167 research outputs found
MUSIC AND THE MONSTER: SOUNDING FEAR AND MENTAL ILLNESS IN \u3ci\u3eCRIMINAL MINDS\u3c/i\u3e
In the post 9/11 world, American media has harnessed social anxieties concerning violence through the negative and antagonistic depiction of social groups seen as the “Other.” During this process, these social groups have become both marginalized and stigmatized. In the contemporary wake of mass violence and a growing public health crisis, mental illness has emerged at the forefront of political debate. Television and film media continually stigmatize representations of mental illness through graphic images enhanced by the strategic uses of music to invoke horror and disgust. Since 2006, Criminal Minds has successfully navigated the post-9/11 media by providing narratives that paint mental illness as a main cause of violence in the form of the serial killer. To accomplish this, the creators of Criminal Minds combine disturbing or grotesque images with pre-existing music that functions in counterpoint to the image. This purposeful combination creates a semantic disturbance between visuals and sound, enhancing a viewer’s negative reaction to the scene or the characters. By appropriating music to promote disgust for a character, the series associates acts of violence with mental illness, and thus furthers a negative stereotype.To demonstrate this, I examine the history and current iterations of the crime drama, and how the genre has developed both thematically and musically. I analyze select scenes and sequences from episodes of Criminal Minds using a Bakhtinian lens to determine how the show promotes a monologic or dialogic agenda. In doing this, I take a close look at the use of pre-existing music during scenes of violence, and analyze how it functions in relation to the portrayals of characters with mental illness. The effects of these portrayals can be seen in popular responses to series, which I also analyze. Combining my own scene analysis with multi-disciplinary sources regarding mental illness characterization, film music analyses, media studies, and medical descriptions of the mental illnesses portrayed in Criminal Minds, I determine that the show’s combination of pre-existing music with violence furthers the tradition of “Othering” present within American media
Mitochondrial Uncoupling Proteins In Mammals And Plants
Uncoupling proteins (UCPs) belong to a distinct cluster of the mitochondrial anion carrier family. Up to five different uncoupling protein types were found in mitochondria of mammals and plants, and recently in fishes, fungi and protozoa. They exhibit a significantly conserved structure with several motifs specific to either the whole cluster or protein type. Uncoupling proteins, as well as the whole mitochondrial anion carrier gene family, probably emerged in evolution before the separation of animal, fungi, and plant kingdoms and originate from an anion/nucleotide or anion/anion transporter ancestor. Mammalian UCP1, UCP2, UCP3, and plant uncoupling proteins pUCP1 and pUCP2 are similar and seem to form one subgroup, whereas UCP4 and BMCP1 belong to a different group. Molecular, biochemical, and phylogenic data suggest that UCP2 could be considered as an UCP-prototype. UCP1 plays its biological role mainly in the non-shivering thermogenesis while the role of the other types is unknown. However, hypotheses have suggested that they are involved in the general balance of basic energy expenditure, protection from reactive oxygen species, and, in plants, in fruit ripening and seed ontogeny.212201212Kuan, J., Saier M.H., Jr., (1993) Res. Microbiol., 144, pp. 671-672Kuan, J., Saier M.H., Jr., (1993) Crit. Rev. Biochem. Mol. Biol., 28, pp. 209-233El Moualij, B., Duyckaerts, C., Lamotte-Brasseur, J., Sluse, F.E., (1997) Yeast, 13, pp. 573-581Palmieri, F., Indiveri, C., Bisaccia, F., Krämer, R., (1993) J. Bioenerg. Biomembr., 25, pp. 525-535Ježek, P., Garlid, K.D., (1990) J. Biol. Chem., 265, pp. 19303-19311Ricquier, D., Kader, J.-C., (1976) Biochem. Biophys. Res. Commun., 73, pp. 577-583Nedergaard, J., Cannon, B., (1992) New Comprehensive Biochemistry: Molecular Mechanisms in Bioenergetics, 23, pp. 385-420. , Ernster, L., ed., Elsevier Science Publishers, AmsterdamKlingenberg, M., (1990) TIBS, 15, pp. 108-112Garlid, K.D., Orosz, D.E., Modrianský, M., Vassanelli, S., Ježek, P., (1996) J. Biol. Chem., 271, pp. 2615-2620Skulachev, V.P., (1991) FEBS Lett., 294, pp. 158-162Fleury, C., (1997) Nature Genetics, 15, pp. 269-272Boss, O., (1997) FEBS Lett., 408, pp. 39-42Mao, W., (1999) FEBS Lett., 443, pp. 326-330Sanchis, D., (1998) J. Biol. Chem., 273, pp. 34611-34615Jaburek, M., (1999) J. Biol. Chem., 274, pp. 26003-26007Ježek, P., Garlid, K.D., (1998) Int. J. Biochem. Cell Biol., 30, pp. 1163-1168Négre-Salvayre, A., (1997) FASEB J., 11, pp. 809-815Solanes, G., Vidal-Puig, A., Grujic, D., Flier, J.S., Lowell, B.B., (1997) J. Biol. Chem., 272, pp. 25433-25436Gong, D.W., He, Y., Karas, M., Reitman, M., (1997) J. Biol. Chem., 272, pp. 24129-24132Zhou, I.-T., (1997) Proc. Nat. Acad. Sci. USA, 94, pp. 6386-6390Vercesi, A.E., Martins, I.S., Silva, M.A.P., Leite, H.M.F., Cuccovia, I.M., Chaimovich, H., (1995) Nature, 375, p. 24Laloi, M., (1997) Nature, 389, pp. 135-136Maia, I.G., Benedetti, C.E., Leite, A., Turcinelli, S.R., Vercesi, A.E., Arruda, P., (1998) FEBS Lett., 429 (3), pp. 403-406Laloi, M., (1997), Accession AJ001264, GeneBankWatanabe, A., Nakazono, M., Tsutsumi, N., Hirai, A., (1999) Plant Cell Physiol., 40, pp. 1160-1166Ito, K., (1999) Plant. Sci., 149, pp. 167-173Borecký, J., (2000) J. Biol. Chem., , unpublished observationJežek, P., Garlid, K.D., (1998) Int. J. Biochem. Cell Biol., 30, pp. 1163-1168Jaburek, M., (1999) J. Biol. Chem., 274, pp. 26003-26007Ježek, P., Costa, A.D.T., Vercesi, A.E., (1996) J. Biol. Chem., 271, pp. 32743-32748Ježek, P., Costa, A.D.T., Vercesi, A.E., (1997) J. Biol. Chem., 272, pp. 24272-24278Costa, A.D.T., Nantes, I.L., Ježek, P., Leite, A., Arruda, P., Vercesi, A.E., (1999) J. Bioenerg. Biomembr., 31, pp. 527-533Vercesi, A.E., Chaimovich, H., Cuccovia, I.M., (1997) Recent Res. Devel. Plant Physiol., 1, pp. 85-91Ježek, P., (1998) Biochim. Biophys. Acta, 1365, pp. 319-327Vercesi, A.E., Ježek, P., Costa, A.D.T., Kowaltowski, A.J., Maia, I.G., Arruda, P., (1998) Plant Mitochondria: From Gene to Function, pp. 435-440. , (Moller, I. M., Gardeström, P., Glimelius, K., and Glaser, E., eds.), Backhuys Publishers, Leiden, The NetherlandsKowaltowski, A.J., Costa, A.D.T., Vercesi, A.E., (1998) FEBS Lett., 425, pp. 213-216Nantes, I.L., Fagian, M.M., Catisti, R., Arruda, P., Maia, I.G., Vercesi, A.E., (1999) FEBS Lett., 457, pp. 103-106Sluse, F.E., Almeida, A.M., Jarmuszkiewicz, W., Vercesi, A.E., (1998) FEBS Lett., 433, pp. 237-240Jarmuszkiewicz, W., Almeida, A.M., Sluse-Goffart, C., Sluse, F.E., Vercesi, A.E., (1998) J. Biol. Chem., 273, pp. 34882-34886Almeida, A.M., Jarmuszkiewicz, W., Khomsi, H., Arruda, P., Vercesi, A.E., Sluse, F.E., (1999) Plant Physiol., 119, pp. 1324-1329Sluse, F.E., Almeida, A.M., Jarmuszkiewicz, W., Vercesi, A.E., (1998) FEBS Lett., 433, pp. 237-240Nicholls, D.G., Locke, R.M., (1984) Physiol. Rev., 64, pp. 1-64Cannon, B., Nedergaard, J., (1985) Essays Biochem., 20, pp. 110-164Himms-Hagen, J., (1990) FASEB J., 4, pp. 2890-2898Klaus, S., Casteilla, L., Bouillaud, F., Ricquier, D., (1991) Int. J. Biochem., 23, pp. 791-801Ricquier, D., Bouillaud, F., (1997) Prog. Nucleic Acid Res. Mol. Biol., 56, pp. 83-108Ricquier, D., Casteilla, L., Bouillaud, F., (1991) FASEB J., 5, pp. 2237-2242Silva, J.E., Rabelo, R., (1997) Eur. J. Endocrinol., 136, pp. 251-264Himms-Hagen, J., Ricquier, D., (1998) Handbook of Obesity, pp. 415-441. , (Bray, G., Bouchard, C., and James, W., eds), Marcel Dekker, New York, Basel, Hong KongBoss, O., Muzzin, P., Giacobino, J.P., (1998) Eur. J. Endocrinol., 139, pp. 1-9Rial, E., Gonzalez-Barroso, M.M., Fleury, C., Bouillaud, F., (1998) Biofactors, 8, pp. 209-219Freake, H.C., (1998) Nutr. Rev., 56, pp. 185-189Klingenberg, M., Huang, S.G., (1999) Biochim. Biophys. Acta, 1415, pp. 271-296Schrauwen, P., Walder, K., Ravussin, E., (1999) Obes. Res., 7, pp. 97-105Ježek, P., Garlid, K.D., (1998) Int. J. Biochem. Cell Biol., 30, pp. 1163-1168Ricquier, D., (1999) J. Intern. Med., 245, pp. 637-642Bailey, T.L., Elkan, C., (1994) Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36. , AAAI Press, Menlo Park, CaliforniaBailey, T.L., Gribskov, M., (1998) Bioinformatics, 14, pp. 48-54Cassard, A.M., (1990) J. Cell. Biochem., 43, pp. 255-264Kozak, L.P., Britton, J.H., Kozak, U.C., Wells, J.M., (1988) J. Biol. Chem., 263, pp. 12274-12277Hilbert, P., (1991) Nature, 353, pp. 521-529Otsen, M., Den Bieman, M., Van Zutphen, L.F., (1993) J. Hered., 84, pp. 149-151Szpirer, C., (1998) Mamm. Genome, 9, pp. 721-734Pecqueur, C., (1999) Biochem. Biophys. Res. Commun., 255, pp. 40-46Gong, D.W., He, Y., Reitman, M.L., (1999) Biochem. Biophys. Res. Commun., 256, pp. 27-32Surwit, R.S., (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 4061-4065Fleury, C., (1997) Nat. Genet., 15, pp. 269-272Kaisaki, P.J., Woon, P.Y., Wallis, R.H., Monaco, A.P., Lathrop, M., Gauguier, D., (1998) Mamm. Genome, 9, pp. 910-912Gimeno, R.E., (1997) Diabetes, 46, pp. 900-906Ricquier, D., Bouillaud, F., (2000) Biochem. J., 345, pp. 161-179Solanes, G., Vidal-Puig, A., Grujic, D., Flier, J.S., Lowell, B.B., (1997) J. Biol. Chem., 272, pp. 25433-25436Laloi, M., Klein, M., Sanchis, D., Fleury, C., (1999) Arabidopsis thaliana ucp gene, exons 1-9, , GeneBank record, ACCESSION Y18291Stuart, J.A., Harper, J.A., Brindle, K.M., Brand, M.D., (1999) Biochim. Biophys. Acta, 1413, pp. 50-54Jarmuszkiewicz, W., Sluse-Goffart, C.M., Hryniewiecka, L., Sluse, F.E., (1999) J. Biol. Chem., 274, pp. 23198-23202Jarmuszkiewicz, W., Milani, G., Fortes, F., Schreiber, A.Z., Sluse, F.E., Vercesi, A., (2000) FEBS Lett., 467, pp. 145-149Uemura, S.A., Luo, S., Moreno, S.N.J., Docampo, R., (2000) J. Biol. Chem., 275, pp. 9709-9715Aquila, H., Link, T., Klingenberg, M., (1985) EMBO J., 4, pp. 2369-2376Winkler, E., Klingenberg, M., (1994) J. Biol. Chem., 269, pp. 2508-2515Haupts, U., Tittor, J., Bamberg, E., Oesterheld, D., (1997) Biochemistry, 36, pp. 2-7Rial, E., (1999) EMBO J., 18, pp. 5827-583
PLAYING JAPAN: THE TRANSNATIONAL CIRCULATION OF JAPAN IN CONTEMPORARY VIDEO GAME MUSIC
Since the 2010s, Japan has become a force of cultural globalization through the exportation of its popular media. As Japanese popular media became desirable in the West, scholars have marked a “shifting identity” in Japanese transnational media from a global aesthetic to one that is now “distinctly Japanese.” Drawing on ludomusicology and sound studies, my thesis examines how “distinctly Japanese” representations of Japan have been reworked and retransmitted through popular media, particularly video games, created in the United States. My research focuses on three separate case studies on video games that represent “distinct Japanese-ness” from both Japanese and U.S. game developers. Beginning with representations of Japan from Japanese game studios, Ryu Ga Gotoku and From Software, I then turn to Ghost of Tsushima (2020), a U.S.-made video game portraying the island of Tsushima during the first Mongol invasion of Japan. By examining the exchange of transnational media products and their methods of representation, I assert that the exchange of media can create a loop of representation, in which ideas are transmitted and returned to their point origin.Master of Art
The 100 most eminent psychologists of the 20th century.
A rank-ordered list was constructed that reports the first 99 of the 100 most eminent psychologists of the 20th century. Eminence was measured by scores on 3 quantitative variables and 3 qualitative variables. The quantitative variables were journal citation frequency, introductory psychology textbook citation frequency, and survey response frequency. The qualitative variables were National Academy of Sciences membership, election as American Psychological Association (APA) president or receipt of the APA Distinguished Scientific Contributions Award, and surname used as an eponym. The qualitative variables were quantified and combined with the other 3 quantitative variables to produce a composite score that was then used to construct a rank-ordered list of the most eminent psychologists of the 20th century. The discipline of psychology underwent a remarkable transformation during the 20th cen-tury, a transformation that included a shift away from the European-influenced philosophical psychology of the late 19th century to th
Glutamatergic Receptors Modulate Normoxic but Not Hypoxic Ventilation and Metabolism in Naked Mole Rats
Naked mole rats (Heterocephalus glaber) are among the most hypoxia-tolerant mammals, but their physiological responses to acute and chronic sustained hypoxia (CSH), and the molecular underpinnings of these responses, are poorly understood. In the present study we evaluated the acute hypoxic ventilatory response and the occurrence of ventilatory acclimatization to hypoxia following CSH exposure (8–10 days in 8% O2) of naked mole rats. We also investigated the role of excitatory glutamatergic signaling in the control of ventilation and metabolism in these conditions. Animals acclimated to normoxia (control) or CSH and then exposed to acute hypoxia (7% O2 for 1 h) exhibited elevated tidal volume (VT), but decreased breathing frequency (fR). As a result, total ventilation (V.E) remained unchanged. Conversely, VT was lower in CSH animals relative to controls, suggesting that there is ventilatory plasticity following acclimatization to chronic hypoxia. Both control and CSH-acclimated naked mole rats exhibited similar 60–65% decreases in O2 consumption rate during acute hypoxia, and as a result their air convection requirement (ACR) increased ∼2.4 to 3-fold. Glutamatergic receptor inhibition decreased fR, V.E, and the rate of O2 consumption in normoxia but did not alter these ventilatory or metabolic responses to acute hypoxia in either the control or CSH groups. Taken together, these findings indicate that ventilatory acclimatization to hypoxia is atypical in naked mole rats, and glutamatergic signaling is not involved in their hypoxic ventilatory or metabolic responses to acute or chronic hypoxia
Identification and characterization of uncoupling protein 4 in fat body and muscle mitochondria from the cockroach Gromphadorhina cocquereliana
Alternative oxidase gene family in Hypericum perforatum L.: characterization and expression at the post-germinative phase
info:eu-repo/semantics/publishedVersio
Management and Management Science in 15 Years: A Vision of the Future under the Influence of New Information Technologies
Uncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes, fungi, and protozoa. Mammalian UCPs and plant uncoupling proteins (PUMPs) form five distinct subfamilies. Only subfamily III contains both plant and animal uncoupling proteins, as well as UCPs from primitive eukaryotic organisms, which suggest that this group may represent an ancestral cluster from which other UCPs/PUMPs may have evolved. Genetic data indicate that UCPs/PUMPs are regulated at the transcriptional, post-transcriptional, and translational levels. Tissue/organ- and stress-specific gene expression suggests that UCPs/PUMPs are involved in the general balance of basic energy expenditure, protection against reactive oxygen species, and thermogenesis. Finally, the simultaneous occurrence of PUMP and alternative oxidase, another energy-dissipating system in plant mitochondria, raises the question of their response to biotic and abiotic stress at the transcriptional and functional levels.254173220922
- …