A webometric analysis of Australian Universities using staff and size dependent web impact factors (WIF)

This study describes how search engines (SE) can be employed for automated, efficient data gathering for Webometric studies using predictable URLs. It then compares the usage of staffrelated Web Impact Factors (WIFs) to sizerelated impact factors for a ranking of Australian universities, showing that rankings based on staffrelated WIFs correlate much better with an established ranking from the Melbourne Institute than commonly used sizedependent WIFs. In fact sizedependent WIFs do not correlate with the Melbourne ranking at all. It also compares WIF data for Australian Universities provided by Smith (1999) for a longitudinal comparison of the WIF of Australian Universities over the last decade. It shows that sizedependent WIF values declined for most Australian universities over the last ten years, while staffdependent WIFs rose

A webometric analysis of Australian Universities using staff and size dependent web impact factors (WIF)

This study describes how search engines (SE) can be employed for automated, efficient data gathering for Webometric studies using predictable URLs. It then compares the usage of staffrelated Web Impact Factors (WIFs) to sizerelated impact factors for a ranking of Australian universities, showing that rankings based on staffrelated WIFs correlate much better with an established ranking from the Melbourne Institute than commonly used sizedependent WIFs. In fact sizedependent WIFs do not correlate with the Melbourne ranking at all. It also compares WIF data for Australian Universities provided by Smith (1999) for a longitudinal comparison of the WIF of Australian Universities over the last decade. It shows that sizedependent WIF values declined for most Australian universities over the last ten years, while staffdependent WIFs rose

Libcitations: A Measure for Comparative Assessment of Book Publications in the Humanities and Social Sciences

Bibliometric measures for evaluating research units in the book-oriented humanities and social sciences are underdeveloped relative to those available for journal-oriented science and technology. We therefore present a new measure designed for book-oriented fields: the “libcitation count.” This is a count of the libraries holding a given book, as reported in a national or international union catalog. As librarians decide what to acquire for the audiences they serve, they jointly constitute an instrument for gauging the cultural impact of books. Their decisions are informed by knowledge not only of audiences but also of the book world, e.g., the reputations of authors and the prestige of publishers. From libcitation counts, measures can be derived for comparing research units. Here, we imagine a matchup between the departments of history, philosophy, and political science at the University of New South Wales and the University of Sydney in Australia. We chose the 12 books from each department that had the highest libcitation counts in the Libraries Australia union catalog during 2000–2006. We present each book’s raw libcitation count, its rank within its LC class, and its LC-class normalized libcitation score. The latter is patterned on the item-oriented field normalized citation score used in evaluative bibliometrics. Summary statistics based on these measures allow the departments to be compared for cultural impact. Our work has implications for programs such as Excellence in Research for Australia and the Research Assessment Exercise in the United Kingdom. It also has implications for data mining in OCLC’s WorldCat

Critical analysis of information security culture definitions

This article aims to advance the understanding of information security culture through a critical reflection on the wide-ranging definitions of information security culture in the literature. It uses the hermeneutic approach for conducting literature reviews. The review identifies 16 definitions of information security culture in the literature. Based on the analysis of these definitions, four different views of culture are distinguished. The shared values view highlights the set of cultural value patterns that are shared across the organization. An action-based view highlights the behaviors of individuals in the organization. A mental model view relates to the abstract view of the individual’s thinking on how information security culture must work. Finally, a problem-solving view emphasizes a combination of understanding from shared value-based and action-based views. The paper analyzes and presents the limitations of these four views of information security culture definitions

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Background: Elevated proinflammatory cytokines are associated with greater COVID-19 severity. We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical (requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19. Methods: We did a 60-day, randomised, double-blind, placebo-controlled, multinational phase 3 trial at 45 hospitals in Argentina, Brazil, Canada, Chile, France, Germany, Israel, Italy, Japan, Russia, and Spain. We included adults (≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection and pneumonia, who required oxygen supplementation or intensive care. Patients were randomly assigned (2:2:1 with permuted blocks of five) to receive intravenous sarilumab 400 mg, sarilumab 200 mg, or placebo. Patients, care providers, outcome assessors, and investigators remained masked to assigned intervention throughout the course of the study. The primary endpoint was time to clinical improvement of two or more points (seven point scale ranging from 1 [death] to 7 [discharged from hospital]) in the modified intention-to-treat population. The key secondary endpoint was proportion of patients alive at day 29. Safety outcomes included adverse events and laboratory assessments. This study is registered with ClinicalTrials.gov, NCT04327388; EudraCT, 2020-001162-12; and WHO, U1111-1249-6021. Findings: Between March 28 and July 3, 2020, of 431 patients who were screened, 420 patients were randomly assigned and 416 received placebo (n=84 [20%]), sarilumab 200 mg (n=159 [38%]), or sarilumab 400 mg (n=173 [42%]). At day 29, no significant differences were seen in median time to an improvement of two or more points between placebo (12·0 days [95% CI 9·0 to 15·0]) and sarilumab 200 mg (10·0 days [9·0 to 12·0]; hazard ratio [HR] 1·03 [95% CI 0·75 to 1·40]; log-rank p=0·96) or sarilumab 400 mg (10·0 days [9·0 to 13·0]; HR 1·14 [95% CI 0·84 to 1·54]; log-rank p=0·34), or in proportions of patients alive (77 [92%] of 84 patients in the placebo group; 143 [90%] of 159 patients in the sarilumab 200 mg group; difference −1·7 [−9·3 to 5·8]; p=0·63 vs placebo; and 159 [92%] of 173 patients in the sarilumab 400 mg group; difference 0·2 [−6·9 to 7·4]; p=0·85 vs placebo). At day 29, there were numerical, non-significant survival differences between sarilumab 400 mg (88%) and placebo (79%; difference +8·9% [95% CI −7·7 to 25·5]; p=0·25) for patients who had critical disease. No unexpected safety signals were seen. The rates of treatment-emergent adverse events were 65% (55 of 84) in the placebo group, 65% (103 of 159) in the sarilumab 200 mg group, and 70% (121 of 173) in the sarilumab 400 mg group, and of those leading to death 11% (nine of 84) were in the placebo group, 11% (17 of 159) were in the sarilumab 200 mg group, and 10% (18 of 173) were in the sarilumab 400 mg group. Interpretation: This trial did not show efficacy of sarilumab in patients admitted to hospital with COVID-19 and receiving supplemental oxygen. Adequately powered trials of targeted immunomodulatory therapies assessing survival as a primary endpoint are suggested in patients with critical COVID-19. Funding: Sanofi and Regeneron Pharmaceuticals

Cleavage modification did not alter blastomere fates during bryozoan evolution

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The study was funded by the core budget of the Sars Centre and by The European Research Council Community’s Framework Program Horizon 2020 (2014–2020) ERC grant agreement 648861 to A