Systems aspects of COBE science data compression

A general approach to compression of diverse data from large scientific projects has been developed and this paper addresses the appropriate system and scientific constraints together with the algorithm development and test strategy. This framework has been implemented for the COsmic Background Explorer spacecraft (COBE) by retrofitting the existing VAS-based data management system with high-performance compression software permitting random access to the data. Algorithms which incorporate scientific knowledge and consume relatively few system resources are preferred over ad hoc methods. COBE exceeded its planned storage by a large and growing factor and the retrieval of data significantly affects the processing, delaying the availability of data for scientific usage and software test. Embedded compression software is planned to make the project tractable by reducing the data storage volume to an acceptable level during normal processing

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. Here, using a cardiac tissue model consisting of filamentous three-dimensional matrices populated with cardiomyocytes derived from healthy wild-type (WT) hiPSCs (WT hiPSC-CMs) or isogenic hiPSCs deficient in the sarcomere protein cardiac myosin-binding protein C (MYBPC3-/- hiPSC-CMs), we show that the WT microtissues adapted to the mechanical environment with increased contraction force commensurate to matrix stiffness, whereas the MYBPC3-/- microtissues exhibited impaired force development kinetics regardless of matrix stiffness and deficient contraction force only when grown on matrices with high fibre stiffness. Under mechanical overload, the MYBPC3-/- microtissues had a higher degree of calcium transient abnormalities, and exhibited an accelerated decay of calcium dynamics as well as calcium desensitization, which accelerated when contracting against stiffer fibres. Our findings suggest that MYBPC3 deficiency and the presence of environmental stresses synergistically lead to contractile deficits in cardiac tissues

IDENTIFICATION OF ERRORS IN COTTON FIBER DATA SETS USING BAYESIAN NETWORKS

Cotton fiber is graded on a series of parameters based on physiological factors (strength, length, and thickness), lint color, and presence of non-lint matter such as leaves, stems or other foreign materials. Cotton lint is graded by the USDA-AMS after harvest and ginning, and the grade determines the price of the lint. Given the importance of cotton fiber quality to the value of the crop, the spatial variability of cotton fiber properties is of particular interest to researchers and producers in developing management scenarios for optimal profitability. Previous research studies have relied on hand-harvesting the cotton at intervals throughout the field to obtain a measure of the cotton fiber quality and the extent of spatial variability. However, hand-harvested cotton has different qualities than that harvested by machine and ginned in the large-scale production gins. Part of this arises from the difference in efficiency of harvest between machine and humans, and part results from the different gins used for the smaller sample sizes. While these studies have demonstrated the extent of spatial variability of fiber properties, handharvesting is not amenable to large-scale or production research efforts. Moreover, the differences in fiber properties limit the extension of the results to the production setting. We have developed a mechanism of sampling cotton from the cotton chute during mechanical harvest. The samples are then ginned on a research gin. This study was undertaken to develop a method of translating these small-scale researcher level results to full-scale production level results. The research reported here is the first step in that effort, and demonstrates the use of Bayesian networks to detect erroneous entries in cotton fiber data sets

Non-magnetic semiconductor spin transistor

We propose a spin transistor using only non-magnetic materials that exploits the characteristics of bulk inversion asymmetry (BIA) in (110) symmetric quantum wells. We show that extremely large spin splittings due to BIA are possible in (110) InAs/GaSb/AlSb heterostructures, which together with the enhanced spin decay times in (110) quantum wells demonstrates the potential for exploitation of BIA effects in semiconductor spintronics devices. Spin injection and detection is achieved using spin-dependent resonant interband tunneling and spin transistor action is realized through control of the electron spin lifetime in an InAs lateral transport channel using an applied electric field (Rashba effect). This device may also be used as a spin valve, or a magnetic field sensor. The electronic structure and spin relaxation times for the spin transistor proposed here are calculated using a nonperturbative 14-band k.p nanostructure model.Comment: Accepted for publication in Applied Physics Letter

Autoantibodies to Hair Follicles in C3H/HeJ Mice With Alopecia Areata–Like Hair Loss

We have previously described spontaneous but reversible hair loss that clinically and histologically resembles human alopecia areata in a colony of C3H/HeJ mice. Alopecia areata in humans is associated with antibodies to hair follicles. This study was conducted to determine whether C3H/HeJ mice with hair loss have a similar abnormal antibody response to hair follicles. Eighteen C3H/HeJ mice with alopecia, 12 unaffected littermates, and 15 control mice were examined for circulating antibodies to C3H/HeJ anagen hair follicles by indirect immunofluorescence and against extracts of isolated C3H/HeJ and human anagen hair follicles by immunoblotting. Using both procedures, antibodies to anagen hair follicles were present in all C3H/HeJ mice with alopecia but in none of the control mice. The antibodies were also present in some unaffected C3H/HeJ littermates but were absent in mice of an unrelated strain with inflammatory skin disease and alopecia, indicating that their appearance did not result from the hair loss. These antibodies reacted to hair follicle–specific antigens of 40–60kDa present in murine and human anagen hair follicles. These antigens were also reactive with human alopecia areata antibodies. Some of the antibodies in both C3H/HeJ mice and humans with alopecia areata reacted to antigens of 44 and 46 kDa, which were identified as hair follicle–specific keratins. This study indicates that C3H/HeJ mice with hair loss have circulating antibodies to hair follicles similar to those present in humans with alopecia areata. These findings confirm that these mice are an appropriate model for human alopecia areata and support the hypothesis that alopecia areata results from an abnormal autoimmune response to hair follicles

Tameness of holomorphic closure dimension in a semialgebraic set

Given a semianalytic set S in a complex space and a point p in S, there is a unique smallest complex-analytic germ at p which contains the germ of S, called the holomorphic closure of S at p. We show that if S is semialgebraic then its holomorphic closure is a Nash germ, for every p, and S admits a semialgebraic filtration by the holomorphic closure dimension. As a consequence, every semialgebraic subset of a complex vector space admits a semialgebraic stratification into CR manifolds satisfying a strong version of the condition of the frontier.Comment: Published versio

Intrinsic Absorption Lines in Seyfert 1 Galaxies. I. Ultraviolet Spectra from the Hubble Space Telescope

We present a study of the intrinsic absorption lines in the ultraviolet spectra of Seyfert 1 galaxies. We find that the fraction of Seyfert 1 galaxies that show absorption associated with their active nuclei is more than one-half (10/17), which is much higher than previous estimates (3 - 10%) . There is a one-to-one correspondence between Seyferts that show intrinsic UV absorption and X-ray ``warm absorbers''. The intrinsic UV absorption is generally characterized by high ionization: C IV and N V are seen in all 10 Seyferts with detected absorption (in addition to Ly-alpha), whereas Si IV is present in only four of these Seyferts, and Mg II absorption is only detected in NGC 4151. The absorption lines are blueshifted (or in a few cases at rest) with respect to the narrow emission lines, indicating that the absorbing gas is undergoing net radial outflow. At high resolution, the absorption often splits into distinct kinematic components that show a wide range in widths (20 - 400 km/s FWHM), indicating macroscopic motions (e.g., radial velocity subcomponents or turbulence) within a component. The strong absorption components have cores that are much deeper than the continuum flux levels, indicating that the regions responsible for these components lie completely outside of the broad emission-line regions. The covering factor of the absorbing gas in the line of sight, relative to the total underlying emission, is C > 0.86, on average. The global covering factor, which is the fraction of emission intercepted by the absorber averaged over all lines of sight, is C > 0.5.Comment: 56 pages, Latex, includes 4 figures (encapsulated postscript), Fig. 1 has 2 parts and Fig. 2 has 3 parts, to appear in the Astrophysical Journa

Extremal discs and the holomorphic extension from convex hypersurfaces

Let D be a convex domain with smooth boundary in complex space and let f be a continuous function on the boundary of D. Suppose that f holomorphically extends to the extremal discs tangent to a convex subdomain of D. We prove that f holomorphically extends to D. The result partially answers a conjecture by Globevnik and Stout of 1991

Infrared, optical, and ultraviolet observations of hydrogen line emission from Seyfert galaxies

Nearly simultaneous observations are reported of Pɑ, Hɑ, and Hβ emission from 18 Seyfert galaxies and of Lyɑ from eight of these galaxies. In many cases, Pɑ is stronger relative to the Balmer lines than is predicted by recombination calculations; reddening appears to be required. Dispersion in the Pɑ/Hɑ/Hβ ratios orthogonal to the reddening track indicates that high densities or optical depths also affect the line flux ratios. Several galaxies, notably NGC 1275, have very low Pɑ/Hɑ ratios. High densities, large optical depths, and reddening probably all contribute to the low observed Lɑ/Hβ ratios

Spin relaxation in (110) and (001) InAs/GaSb superlattices

We report an enhancement of the electron spin relaxation time (T1) in a (110) InAs/GaSb superlattice by more than an order of magnitude (25 times) relative to the corresponding (001) structure. The spin dynamics were measured using polarization sensitive pump probe techniques and a mid-infrared, subpicosecond PPLN OPO. Longer T1 times in (110) superlattices are attributed to the suppression of the native interface asymmetry and bulk inversion asymmetry contributions to the precessional D'yakonov Perel spin relaxation process. Calculations using a nonperturbative 14-band nanostructure model give good agreement with experiment and indicate that possible structural inversion asymmetry contributions to T1 associated with compositional mixing at the superlattice interfaces may limit the observed spin lifetime in (110) superlattices. Our findings have implications for potential spintronics applications using InAs/GaSb heterostructures.Comment: 4 pages, 2 figure