Simulation of complex environments:the Fuzzy Cognitive Agent

The world is becoming increasingly competitive by the action of liberalised national and global markets. In parallel these markets have become increasingly complex making it difficult for participants to optimise their trading actions. In response, many differing computer simulation techniques have been investigated to develop either a deeper understanding of these evolving markets or to create effective system support tools. In this paper we report our efforts to develop a novel simulation platform using fuzzy cognitive agents (FCA). Our approach encapsulates fuzzy cognitive maps (FCM) generated on the Matlab Simulink platform within commercially available agent software. We firstly present our implementation of Matlab Simulink FCMs and then show how such FCMs can be integrated within a conceptual FCA architecture. Finally we report on our efforts to realise an FCA by the integration of a Matlab Simulink based FCM with the Jack Intelligent Agent Toolkit

A British university case study of the transitional experiences of student-athletes

OBJECTIVES. Within Great Britain, increasing numbers of elite sport performers are attending higher education institutions. The current study presents an exploration of the transitional experiences of these individuals at a specific British university. Wylleman and Lavallee's (2004) developmental model on transitions faced by athletes and Stambulova's (1997, 2003) athletic career transition model were used to provide the theoretical foundation of inquiry. DESIGN AND METHOD. An instrumental case study design was adopted to provide an in-depth analysis of student-athletes’ experiences at a university. The case university was selected based on its provision of elite sport support services. To acquire a holistic understanding, interviews were conducted with current and recently graduated student-athletes from the university, and focus groups were run with university staff (viz. administrators, coaches, and support staff). Qualitative data were analyzed using a thematic framework approach. RESULTS. Elite student-athletes at the British university were found to experience simultaneous athletic, academic, psychological, and psychosocial transitions. To overcome the transitional demands, student-athletes were found to draw on a variety of internal (e.g., self-awareness) and external (e.g., academic flexibility) resources and to implement coping strategies (e.g., seeking social support). Potential barriers to successful transitions were also identified (e.g., parental overprotection). CONCLUSIONS. These findings advance the limited existing literature on British university student-athletes’ transitional experiences and suggestions are provided for how other universities can enhance provision for their elite student-athletes

A British university case study of the transitional experiences of student-athletes

This paper was accepted for publication in the journal Psychology of Sport and Exercise and the definitive published version is available at http://dx.doi.org/10.1016/j.psychsport.2015.04.002OBJECTIVES. Within Great Britain, increasing numbers of elite sport performers are attending higher education institutions. The current study presents an exploration of the transitional experiences of these individuals at a specific British university. Wylleman and Lavallee's (2004) developmental model on transitions faced by athletes and Stambulova's (1997, 2003) athletic career transition model were used to provide the theoretical foundation of inquiry. DESIGN AND METHOD. An instrumental case study design was adopted to provide an in-depth analysis of student-athletes’ experiences at a university. The case university was selected based on its provision of elite sport support services. To acquire a holistic understanding, interviews were conducted with current and recently graduated student-athletes from the university, and focus groups were run with university staff (viz. administrators, coaches, and support staff). Qualitative data were analyzed using a thematic framework approach. RESULTS. Elite student-athletes at the British university were found to experience simultaneous athletic, academic, psychological, and psychosocial transitions. To overcome the transitional demands, student-athletes were found to draw on a variety of internal (e.g., self-awareness) and external (e.g., academic flexibility) resources and to implement coping strategies (e.g., seeking social support). Potential barriers to successful transitions were also identified (e.g., parental overprotection). CONCLUSIONS. These findings advance the limited existing literature on British university student-athletes’ transitional experiences and suggestions are provided for how other universities can enhance provision for their elite student-athletes

Walking the walk: a phenomenological study of long distance walking

Evidence suggests that regular walking can elicit significant psychological benefits although little evidence exists concerning long distance walking. The purpose of this study was to provide detailed accounts of the experiences of long distance walkers. Phenomenological interviews were conducted with six long distance walkers. Data were transcribed verbatim before researchers independently analyzed the transcripts. Participants reported a cumulative effect with positive feelings increasing throughout the duration of the walk. Long distance walking elicited positive emotions, reduced the effects of life-stress, and promoted an increased sense of well-being and personal growth. Results are aligned to theories and concepts from positive psychology

Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs

Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the underlying pathophysiology is not described yet. Here, using Glra2-knockout mice, we found a GlyR-dependent effect on neonatal spontaneous activity of dorsal striatum medium spiny neurons (MSNs) and maturation of the incoming glutamatergic innervation. Our data demonstrate that functional GlyRs are highly expressed in MSNs of one-week-old mice, but they do not generate endogenous chloride-mediated tonic or phasic current. Despite of that, knocking out the Glra2 severely affects the shape of action potentials and impairs spontaneous activity and the frequency of miniature AMPA receptor-mediated currents in MSNs. This reduction in spontaneous activity and glutamatergic signaling can attribute to the observed changes in neonatal behavioral phenotypes as seen in ultrasonic vocalizations and righting reflex. In adult Glra2-knockout animals, the glutamatergic synapses in MSNs remain functionally underdeveloped. The number of glutamatergic synapses and release probability at presynaptic site remain unaffected, but the amount of postsynaptic AMPA receptors is decreased. This deficit is a consequence of impaired development of the neuronal circuitry since acute inhibition of GlyRs by strychnine in adult MSNs does not affect the properties of glutamatergic synapses. Altogether, these results demonstrate that GlyR-mediated signaling supports neonatal spontaneous MSN activity and, in consequence, promotes the functional maturation of glutamatergic synapses on MSNs. The described mechanism might shed light on the pathophysiological mechanisms in GLRA2-linked autism spectrum disorder cases

Hidden components in aqueous "Gold-144' fractionated by PAGE: high resolution orbitrap ESI-MS identifies the Gold-102 and higher all-aromatic Au-pMBA cluster compounds

Accepted author manuscriptExperimental and theoretical evidence reveals the resilience and stability of the larger aqueous gold clusters protected with p-mercaptobenzoic acid ligands (pMBA) of composition Aun(pMBA)p or (n, p). The Au144(pMBA)60, (144, 60), or gold-144 aqueous gold cluster is considered special because of its high symmetry, abundance, and icosahedral structure as well as its many potential uses in material and biological sciences. Yet, to this date, direct confirmation of its precise composition and total structure remains elusive. Results presented here from characterization via high-resolution electrospray ionization mass spectrometry on an Orbitrap instrument confirm Au102(pMBA)44 at isotopic resolution. Further, what usually appears as a single band for (144, 60) in electrophoresis (PAGE) is shown to also contain the (130, 50), recently determined to have a truncated-decahedral structure, and a (137, 56) component in addition to the dominant (144, 60) compound of chiral-icosahedral structure. This finding is significant in that it reveals the existence of structures never before observed in all-aromatic water-soluble species while pointing out the path toward elucidation of the thermodynamic control of protected gold nanocrystal formation.Ye

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.

BackgroundThe Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.MethodsThe COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.ResultsThe CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.ConclusionAvailability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years