The Dramatist And Crime Management For National Stability: An Analysis of Tracie Utoh’s The Night of a Thousand Truths

Dramatists have used their dramatic ingenuity to comment on political, social, economic and security challenges in their societies over the years. The dramatists do this in order to chart the way forward for a stable political, economic and social system. It is in this wise that, Tracie Utoh-Ezeajuh has used her knowledge of drama to comment on serious issues bedevilling the progress and stability of the nation. The security challenges bedevilling the nation are linked to the fragile family system and what happened as regards the children’s upbringing by their respective families. This paper analyses one of Utoh’s plays, The Night of a Thousand Truths with a view to educating Nigerian families on what is expected of them as far as the issue of national security and social stability is concerned. This is done with the realisation that the family is the first unit of socialisation. The proper socialisation of children by their parent is therefore a stepping stone for national security and social stability

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Real world, multicentre patterns of treatment and survival in metastatic renal cell carcinoma with the UK Renal Oncology Collaborative (UK ROC): Is it time to look favourably on first-line immunotherapy containing combinations in all IMDC groups?

\ua9 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.Introduction: Clinical trials show improved progression-free survival (PFS) and overall survival (OS) in first-line metastatic renal cell carcinoma (mRCC) patients with immunotherapy containing systemic anti-cancer therapies (SACT). However, in the favourable international metastatic renal cell cancer database consortium (IMDC) group there is no trial evidence for OS benefit despite clear PFS improvement when comparing anti-VEGF tyrosine kinase inhibitor (TKI) monotherapy and (immunotherapy and TKI) IO/TKI combinations. Objective: To assess the impact of first-line SACT choice on the clinical outcomes of PFS and OS in mRCC. To evaluate this impact of initial SACT for allcomers and the favourable IMDC group. Methods: A multicentre retrospective review of patients who started SACT for mRCC (01/01/2018–30/06/2021) at 17 UK NHS trusts. Patient demographics and IMDC group were analysed. Survival data were compared using Kaplan–Meier curves, and the statistical significance of differences in outcome between the groups was assessed with the log-rank test. Univariable and multivariable Cox proportional hazard modelling estimate the hazard ratios (HRs) for survival outcomes associated with IMDC and treatment subtype. Results: One thousand three hundred and nineteen patients were identified with a median age of 64. 294 (22.3%), 695 (52.7%) and 321 (24.3%) were IMDC group favourable, intermediate and poor, respectively. 311 (23.6%), 197 (14.9%) and 778 (59%) patients received checkpoint inhibitor and anti-CTLA4 monoclonal antibody (IO/IO), IO/TKI and TKI first-line SACT across all IMDC groups. Significant PFS improvement favouring IO/TKI versus TKI was demonstrated in allcomers HR = 0.61. In the favourable risk group, Log rank testing demonstrated a significant benefit for IO/TKI over TKI for PFS (HR = 0.60, 95% CI [0.39, 0.91]) and OS (HR = 0.42, 95% CI [0.18, 0.99]). Conclusion: In this real-world evidence cohort, we have shown OS and PFS benefit with IO/TKI versus TKI in the favourable IMDC risk group. This has not been previously reported from trial outcomes and would support use of front-line IO/TKI in mRCC favourable risk patients

Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom

\ua9 The Author(s) 2024.Background: Treatment options for pre-treated patients with metastatic triple-negative breast cancer (mTNBC) remain limited. This is the first study to assess the real-world safety and efficacy of sacituzumab govitecan (SG) in the UK. Methods: Data was retrospectively collected from 16 tertiary UK cancer centres. Pts had a diagnosis of mTNBC, received at least two prior lines of treatment (with at least one being in the metastatic setting) and received at least one dose of SG. Results: 132 pts were included. Median age was 56 years (28–91). All patients were ECOG performance status (PS) 0-3 (PS0; 39, PS1; 76, PS2; 16, PS3;1). 75% (99/132) of pts had visceral metastases including 18% (24/132) of pts with CNS disease. Median PFS (mPFS) was 5.2 months (95% CI 4.5–6.6) with a median OS (mOS) of 8.7 months (95% CI 6.8-NA). The most common adverse events (AEs) were fatigue (all grade; 82%, G3/4; 14%), neutropenia (all grade; 55%, G3/4; 29%), diarrhoea (all grade; 58%, G3/4, 15%), and nausea (all grade; 38%, G3/4; 3%). SG dose reduction was required in 54% of pts. Conclusion: This study supports significant anti-tumour activity in heavily pre-treated pts with mTNBC. Toxicity data aligns with clinical trial experience

Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

Objective: Assess ustekinumab efficacy (week 24/week 52) and safety (week 16/week 24/week 60) in patients with active psoriatic arthritis (PsA) despite treatment with conventional and/or biological anti-tumour necrosis factor (TNF) agents. Methods: In this phase 3, multicentre, placebo-controlled trial, 312 adults with active PsA were randomised (stratified by site, weight (≤100 kg/>100 kg), methotrexate use) to ustekinumab 45 mg or 90 mg at week 0, week 4, q12 weeks or placebo at week 0, week 4, week 16 and crossover to ustekinumab 45 mg at week 24, week 28 and week 40. At week 16, patients with <5% improvement in tender/swollen joint counts entered blinded early escape (placebo→45 mg, 45 mg→90 mg, 90 mg→90 mg). The primary endpoint was ≥20% improvement in American College of Rheumatology (ACR20) criteria at week 24. Secondary endpoints included week 24 Health Assessment Questionnaire-Disability Index (HAQ-DI) improvement, ACR50, ACR70 and ≥75% improvement in Psoriasis Area and Severity Index (PASI75). Efficacy was assessed in all patients, anti-TNF-naïve (n=132) patients and anti-TNF-experienced (n=180) patients. Results: More ustekinumab-treated (43.8% combined) than placebo-treated (20.2%) patients achieved ACR20 at week 24 (p<0.001). Significant treatment differences were observed for week 24 HAQ-DI improvement (p<0.001), ACR50 (p≤0.05) and PASI75 (p<0.001); all benefits were sustained through week 52. Among patients previously treated with ≥1 TNF inhibitor, sustained ustekinumab efficacy was also observed (week 24 combined vs placebo: ACR20 35.6% vs 14.5%, PASI75 47.1% vs 2.0%, median HAQ-DI change −0.13 vs 0.0; week 52 ustekinumab-treated: ACR20 38.9%, PASI75 43.4%, median HAQ-DI change −0.13). No unexpected adverse events were observed through week 60. Conclusions: The interleukin-12/23 inhibitor ustekinumab (45/90 mg q12 weeks) yielded significant and sustained improvements in PsA signs/symptoms in a diverse population of patients with active PsA, including anti-TNF-experienced PsA patients

El mapa conceptual, herramienta did?ctica que contribuye al desarrollo de procesos de comprensi?n lectora a trav?s de la metacognici?n en los estudiantes del grado sexto del gimnasio nuevo Suba de localidad 11

100 p. Recurso Electr?nicoEl proyecto de intervenci?n pedag?gica "el mapa conceptual, herramienta did?ctica que contribuye al desarrollo de procesos de comprensi?n lectora a trav?s de la metacognici?n en los estudiantes de grado sexto del Gimnasio Nuevo Suba de la localidad 11?, se basa en las dificultades encontradas en el ?rea de lengua castellana; realizando un enfoque en estudiantes con dificultades en comprensi?n lectora, efectuando entrevistas a educandos y educadores, grupos focales y talleres cuyo prop?sito es estudiar y determinar las variables que les dificultan la comprensi?n de diferentes textos, as? se evidenci? el bajo desarrollo de habilidades b?sicas, impidiendo la interiorizaci?n de informaci?n para crear un mundo de posibilidades y con ello la construcci?n del conocimiento. De ah?, la elaboraci?n, el dise?o y aplicaci?n del proyecto de intervenci?n pedag?gica, empleando para ello 20 sesiones, enfocadas en el uso de organizadores gr?ficos como el mapa conceptual, para implementarlos como herramienta did?ctica en el desarrollo del conocimiento consciente de ciertos procesos cognitivos (metacognici?n); en la medida en que se lleve a cabo cada una de las actividades propuestas. Finalmente, se espera que con la incorporaci?n de los Mapas Conceptuales como estrategia pedag?gica en las actividades de aula, se garantice la eficiencia en el proceso de ense?anza, mejorando las competencias investigativas, comunicativas, de an?lisis, interpretaci?n y s?ntesis, mediante las destrezas de la metacognici?n, en los estudiantes de grado sexto del Gimnasio nuevo Suba. Palabras Clave: Metacognici?n, autorregulaci?n, organizadores gr?ficos, mapa conceptual, proceso cognitivo, aprendizaje significativo.The pedagogical intervention project "THE CONCEPT MAP, TEACHING TOOL THAT CONTRIBUTES TO THE DEVELOPMENT OF PROCESSES OF READING COMPREHENSION PROCESSESTHROUGH METACOGNICI?N IN SIXTH GRADE STUDENTS RAISE NEW GYM SUBA IN THE TOWN 11", It is based on the difficulties encountered in the along the Participatory Action (IAP), Research such as the diary, based on direct observation of classes, especially in the area of Spanish language; case studies, focusing on students with difficulties in reading, interviewing students and teachers; and focus groups, developed through workshops whose purpose is to study and determine the variables that make it difficult for them to understand different texts, and low development of basic skills such as observation and therefore the perception is evidenced by preventing internalization of information create a world of possibilities and thus the construction of knowledge. Hence, the development, design and implementation of pegadogical intervention project, employing 20 sessions, focused on the use of graphic organizers such as concept mapping, to implement them as a teaching tool in the development of conscious awareness of certain cognitive processes (metacognition); insofar as it takes place each of proposed activities. Finally, it is expected that the incorporation of Concept Maps as a teaching strategy in the classroom activities, the efficiency of the teaching is guaranteed, improving investigative, communication skills, analysis, interpretation and synthesis, using the skills of metacognition, students sixth graders of the New Gym Suba. Keywords: metacognition, self, graphic organizers, concept maps, cognitive process, meaningful learning

A characteristics framework for Semantic Information Systems Standards

Semantic Information Systems (IS) Standards play a critical role in the development of the networked economy. While their importance is undoubted by all stakeholders—such as businesses, policy makers, researchers, developers—the current state of research leaves a number of questions unaddressed. Terminological confusion exists around the notions of “business semantics”, “business-to-business interoperability”, and “interoperability standards” amongst others. And, moreover, a comprehensive understanding about the characteristics of Semantic IS Standards is missing. The paper addresses this gap in literature by developing a characteristics framework for Semantic IS Standards. Two case studies are used to check the applicability of the framework in a “real-life” context. The framework lays the foundation for future research in an important field of the IS discipline and supports practitioners in their efforts to analyze, compare, and evaluate Semantic IS Standard

Application of Chinese Jun-Cao technique for the production of Brazilian Ganoderma lucidum strains

Ganoderma lucidum is a medicinal mushroom traditionally used in China against a wide range of diseases such as cancer and also for its prevention. In this work, commercial Chinese strains G. lucidum were compared to wild Brazilian strains aiming to determine the cultivation potential through the use of Jun-Cao. Six formulations were tested and the strains presented good response to the applied method. In general, the mixture between the grass and wood was well suited for the basidiomycetes, contributing to the preparation of substrates that generated better results in Jun Cao

Tenure, gender and household structure

Starting with a review of recent literature on gender and housing, this paper goes on to develop a new theory of household structure, in which concepts of gender and generation play a key role. The utility of this theory is then demonstrated in the analysis of data from a survey of households in the City of Salford