90 research outputs found
ΠΡΠΎΡΡΠΎΠΉ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ Π΄ΠΈΠ°Π·ΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ-ΠΈΠΎΠ΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°ΠΌΠΈΠ½ΠΎΠ² Π² Π²ΠΎΠ΄Π½ΡΡ ΠΏΠ°ΡΡΠ°Ρ ΠΏΠΎΠ΄ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΡΠΈΡΡΠ΅ΠΌ: NaNO[2]/ΠΏ-ΡΠΎΠ»ΡΠΎΠ»ΡΡΠ»ΡΡΠΎΠΊΠΈΡΠ»ΠΎΡΠ° ΠΈ NaNO[2]/NaHSO[4]
ΠΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ Π½ΠΎΠ²ΡΠΉ, ΡΠ΄ΠΎΠ±Π½ΡΠΉ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠΎΠ΄ΠΈΠ΄ΠΎΠ² ΠΈΠ· Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ² ΡΠ΅Π°ΠΊΡΠΈΠ΅ΠΉ Π΄ΠΈΠ°Π·ΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ-ΠΈΠΎΠ΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ NaNO[2]/KI/p-TsOH ΠΈΠ»ΠΈ NaHSO[4] ΠΏΡΠΈ 20 Β°Π‘ Π² Π²ΠΎΠ΄Π½ΠΎΠΉ ΠΏΠ°ΡΡΠ΅. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΡΠ²Π΅ΡΠ°Π΅Ρ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡΠΌ "Π·Π΅Π»Π΅Π½ΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΈ", ΠΏΡΠ΅Π΄ΡΡΠ²Π»ΡΠ΅ΠΌΡΠΌ ΠΊ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌ
Effect of Symptoms of Adult Attention Deficit Hyperactivity Disorder on Symptoms of Post Traumatic Stress Disorder in Korean Conscripts
Clinical Significance of Observation without Repeated Radioiodine Therapy in Differentiated Thyroid Carcinoma Patients with Positive Surveillance Whole-Body Scans and Negative Thyroglobulin
Relationship between Vitamin D, Parathyroid Hormone, and Bone Mineral Density in Elderly Koreans
There is controversy regarding definition of vitamin D inadequacy. We analyzed threshold 25-hydroxyvitamin D (25[OH]D) below which intact parathyroid hormone (iPTH) increases, and examined age- and sex-specific changes of 25(OH)D and iPTH, and association of 25(OH)D and iPTH with bone mineral density (BMD) in elderly Koreans. Anthropometric parameters, serum 25(OH)D and iPTH, lumbar spine and femur BMD by dual-energy radiography absorptiometry (DXA) were measured in 441 men and 598 postmenopausal women. iPTH increased below serum 25(OH) of 36.7 ng/mL in men, but failed to reach plateau in women. Femur neck BMD above and below threshold differed when threshold 25(OH)D concentrations were set at 15-27.5 ng/mL in men, and 12.5-20 ng/mL in postmenopausal women. Vitamin D-inadequate individuals older than 75 yr had higher iPTH than those aged β€ 65 yr. In winter, age-associated iPTH increase in women was steeper than in summer. In conclusion, vitamin D inadequacy threshold cannot be estimated based on iPTH alone, and but other factors concerning bone health should also be considered. Older people seemingly need higher 25(OH)D levels to offset age-associated hyperparathyroidism. Elderly vitamin D-inadequate women in the winter are most vulnerable to age-associated hyperparathyroidism
The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells
Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies have suggested that statins may also have bone protective effects. This study assessed the effects of simvastatin on the proliferation and differentiation of human bone marrow stromal cells (BMSCs) in an ex vivo culture. The bone marrow was obtained from healthy donors. Mononuclear cells were isolated and cultured to osteoblastic lineage. In the primary culture, 10-6 M simvastatin diminished the mean size of the colony forming units-fibroblastic (CFU-Fs) and enhanced matrix calcification. At near confluence, the cells were sub-cultured. Thereafter, the alkaline phosphatase (ALP) activities of each group were measured by the time course of the secondary culture. Simvastatin increased the ALP activity in a dose dependent manner, and this stimulatory effect was more evident during the early period of culture. A 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay was performed during the secondary culture in order to estimate the effect of simvastatin on the proliferation of human BMSCs. When compared to the control group, simvastatin significantly decreased the proliferation of cells of each culture well. 10-6 M of simvastatin also significantly enhanced the osteocalcin mRNA expression level. This study shows that simvastatin has a stimulatory effect on bone formation through osteoblastic differentiation, and has an inhibitory effect on the proliferative potential of human BMSC
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Simultaneous Detection of EGFR and VEGF in Colorectal Cancer using Fluorescence-Raman Endoscopy
Fluorescence endomicroscopy provides quick access to molecular targets, while Raman spectroscopy allows the detection of multiple molecular targets. Using a simultaneous fluorescence-Raman endoscopic system (FRES), we herein demonstrate its potential in cancer diagnosis in an orthotopically induced colorectal cancer (CRC) xenograft model. In the model, epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) were targeted with antibody-conjugated fluorescence and surface-enhanced Raman scattering (F-SERS) dots. FRES demonstrated fast signal detection and multiplex targeting ability using fluorescence and Raman signals to detect the F-SERS dots. In addition, FRES showed a multiplex targeting ability even on a subcentimeter-sized CRC after spraying with a dose of 50 Β΅g F-SERS dots. In conclusion, molecular characteristics of tumor cells (EGFR in cancer cell membranes) and tumor microenvironments (VEGF in the extracellular matrix) could be simultaneously investigated when performing a colonoscopy
Response: Effects of High-Dose Ξ±-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea (Diabetes Metab J 2017;41:275-83)
Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association
Diabetic peripheral neuropathy (DPN) is the most common complication associated with diabetes. DPN can present as a loss of sensation, may lead to neuropathic ulcers, and is a leading cause of amputation. Reported estimates of the prevalence of DPN vary due to differences in study populations and diagnostic criteria. Furthermore, the epidemiology and clinical characteristics of DPN in Korean patients with type 2 diabetes mellitus (T2DM) are not as well understood as those of other complications of diabetes such as retinal and renal disease. Recently, the Diabetic Neuropathy Study Group of the Korean Diabetes Association (KDA) conducted a study investigating the impact of DPN on disease burden and quality of life in patients with T2DM and has published some data that are representative of the nation. This review investigated the prevalence and associated clinical implications of DPN in Korean patients with diabetes based on the KDA study
Clinical application of an intraoral scanner for serial evaluation of orthodontic tooth movement: A preliminary study
Morphological Change in Pancreatic Islets, Insulin Binding and Intracellular Glucose Metabolism in Adipocytes of Streptozotocin-induced Diabetic Rats
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