175 research outputs found
Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype
The ubiquitous fungus Aspergillus fumigatus is associated with chronic diseases such as invasive pulmonary aspergillosis in immunosuppressed patients and allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis or severe asthma. Because of constant exposure to this fungus, it is critical for the host to exercise an immediate and decisive immune response to clear fungal spores to ward off disease. In this study, we observed that rapidly after infection by A. fumigatus, alveolar macrophages predominantly express Arginase 1 (Arg1), a key marker of alternatively activated macrophages (AAMs). The macrophages were also found to express Ym1 and CD206 that are also expressed by AAMs but not NOS2, which is expressed by classically activated macrophages. The expression of Arg1 was reduced in the absence of the known signaling axis, IL-4Rα/STAT6, for AAM development. While both Dectin-1 and TLR expressed on the cell surface have been shown to sense A. fumigatus, fungus-induced Arg1 expression in CD11c+ alveolar macrophages was not dependent on either Dectin-1 or the adaptor MyD88 that mediates intracellular signaling by most TLRs. Alveolar macrophages from WT mice efficiently phagocytosed fungal conidia, but those from mice deficient in Dectin-1 showed impaired fungal uptake. Depletion of macrophages with clodronate-filled liposomes increased fungal burden in infected mice. Collectively, our studies suggest that alveolar macrophages, which predominantly acquire an AAM phenotype following A. fumigatus infection, have a protective role in defense against this fungus
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Updated measurement of time-dependent CP -violating observables in Bs0âJ/Ï<sup>K+</sup><sup>K-</sup> decays
The decay-time-dependent asymmetry in
decays is measured using proton-proton collision data, corresponding to an
integrated luminosity of , collected with the LHCb
detector at a centre-of-mass energy of in 2015 and 2016.
Using a sample of approximately 117\,000 signal decays with an invariant mass in the vicinity of the resonance, the -violating
phase is measured, along with the difference in decay widths of the
light and heavy mass eigenstates of the - system,
. The difference of the average and meson
decay widths, , is determined using in addition a sample of
decays. The values obtained are , and , where the first uncertainty is statistical and the
second systematic. These are the most precise single measurements of these
quantities to date and are consistent with expectations based on the Standard
Model and with a previous LHCb analysis of this decay using data recorded at
centre-of-mass energies 7 and 8 TeV. Finally, the results are combined with
recent results from decays obtained using
the same dataset as this analysis, and with previous independent LHCb results
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Observation of the Îb0âÏc1 (3872) pK<sup>â</sup> decay
Using proton-proton collision data, collected with the LHCb detector and
corresponding to 1.0, 2.0 and 1.9fb of integrated luminosity at the
centre-of-mass energies of 7, 8, and 13 TeV, respectively, the decay
with is
observed for the first time. The significance of the observed signal is in
excess of seven standard deviations. It is found that of the
decays proceed via the two-body intermediate state
. The~branching fraction with respect to that of
the decay mode, where the
~meson is reconstructed in the final state, is
measured to be: \begin{equation*}
\frac{\Lambda_b^0\to\chi_{c1}(3872)pK^-}{\Lambda_b\to\psi(2S)p K^-} \times
\frac{\mathcal{B}(\chi_{c1} \to J/\psi \pi^+\pi^-)}{\mathcal{B}(\psi(2S)\to
J/\psi \pi^+\pi^-)} = \left(5.4 \pm 1.1 \pm 0.2\right)\times 10^{-2}\,,
\end{equation*} where the first uncertainty is statistical and the second is
systematic
Test of lepton universality in decays
The first simultaneous test of muon-electron universality using
and decays is performed, in two ranges of the dilepton
invariant-mass squared, . The analysis uses beauty mesons produced in
proton-proton collisions collected with the LHCb detector between 2011 and
2018, corresponding to an integrated luminosity of 9 . Each
of the four lepton universality measurements reported is either the first in
the given interval or supersedes previous LHCb measurements. The
results are compatible with the predictions of the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-046.html (LHCb
public pages
Precision measurement of violation in the penguin-mediated decay
A flavor-tagged time-dependent angular analysis of the decay
is performed using collision data collected
by the LHCb experiment at % at TeV, the center-of-mass energy of
13 TeV, corresponding to an integrated luminosity of 6 fb^{-1}. The
-violating phase and direct -violation parameter are measured
to be rad and
, respectively, assuming the same values
for all polarization states of the system. In these results, the
first uncertainties are statistical and the second systematic. These parameters
are also determined separately for each polarization state, showing no evidence
for polarization dependence. The results are combined with previous LHCb
measurements using collisions at center-of-mass energies of 7 and 8 TeV,
yielding rad and . This is the most precise study of time-dependent violation
in a penguin-dominated meson decay. The results are consistent with
symmetry and with the Standard Model predictions.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-001.html (LHCb
public pages
Observation of Two New Excited Îb0 States Decaying to Îb0 K-Ï+
Two narrow resonant states are observed in the Îb0K-Ï+ mass spectrum using a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 6 fb-1. The minimal quark content of the Îb0K-Ï+ system indicates that these are excited Îb0 baryons. The masses of the Îb(6327)0 and Îb(6333)0 states are m[Îb(6327)0]=6327.28-0.21+0.23±0.12±0.24 and m[Îb(6333)0]=6332.69-0.18+0.17±0.03±0.22 MeV, respectively, with a mass splitting of Îm=5.41-0.27+0.26±0.12 MeV, where the uncertainties are statistical, systematic, and due to the Îb0 mass measurement. The measured natural widths of these states are consistent with zero, with upper limits of Î[Îb(6327)0]<2.20(2.56) and Î[Îb(6333)0]<1.60(1.92) MeV at a 90% (95%) credibility level. The significance of the two-peak hypothesis is larger than nine (five) Gaussian standard deviations compared to the no-peak (one-peak) hypothesis. The masses, widths, and resonant structure of the new states are in good agreement with the expectations for a doublet of 1D Îb0 resonances
Observation of a resonant structure near the threshold in the decay
An amplitude analysis of the decay is carried out to
study for the first time its intermediate resonant contributions, using
proton-proton collision data collected with the LHCb detector at centre-of-mass
energies of 7, 8 and 13 TeV. A near-threshold peaking structure, referred to as
, is observed in the invariant-mass spectrum with
significance greater than 12 standard deviations. The mass, width and the
quantum numbers of the structure are measured to be MeV,
MeV and , respectively, where the first
uncertainties are statistical and the second systematic. The properties of the
new structure are consistent with recent theoretical predictions for a state
composed of quarks. Evidence for an additional structure is
found around 4140 MeV in the invariant mass, which might be
caused either by a new resonance with the assignment or by a coupled-channel effect.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-018.html (LHCb
public pages
Measurement of the differential branching fraction
The branching fraction of the rare decay is measured for the first time, in the squared dimuon mass
intervals, , excluding the and regions. The data
sample analyzed was collected by the LHCb experiment at center-of-mass energies
of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of $9\
\mathrm{fb}^{-1}q^{2}q^{2} >15.0\
\mathrm{GeV}^2/c^4$, where theoretical predictions have the smallest model
dependence, agrees with the predictions.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-050.html (LHCb
public pages
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Study of Bs0 â J/ÏÏ<sup>+</sup>Ï<sup>â</sup>K<sup>+</sup>K<sup>â</sup> decays
The decays are studied using a
data set corresponding to an integrated luminosity of 9fb, collected
with the LHCb detector in proton-proton collisions at centre-of-mass energies
of 7, 8 and 13TeV. The decays and , where the
pair does not originate from a meson, are observed for the
first time. Precise measurements of the ratios of branching fractions between
intermediate , ,
and states are reported. A structure,
denoted as , is observed in the mass spectrum and,
assuming a Breit-Wigner parameterisation, its mass and width are determined to
be \begin{eqnarray*} m_{X(4740)} & = & 4741 \pm 6 \pm 6\,{\mathrm{MeV}}/c^2 \,,
\\ \Gamma_{X(4740)} & = & 53 \pm 15 \pm 11\,{\mathrm{MeV}} \,, \end{eqnarray*}
where the first uncertainty is statistical and the second is systematic. In
addition, the most precise single measurement of the mass of the meson
is performed and gives a value of
m_{B^0_s} = 5366.98 \pm 0.07 \pm 0.13\,{\mathrm{MeV}}/c^2\,. $
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