SISTEMI DI TELECONTROLLO SU RETE ETHERNET EGSM PER STAZIONI SISMICHE

La gestione e la manutenzione di sistemi di monitoraggio remoti richiede notevole dispendio di risorse umane. La complessità dei sistemi utilizzati necessita di metodi di protezione hardware e software (watchdog) atti a limitare interferenze esterne quali sovratensioni sulle linee di segnale e di alimentazione o blocchi indesiderati. Può talvolta accadere che per cause impreviste, quali ad esempio scariche atmosferiche a breve distanza, i sistemi elettronici si pongano in una condizione di blocco, pur senza subire danni strutturali significativi. Tale situazione è spesso risolvibile con una procedura di spegnimento e successivo riavvio dei sistemi. Si comprende come tale semplice procedura richieda l’impiego di risorse nel caso di apparecchiature poste a grande distanza o in siti difficilmente raggiungibili in avverse condizioni meteorologiche , come i sistemi di monitoraggio della Rete sismica di Stromboli e alcune installazioni della Rete Sismica Vesuvio. Per minimizzare la necessità di tali interventi di manutenzione è stato realizzato un sistema di controllo remoto, che consente operazioni di comando e verifica a distanza. È possibile controllare qualsiasi tipo di dispositivo tramite rete ethernet. In alternativa a tale supporto è stato sviluppato un telecontrollo che utilizza la rete cellulare GSM. Il primo sistema utilizza la rete ethernet e consente un reset completo dei sistemi ad esso collegati. Anche il secondo permette di resettare i sistemi ad esso collegati, ma differisce dal primo sia per l’utilizzo della rete GSM che per la funzione che consente il monitoraggio h24 dell’alimentazione. Non sempre è presente la rete ethernet o una sufficiente copertura del segnale GSM in corrispondenza dei siti presso i quali sono effettuate installazioni; per tale motivo sono stati sviluppati sistemi che sfruttano mezzi di trasmissione diversi. Di seguito saranno descritti: 1. Sistema di telecontrollo su rete ethernet. 2. Sistema di telecontrollo su rete GSM

Regulation of p27kip1 and p57kip2 functions by natural polyphenols

In numerous instances, the fate of a single cell not only represents its peculiar outcome but also contributes to the overall status of an organism. In turn, the cell division cycle and its control strongly influence cell destiny, playing a critical role in targeting it towards a specific phenotype. Several factors participate in the control of growth, and among them, p27Kip1 and p57Kip2, two proteins modulating various transitions of the cell cycle, appear to play key functions. In this review, the major features of p27 and p57 will be described, focusing, in particular, on their recently identified roles not directly correlated with cell cycle modulation. Then, their possible roles as molecular effectors of polyphenols’ activities will be discussed. Polyphenols represent a large family of natural bioactive molecules that have been demonstrated to exhibit promising protective activities against several human diseases. Their use has also been proposed in association with classical therapies for improving their clinical effects and for diminishing their negative side activities. The importance of p27Kip1 and p57Kip2 in polyphenols’ cellular effects will be discussed with the aim of identifying novel therapeutic strategies for the treatment of important human diseases, such as cancers, characterized by an altered control of growth

Body Image Problems in Individuals with Type 1 Diabetes: A Review of the Literature

Despite type 1 diabetes' (T1D) potential influence on adolescents' physical development, the occurrence of body image problems of adolescents with diabetes remains unclear. No research synthesis has yet addressed this issue. This study aims to systematically evaluate the empirical evidence concerning body image in individuals with T1D in order to provide an overview of the existing literature. Using PRISMA methodology, 51 relevant studies that fulfilled the eligibility criteria were found, the majority of them (N = 48) involving youth. The findings varied across studies: 17 studies indicated that in youth with T1D, body dissatisfaction was common and that body concerns were generally greater in youth with T1D than in controls; nine studies did not find any differences in body image problems between participants with and without T1D; three studies described higher body satisfaction in youth with diabetes than in controls; and three studies reported mixed results. Body concerns in individuals with T1D were often found to be associated with negative medical and psychological functioning. The variability and limits in assessment tools across studies, the overrepresentation of female subjects, and the fact that most research in this field is based on cross-sectional data are stressed in the interpretation of these mixed findings. Future research directions that could improve the understanding of body image concerns and clinical implications are discussed

Arbuscular Mycorrhizal Fungi and their Value for Ecosystem Management

Arbuscular Mycorrhizal Fungi (AMF) are root obligate symbionts of nearly all the plants living on Earth. They are considered as living fossils: there are evidences that date back to 460 million years ago their presence on our planet. Taxonomically, they belong to the Glomeromycota phylum. They are found in roots of 80% of plant species and give and get back benefits to their partners, as happens in all mutual symbiotic relationships. They build up a bridge between plant and soil, growing their mycelia both inside and outside plant roots. AMF provide the plant with water, soil mineral nutrients (mainly phosphorus and nitrogen), and pathogen protection. In exchange, photosynthetic compounds are transferred to the fungus. Besides physiological benefits to the host-plant, AMF play an important ecological role. They are important in soil structuring thanks to their thick extraradical hyphal network able to aggregate soil particles. They help plants establish in degraded ecosystems (e.g. desert areas and mine spoils) and positively affect phytoremediation. They can influence processes (i.e. soil carbon sequestration) related to climate change. Last but not least, their belowground presence and diversity can positively affect the aboveground plant biodiversity and productivity. These roles played by AMF for the ecosystem functioning lead to consider them as key soil organisms. Therefore, every AMF aspect is extensively studied: from biological features, through biogeography and biodiversity, to phylogeny. [...]JRC.H.5-Land Resources Managemen

A Beckwith–Wiedemann-associated CDKN1C mutation allows the identification of a novel nuclear localization signal in human p57Kip2

p57Kip2 protein is a member of the CIP/Kip family, mainly localized in the nucleus where it exerts its Cyclin/CDKs inhibitory function. In addition, the protein plays key roles in embryogenesis, differentiation, and carcinogenesis depending on its cellular localization and interactors. Mutations of CDKN1C, the gene encoding human p57Kip2, result in the development of different genetic diseases, including Beckwith–Wiedemann, IMAGe and Silver–Russell syndromes. We investigated a specific Beckwith–Wiedemann associated CDKN1C change (c.946 C>T) that results in the substitution of the C-terminal amino acid (arginine 316) with a tryptophan (R316W-p57Kip2). We found a clear redistribution of R316W-p57Kip2, in that while the wild-type p57Kip2 mostly occurs in the nucleus, the mutant form is also distributed in the cytoplasm. Transfection of two expression constructs encoding the p57Kip2 N-and C-terminal domain, respectively, allows the mapping of the nuclear localization signal(s) (NLSs) between residues 220–316. Moreover, by removing the basic RKRLR sequence at the protein C-terminus (from 312 to 316 residue), p57Kip2 was confined in the cytosol, implying that this sequence is absolutely required for nuclear entry. In conclusion, we identified an unreported p57Kip2 NLS and suggest that its absence or mutation might be of relevance in CDKN1C-associated human diseases determining significant changes of p57Kip2 localization/regulatory roles

Sub-horizon Perturbation Behavior in Extended Quintessence

In the general context of scalar-tensor theories, we consider a model in which a scalar field coupled to the Ricci scalar in the gravitational sector of the Lagrangian, is also playing the role of an ``Extended Quintessence'' field, dominating the energy content of the Universe at the present time. In this framework, we study the linear evolution of the perturbations in the Quintessence energy density, showing that a new phenomenon, named here ``gravitational dragging'', can enhance the scalar field density perturbations as much as they reach the non-linear regime. The possibility of dark energy clumps formation is thus discussed.Comment: Proceedings of the 5th International UCLA Symposium on Sources and Detection of Dark Matter and Dark Energy in the Universe (Dark Matter 2002), Marina del Rey, California, USA, 20-22 February 200

Vanillin prevents doxorubicin-induced apoptosis and oxidative stress in rat H9c2 cardiomyocytes

Doxorubicin (doxo) is an effective anticancer compound in several tumor types. However, as a consequence of oxidative stress induction and ROS overproduction, its high cardiotoxicity demands urgent attention. Vanillin possesses antioxidant, antiproliferative, antidepressant and anti-glycating properties. Therefore, we investigated the potential vanillin protective effects against doxo-induced cardiotoxicity in H9c2 cells. Using multiparametric approach, we demonstrated that vanillin restored both cell viability and damage in response to doxo exposure. Contextually, vanillin decreased sub-G1 appearance and caspase-3 and PARP1 activation, reducing the doxo-related apoptosis induction. From a mechanistic point of view, vanillin hindered doxo-induced ROS accumulation and impaired the ERK phosphorylation. Notably, besides the cardioprotective effects, vanillin did not counteract the doxo effectiveness in osteosarcoma cells. Taken together, our results suggest that vanillin ameliorates doxo-induced toxicity in H9c2 cells, opening new avenues for developing alternative therapeutic approaches to prevent the anthracycline-related cardiotoxicity and to improve the long-term outcome of antineoplastic treatment

Molecular Detection of Babesia spp. (Apicomplexa: Piroplasma) in Free-Ranging Canids and Mustelids From Southern Italy.

Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites with widespread geographical distribution and various wildlife species as reservoir hosts. The aims of this study were to investigate the prevalence and assess the role of free-ranging canids and mustelids in the maintenance of Babesia spp. in southern Italy. PCR analysis of splenic samples targeting the 18S rRNA gene revealed the presence of Babesia spp. in 36 of 82 (43.9%) red foxes (Vulpes vulpes) including 29 (58%) from Campania region and seven (21.8%) from Calabria region, in seven of 13 (53.8%) Eurasian badgers (Meles meles), and in one of 13 (7.7%) gray wolves (Canis lupus). Samples from other host species including 9 Eurasian otters (Lutra lutra), 1 stone marten (Martes foina), 1 least weasel (Mustela nivalis), and 1 European polecat (Mustela putorius) tested Babesia spp. negative. Sequence analysis of the 18S rRNA gene demonstrated the presence of B. vulpes in the red fox and two sequence types of badger-associated Babesia spp. in the Eurasian badger. The Babesia sp. sequence detected in the gray wolf was identical to a badger-associated Babesia sp. This study shows that the number of Babesia spp. infecting free-ranging carnivores in Italy is higher than currently believed, and suggests that these hosts may play an important role in the maintenance of the sylvatic cycle of these parasites. It is the first report of badger-associated Babesia spp. in Italy and in a gray wolf

A customized knee antibiotic-loaded pmma spacer: A preliminary design analysis

A preliminary design of customized antibiotic-loaded poly-methyl-methacrylate (ALP-MMA) spacer characterized by an appropriate footprint according to the specific patient’s anatomy and a reliable mechanical response to severe functional loads (i.e., level walking and 45◦ bent knee) is reported. The targeted virtual prototyping process takes origin from a novel patented 3D geometrical conceptualization characterized by added customization features and it is validated by a preliminary FEM-based analysis. Mechanical and thermomechanical properties of the antibiotic-doped orthopedic PMMA cement, which will be used for the future prototype manufacturing, were measured experimentally by testing samples taken during a real day-running orthopedic surgery and manufactured according to the surgeon protocol. FEM analysis results indicate that small area is subjected to intensive stresses, validating the proposed geometry from the mechanical point of view, under the two loading scenarios, moreover the value of safety margins results positive, and this is representa-tive of the lower stress magnitude compared to the critical material limits. The experimental data confirm that the presence of antibiotic will last during the surgeon period moreover, the temperature dependent modulus of the bone cement is slightly affected by the body range temperature whereas it will drastically drop for higher temperature out the range of interest. A complete customization, according to a patient anatomy, and the corresponding real prototype spacer will be manufactured by 3D printing techniques, and it will be validated by destructive testing during the second stage of this activity before commercialization