25 research outputs found
TRP channels, omega-3 fatty acids, and oxidative stress in neurodegeneration: from the cell membrane to intracellular cross-links
The Moonwalker Mouse: New Insights into TRPC3 Function, Cerebellar Development, and Ataxia
Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity
Niemann-Pick type C1 (NPC1) protein is essential for the transport of externally derived cholesterol from lysosomes to other organelles. Deficiency of NPC1 underlies the progressive NPC1 neurodegenerative disorder. Currently, there are no curative therapies for this fatal disease. Given the C