Design of Drum Type Apparatus for Processing of Bulk Materials

The article presents the development and research of drum continuous mixers, most attention is paid to the results of theoretical (using of cybernetic approach) and experimental studies of longitudinal mixing particulate material in rotating drums of continuous action, the influence of internal recycles of material flows, intensifying the process of smoothing the input fluctuations. The authors analyzed the influence of internal recycles material flows, intensifying the process of smoothing the input fluctuations. The results presented in this paper were obtained by the experiments on the smoothing ability determination during which they change the frequency of the drum rotation, the location of the Г-shaped mixer blades on the drum mixer. The article reported that the studies were conducted on three mixtures which components have different physical and mechanical systems with various dispersed liquid additives and without it

Reception of two and three-phase combined dispersive systems with the use of centrifugal mixer

The article presents the theory of the formation of disperse combined systems, the greatest attention is paid to the three-phase system consisting of fine particles, gas and liquid. The authors suggest the equation describing the impact of different energies on combined particulate system. Possible conversion processes of surface energy into thermal, mechanical and chemical energy were shown. Also presents the results obtained by various dispersed systems with liquid additives and without them on the continuos mixer of centrifugal type. The study of using of volumetric ratio phases revealed major technological methods that enable to purposefully influence the ratio of different phases in order to obtain materials with the desired properties. The addition of a small amount of a liquid mixture of 4% with a viscosity of 50 Pa sec reduces the coefficient of inhomogeneity and to reduce the segregation of the mixture obtained in the dusty area and, consequently, to increase the quality of the final product (uniformity of a three-phase system)

Relativistic quantum model of confinement and the current quark masses

We consider a relativistic quantum model of confined massive spinning quarks and antiquarks which describes leading Regge trajectories of mesons. The quarks are described by the Dirac equations and the gluon contribution is approximated by the Nambu-Goto straight-line string. The string tension and the current quark masses are the main parameters of the model. Additional parameters are phenomenological constants which approximate nonstring short-range contributions. Comparison of the measured meson masses with the model predictions allows one to determine the current quark masses (in MeV) to be $m_s = 227 \pm 5,~ m_c = 1440 \pm 10,~ m_b = 4715 \pm 20$. The chiral $SU_3$ model[23] makes it possible to estimate from here the $u$- and $d$-quark masses to be $m_u = 6.2 \pm 0.2$~ Mev and $m_d = 11.1 \pm 0.4$ Mev.Comment: 15 pages, LATEX, 2 tables. (submitted to Phys.Rev.D

Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals

( )The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and white blood cell transcriptomic markers in healthy, normal-weight individuals. The current study examined 42 healthy, young (age: 27.5 +/- 4.0 years), normal-weight (body mass index, BMI: 23.4 +/- 1.7 kg/m(2)) female athletes, of which 25 belong to the weight loss and regain group (diet group), and 17 to the control group. Participants were evaluated, and fasting blood samples were drawn at three time points: at baseline (PRE); at the end of the weight loss period (MID: 21.1 +/- 3.1 weeks after PRE); and at the end of the weight regain period (POST: 18.4 +/- 2.9 weeks after MID). Following the weight loss period, the diet group experienced a similar to 73% reduction (similar to 0.69 kg) in visceral fat mass (false discovery rate, FDR <2.0 x 10(-16)), accompanied by anti-atherogenic effects on transcriptomic markers, decreased low-grade inflammation (e.g., as alpha(1)-acid glycoprotein (FDR = 3.08 x 10(-13)) and hs-CRP (FDR = 2.44 x 10(-3))), and an increase in functionally important anti-atherogenic high-density lipoprotein -associated metabolites (FDR <0.05). This occurred even though these values were already at favorable levels in these participants, who follow a fitness-lifestyle compared to age- and BMI-matched females from the general population (n = 58). Following the weight regain period, most of the observed beneficial changes in visceral fat mass, and meta bolomic and transcriptomic profiles dissipated. Overall, the beneficial anti-atherogenic effects of weight loss can be observed even in previously healthy, normal-weight individuals.Peer reviewe

Heuristic Models of Two-Fermion Relativistic Systems with Field-Type Interaction

We use the chain of simple heuristic expedients to obtain perturbative and exactly solvable relativistic spectra for a family of two-fermionic bound systems with Coulomb-like interaction. In the case of electromagnetic interaction the spectrum coincides up to the second order in a coupling constant with that following from the quantum electrodynamics. Discrepancy occurs only for S-states which is the well-known difficulty in the bound-state problem. The confinement interaction is considered too. PACS number(s): 03.65.Pm, 03.65.Ge, 12.39.PnComment: 16 pages, LaTeX 2.0

The electroweak chiral Lagrangian reanalyzed

In this paper we reanalyze the electroweak chiral Lagrangian with particular focus on two issues related to gauge invariance. Our analysis is based on a manifestly gauge-invariant approach that we introduced recently. It deals with gauge-invariant Green's functions and provides a method to evaluate the corresponding generating functional without fixing the gauge. First we show, for the case where no fermions are included in the effective Lagrangian, that the set of low-energy constants currently used in the literature is redundant. In particular, by employing the equations of motion for the gauge fields one can choose to remove two low-energy constants which contribute to the self-energies of the gauge bosons. If fermions are included in the effective field theory analysis the situation is more involved. Even in this case, however, these contributions to the self-energies of the gauge bosons can be removed. The relation of this result to the experimentally determined values for the oblique parameters S, T, and U is discussed. In the second part of the paper we consider the matching relation between a full and an effective theory. We show how the low-energy constants of the effective Lagrangian can be determined by matching gauge-invariant Green's functions in both theories. As an application we explicitly evaluate the low-energy constants for the standard model with a heavy Higgs boson. The matching at the one-loop level and at next-to-leading order in the low-energy expansion is performed employing functional methods.Comment: 44 pages, Revtex. v2: Sections II and III interchanged. New section II now self-contained. Discussions improved in sections I, II, V.C and VI. Conclusions unchanged. Published versio

Standard Model Higgs-Boson Branching Ratios with Uncertainties

We present an update of the branching ratios for Higgs-boson decays in the Standard Model. We list results for all relevant branching ratios together with corresponding uncertainties resulting from input parameters and missing higher-order corrections. As sources of parametric uncertainties we include the masses of the charm, bottom, and top quarks as well as the QCD coupling constant. We compare our results with other predictions in the literature.Comment: 32 pages, 4 figures, contribution to LHC Higgs Cross Section Working Group https://twiki.cern.ch/twiki/bin/view/LHCPhysics/CrossSections, theoretical uncertainties for H->\mu\mu{} added, version to appear in European Physical Journal

Probing Anomalous Quartic Couplings in e-gamma and gamma-gamma Colliders

We analyze the potential of the e+e- Linear Colliders, operating in the e-gamma and gamma-gamma modes, to probe anomalous quartic vector--boson interactions through the multiple production of W's and Z's. We examine all $SU(2)_L \otimes U(1)_Y$ chiral operators of order p^4 that lead to new four--gauge--boson interactions but do not alter trilinear vertices. We show that the e-gamma and gamma-gamma modes are able not only to establish the existence of a strongly interacting symmetry breaking sector but also to probe for anomalous quartic couplings of the order of 10^{-2} at 90% CL. Moreover, the information gathered in the e-gamma mode can be used to reduced the ambiguities of the e+e- mode.Comment: Revtex, 18 pages, 6 figure

A systematic review of changes in women’s physical activity before and during pregnancy and the postnatal period

Objectives: To determine the magnitude and type of naturally occuring physical activity changes in women around the time of pregnancy. Background: This systematic review synthesises the results of studies examining naturally occurring physical activity in women before they become pregnant and the magnitude and type of changes during pregnancy and the postnatal period. Methods: Electronic databases were searched for relevant articles and PRISMA guidelines for selection of articles were used. Only studies examining naturally occurring, non-intervention changes in regular activity levels were included. The quality assessment was based on protocols of the Cochrane Database of Systematic Reviews. Of the initial 720 titles, 24 studies met the inclusion criteria and were included in the final review. Results: Compared to pre-pregnancy, the magnitude of physical activity decreased over the course of pregnancy and postnatally and the types of activities tended to be of lesser intensity than pre-pregnancy. The quality of the research was varied; methodological limitations included using subjective methods of assessment of physical activity (9/24), failing to report reliabilities or validity of measures used (8/24), no information on parity (13/24) or level of fitness prior to pregnancy (11/24). Conclusion: The evidence suggests a marked decrease in the amount and type of moderate to strenuous physical activity during the transition to motherhood, which does not always increase again postpartum. Patient education targeting specific physical activities at regular intervals during and after pregnancy to improve long-term maternal health is necessary

Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies

Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, such as spectral details and fragmentation characteristics to determine components of unknown metabolites. Here, we propose a systems biology model exploiting the internal correlation structure of metabolite levels in combination with existing biochemical and genetic information to characterize properties of unknown molecules. Levels of 758 metabolites (439 known, 319 unknown) in human blood samples of 2279 subjects were measured using a non-targeted metabolomics platform (LC-MS and GC-MS). We reconstructed the structure of biochemical pathways that are imprinted in these metabolomics data by building an empirical network model based on 1040 significant partial correlations between metabolites. We further added associations of these metabolites to 134 genes from genome-wide association studies as well as reactions and functional relations to genes from the public database Recon 2 to the network model. From the local neighborhood in the network, we were able to predict the pathway annotation of 180 unknown metabolites. Furthermore, we classified 100 pairs of known and unknown and 45 pairs of unknown metabolites to 21 types of reactions based on their mass differences. As a proof of concept, we then looked further into the special case of predicted dehydrogenation reactions leading us to the selection of 39 candidate molecules for 5 unknown metabolites. Finally, we could verify 2 of those candidates by applying LC-MS analyses of commercially available candidate substances. The formerly unknown metabolites X-13891 and X-13069 were shown to be 2-dodecendioic acid and 9-tetradecenoic acid, respectively. Our data-driven approach based on measured metabolite levels and genetic associations as well as information from public resources can be used alone or together with methods utilizing spectral patterns as a complementary, automated and powerful method to characterize unknown metabolites