Aneurysmal bone cyst primary - about eight pediatric cases: radiological aspects and review of the literature

The aneurysmal bone cyst is a pseudotumoral lesion that can take several aspects. This is a rare lesion representing 1% of bone tumors. It appears usually during the first 30 years of life. The pathogenesis is that of a process of "dysplasia/hyperplasia", favored by a circulatory deficiency and hemorrhage within the lesion and the phenomena of osteoclasis. The objective of this work is to illustrate with analysis, the specific forms and atypical aneurysmal bone cyst which often pose a diagnostic challenge requiring radiological investigation with histological confirmation. We report eight pediatric cases of aneurysmal cysts collected over a period of 3 years, 3 boys and 5 girls. All patients had standard radiographs. MRI was performed in three patients. The diagnosis was confirmed histologically. The atypia has been in the seat: fibula (1 case), metaphyseal (2 cases), diaphyseal (4 cases) and metatarsal (1 case). Aneurysmal bone cyst is a rare benign tumor with predilection to the metaphysis of long bones. Atypical forms even fewer are dominated by the atypical seat.Key words: Bone cyst, aneurysm, osteolytic lesio

Une pneumopathie interstitielle diffuse révélant un syndrome des antisynthétases: à propos de 2 cas

Le syndrome des antisynthétases (SAS) est une myopathie inflammatoire fréquemment associée à une atteinte pulmonaire, surtout parenchymateuse (pneumopathie infiltrante diffuse). Les manifestations extrathoraciques associées à l'atteinte pulmonaire peuvent orienter le diagnostic: myalgies, polyarthralgies, syndrome de Raynaud, hyperkératose érythémateuse palmaire fissuraire et fièvre. Devant un tableau clinique et radiologique évocateur, la présence d'anticorps anti-ARN-t synthétases permet de confirmer notamment les anti-Jo-1. L'atteinte pulmonaire constitue un facteur pronostic majeur d'où l'indication une thérapie immunosuppressive intensive fondée sur la corticothérapie, les immunosuppresseurs ou l'association des deux. Une meilleure sensibilisation pour cette affection à révélation pulmonaire permettra d'adopter une prise en charge rapide et adéquate, et d'améliorer par conséquent le pronostic

Les ostéochondromes: aspects clinico-radiologiques, à propos de 12 cas

L’ostéochondrome est l’une des tumeurs osseuses bénignes les plus fréquentes des membres. A travers une série de 12 observations d’ostéochondromes, les auteurs ont prélevés leurs aspects clinico-radiologiques et proposent une revue de la littérature à propos de cette tumeur, en précisant ses aspects cliniques, radiologiques et ses formes compliquées.Pan African Medical Journal 2016; 2

Apport de l'IRM dans la maladie de Creutzfeldt-Jakob: à propos d'un cas

La maladie de Creutzfeld-Jacob (MCJ) est une affection très rare et fatale qui atteint le système nerveux central. Elle est caractérisée par une détérioration mentale aboutissant à une démence progressive, une symptomatologie pyramidale et extra-pyramidale ainsi que des myolclonies. Un diagnostic précoce est essentiel pour prévenir la transmission interhumaine. Nous rapportons le cas d'un patient âgé de 62 ans chez qui le diagnostic de MCJ sporadique a été retenu, en se basant sur le tableau clinique fait de syndrome démentiel avec myoclonies précédées de troubles du comportement, des hallucinations et de dépression, et sur les données de l'IRM encéphalique qui a montré des hyper signaux au niveau du striatum et au niveau cortical en séquences pondérées Flair et diffusion

Syndrome de Sturge Weber Krabbe: entité exceptionnelle (à propos d'un cas)

Nous rapportons le cas d'un syndrome de Sturge Weber diagnostiqué au sein du Service de Radiologie de CHU Hassan II de Fès. A partir de cette observation, nous montrons les aspects cliniques, diagnostiques et thérapeutiques ainsi qu'évolutifs de cette entité neuro radiologique exceptionnelle

Ultra-small fatty acid-stabilized magnetite nanocolloids synthesized by in situ hydrolytic precipitation

© 2015 Kheireddine El-Boubbou et al. Simple, fast, large-scale, and cost-effective preparation of uniform controlled magnetic nanoparticles remains a major hurdle on the way towards magnetically targeted applications at realistic technical conditions. Herein, we present a unique one-pot approach that relies on simple basic hydrolytic in situ coprecipitation of inexpensive metal salts (Fe<sup>2+</sup> and Fe<sup>3+</sup>) compartmentalized by stabilizing fatty acids and aided by the presence of alkylamines. The synthesis was performed at relatively low temperatures (80°C) without the use of high-boiling point solvents and elevated temperatures. This method allowed for the production of ultra-small, colloidal, and hydrophobically stabilized magnetite metal oxide nanoparticles readily dispersed in organic solvents. The results reveal that the obtained magnetite nanoparticles exhibit narrow size distributions, good monodispersities, high saturation magnetizations, and excellent colloidal stabilities. When the [fatty acid]: [Fe] ratio was varied, control over nanoparticle diameters within the range of 2-10 nm was achieved. The amount of fatty acid and alkylamine used during the reaction proved critical in governing morphology, dispersity, uniformity, and colloidal stability. Upon exchange with water-soluble polymers, the ultra-small sized particles become biologically relevant, with great promise for theranostic applications as imaging and magnetically targeted delivery vehicles

Idiopathic encapsulating peritonitis revealed by an acute bowel occlusion in a young patient

La péritonite encapsulante est une péritonite chronique aboutissant à une membrane fibreuse épaisse, blanc nacré. C’est une affection rare dont la physiopathologie reste mal expliquée et le diagnostic est souvent porté en peropératoire ; elle peut être la cause d’une urgence chirurgicale, le caractère idiopathique est exceptionnel, retrouvé chez l’adolescent provenant des régions tropicales et subtropicales, jamais dans le Maghreb. Nous rapportons l’observation d’une jeune patiente marocaine de 18 ans, opérée pour une occlusion intestinale, chez qui le diagnostic d’une péritonite encapsulante a été posé en peropératoire.Encapsulating peritonitis is a chronic peritonitis leading to the constitution of a thick pearly-white fibrosis membrane. It is a rare affection, which physiopathology is poorly elucidated. Diagnosis is usually assessed during surgery; the idiopathic character is exceptional, occurring in teenagers coming from the tropical and subtropical countries, never in Maghreb. We report an unpublished case of an 18-year-old patient, admitted for bowel obstruction; diagnosis was made during surgery revealing an encapsulating peritonitis

Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin

Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic

SR proteins and galectins: what's in a name?

Although members of the serine (S)- and arginine (R)-rich splicing factor family (SR proteins) were initially purified on the basis of their splicing activity in the nucleus, there is recent documentation that they exhibit carbohydrate-binding activity at the cell surface. In contrast, galectins were isolated on the basis of their saccharide-binding activity and cell surface localization. Surprisingly, however, two members (galectin-1 and galectin-3) can be found in association with nuclear ribonucleoprotein complexes including the spliceosome and, using a cell-free assay, have been shown to be required splicing factors. Thus, despite the difference in terms of their original points of interest, it now appears that members of the two protein families share four key properties: (a) nuclear and cytoplasmic distribution; (b) pre-mRNA splicing activity; (c) carbohydrate-binding activity; and (d) cell surface localization in specific cells. These findings provoke stimulating questions regarding the relationship between splicing factors in the nucleus and carbohydrate-binding proteins at the cell surface

An Overview of Recent Strategies in Pathogen Sensing

Pathogenic bacteria are one of the major concerns in food industries and water treatment facilities because of their rapid growth and deleterious effects on human health. The development of fast and accurate detection and identification systems for bacterial strains has long been an important issue to researchers. Although confirmative for the identification of bacteria, conventional methods require time-consuming process involving either the test of characteristic metabolites or cellular reproductive cycles. In this paper, we review recent sensing strategies based on micro- and nano-fabrication technology. These technologies allow for a great improvement of detection limit, therefore, reduce the time required for sample preparation. The paper will be focused on newly developed nano- and micro-scaled biosensors, novel sensing modalities utilizing microfluidic lab-on-a-chip, and array technology for the detection of pathogenic bacteria