Application of Single-Station Sigma and Site-Response Characterization in a Probabilistic Seismic-Hazard Analysis for a New Nuclear Site

Aleatory variability in ground-motion prediction, represented by the standard deviation (sigma) of a ground-motion prediction equation, exerts a very strong influence on the results of probabilistic seismic-hazard analysis (PSHA). This is especially so at the low annual exceedance frequencies considered for nuclear facilities; in these cases, even small reductions in sigma can have a marked effect on the hazard estimates. Proper separation and quantification of aleatory variability and epistemic uncertainty can lead to defensible reductions in sigma. One such approach is the single-station sigma concept, which removes that part of sigma corresponding to repeatable site-specific effects. However, the site-to-site component must then be constrained by site-specific measurements or else modeled as epistemic uncertainty and incorporated into the modeling of site effects. The practical application of the single-station sigma concept, including the characterization of the dynamic properties of the site and the incorporation of site-response effects into the hazard calculations, is illustrated for a PSHA conducted at a rock site under consideration for the potential construction of a nuclear power plant.Civil, Architectural, and Environmental Engineerin

The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases

Homologues of the putative dehydrogenase YjhC are found in operons involved in the metabolism of N-acetylneuraminate (Neu5Ac) or related compounds. We observed that purified recombinant YjhC forms Neu5Ac from two dehydrated forms of this compound, 2,7-anhydro-N-acetylneuraminate (2,7-AN) and 2-deoxy-2,3-didehydro-N-acetylneuraminate (2,3-EN) that are produced during the degradation of sialoconjugates by some sialidases. The conversion of 2,7-AN into Neu5Ac is reversible and reaches its equilibrium when the ratio of 2,7-AN to Neu5Ac is ≈1/6. The conversion of 2,3-EN is irreversible, leading to a mixture of Neu5Ac and 2,7-AN. NMR analysis of the reaction catalysed by YjhC on 2,3-EN indicated that Neu5Ac was produced as the α-anomer. All conversions require NAD+ as a cofactor, which is regenerated in the reaction. They appear to involve the formation of keto (presumably 4-keto) intermediates of 2,7-AN, 2,3-EN and Neu5Ac, which were detected by liquid chromatography-mass spectrometry (LC-MS). The proposed reaction mechanism is reminiscent of the one catalysed by family 4 β-glycosidases, which also use NAD+ as a cofactor. Both 2,7-AN and 2,3-EN support the growth of Escherichia coli provided the repressor NanR, which negatively controls the expression of the yjhBC operons, has been inactivated. Inactivation of either YjhC or YjhB in NanR-deficient cells prevents the growth on 2,7-AN and 2,3-EN. This confirms the role of YjhC in 2,7-AN and 2,3-EN metabolism and indicates that transport of 2,7-AN and 2,3-EN is carried out by YjhB, which is homologous to the Neu5Ac transporter NanT

Selection of earthquake ground motions for multiple objectives using genetic algorithms

Existing earthquake ground motion (GM) selection methods for the seismic assessment of structural systems focus on spectral compatibility in terms of either only central values or both central values and variability. In this way, important selection criteria related to the seismology of the region, local soil conditions, strong GM intensity and duration as well as the magnitude of scale factors are considered only indirectly by setting them as constraints in the pre-processing phase in the form of permissible ranges. In this study, a novel framework for the optimum selection of earthquake GMs is presented, where the aforementioned criteria are treated explicitly as selection objectives. The framework is based on the principles of multi-objective optimization that is addressed with the aid of the Weighted Sum Method, which supports decision making both in the pre-processing and post-processing phase of the GM selection procedure. The solution of the derived equivalent single-objective optimization problem is performed by the application of a mixed-integer Genetic Algorithm and the effects of its parameters on the efficiency of the selection procedure are investigated. Application of the proposed framework shows that it is able to track GM sets that not only provide excellent spectral matching but they are also able to simultaneously consider more explicitly a set of additional criteria

Imbibition in mesoporous silica: rheological concepts and experiments on water and a liquid crystal

We present, along with some fundamental concepts regarding imbibition of liquids in porous hosts, an experimental, gravimetric study on the capillarity-driven invasion dynamics of water and of the rod-like liquid crystal octyloxycyanobiphenyl (8OCB) in networks of pores a few nanometers across in monolithic silica glass (Vycor). We observe, in agreement with theoretical predictions, square root of time invasion dynamics and a sticky velocity boundary condition for both liquids investigated. Temperature-dependent spontaneous imbibition experiments on 8OCB reveal the existence of a paranematic phase due to the molecular alignment induced by the pore walls even at temperatures well beyond the clearing point. The ever present velocity gradient in the pores is likely to further enhance this ordering phenomenon and prevent any layering in molecular stacks, eventually resulting in a suppression of the smectic phase in favor of the nematic phase.Comment: 18 pages, 8 figure

Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs

Objectives: This study's aim was to investigate the safety and performance of a self-assembling peptide matrix (SAPM) P11-4 for the treatment of periodontal disease in a controlled pre-clinical study. Materials and methods: Acute buccal bony dehiscence defects (LxW: 5 × 3 mm) were surgically created on the distal root of four teeth on one mandible side of 7 beagle dogs followed by another identical surgery 8 weeks later on the contralateral side. SAPM P11-4 (with and without root conditioning with 24% EDTA (T1, T2)), Emdogain® (C) and a sham intervention (S) were randomly applied on the four defects at each time point. Four weeks after the second surgery and treatment, the animals were sacrificed, the mandibles measured by micro-computed tomography (µ-CT) and sections of the tissue were stained and evaluated histologically. Results: Clinically and histologically, no safety concerns or pathological issues due to the treatments were observed in any of the study groups at any time point. All groups showed overall similar results after 4 and 12 weeks of healing regarding new cementum, functionality of newly formed periodontal ligament and recovery of height and volume of the new alveolar bone and mineral density. Conclusion: A controlled clinical study in humans should be performed in a next step as no adverse effects or safety issues, which might affect clinical usage of the product, were observed. Clinical relevance: The synthetic SAPM P11-4 may offer an alternative to the animal-derived product Emdogain® in the future

Simulations for the development of a ground motion model for induced seismicity in the Groningen gas field, the Netherlands

We present simulations performed for the development of a ground motion model for induced earthquakes in the Groningen gas field. The largest recorded event, with M3.5, occurred in 2012 and, more recently, a M3.4 event in 2018 led to recorded ground accelerations exceeding 0.1 g. As part of an extensive hazard and risk study, it has been necessary to predict ground motions for scenario earthquakes up to M7. In order to achieve this, while accounting for the unique local geology, a range of simulations have been performed using both stochastic and full-waveform finite-difference simulations. Due to frequency limitations and lack of empirical calibration of the latter approach, input simulations for the ground motion model used in the hazard and risk analyses have been performed with a finite-fault stochastic method. However, in parallel, extensive studies using the finite-difference simulations have guided inputs and modelling considerations for these simulations. Three approaches are used: (1) the finite-fault stochastic method, (2) elastic point- and (3) finite-source 3D finite-difference simulations. We present a summary of the methods and their synthesis, including both amplitudes and durations within the context of the hazard and risk model. A unique form of wave-propagation with strong lateral focusing and defocusing is evident in both peak amplitudes and durations. The results clearly demonstrate the need for a locally derived ground motion model and the potential for reduction in aleatory variability in moving toward a path-specific fully non-ergodic model

Hazard-consistent response spectra in the Region of Murcia (Southeast Spain): comparison to earthquake-resistant provisions

Hazard-consistent ground-motion characterisations of three representative sites located in the Region of Murcia (southeast Spain) are presented. This is the area where the last three damaging events in Spain occurred and there is a significant amount of data for comparing them with seismic hazard estimates and earthquake-resistant provisions. Results of a probabilistic seismic hazard analysis are used to derive uniform hazard spectra (UHS) for the 475-year return period, on rock and soil conditions. Hazard deaggregation shows that the largest hazard contributions are due to small, local events for short-period target motions and to moderate, more distant events for long-period target motions. For each target motion and site considered, the associated specific response spectra (SRS) are obtained. It is shown that the combination of two SRS, for short- and long-period ground motions respectively, provides a good approximation to the UHS at each site. The UHS are compared to design response spectra contained in current Spanish and European seismic codes for the 475-year return period. For the three sites analysed, only the Eurocode 8 (EC8) type 2 spectrum captures the basic shape of the UHS (and not the EC8 type 1, as could be expected a priori). An alternative response spectrum, anchored at short- and long-period accelerations, is tested, providing a close match to the UHS spectra at the three sites. Results underline the important contribution of the frequent, low-to-moderate earthquakes that characterize the seismicity of this area to seismic hazard (at the 475-year return period)

Ground-motion networks in the Groningen field: usability and consistency of surface recordings

Several strong-motion networks have been installed in the Groningen gas field in the Netherlands to record ground motions associated with induced earthquakes. There are now more than 450 permanent surface accelerographs plus a mobile array of 450 instruments, which, in addition to many instrumented boreholes, yield a wealth of data. The database of recordings has been of fundamental importance to the development of ground-motion models that form a key element of the seismic hazard and risk estimations for the field. In order to maximise the benefit that can be derived from these recordings, this study evaluates the usability of the recordings from the different networks, in general terms and specifically with regards to the frequency ranges with acceptable signal-to-noise ratios. The study also explores the consistency among the recordings from the different networks, highlighting in particular how a configuration error was identified and resolved. The largest accelerograph network consists of instruments housed in buildings around the field, frequently installed on the lower parts of walls rather than on the floor. A series of experiments were conducted, using additional instruments installed adjacent to these buildings and replicating the installation configuration in full-scale shake table tests, to identify the degree to which structural response contaminated the recordings. The general finding of these efforts was that for PGV and oscillator periods above 0.1 s, the response spectral ordinates from these recordings can be used with confidence

A database of ground-motion recordings, site profiles, and amplification factors from the Groningen gas field in the Netherlands

A comprehensive database that has been used to develop ground motion models for induced earthquakes in the Groningen gas field is provided in a freely accessible online repository. The database includes more than 8500 processed ground motion recordings from 87 earthquakes of local magnitude ML between 1.8 and 3.6, obtained from a large network of surface accelerographs and borehole geophones placed at 50 m depth intervals to a depth of 200 m. The 5%-damped pseudo-acceleration spectra and Fourier amplitude spectra of the records are also provided. Measured shear-wave velocity (VS) profiles, obtained primarily from seismic Cone Penetration Tests (CPTs), are provided for 80 of the ∼100 recording stations. A model representing the regional dynamic soil properties is presented for the entire gas field plus a 5 km onshore buffer zone, specifying lithology, VS, and damping for all layers above the reference baserock horizon located at about 800 m depth. Transfer functions and frequency-dependent amplification factors from the reference rock horizon to the surface for the locations of the recording stations are also included. The database provides a valuable resource for further refinement of induced seismic hazard and risk modeling in Groningen as well as for generic research in site response of thick, soft soil deposits and the characteristics of ground motions from small-magnitude, shallow-focus induced earthquakes