Trees and water: smallholder agroforestry on irrigated lands in Northern India

Trees / Populus deltoids / Agroforestry / Afforestation / Reforestation / Models / Water use / Water balance / Evapotranspiration / Precipitation / Remote sensing / Irrigation requirements / India

Fertilización de alfalfa en suelos de la región semiárida Argentina

The objetive of the present study which was carried out in the south of Córdoba is the evaluation of the response of alfalfa production to N, P and S fertilization in simple and mixes applications. The experiment consists in cross-banded applications of N, P and S at rates  of 34.5; 65 and 37.5 Kg respectively, resulting in the folIowing treatments: NPA, NP, N, P, S and Control. Dry matter production was measured in three cuts of 1 m2 portions of the pasture.  There was no statistically significant yield response to fertilization in any treatment. Further analysis showed that rainfall was very deficient in the period, possibly limiting alfalfa growth and yield response to fertilization. A very marked relation between dry matter production and soil moisture content was encountered, indicating that moisture was the limiting growth factor.Director: Ing. Agr. Elke Noellemeyer. Cátedra de Edafología, Manejo, y Conservación y Fertilidad del suelo. Facultad de Agronomía. Universidad Nacional de La Pampa

S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus

Proper localization of receptors for synaptic organizing factors is crucial for synapse formation. Wnt proteins promote synapse assembly through Frizzled (Fz) receptors. In hippocampal neurons, the surface and synaptic localization of Fz5 is regulated by neuronal activity, but the mechanisms involved remain poorly understood. Here, we report that all Fz receptors can be post-translationally modified by S-acylation and that Fz5 is S-acylated on three C-terminal cysteines by zDHHC5. S-acylation is essential for Fz5 localization to the cell surface, axons, and presynaptic sites. Notably, S-acylation-deficient Fz5 is internalized faster, affecting its association with signalosome components at the cell surface. S-acylation-deficient Fz5 also fails to activate canonical and divergent canonical Wnt pathways. Fz5 S-acylation levels are regulated by the pattern of neuronal activity. In vivo studies demonstrate that S-acylation-deficient Fz5 expression fails to induce presynaptic assembly. Our studies show that S-acylation of Frizzled receptors is a mechanism controlling their localization and function

Long-Term Remission Achieved by Ponatinib and Donor Lymphocytes Infusion in a Ph+ Acute Lymphoblastic Leukemia Patient in Molecular Relapse After Allogenic Stem Cell Transplant and Dasatinib: A Case Report

Currently, the prognosis of Ph+ acute lymphoblastic leukemia (Ph+ ALL) patients relapsing after an allogenic hematopoietic stem cell transplantation (allo-SCT) remains poor, with few therapeutic options available. Here we present the case of a 32 years old patient with dasatinib-resistant post-transplant molecular relapse of ALL, who received, as second-line therapy, the combination of ponatinib and donor lymphocyte infusion (DLI). The therapy was safe and the patient achieved a sustained minimal residual disease negative disease, still ongoing after 22 months, which was accompanied by several changes in the immune populations distribution within the bone marrow (i.e., the increase in the CD8/CD4 lymphocytes ratio). Our report provides evidence of the efficacy of the third generation TKI inhibitor ponatinib in combination with DLI as second line therapy for Ph+ ALL relapsing after an allo-SCT

Banco para emulación de turbinas eólicas

En este trabajo se propone la implementación de un banco de ensayos para sistemas de generación eléctrica (generadores eléctricos, incluyendo sus controles y cargas) de uso en turbinas eólicas. Este banco de ensayos permite emular la dinámica de una turbina conectada al generador. Esto se consigue a través del control de par de una Máquina de Corriente Continua (M CQ en función de un perfil de viento predeterminado. El control de par se realiza a través de la simulación en tiempo real de la característica y de la dinámica de la turbina (incluyendo inercia, rozamiento, etc ). El objetivo de este banco es realizar ensayos de rendimiento y determinar la respuesta dinámica del control de diferentes tipos de generadores.Tema: Energía eólica, geotermia y otras energías no convencionales.Asociación Argentina de Energía Sola

Banco para emulación de turbinas eólicas

En este trabajo se propone la implementación de un banco de ensayos para sistemas de generación eléctrica (generadores eléctricos, incluyendo sus controles y cargas) de uso en turbinas eólicas. Este banco de ensayos permite emular la dinámica de una turbina conectada al generador. Esto se consigue a través del control de par de una Máquina de Corriente Continua (M CQ en función de un perfil de viento predeterminado. El control de par se realiza a través de la simulación en tiempo real de la característica y de la dinámica de la turbina (incluyendo inercia, rozamiento, etc ). El objetivo de este banco es realizar ensayos de rendimiento y determinar la respuesta dinámica del control de diferentes tipos de generadores.Tema: Energía eólica, geotermia y otras energías no convencionales.Asociación Argentina de Energía Sola

The role of soil carbon in natural climate solutions

Acknowledgements. This study was made possible by funding from the Craig and Susan McCaw Foundation. Data Deposition A global spatial dataset of reforestation opportunities is available on Zenodo (https://zenodo.org/record/883444). Figures 1 and 2 have associated raw data that can be made available upon request.Peer reviewedPostprin

Characterization of the structure and control of the blood-nerve barrier identifies avenues for therapeutic delivery

The blood barriers of the nervous system protect neural environments but can hinder therapeutic accessibility. The blood-brain barrier (BBB) is well characterized, consisting of endothelial cells with specialized tight junctions and low levels of transcytosis, properties conferred by contacting pericytes and astrocytes. In contrast, the blood-nerve barrier (BNB) of the peripheral nervous system is poorly defined. Here, we characterize the structure of the mammalian BNB, identify the processes that confer barrier function, and demonstrate how the barrier can be opened in response to injury. The homeostatic BNB is leakier than the BBB, which we show is due to higher levels of transcytosis. However, the barrier is reinforced by macrophages that specifically engulf leaked materials, identifying a role for resident macrophages as an important component of the BNB. Finally, we demonstrate the exploitation of these processes to effectively deliver RNA-targeting therapeutics to peripheral nerves, indicating new treatment approaches for nervous system pathologies

The first search for bosonic super-WIMPs with masses up to 1 MeV/c2^2 with GERDA

We present the first search for bosonic super-WIMPs as keV-scale dark matter candidates performed with the GERDA experiment. GERDA is a neutrinoless double-beta decay experiment which operates high-purity germanium detectors enriched in $^{76}$Ge in an ultra-low background environment at the Laboratori Nazionali del Gran Sasso (LNGS) of INFN in Italy. Searches were performed for pseudoscalar and vector particles in the mass region from 60 keV/c$^2$ to 1 MeV/c$^2$. No evidence for a dark matter signal was observed, and the most stringent constraints on the couplings of super-WIMPs with masses above 120 keV/c$^2$ have been set. As an example, at a mass of 150 keV/c$^2$ the most stringent direct limits on the dimensionless couplings of axion-like particles and dark photons to electrons of $g_{ae} < 3 \cdot 10^{-12}$ and ${\alpha'}/{\alpha} < 6.5 \cdot 10^{-24}$ at 90% credible interval, respectively, were obtained.Comment: 6 pages, 3 figures, submitted to Physical Review Letters, added list of authors, updated ref. [21