The impact of COVID-19-related living restrictions on eating behaviours in children and adolescents: a systematic review

The COVID-19 pandemic prompted the imposition of physical and social distancing measures worldwide. Emerging data suggest that younger age groups may be particularly vulnerable to the adverse mental health impacts of the pandemic. Since the start of the COVID-19 pandemic, there has been an unprecedented increase in demand for child and adolescent eating disorder services. The aim of this review was to systematically review and appraise the current literature on the impact of COVID-19-related living restrictions on the eating behaviours of children and adolescents. Searches of eight electronic databases were conducted in March 2021 and December 2021 for published and grey literature on eating behaviours of population samples of children and adolescents (aged 18 months to 18 years old) who were exposed to COVID-19-related living restrictions. Of 3165 retrieved references, sixteen studies were included in this review, comprising data from 125, 286 participants. There was a pattern towards healthier eating behaviours among children and adolescents during the COVID-19 lockdown. However, young people from lower socioeconomic groups showed a tendency towards more unhealthy eating behaviours, and there was an association between mood difficulties and greater changes in eating; this suggests that such groups may be more vulnerable to the adverse health consequences of lockdowns

Completion gastrectomy with esophagojejunostomy for management of complications of benign foregut surgery

Background: With the worldwide epidemic of obesity, an increasing number of bariatric operations and antireflux fundoplications are being performed. Despite low morbidity of the primary foregut surgery, completion gastrectomy may be necessary as a definitive procedure for complications of prior foregut surgery; however, the literature evaluating outcomes after completion gastrectomy with esophagojejunostomy (EJ) for benign diseases is limited. We present our experience of completion gastrectomy with Roux-en-Y EJ in the setting of benign disease at a single tertiary center. Methods and Procedures: All patients who underwent total, proximal, or completion gastrectomy with EJ for complications of benign foregut surgery from January 2006 to December 2015 were retrospectively identified. All cancer operations were excluded. Results: There were 23 patients who underwent gastrectomy with EJ (13 laparoscopic EJ [LEJ] and 10 open EJ). The index operations included 12 antireflux, 9 bariatric, and 2 peptic ulcer disease surgeries. Seventy-eight percent of patients had surgical or endoscopic interventions before EJ, with a median of one prior intervention and a median interval from the index operation to EJ of 25 months (interquartile range 9–87). The 30-day perioperative complication rate was 30% with 17% classified being major (Clavien–Dindo ≥ III) and no 30-day perioperative mortality. Comparing laparoscopic and open approaches showed similar operative times, estimated blood loss, and overall complication rate. LEJ was associated with a shorter length of stay (LOS) (P < .001), fewer postoperative ICU days (P = .002), fewer 6-month complication rates (P < .007), and decreased readmission rate (P = .024). Conclusion: Our series demonstrates that EJ is a reasonable option for reoperative foregut surgery. The laparoscopic approach appears to be associated with decreased LOS and readmissions

Protein Expression in the Nucleus Accumbens of Rats Exposed to Developmental Vitamin D Deficiency

Introduction: Developmental vitamin D (DVD) deficiency is a candidate risk factor for schizophrenia. Animal models have confirmed that DVD deficiency is associated with a range of altered genomic, proteomic, structural and behavioural outcomes in the rat. Because the nucleus accumbens has been implicated in neuropsychiatric disorders, in the current study we examined protein expression in this region in adult rats exposed to DVD deficienc

Contributions of Dopamine-Related Genes and Environmental Factors to Highly Sensitive Personality: A Multi-Step Neuronal System-Level Approach

Traditional behavioral genetic studies (e.g., twin, adoption studies) have shown that human personality has moderate to high heritability, but recent molecular behavioral genetic studies have failed to identify quantitative trait loci (QTL) with consistent effects. The current study adopted a multi-step approach (ANOVA followed by multiple regression and permutation) to assess the cumulative effects of multiple QTLs. Using a system-level (dopamine system) genetic approach, we investigated a personality trait deeply rooted in the nervous system (the Highly Sensitive Personality, HSP). 480 healthy Chinese college students were given the HSP scale and genotyped for 98 representative polymorphisms in all major dopamine neurotransmitter genes. In addition, two environment factors (stressful life events and parental warmth) that have been implicated for their contributions to personality development were included to investigate their relative contributions as compared to genetic factors. In Step 1, using ANOVA, we identified 10 polymorphisms that made statistically significant contributions to HSP. In Step 2, these polymorphism's main effects and interactions were assessed using multiple regression. This model accounted for 15% of the variance of HSP (p<0.001). Recent stressful life events accounted for an additional 2% of the variance. Finally, permutation analyses ascertained the probability of obtaining these findings by chance to be very low, p ranging from 0.001 to 0.006. Dividing these loci by the subsystems of dopamine synthesis, degradation/transport, receptor and modulation, we found that the modulation and receptor subsystems made the most significant contribution to HSP. The results of this study demonstrate the utility of a multi-step neuronal system-level approach in assessing genetic contributions to individual differences in human behavior. It can potentially bridge the gap between the high heritability estimates based on traditional behavioral genetics and the lack of reproducible genetic effects observed currently from molecular genetic studies

Mountain glacier fluctuations during the Lateglacial and Holocene on Clavering Island (northeastern Greenland) from 10Be moraine dating

Despite an increasing interest in Greenlandic mountain glaciers over the last decades, their evolution during the Lateglacial and Holocene still needs to be better constrained. Here we present 25 10Be cosmic-ray exposure (CRE) ages of boulders collected on moraines from three glaciers located on Clavering Island (northeastern Greenland). CRE ages span 16.29±0.79 ka to 0.37±0.05 ka and reveal three periods of moraine formation during the Lateglacial, the early and the late Holocene. Data show a multimodal distribution of the ages during the Lateglacial with exposure ages spanning from 16.29±0.79 ka to 12.31±1.3 ka. At least two glaciers experienced a greater expansion at the beginning of the Holocene than at the end of the Holocene, dated to 11.3±0.3 ka and 10.8±0.6 ka, respectively. At the end of the Holocene, glacial advances occurred during the Dark Ages Cold Period and the during the Little Ice Age (LIA), synchronous with glacial advances documented in nearby lake sediments. This new CRE chronology highlights that the LIA extent is not the largest glacier advance in the Late Holocene in Clavering Island. This broadly corresponds with other mountain glaciers of western and northern Greenland, and does not appear to reflect northern high latitude summer insolation that would suggest progressive temperature decrease, but instead mimics recent regional continental temperature reconstructions that show a long term warming driven by different forcing

From locked-down to locked-in? COVID-induced social practice change across four consumption domains

The COVID-19 pandemic has disrupted everyday living and social practices, prompting questions of whether more sustainable consumption patterns are emerging and the likelihood of their long-term retention. To examine these questions, we apply a practice-based approach to a quantitative study of COVID-driven practice changes in the domains of food, material consumption, housing, and mobility conducted in four global North countries (Germany, Italy, Japan, and the United States). We discuss the trends emerging from our analysis from a sustainability perspective and address the role of social practice elements – materials, meanings, competences – in the establishment and discontinuation of sustainable consumption practices. Observed sustainability gains in specific practices and domains (such as a decrease in material consumption and more sustainable food practices and diets), may be offset by other practices, particularly a renewed desire for air travel and larger housing. The uptake and lock-in of sustainable practices are driven by a combination of meaning and material-related practice elements such as the alignment with interests and personal values; the availability of labor, energy, or time; and the ability to routinize practices. However, new policies to support emerging lifestyle shifts, as well as the development of businesses catering to and encouraging low-impact practices, may ultimately determine the formation of a more sustainable “new normal.” We also reflect on the strengths and limitations of using quantitative research methods in studies of sustainable consumption informed by social practice theories