Future fuels and engines for railroad locomotives. Volume 1: Summary

The potential for reducing the dependence of railroads on petroleum fuel, particularly Diesel No. 2 was investigated. Two approaches are studied: (1) to determine how the use of Diesel No. 2 can be reduced through increased efficiency and conservation, and (2) to use fuels other than Diesel No. 2 both in Diesel and other types of engines. Because synthetic hydrocarbon fuels are particularly suited to medium speed diesel engines, the first commercial application of these fuels may be by the railroad industry

Persepsi Pemandu/petandu terhadap Pembentukan Kelompok Ipphti, Jawa Barat

IPPHTI (Ikatan Petani Pengendalian Hama Terpadu Indonesia) nasional berawal dari kegiatan-kegiatan terkait dengan Sekolah Lapangan (SL). Tujuan studi ini adalah meneliti persepsi pemandu/petandu IPPHTI berkaitan dengan faktor-faktor yang mempengaruhi pembentukan kelompok IPPHTI, Jawa Barat. Profil demografik dari survei menunjukkan mayoritas laki-laki (partisipasi wanita 30%), bersuku Sunda, berpendidikan SD dan telah menamatkan SL. Faktor-faktor yang mempengaruhi pembentukan kelompok IPPHTI adalah tersedianya sumberdaya manusia (SDM) dan adanya jaringan organisasi-organisasi. Kategori ilmu dan pengetahuan membuktikan ada kaitan dengan keinginan tahu dan hak-hak asasi manusia khususnya hak milik tanah. Jenis kelaminan, kesukuan, status kepemimpinan, dan penggarapan atas tanah tidak membuktikan adanya perbedaan berarti dalam persepsi antara berbagai status pendidikan dan pembentukan IPPHTI. Meskipun demikian, terdapat perbedaan berarti dalam persepsi antara berbagai status pendidikan dan pembentukan kelompok IPPHTI. Para pemandu/petandu siap berdiskusi dengan pemerintah setempat dan Dinas Pertanian terkait mengenai hasil survei ini. Hasil dari survei, yang dilaksanakan April 2004, sudah dilaporkan ke responden (IPPHTI, Jawa Barat). Diskusi yang berlangsung meliputi tiga pertanyaan: 1. Mengapa status pendidikan mempengaruhi hasil survei? 2. Apakah dasar dari korelasi antara pengetahuan yang diperoleh dan hak milik tanah? 3. Mengapa SDM lebih bernilai daripada bantuan ekonomi dalam mengembangkan IPPHTI? Pendapat yang muncul dari diskusi-diskusi adalah apabila pelatihan SDM tersedia, maka sumberdaya ekonomi dari pemerintah dan swasta serta penelitian universitas akan lebih baik dimanfaatkan yang dilatih SL. Memperoleh informasi yang secara konkret dapat memperbaiki penghidupan petani selalu menjadi tujuan utama dari IPPHTI

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

The concept that cellular terminal differentiation is stably maintained once development is complete has been questioned by numerous observations showing that differentiated epithelium may undergo an epithelial-to-mesenchymal transition (EMT) program. EMT and the reverse process, mesenchymal-to-epithelial transition (MET), are typical events of development, tissue repair, and tumor progression. In this study, we aimed to clarify the molecular mechanisms underlying these phenotypic conversions in hepatocytes. Hepatocyte nuclear factor 4α (HNF4α) was overexpressed in different hepatocyte cell lines and the resulting gene expression profile was determined by real-time quantitative polymerase chain reaction. HNF4α recruitment on promoters of both mesenchymal and EMT regulator genes was determined by way of electrophoretic mobility shift assay and chromatin immunoprecipitation. The effect of HNF4α depletion was assessed in silenced cells and in the context of the whole liver of HNF4 knockout animals. Our results identified key EMT regulators and mesenchymal genes as new targets of HNF4α. HNF4α, in cooperation with its target HNF1α, directly inhibits transcription of the EMT master regulatory genes Snail, Slug, and HMGA2 and of several mesenchymal markers. HNF4α-mediated repression of EMT genes induces MET in hepatomas, and its silencing triggers the mesenchymal program in differentiated hepatocytes both in cell culture and in the whole liver. Conclusion: The pivotal role of HNF4α in the induction and maintenance of hepatocyte differentiation should also be ascribed to its capacity to continuously repress the mesenchymal program; thus, both HNF4α activator and repressor functions are necessary for the identity of hepatocytes. Copyright © 2011 American Association for the Study of Liver Diseases

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4\uce\ub1

The concept that cellular terminal differentiation is stably maintained once development is complete has been questioned by numerous observations showing that differentiated epithelium may undergo an epithelial-to-mesenchymal transition (EMT) program. EMT and the reverse process, mesenchymal-to-epithelial transition (MET), are typical events of development, tissue repair, and tumor progression. In this study, we aimed to clarify the molecular mechanisms underlying these phenotypic conversions in hepatocytes. Hepatocyte nuclear factor 4\uce\ub1 (HNF4\uce\ub1) was overexpressed in different hepatocyte cell lines and the resulting gene expression profile was determined by real-time quantitative polymerase chain reaction. HNF4\uce\ub1 recruitment on promoters of both mesenchymal and EMT regulator genes was determined by way of electrophoretic mobility shift assay and chromatin immunoprecipitation. The effect of HNF4\uce\ub1 depletion was assessed in silenced cells and in the context of the whole liver of HNF4 knockout animals. Our results identified key EMT regulators and mesenchymal genes as new targets of HNF4\uce\ub1. HNF4\uce\ub1, in cooperation with its target HNF1\uce\ub1, directly inhibits transcription of the EMT master regulatory genes Snail, Slug, and HMGA2 and of several mesenchymal markers. HNF4\uce\ub1-mediated repression of EMT genes induces MET in hepatomas, and its silencing triggers the mesenchymal program in differentiated hepatocytes both in cell culture and in the whole liver. Conclusion: The pivotal role of HNF4\uce\ub1 in the induction and maintenance of hepatocyte differentiation should also be ascribed to its capacity to continuously repress the mesenchymal program; thus, both HNF4\uce\ub1 activator and repressor functions are necessary for the identity of hepatocytes. Copyright \uc2\ua9 2011 American Association for the Study of Liver Diseases

International entrepreneurship in SMEs: a study of influencing factors in the textile industry

The final publication is available at Springer via http://dx.doi.org/10.1007/s11365-012-0242-3International entrepreneurship is an incipient research area with a rapidly increasing body of knowledge and contributions. An important part of this literature has focused on the analysis of the contributing factors to IE development. From these studies, this work attempts to analyse and validate through an integrative model the effect on this construct in SME of some of the main factors proposed by the literature such as Skills and Competences, Attitude and Proactiveness, Creativity and Innovation, Networking, Employees and Activity. To proceed with this aim, we conducted an empirical research focused on 174 textile SME in Spain. The results obtained confirm a positive relationship between the studied factors and the IE development. In consequence, this work agrees with previous literature that point out the need to use multi-theoretical perspectives, combining multiple factors.Gil Pechuán, I.; Expósito Langa, M.; Tomas Miquel, JV. (2013). International entrepreneurship in SMEs: a study of influencing factors in the textile industry. International Entrepreneurship and Management Journal. 9(1):45-57. doi:10.1007/s11365-012-0242-3S455791Akgün, A., Keskin, H., & Byrne, J. (2012). Organizational emotional memory. Management Decision, 50(1), 95–114.Andersén, J. (2011). Strategic resources and firm performance. Management Decision, 49(1), 87–98.Anderson, A. R., Dodd, S. D., & Jack, S. L. (2012). Entrepreneurship as connecting: some implications for theorising and practice. Management Decision, 50(5), 958–971.Appelbaum, S. H., Roy, M., & Gilliland, T. (2011). Globalization of performance appraisals: theory and applications. Management Decision, 49(4), 570–585.Arribas, I., Hernández, P., Urbano, A., & Vila, J. E. (2012). Are social and entrepreneurial attitudes compatible? A behavioral and self-perceptional analysis. Management Decision, 50(10), 1739–1757.Audretsch, D. (2012). Entrepreneurship research. Management Decision, 50(5), 755–764.Autio, E., Sapienza, H. J., & Almeida, J. G. (2000). Effects of age at entry, knowledge intensity, and imitability on international growth. Academy of Management Journal, 43, 909–924.Bannon, L. (1998). Mattel plans to double sales abroad. Wall Street Journal, February 11, (A3 and A8).Battistella, C., Biotto, G., & De Toni, A. (2012). From design driven innovation to meaning strategy. Management Decision, 50(4), 718–743.Bell, J., McNaughton, J., Young, R., & Crick, D. (2003). Towards an integrative model of small firm internationalization. Journal of International Entrepreneurship, 1, 339–362.Bonzo, P., Valadares de Oliveira, P., & McCormarck. (2012). Planning, capabilities, and performance: an integrated value approach. Management Decision, 50(6), 1001–1021.Bossak, J., & Nagashima, S. (1997). Corporate strategies for a borderless world: sharpening your competitive edge. Tokyo: Asian Productivity Organization.Cambra-Fierro, J., Florin, J., Perez, L., & Whitelock, J. (2011). Inter-firm market orientation as antecedent of knowledge transfer, innovation and value creation in networks. Management Decision, 49(3), 444–467.Cantarello, S., Nosella, A., Petroni, G., & Venturini, K. (2011). External technology sourcing: evidence from design-driven innovation. Management Decision, 49(6), 962–983.Chang, Y. Y., Hughes, M., & Hotho, S. (2011). Internal and external antecedents of SMEs’ innovation ambidexterity outcomes. Management Decision, 49(10), 1658–1676.Chaston, I., & Scott, G. J. (2012). Entrepreneurship and open innovation in an emerging economy. Management Decision, 50(7), 1161–1177.Coviello, N. E., & Jones, M. V. (2004). Methodological issues in international entrepreneurship research. Journal of Business Venturing, 19, 485–508.Coviello, N. E., & McAuley, A. (1999). Internationalization and the smaller firm: a review of contemporary empirical research. Management International Review, 39, 223–256.Covin, J., & Slevin, D. (1989). Strategic management of small firms in hostile and benign environments. Strategic Management Journal, 10(1), 75–87.Covin, J., & Slevin, D. (1991). A conceptual model of entrepreneurship as firm behavior. Entrepreneurship Theory and Practice, 16, 7–25.Davis, D., Morris, M., & Allen, J. (1991). Perceived environmental turbulence and its effect on selected entrepreneurship, marketing, and organizational characteristics in industrial firms. Journal of the Academy of Marketing Science, 19(1), 43–51.Dean, C. C., Thibodeaux, M. S., Beyerlein, M., Ebrahimi, B., & Molina, D. (1993). Corporate entrepreneurship and competitive aggressiveness. A comparison of U.S. firms operating in eastern Europe and the Commonwealth of Independent States with U.S. firms in other high-risk environments. Advances in International Comparative Management, 8, 31–54.Dess, G. G., & Robinson, R. B. (1984). Measuring organizational performance in the absence of objective measures: the case of privately held firms and conglomerate business units. Strategic Management Journal, 5, 265–273.Dess, G. G., Lumpkin, G. T., & Covin, J. G. (1997). Entrepreneurial strategy making and firm performance: tests of contingency and configurational models. Strategic Management Journal, 18, 677–695.Díaz-Casero, J. C., Díaz-Aunión, A., Sánchez-Escobedo, M. C., Coduras-Martinez, A., & Hernández-Mogollón, R. (2012). Economic freedom and entrepreneurial activity. Management Decision, 50(9), 1686–1711.Dimitratos, P., & Plakoyiannaki, E. (2003). Theoretical foundations of an international entrepreneurial culture. Journal of International Entrepreneurship, 1, 187–215.Dubini, P., & Aldrich, H. (1991). Personal and extended networks are central to the entrepreneurial process. Journal of Business Venturing, 6, 305–313.Felício, J. A., Rodrigues, R., & Caldeirinha, V. R. (2012). The effect of intrapreneurship on corporate performance. Management Decision, 50(10), 1717–1738.Goktan, A. B., & Miles, G. (2011). Innovation speed and radicalness: are they inversely related? Management Decision, 49(4), 533–547.Gómez-Haro, S., Aragón-Correa, J. A., & Cordón-Pozo, E. (2011). Differentiating the effects of the institutional environment on corporate entrepreneurship. Management Decision, 49(10), 1677–1693.Hitt, M. A., Ireland, R. D., Camp, S. M., & Sexton, L. D. (2001). Strategic entrepreneurship: entrepreneurial strategies for wealth creation [Special Issue]. Strategic Management Journal, 22(6), 479–492.Hotho, S., & Champion, K. (2011). Small businesses in the new creative industries: innovation as a people management challenge. Management Decision, 49(1), 29–54.Hu, Y.-S. (1995). The international transferability of competitive advantage. California Management Review, 37(4), 73–88.Huarng, K. H., & Yu, T. H. K. (2011). Entrepreneurship, process innovation and value creation by a non-profit SME. Management Decision, 49(2), 284–296.Jones, M. V. (1999). The internationalization of small UK high technology based firms. Journal of International Marketing, 7, 15–41.Jones, M. V., & Coviello, N. E. (2005). Internationalization: conceptualising and entrepreneurial process of behaviour in time. Journal of International Business Studies, 36(3):284–303.Khandwalla, P. (1977). The design of organizations. New York: Harcourt Brace Jovanovich.Knight, G. A., & Cavusgil, S. T. (2004). Innovation, organization capabilities, and the born-global firm. Journal of International Business Studies, 35, 124–141.Kropp, F., Lindsay, N. J., & Shoham, A. (2006). Entrepreneurial, market, and learning orientations and international entrepreneurial business venture performance in South African firms. International Marketing Review, 23(5), 504–523.Liebeskind, J. P. (1996). Knowledge, strategy, and the theory of the firm. Strategic Management Journal, 17, 93–107.Lumpkin, G. T., & Dess, G. G. (1996). Clarifying the entrepreneurial construct and linking it to performance. Academy of Management Review, 21, 135–172.McDougall, P. P., & Oviatt, B. M. (2000). International entrepreneurship: the intersection of two research paths. Academy of Management Journal, 43, 902–908.McDougall, P. P., Shane, S., & Oviatt, B. M. (1994). Explaining the formation of international new ventures: the limits of theories from international business research. Journal of Business Venturing, 9, 469–487.McGrath, R. G., MacMillan, I. C., & Venkataraman, S. (1995). Global dimensions of new competencies. In S. Birley & I. C. MacMillan (Eds.), International entrepreneurship. New York: Routledge.McNaughton, R. B. (2001). The export mode decision-making process in small knowledge- intensive firms. Market Intelligence and Planning, 19, 12–20.McNaughton, R. B. (2003). The number of export markets that a firm serves: process models versus the born-global phenomenon. Journal of International Entrepreneurship, 1, 297–311.Miles, R. E., & Snow, C. C. (1978). Organizational strategy, structure and process. New York: McGraw-Hill.Miller, D. (1983). The correlates of entrepreneurship in three types of firms. Management Science, 29(7), 770–791.Miller, D., & Friesen, P. (1984). Organizations: a quantum view. Englewood Cliffs: Prentice-Hall.Morrow, J. F. (1988). International entrepreneurship: a new growth opportunity. New Management, 3, 59–61.Murphy, G. B., Trailer, J. W., & Hill, R. C. (1996). Measuring performance in entrepreneurship research. Journal of Business Research, 36, 15–23.Naman, J. L., & Slevin, D. P. (1993). Entrepreneurship and the concept of fit: a model and empirical tests. Strategic Management Journal, 14, 137–153.Naranjo-Valencia, J. C., Jiménez-Jiménez, D., & Sanz-Valle, R. (2011). Innovation or imitation? The role of organizational culture. Management Decision, 49(1), 55–72.Oviatt, B. M., & McDougall, P. P. (1994). Toward a theory of international new ventures. Journal of International Business Studies, 25(1), 45–64.Oviatt, B. M., & McDougall, P. P. (1999). A framework for understanding accelerated international entrepreneurship. In R. Wright (Ed.), Research in global strategic management (pp. 23–40). Stamford: JAI Press.Oviatt, B. M., & McDougall, P. P. (2005). Defining international entrepreneurship and modeling the speed of internalization. Entrepreneurship Theory & Practice, 29(5), 537–554.Peiris, I.K., Akoorie, M.E.M., & Sinha, P.N. (2012). International entrepreneurship: A critical analysis of studies in the past two decades and future directions for research. Journal of International Entrepreneurship. Article in press.Pinchot, G., III. (1985). Intrapreneuring: why you don’t have to leave the corporation to become entrepreneur. New York: Harper and Row Publishers.Porter, M. (1990). The competitive advantage of nations. London: Collier-Macmillan.Renko, M., Shrader, R. C., & Simon, M. (2012). Perception of entrepreneurial opportunity: a general framework. Management Decision, 50(7), 1233–1251.Sandulli, F. D., Fernandez-Menendez, J., Rodriguez-Duarte, A., & Lopez-Sanchez, J. I. (2012). Testing the Schumpeterian hypotheses on an open innovation framework. Management Decision, 50(7), 1222–1232.Santos, F. J., Romero, I., & Fernández-Serrano, J. (2012). SMEs and entrepreneurial quality from a macroeconomic perspective. Management Decision, 50(8), 1382–1395.Shama, A. (1995). Entry strategies of U.S. firms to the former Soviet Bloc and Eastern Europe. California Management Review, 37(3), 90–109.Simon, H. (1996). Hidden champions: lessons from 500 of the world’s best unknown companies. Boston: Harvard Business School Press.Singh, S., Darwish, T. K., Costa, A. C., & Anderson, N. (2012). Measuring HRM and organisational performance: concepts, issues, and framework. Management Decision, 50(4), 651–667.Smart, T. (1996). GE’s Welch: ‘Fighting like hell to be No. 1’. Business Week, July 8, 48.Snow, C., & Hrebiniak, L. (1980). Strategy, distinctive competence, and organizational performance. Administrative Science Quarterly, 25, 317–336.Stevenson, H. H., & Jarillo, J. C. (1990). A paradigm of entrepreneurship: entrepreneurial management. Strategic Management Journal, 11, 17–27.Styles, C., & Seymour, R. G. (2006). Opportunities for marketing researchers in international entrepreneurship. International Marketing Review, 23(2), 126–145.Turner, R., Ledwith, A., & Kelly, J. (2012). Project management in small to medium-sized enterprises: tailoring the practices to the size of company. Management Decision, 50(5), 942–957.Venkatraman, N., & Ramanujam, V. (1986). Measurement of business performance in strategy research: a comparison of approaches. Academy of Management Review, 11, 801–814.Vlasic, B. (1998). The little car that could carry Chrysler overseas. Business Week, 19, 39.Welbourne, T. M., Neck, H., & Meyer, G. D. (2012). The entrepreneurial growth ceiling: using people and innovation to mitigate risk and break through the growth ceiling in initial public offerings. Management Decision, 50(5), 778–796.Williamson, P. J. (1997). Asia’s new competitive game. Harvard Business Review, 75(5), 55–67.Yeoh, P. L. (2004). International learning: antecedents and performance implications among newly internationalizing companies in an exporting context. International Marketing Review, 21(4/5), 511–535.Zahra, S. A. (1991). Predictors and financial outcomes of corporate entrepreneurship. An exploratory study. Journal of Business Venturing, 6(4), 259–285.Zahra, S. A. (1993a). Environment, corporate entrepreneurship and financial performance. A taxonomic approach. Journal of Business Venturing, 8(4), 319–340.Zahra, S. A. (1993b). A conceptual model of entrepreneurship as firm behavior: a critique and extensión. Entrepreneurship Theory and Practice, 17(4), 5–21.Zahra, S. A., & George, G. (2002). International entrepreneurship: the current status of the field and future agenda. In M. A. Hitt, R. D. Ireland, S. M. Camp, & D. L. Sexton (Eds.), Strategic entrepreneurship: creating a new mindset. Oxford: Blackwell Publishers.Zahra, S. A., Jennings, D. F., & Kuratko, D. F. (1999). The antecedents and consequences of firm-level entrepreneurship: the state of the field. Entrepreneurship Theory and Practice, 24(2), 45–63.Zhou, L. (2007). The effects of entrepreneurial proclivity and foreign market knowledge on early internationalization. Journal of World Business, 42(3), 281–293

Community development of a philosophy-in-practice for a networked learning module.

This roundtable discussion is based on the development a philosophy-in-practice for one module in a doctoral programme, focusing on researching groups and communities in technology enhanced/networked learning environments. The discussion will open with an overview of the tutor’s initial vision for the module and will include experiences of the members of the first cohort of doctoral candidates who participated in the module. Principles of participatory design and assessment will be examined. Examples from the module will be provided. Questions on community development of a philosophy-in-practice for networked learning will provide a basis for opening the roundtable discussio