Opening up the classroom : Enabling and interrupting digital media practices in School

Funding The research was supported by the Bürgerstiftung Braunschweig.Peer reviewedPublisher PD

Delayed Fluorescence by Triplet–Triplet Annihilation from Columnar Liquid Crystal Films

Delayed fluorescence (DF) by triplet–triplet annihilation (TTA) is observed in solutions of a benzoperylene-imidoester mesogen that shows a hexagonal columnar mesophase at room temperature in the neat state. A similar benzoperylene-imide with a slightly smaller HOMO–LUMO gap, that also is hexagonal columnar liquid crystalline at room temperature, does not show DF in solution, and mixtures of the two mesogens show no DF in solution either, because of collisional quenching of the excited triplet states on the imidoester by the imide. In contrast, DF by TTA from the imide but not from the imidoester is observed in condensed films of such mixtures, even though neat films of either single material are not displaying DF. In contrast to the DF from the monomeric imidoester in solution, DF of the imide occurs from dimeric aggregates in the blend films, assisted by the imidoester. Thus, the close contact of intimately stacked molecules of the two different species in the columnar mesophase leads to a unique mesophase-assisted aggregate DF. This constitutes the first observation of DF by TTA from the columnar liquid crystalline state. If the imide is dispersed in films of polybromostyrene, which provides an external heavy-atom effect facilitating triplet formation, DF is also observed. Organic light-emitting diodes (OLEDs) devices incorporating these liquid crystal molecules demonstrated high external quantum efficiency (EQE). On the basis of the literature and to the best of our knowledge, the EQE reported is the highest among nondoped solution-processed OLED devices using a columnar liquid crystal molecule as the emitting layer

Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in Brazil

Abstract\ud \ud Background\ud Approximately 8–15% epithelial ovarian cancer patients are BRCA1 or BRCA2 germline mutation carriers. Brazilian inhabitants may have peculiar genetic characteristics associated with ethnic diversity, and studies focusing on the entire BRCA1/BRCA2 gene sequencing in Brazilian ovarian cancer patients are still lacking. The aim of this study was to evaluate BRCA1/2 mutations, through entire gene sequencing, in a Brazilian population of women with epithelial ovarian cancer.\ud \ud \ud Methods\ud In a cross sectional study performed in one reference centre for cancer treatment in São Paulo, Brazil, 100 patients diagnosed with epithelial ovarian cancer unselected for family history of breast and/or ovarian cancer were included. The complete coding sequence of BRCA1/2 genes was evaluated through Next-Generation or capillary sequencing. Large deletions were investigated through Multiplex Ligation-dependent Probe Amplification (MLPA).\ud \ud \ud Results\ud Nineteen pathogenic mutations (BRCA1: n = 17 and BRCA2: n = 2) featuring 14 different mutations, including two large deletions in BRCA1 (exon 1–2 deleted and exon 5–7 deleted) were identified. Three mutations were detected more than once (c.3331_3334delCAAG, c.5266dupC and c.4484G > T). Two novel frameshift mutations were identified, one in BRCA1 (c.961_962delTG) and one in BRCA2 (c.1963_1963delC). BRCA1/2 mutations were seen in 35.5% of the patients with first and/or second-degree relatives with breast and/or ovarian cancer. Nineteen variants of uncertain significance (VUS) were detected (BRCA1: n = 2 and BRCA2: n = 17), including five distinct missense variants (BRCA1: c.5348 T > C; BRCA2: c.2350A > G, c.3515C > T, c.7534C > T, and c.8351G > A).\ud \ud \ud Conclusions\ud Among epithelial ovarian cancer patients unselected for family history of cancer, 19% were BRCA1/2 germline mutation carriers. Almost ¾ of the BRCA mutations, including two large deletions, were detected only once. Our work emphasizes the need of entire gene sequencing and MLPA screening in Brazil.Geertruida Hendrika de Bock received a grant of Coordenação de Aperfeiçoamento\ud de Pessoal de Nível Superior (CAPES), Programa Pesquisador Visitante Especial (PVE\ud #029/2012), Simone Maistro received a postdoctoral scholarship by Coordenação\ud de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, PVE #029/2012), Giselly\ud Encinas received a PhD scholarship grant by São Paulo Research Foundation\ud (FAPESP, #2011/09572-1) and Natalia Teixeira received a scholarship grant by São\ud Paulo Research Foundation (FAPESP, #2012/05754-1).\ud This work was in part supported by a grant from Diagnósticos da América\ud -DASA and by a grant from NAP-Biobanco/USP

Abschlussbericht des Forschungsprojekts "Broker für Dynamische Produktionsnetzwerke"

Der Broker für dynamische Produktionsnetzwerke (DPNB) ist ein vom Bundesministerium für Bildung und Forschung (BMBF) gefördertes und durch den Projektträger Karlsruhe (PTKA) betreutes Forschungsprojekt zwischen sieben Partnern aus Wissenschaft und Wirtschaft mit einer Laufzeit von Januar 2019 bis einschließlich Dezember 2021. Über den Einsatz von Cloud Manufacturing sowie Hard- und Software-Komponenten bei den teilnehmenden Unternehmen, sollen Kapazitätsanbieter mit Kapazitätsnachfrager verbunden werden. Handelbare Kapazitäten sind in diesem Falle Maschinen-, sowie Transport- und Montagekapazitäten, um Supply Chains anhand des Anwendungsfalls der Blechindustrie möglichst umfassend abzubilden. Der vorliegende Abschlussbericht fasst den Stand der Technik sowie die Erkenntnisse aus dem Projekt zusammen. Außerdem wird ein Überblick über die Projektstruktur sowie die Projektpartner gegeben

Opening up the classroom: Enabling and interrupting digital media practices in School

Rooted in media and communication studies, and drawing on Structuration theory, this feature utilises the concept of open spaces as analytical lenses to observe how ‘digital education’ is unfolding in classrooms today. We conducted in-depth fieldwork in one German school in a long-term project from 2012 to 2017. We present theoretically and empirically based research from classroom observation and teacher interviews that informs debates about open education and innovative digital media pedagogies. The feature embeds the project’s findings in a reflection on digital practices in schools and, more broadly, in the contemporary global debate over the implementation of digital media in schools

När sorgen blir för mycket : En hjälpande hand vid utdragen sorg

Examensarbetet skrevs inom projektet Må bra i Finland! som behandlar psykisk ohälsa. Examensarbetets ämne är utdragen sorg som är en ny diagnos i ICD-11, vilken kommer att tas i bruk i Finland inom några år. Syftet med examensarbetet var att öka medvetenheten om utdragen sorg, normal sorg och särskilja diagnosen från depression och PTSD. Examensarbetet resulterade i artikeln När sorgen blir för mycket som kommer att publiceras i sjukskötarföreningens tidskrift Vård i fokus och bygger på examensarbetets litteraturöversikt. Examensarbetet utfördes som en litteraturöversikt och stöddes av två konsultationer med verksamma yrkeslivet. Konsultationerna gjordes med krisarbetare i SOS-centret och arbetsgruppen Feeniks. Krisarbetarna ansåg att diagnosen kommer att vara till nytta, eftersom felaktiga diagnoser kan leda till långdragen behandling som inte är adekvat för personens vårdbehov. Oändamålsenlig behandling ökar risken för nedsatt funktionsförmåga som kan leda till utmaningar i vardagen. Examensarbetet är avgränsat till att omfatta sorg efter en förlust. Examensarbetet beskriver skillnaden mellan normal sorg och utdragen sorg. Utdragen sorg orsakar en intensiv längtan efter en närstående som avlidit. Genom att upprätthålla ett undvikande beteende gentemot utlösande faktorer skyddar sig personen från den smärta som sorgen orsakar. Examensarbetet behandlar även kriser eftersom en person som mist en närstående människa på ett traumatiskt sätt kan gå in i en traumatisk kris. Det är många som blir feldiagnostiserade med depression och PTSD fastän de egentligen lider av utdragen sorg. Examensarbetet behandlar dessa diagnoser för att särskilja sjukdomsbilden och behandlingen. Till skillnad från depression och PTSD är kriterier för att bli diagnostiserad med utdragen sorg att en person varit med om en förlust och att sorgen pågått i minst 6 månader

Effects of P2, a peptide derived from a homophilic binding site in the neural cell adhesion molecule on learning and memory in rats

The neural cell adhesion molecule (NCAM) plays a pivotal role in neural development, regeneration, synaptic plasticity, and memory processes. P2 is a 12-amino-acid peptide derived from the second immunoglobulin-like (Ig) module of NCAM mediating cis-homophilic interactions between NCAM molecules present on the same cell. P2 is a potent NCAM agonist, capable of promoting neuronal differentiation and survival in vitro. The aim of this study was to assess the effect of P2 on learning and memory. Rats treated with P2 intracerebroventricularly (1 h prior to test) performed significantly better than controls in the reinforced T-maze, a test of spatial working memory. Further, rats treated with P2 exhibited decreased anxiety-like behavior while learning the T-maze task. In the social recognition test, both intracerebroventricular (1 h prior to test) and systemic (1 and 24 h prior to test) P2 treatment enhanced short-term social memory and counteracted (administration 24 h prior test) scopolamine-induced social memory impairment. In contrast, P2 (1 h prior to test) did not significantly improve long-term (24 h) retention of social memory, nor did it have any significant effects on long-term memory evaluated by the Morris water maze (administration between 2 days before training and 5.5 h posttraining). In the open field test, P2 (1 h prior to test) decreased general locomotion and rearing, but did not influence any other anxiety-related behaviors, indicating only a minimal influence on baseline anxiety levels. Taken together, these data indicate that in vivo P2 enhances short-term memory and protects against the amnestic effects of scopolamine, while modulating emotional behavior in a learning or novelty-related tas

Additional file 1: of Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in Brazil

Supplementary Methods. Table S1. Clinical and pathological characteristics, BRCA sequencing and MLPA results. Table S2. BRCA1 gene variants. Table S3. BRCA2 gene variants. (ZIP 73.7 kb