadmap, we provide an extensive review on the status of all common parts, needs, and subsystems for the application of atom-based interferometers in space, in order to push for the development of generic technology components
Terrestrial Very-Long-Baseline Atom Interferometry:Workshop Summary
This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions
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