110 research outputs found

    Comparative assessment of the comfort of two soft contact lenses

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    Background: Perception of lens comfort is a critical factor and predictor of whether or not an individual will be able to successfully achieve refractive correction with contact lenses. Recent advances in lens materials raise the question of which materials are the best to prescribe. It is important to have some basis on which to compare the various materials in regards to comfort in addition to standard lab bench tests such as Dk and hydration percentage. Methods: The purpose of this study was to compare Brand A, a silicone hydrogel lens, with Brand B, a conventional hydrogel lens, in regards to wearer comfort. Twenty-nine subjects were randomly assigned to wear either Brand A or Brand B for four weeks and then the other brand for four weeks. Twenty-six subjects successfully completed the study. Subjects returned for follow-up visits at two and four week intervals after the initial fitting of each brand. Comfort was rated by acquiring subjective reports regarding comfortable wearing time and by marking an analogue comfort scale. Subjects also kept a home journal for recording comfort levels. Results: Statistical analysis showed virtually no difference in the subjects\u27 responses between the left and right eyes. As such only the data for the right eye was fully analyzed. The order in which the lenses were assigned was determined to not have a significant effect in the results; consequently, data was analyzed by brand without concern for an order effect. A slight decrease in comfort was noted for both brands from the two week reporting time to the 4 week reporting time. Conclusion: The data showed no significant difference between the brands in either subject comfort response or subjective hours of comfortable wear. It can be inferred that both Brand A and Brand B performed equally well in the perceived wearer comfort. This suggests that current silicone hydrogel lenses are as effective at maintaining sufficient lens hydration as conventional hydrogel lenses thereby providing an equally effective level of comfort longevity

    Creep deformation and buttressing capacity of damaged ice shelves: theory and application to Larsen C ice shelf

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    Around the perimeter of Antarctica, much of the ice sheet discharges to the ocean through floating ice shelves. The buttressing provided by ice shelves is critical for modulating the flux of ice into the ocean, and the presently observed thinning of ice shelves is believed to be reducing their buttressing capacity and contributing to the acceleration and thinning of the grounded ice sheet. However, relatively little attention has been paid to the role that fractures play in the ability of ice shelves to sustain and transmit buttressing stresses. Here, we present a new framework for quantifying the role that fractures play in the creep deformation and buttressing capacity of ice shelves. We apply principles of continuum damage mechanics to derive a new analytical relation for the creep of an ice shelf that accounts for the softening influence of fractures on longitudinal deformation using a state damage variable. We use this new analytical relation, combined with a temperature calculation for the ice, to partition an inverse method solution for ice shelf rigidity into independent solutions for softening damage and stabilizing backstress. Using this new approach, field and remote sensing data can be utilized to monitor the structural integrity of ice shelves, their ability to buttress the flow of ice at the grounding line, and thus their indirect contribution to ice sheet mass balance and global sea level. We apply this technique to the Larsen C ice shelf using remote sensing and Operation IceBridge data, finding damage in areas with known crevasses and rifts. Backstress is highest near the grounding line and upstream of ice rises, in agreement with patterns observed on other ice shelves. The ice in contact with the Bawden ice rise is weakened by fractures, and additional damage or thinning in this area could diminish the backstress transmitted upstream. We model the consequences for the ice shelf if it loses contact with this small ice rise, finding that flow speeds would increase by 25% or more over an area the size of the former Larsen B ice shelf. Such a perturbation could potentially destabilize the northern part of Larsen C along pre-existing lines of weakness, highlighting the importance of the feedback between buttressing and fracturing in an ice shelf

    Optimal numerical solvers for transient simulations of ice flow using the Ice Sheet System Model (ISSM versions 4.2.5 and 4.11)

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    Identifying fast and robust numerical solvers is a critical issue that needs to be addressed in order to improve projections of polar ice sheets evolving in a changing climate. This work evaluates the impact of using advanced numerical solvers for transient ice-flow simulations conducted with the JPL–UCI Ice Sheet System Model (ISSM). We identify optimal numerical solvers by testing a broad suite of readily available solvers, ranging from direct sparse solvers to preconditioned iterative methods, on the commonly used Ice Sheet Model Intercomparison Project for Higher-Order ice sheet Models benchmark tests. Three types of analyses are considered: mass transport, horizontal stress balance, and incompressibility. The results of the fastest solvers for each analysis type are ranked based on their scalability across mesh size and basal boundary conditions. We find that the fastest iterative solvers are  ∼ 1.5–100 times faster than the default direct solver used in ISSM, with speed-ups improving rapidly with increased mesh resolution. We provide a set of recommendations for users in search of efficient solvers to use for transient ice-flow simulations, enabling higher-resolution meshes and faster turnaround time. The end result will be improved transient simulations for short-term, highly resolved forward projections (10–100 year time scale) and also improved long-term paleo-reconstructions using higher-order representations of stresses in the ice. This analysis will also enable a new generation of comprehensive uncertainty quantification assessments of forward sea-level rise projections, which rely heavily on ensemble or sampling approaches that are inherently expensive

    The effectiveness of surgical correction of uterine prolapse: cervical amputation with uterosacral ligament plication (modified Manchester) versus vaginal hysterectomy with high uterosacral ligament plication

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    Item does not contain fulltextINTRODUCTION AND HYPOTHESIS: The objective of this study is to evaluate cervical amputation with uterosacral ligament plication (modified Manchester) and compare it to vaginal hysterectomy with high uterosacral ligament plication procedure with special regard to the middle compartment. METHODS: Consecutive women with pelvic organ prolapse who underwent either vaginal hysterectomy or a modified Manchester procedure were included. Assessments were made preoperatively and at 1-year follow-up, including physical examination with pelvic organ prolapse quantification standardised questionnaires (incontinence impact questionnaire, urogenital distress inventory, and defaecatory distress inventory). RESULTS: Between 2002 and 2007, 156 patients were included. Ninety-eight patients returned for a 1-year follow-up. In the modified Manchester group, we found no middle compartment recurrence versus two (4%) in the vaginal hysterectomy group. Anterior and posterior compartment prolapse recurrences (stage >or=2) were similar (approximately 50%). Considering operating time and blood loss, modified Manchester was more favourable. There was no difference in the pre- and postoperative subjective scores. The overall functional outcome was acceptable. CONCLUSIONS: We found an excellent performance of both procedures regarding middle compartment recurrences

    Protocol for the CUPIDO trials; multicenter randomized controlled trials to assess the value of combining prolapse surgery and incontinence surgery in patients with genital prolapse and evident stress incontinence (CUPIDO I) and in patients with genital prolapse and occult stress incontinence (CUPIDO II)

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    Background: About 40% of all patients with genital prolapse report stress-incontinence. In about half of the 60% patients that do not report stress-incontinence, occult urinary stress-incontinence can be detected. In these patients stress-incontinence is masked due to kinking or compression of the urethra by the prolapse. In case surgical correction is indicated there are two strategies to manage patients with combined prolapse and (occult) stress incontinence. This strategy is either (i) a combination of prolapse surgery and stress-incontinence surgery or (ii) to correct the prolapse first and evaluate afterwards whether additional stress-incontinence surgery is indicated. The advantage of combining prolapse and stress-incontinence surgery is that only few patients report stress-incontinence following such combination. However, this combination has been associated with an increased risk on complications, of which the development of obstructive micturition symptoms, overactive bladder symptoms and bladder retention are the most important ones. Furthermore, combining two procedures may be unnecessary as performing only prolapse surgery may cure stress-incontinence In the randomized CUPIDO trials both strategies are compared in patients with prolapse and evident stress incontinence (CUPIDO I trial) and in patients with prolapse and occult stress incontinence (CUPIDO II trial). Methods/Design: The CUPIDO trials are two multicenter randomized controlled trials in which women with stress urinary incontinence (SUI) or occult stress urinary incontinence (OSUI) are randomized to prolapse surgery combined with anti incontinence surgery (concomitant surgery) or to prolapse surgery only. Patients with at least stage 2 POP are eligible, women with evident SUI are randomized in CUPIDO I. Patients without SUI are eligible for CUPIDO II and will have urodynamic evaluation or a standardized redression test. Women with OSUI are randomized, women without OSUI are followed up but not randomized. The primary outcome measure is absence of SUI twelve months after surgery. Furthermore, economic evaluations are conducted, and the effectiveness of urodynamic investigation is evaluated against a non-invasive way to determine SUI in women with POP. A total of 450 women will be included in the study

    The pectoralis minor length test: a study of the intra-rater reliability and diagnostic accuracy in subjects with and without shoulder symptoms

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedBackground. Postural abnormality and muscle imbalance are thought to contribute to pain and a loss of normal function in the upper body. A shortened pectoralis minor muscle is commonly identified as part of this imbalance. Clinical tests have been recommended to test for shortening of this muscle. The aim of this study was to evaluate the intra-rater reliability and diagnostic accuracy of the pectoralis minor length test. Methods. Measurements were made in 45 subjects with and 45 subjects without shoulder symptoms. Measurements were made with the subjects lying in supine. In this position the linear distance from the treatment table to the posterior aspect of the acromion was measured on two occasions (separated by a minimum of 30 minutes and additional data collection on other subjects to reduce bias) by one rater. The reliability of the measurements was analyzed using intraclass correlation coefficients (ICC), 95% confidence intervals (CI) and standard error of measurement (SEM). The diagnostic accuracy of the test was investigated by determining the sensitivity, specificity, positive and negative likelihood ratios of the test against a 'gold standard' reference. The assessor remained 'blinded' to data input and the measurements were staggered to reduce examiner bias. Results. The pectoralis minor length test was found to have excellent intra-rater reliability for dominant and non-dominant side of the subjects without symptoms, and for the painfree and painful side of the subjects with symptoms. The values calculated for the sensitivity, specificity, positive and negative likelihood ratios suggest this test performed in the manner investigated in this study and recommended in the literature, lacks diagnostic accuracy. Conclusion. The findings of this study suggest that although the pectoralis minor length test demonstrates acceptable clinical reliability, its lack of specificity suggests that clinicians using this test to inform the clinical reasoning process with regard treatment planning must do so with caution. Trial registration. National Research Register: N0060148286.Peer reviewe

    The reliability of three-dimensional scapular attitudes in healthy people and people with shoulder impingement syndrome

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    <p>Abstract</p> <p>Background</p> <p>Abnormal scapular displacements during arm elevation have been observed in people with shoulder impingement syndrome. These abnormal scapular displacements were evaluated using different methods and instruments allowing a 3-dimensional representation of the scapular kinematics. The validity and the intrasession reliability have been shown for the majority of these methods for healthy people. However, the intersession reliability on healthy people and people with impaired shoulders is not well documented. This measurement property needs to be assessed before using such methods in longitudinal comparative studies. The objective of this study is to evaluate the intra and intersession reliability of 3-dimensional scapular attitudes measured at different arm positions in healthy people and to explore the same measurement properties in people with shoulder impingement syndrome using the Optotrak Probing System.</p> <p>Methods</p> <p>Three-dimensional scapular attitudes were measured twice (test and retest interspaced by one week) on fifteen healthy subjects (mean age 37.3 years) and eight subjects with subacromial shoulder impingement syndrome (mean age 46.1 years) in three arm positions (arm at rest, 70° of humerothoracic flexion and 90° of humerothoracic abduction) using the Optotrak Probing System. Two different methods of calculation of 3-dimensional scapular attitudes were used: relative to the position of the scapula at rest and relative to the trunk. Intraclass correlation coefficient (ICC) and standard error of measure (SEM) were used to estimate intra and intersession reliability.</p> <p>Results</p> <p>For both groups, the reliability of the three-dimensional scapular attitudes for elevation positions was very good during the same session (ICCs from 0.84 to 0.99; SEM from 0.6° to 1.9°) and good to very good between sessions (ICCs from 0.62 to 0.97; SEM from 1.2° to 4.2°) when using the method of calculation relative to the trunk. Higher levels of intersession reliability were found for the method of calculation relative to the trunk in anterior-posterior tilting at 70° of flexion compared to the method of calculation relative to the scapula at rest.</p> <p>Conclusion</p> <p>The estimation of three-dimensional scapular attitudes using the method of calculation relative to the trunk is reproducible in the three arm positions evaluated and can be used to document the scapular behavior.</p
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