173 research outputs found
CP Violation and the Width
We discuss the effect of CP-violating , and
couplings on the width . The
presence of such couplings leads in a natural way to an increase of this width
relative to the prediction of the standard model. Various strategies of a
direct search for such CP-violating couplings by using CP-odd observables are
outlined. The number of bosons required to obtain significant information
on the couplings in this way is well within the reach of present LEP
experiments.Comment: 18 pages, LaTeX, no figure
Bioassay-guided isolation and identification of antimicrobial compounds from thyme essential oil by means of overpressured layer chromatography, bioautography and GC-MS
A simple method is described for efficient isolation of compounds having an antibacterial effect.
Two thyme (Thymus vulgaris) essential oils, obtained from the market, were chosen as
prospective materials likely to feature several bioactive components when examined by thin layer
chromatography coupled with direct bioautography as a screening method. The newly developed
infusion overpressured layer chromatographic separation method coupled with direct
bioautography assured that only the active components were isolated by means of overrun
overpressured layer chromatography with online detection and fractionation. Each of the 5
collected fractions represented one of the five antimicrobial essential oil components designated
at the screening. The purity and the activity of the fractions were confirmed with chromatography
coupled various detection methods (UV, vanillin-sulphuric acid reagent, direct bioautography).
The antibacterial components were identified with GC-MS as thymol, carvacrol, linalool, diethylphthalate,
and alpha-terpineol. The oil component diethyl-phthalate is an artificial compound,
used as plasticizer or detergent bases in the industry. Our results support that exploiting its
flexibility and the possible hyphenations, overpressured layer chromatography is especially
attractive for isolation of antimicrobial components from various matrixes
Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms
Neuroimmune interactions may contribute to severe pain and regional inflammatory and autonomic signs in complex regional pain syndrome (CRPS), a posttraumatic pain disorder. Here, we investigated peripheral and central immune mechanisms in a translational passive transfer trauma mouse model of CRPS. Small plantar skin–muscle incision was performed in female C57BL/6 mice treated daily with purified serum immunoglobulin G (IgG) from patients with longstanding CRPS or healthy volunteers followed by assessment of paw edema, hyperalgesia, inflammation, and central glial activation. CRPS IgG significantly increased and prolonged swelling and induced stable hyperalgesia of the incised paw compared with IgG from healthy controls. After a short-lasting paw inflammatory response in all groups, CRPS IgG-injected mice displayed sustained, profound microglia and astrocyte activation in the dorsal horn of the spinal cord and pain-related brain regions, indicating central sensitization. Genetic deletion of interleukin-1 (IL-1) using IL-1αβ knockout (KO) mice and perioperative IL-1 receptor type 1 (IL-1R1) blockade with the drug anakinra, but not treatment with the glucocorticoid prednisolone, prevented these changes. Anakinra treatment also reversed the established sensitization phenotype when initiated 8 days after incision. Furthermore, with the generation of an IL-1β floxed(fl/fl) mouse line, we demonstrated that CRPS IgG-induced changes are in part mediated by microglia-derived IL-1β, suggesting that both peripheral and central inflammatory mechanisms contribute to the transferred disease phenotype. These results indicate that persistent CRPS is often contributed to by autoantibodies and highlight a potential therapeutic use for clinically licensed antagonists, such as anakinra, to prevent or treat CRPS via blocking IL-1 actions
Non-inflammatory autoantibody-induced glia activation in a passive transfer-trauma mouse model of complex regional pain syndrome
Soft Color Interactions and Diffractive Hard Scattering at the Fermilab Tevatron
An improved understanding of nonperturbative QCD can be obtained by the
recently developed soft color interaction models. Their essence is the
variation of color string-field topologies, giving a unified description of
final states in high energy interactions, e.g., diffractive and nondiffractive
events in ep and ppbar. Here we present a detailed study of such models (the
soft color interaction model and the generalized area law model) applied to
ppbar, considering also the general problem of the underlying event including
beam particle remnants. With models tuned to HERA ep data, we find a good
description also of Tevatron data on production of W, beauty and jets in
diffractive events defined either by leading antiprotons or by one or two
rapidity gaps in the forward or backward regions. We also give predictions for
diffractive J/psi production where the soft exchange mechanism produces both a
gap and a color singlet ccbar state in the same event. This soft color
interaction approach is also compared with Pomeron-based models for
diffraction, and some possibilities to experimentally discriminate between
these different approaches are discussed.Comment: 35 pages, 15 figures, uses REVTeX. Minor changes, version to appear
in Phys. Rev.
Cruise Report Poseidon 229a/b Kolbeinsey Ridge, Akureyri - Reykjavik, 22.05.1997 - 11.06.1997
General Subject of research: Detailed study of the shallow water hydrothermal system around Kolbeinsey and Grimsey island
Soft Photons in Hadron-Hadron Collisions: Synchrotron Radiation from the QCD Vacuum?
We discuss the production of soft photons in high energy hadron-hadron
collisions. We present a model where quarks and antiquarks in the hadrons emit
``synchrotron light'' when being deflected by the chromomagnetic fields of the
QCD vacuum, which we assume to have a nonperturbative structure. This gives a
source of prompt soft photons with frequencies in the c.m.
system of the collision in addition to hadronic bremsstrahlung. In comparing
the frequency spectrum and rate of ``synchrotron'' photons to experimental
results we find some supporting evidence for their existence. We make an
exclusive--inclusive connection argument to deduce from the ``synchrotron''
effect a behaviour of the neutron electric formfactor proportional
to for . We find this to be consistent with
available data. In our view, soft photon production in high energy
hadron-hadron and lepton-hadron collisions as well as the behaviour of
electromagnetic hadron formfactors for low are thus sensitive probes of
the nonperturbative structure of the QCD vacuum.Comment: Heidelberg preprint HD-THEP-94-36, 31 pages, LaTeX + ZJCITE.sty
(included), 12 figures appended as uuencoded compressed ps-fil
Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.
Semicarbazide-sensitive amine oxidase (SSAO) catalyses oxidative deamination of primary amines. Since there is no data about its function in pain and arthritis mechanisms, we investigated the effects of our novel SSAO inhibitor SzV-1287 in chronic mouse models of joint inflammation. Effects of SzV-1287 (20 mg/kg i.p./day) were investigated in the K/BxN serum-transfer and complete Freund's adjuvant (CFA)-evoked active immunization models compared to the reference SSAO inhibitor LJP-1207. Mechanonociception was assessed by aesthesiometry, oedema by plethysmometry, clinical severity by scoring, joint function by grid test, myeloperoxidase activity by luminescence, vascular leakage by fluorescence in vivo imaging, histopathological changes by semiquantitative evaluation, and cytokines by Luminex assay. SzV-1287 significantly inhibited hyperalgesia and oedema in both models. Plasma leakage and keratinocyte chemoattractant production in the tibiotarsal joint, but not myeloperoxidase activity was significantly reduced by SzV-1287 in K/BxN-arthritis. SzV-1287 did not influence vascular and cellular mechanisms in CFA-arthritis, but significantly decreased histopathological alterations. There was no difference in the anti-hyperalgesic and anti-inflammatory actions of SzV-1287 and LJP-1207, but only SzV-1287 decreased CFA-induced tissue damage. Unlike SzV-1287, LJP-1207 induced cartilage destruction, which was confirmed in vitro. SzV-1287 exerts potent analgesic and anti-inflammatory actions in chronic arthritis models of distinct mechanisms, without inducing cartilage damage
Evaluation of Hungarian Wines for Resveratrol by Overpressured Layer Chromatography
A method, including solid phase extraction sample preparation, overpressured layer chromatographic separation and subsequent densitometric evaluation, was developed for measurement of total resveratrol (cis- and trans-isomers) content of wine. The amount of resveratrol was determined in wine samples from different winemaking regions of Hungary. The total resveratrol was high in Hungarian red wines (3.6–11 mg/L), and much lower in white ones (0.04–1.5 mg/L)
First observations of high-temperature submarine hydrothermal vents and massive anhydrite deposits off the north coast of Iceland
High-temperature (250°C) hydrothermal vents and massive anhydrite deposits have been found in a shallow water, sediment-filled graben near 66°36′N in the Tjornes Fracture Zone north of Iceland. The site is located about 30 km offshore, near the small island of Grimsey. The main vent field occurs at a depth of 400 m and consists of about 20 large-diameter (up to 10 m) mounds and 1–3 m chimneys and spires of anhydrite and talc. A north–south alignment of the mounds over a 1-km strike length of the valley floor suggests that their distribution is controlled by a buried fault. Widespread shimmering water and extensive white patches of anhydrite in the sediment between the mounds indicates that the entire 1-km2 area occupied by the vents is thermally active. A 2-man research submersible JAGO was used to map the area and to sample vent waters, gases, and chimneys. Actively boiling hydrothermal vents occur on most of the mounds, and extensive two-phase venting indicates that the field is underlain by a large boiling zone (200×300 m). The presence of boiling fluids in shallow aquifers beneath the deposits was confirmed by sediment coring. The highest-temperature pore fluids were encountered in talc- and anhydrite-rich sedimentary layers that occur up to 7 m below the mounds. Baked muds underlie the talc and anhydrite layers, and pyrite is common in stockwork-like fractures and veins in the hydrothermally altered sediments. However, massive sulfides (pyrite–marcasite crusts) were found in only one relict mound. Subseafloor boiling has likely affected the metal-carrying capacity of the hydrothermal fluids, and deposition of sulfides may be occurring at greater depth. Although the mounds and chimneys at Grimsey resemble other deposits at sedimented ridges (e.g. Middle Valley, Escanaba Trough, Guaymas Basin), the shallow water setting and extensive boiling of the hydrothermal fluids represent a distinctive new type of seafloor hydrothermal system
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