The hidden burden of adult allergic rhinitis : UK healthcare resource utilisation survey

Funding Funding for this survey was provided by Meda Pharma.Peer reviewedPublisher PD

Direct evidence for ferroelectric polar distortion in ultrathin lead titanate perovskite films

X-ray photoelectron diffraction is used to directly probe the intra-cell polar atomic distortion and tetragonality associated with ferroelectricity in ultrathin epitaxial PbTiO3 films. Our measurements, combined with ab-initio calculations, unambiguously demonstrate non-centro-symmetry in films a few unit cells thick, imply that films as thin as 3 unit cells still preserve a ferroelectric polar distortion, and also show that there is no thick paraelectric dead layer at the surface

Confluence of geodesic paths and separating loops in large planar quadrangulations

We consider planar quadrangulations with three marked vertices and discuss the geometry of triangles made of three geodesic paths joining them. We also study the geometry of minimal separating loops, i.e. paths of minimal length among all closed paths passing by one of the three vertices and separating the two others in the quadrangulation. We concentrate on the universal scaling limit of large quadrangulations, also known as the Brownian map, where pairs of geodesic paths or minimal separating loops have common parts of non-zero macroscopic length. This is the phenomenon of confluence, which distinguishes the geometry of random quadrangulations from that of smooth surfaces. We characterize the universal probability distribution for the lengths of these common parts.Comment: 48 pages, 33 color figures. Final version, with one concluding paragraph and one reference added, and several other small correction

Multicritical continuous random trees

We introduce generalizations of Aldous' Brownian Continuous Random Tree as scaling limits for multicritical models of discrete trees. These discrete models involve trees with fine-tuned vertex-dependent weights ensuring a k-th root singularity in their generating function. The scaling limit involves continuous trees with branching points of order up to k+1. We derive explicit integral representations for the average profile of this k-th order multicritical continuous random tree, as well as for its history distributions measuring multi-point correlations. The latter distributions involve non-positive universal weights at the branching points together with fractional derivative couplings. We prove universality by rederiving the same results within a purely continuous axiomatic approach based on the resolution of a set of consistency relations for the multi-point correlations. The average profile is shown to obey a fractional differential equation whose solution involves hypergeometric functions and matches the integral formula of the discrete approach.Comment: 34 pages, 12 figures, uses lanlmac, hyperbasics, eps

First experimental demonstration of temporal hypertelescope operation with a laboratory prototype

In this paper, we report the first experimental demonstration of a Temporal HyperTelescope (THT). Our breadboard including 8 telescopes is firstly tested in a manual cophasing configuration on a 1D object. The Point Spread Function (PSF) is measured and exhibits a dynamics in the range of 300. A quantitative analysis of the potential biases demonstrates that this limitation is related to the residual phase fluctuation on each interferometric arm. Secondly, an unbalanced binary star is imaged demonstrating the imaging capability of THT. In addition, 2D PSF is recorded even if the telescope array is not optimized for this purpose.Comment: Accepted for publication in MNRAS. 11 pages, 25 figure

Loop models on random maps via nested loops: case of domain symmetry breaking and application to the Potts model

We use the nested loop approach to investigate loop models on random planar maps where the domains delimited by the loops are given two alternating colors, which can be assigned different local weights, hence allowing for an explicit Z_2 domain symmetry breaking. Each loop receives a non local weight n, as well as a local bending energy which controls loop turns. By a standard cluster construction that we review, the Q = n^2 Potts model on general random maps is mapped to a particular instance of this problem with domain-non-symmetric weights. We derive in full generality a set of coupled functional relations for a pair of generating series which encode the enumeration of loop configurations on maps with a boundary of a given color, and solve it by extending well-known complex analytic techniques. In the case where loops are fully-packed, we analyze in details the phase diagram of the model and derive exact equations for the position of its non-generic critical points. In particular, we underline that the critical Potts model on general random maps is not self-dual whenever Q \neq 1. In a model with domain-symmetric weights, we also show the possibility of a spontaneous domain symmetry breaking driven by the bending energy.Comment: 44 pages, 13 figure

Treatment trends in allergic rhinitis and asthma: a British ENT survey

<p>Abstract</p> <p>Background</p> <p>Allergic Rhinitis is a common Ear, Nose and Throat disorder. Asthma and Allergic Rhinitis are diseases with similar underlying mechanism and pathogenesis. The aim of this survey was to highlight current treatment trends for Allergic Rhinitis and Asthma.</p> <p>Method</p> <p>A questionnaire was emailed to all registered consultant members of the British Association of Otorhinolaryngologists - Head and Neck Surgeons regarding the management of patients with Allergic Rhinitis and related disorders.</p> <p>Results</p> <p>Survey response rate was 56%. The results indicate a various approach in the investigation and management of Allergic Rhinitis compatible with recommendations from the Allergic Rhinitis and Its Impact on Asthma guidelines in collaboration with the World Health Organisation.</p> <p>Conclusion</p> <p>A combined management approach for patients with Allergic Rhinitis and concomitant Asthma may reduce medical treatment costs for these conditions and improve symptom control and quality of life.</p

Clinical and biological heterogeneity in children with moderate asthma

To evaluate the relationship between inflammatory markers and severity of asthma in children, the amount of interleukin-8 (IL-8) and granulocyte/macrophage colony-stimulating factor (GM-CSF) released by peripheral blood mononuclear cells, exhaled nitric oxide (FE NO) levels, p65 nuclear factor-kappaB subunit, and phosphorylated IkBalpha expression by peripheral blood mononuclear cells were assessed in six control subjects, 12 steroid-naives subjects with intermittent asthma, and 17 children with moderate asthma. To investigate their predictive value, biomarker levels were correlated with the number of exacerbations during a 18-month follow-up period. We found that GM-CSF release was higher in moderate and intermittent asthmatics than in control subjects, whereas IL-8 release was higher in moderate than in intermittent asthmatics and control subjects. FE NO levels were similar among study groups. In moderate asthmatics, IL-8, GM-CSF, and FE NO significantly correlated with the exacerbation numbers. Moreover, p65 and phosphorylated IkBalpha levels were greater in moderate than in intermittent asthmatics and control subjects. According to GM-CSF, IL-8, and FE NO levels, two distinct subgroups of moderate asthmatics (low and high producers) were identified. High producers experienced more exacerbations than low producers. This study shows ongoing inflammation associated with biological and clinical heterogeneity in moderate asthmatics despite regular treatment and proposes that large prospective studies confirm the importance of biomarkers to assess inflammation and asthma control in children with asthma

Supportive networks among companies: Key factors of success and failure

The role of entrepreneurial networks in the development of Small and Medium-sized Enterprises (SMEs) and the associated entrepreneurial activities are a core topic in both the networks and IMP literature. However the effectiveness of these networks remains little understood. This paper investigates a specific form of formal entrepreneurial network: the supportive networks among companies. More precisely, it seeks to identify the key factors of success and failure of these networks in their actions to support small and new business development by focusing on the interactions between the three categories of actors embedded in these networks. Eleven case studies were undertaken focusing on three French supportive networks between companies. The results showed that convergent interests - altruistic as well as economic - shared both between and within companies is the overarching reason why supportive action succeeds. We also found that interactions driven by non-trading interests contribute favourably to the development of the dynamics of these networks