Finasteride quantification in human plasma by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry. application to a comparative pharmacokinetics study

A specific, fast and sensitive LC-MS/MS assay was developed for the determination of finasteride in human plasma using betamethsone dipropionate as the internal standard (IS). The limit of quantification was 1.0 ng/ml and the method was linear in the range of 1.0–25.0 ng/ml. The retention times were 0.75 min for finasteride and 0.85 min for IS. Method intra-batch precision and accuracy ranged from 3.6 to 7.1%, and 96.6 to 103.9%, respectively. Inter-batch precision ranged from 2.5 to 3.4%, while Inter-batch accuracy ranged from 100.3 to 103.5%. The analytical method was applied to evaluate the pharmacokinetic and relative bioavailability of 2 different pharmaceutical formulations containing 1.0 mg of finasteride. This study evaluated 38 volunteers in a randomized, 2-period crossover study with 7 days washout period between doses. The geometric mean and respective 90% CI of finasteride test/reference percent ratios were 95.68% (91.2 – 104.6%) for Cmax, 97.5% (92.1 –103.3%) for AUC0-t and 98.1 (92.67−103.8) for AUC0-inf. Based on the 90% confidence interval of the individual ratios (test formulation/reference formulation) for Cmax and AUC0-inf, it was concluded that the test formulation is bioequivalent to the reference one with respect to the rate and extent of absorption of finasteride65944945

Possibilities for charged Higgs bosons at the LHC in a SU(3)_L\otimesU(1)_N Model

We have studied the branching ratios of doubly charged Higgs bosons at the LHC using a version of the SU(3)_L\otimesU(1)_N electroweak model. At the end of this work we have made a very simple plotting comparating the total cross section of this model using Drell-Yan, gluon-gluon fusion and Left-right symmetric model.Comment: Talk given at 18th International IUPAP Conference on Few-Body Problems in Physics (FB18), Santos, Sao Paulo, Brazil, 21-26 Aug 200

Lipidomic profile as a non-invasive tool to predict endometrial receptivity in freeze-all cycles

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The advantages of semiochemical-based attract and kill techniques in insect pest management.

Introduction: Semiochemicals (chemicals impacting insect behavior) have been employed in species-specific, ecologically friendly insect pest control strategies through a wide variety of mechanisms, many of which do not require the application of conventional insecticides. These include mating disruption?application of sex pheromones in such a way that male insects are unable to locate a female mate, reducing the size of the pest population in the treated area over time?mass trapping, and repellency. However, semiochemical attractants can also be used in combination with small amounts of chemical toxicants, a strategy called attract and kill (A&K)

Nonextensive Thermostatistics and the H-Theorem

The kinetic foundations of Tsallis' nonextensive thermostatistics are investigated through Boltzmann's transport equation approach. Our analysis follows from a nonextensive generalization of the ``molecular chaos hypothesis". For $q>0$, the $q$-transport equation satisfies an $H$-theorem based on Tsallis entropy. It is also proved that the collisional equilibrium is given by Tsallis' $q$-nonextensive velocity distribution.Comment: 4 pages, no figures, corrected some typo

The advantages of semiochemical-based attract and kill techniques in insect pest management: agricultural case studies.

Introduction: While the advantages of semiochemical-based pest control technologies over traditional insecticides are well-documented (reduced hazards to non-targets and the environment, lower risk of resistance, etc.), many strategies employing these behavior-manipulating compounds to protect agricultural crops are relegated to small niche markets,due to their limited applicability. Since most semiochemicals are species-specific, they can usually target only one pest at a time. However, this is not always the case, as we will demonstrate through this discussion of four of ISCA Technologies? attract and kill (A&K) formulations