543 research outputs found

    The Wildland-Urban Interface and the Design Professions

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    This paper defines the wildland-urban interface and identifies opportunities for the design professions in the design, planning, and management of development in the wildland-urban interface. The paper explores the wildland-urban interface and the design professions role through understanding fire's history, a case study of a fire-damaged community, policies, codes, and ordinances, and Firewise

    The Copernicus project

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    The Copernicus spacecraft, to be launched on May 4, 2009, is designed for scientific exploration of the planet Pluto. The main objectives of this exploration is to accurately determine the mass, density, and composition of the two bodies in the Pluto-Charon system. A further goal of the exploration is to obtain precise images of the system. The spacecraft will be designed for three axis stability control. It will use the latest technological advances to optimize the performance, reliability, and cost of the spacecraft. Due to the long duration of the mission, nominally 12.6 years, the spacecraft will be powered by a long lasting radioactive power source. Although this type of power may have some environmental drawbacks, currently it is the only available source that is suitable for this mission. The planned trajectory provides flybys of Jupiter and Saturn. These flybys provide an opportunity for scientific study of these planets in addition to Pluto. The information obtained on these flybys will supplement the data obtained by the Voyager and Galileo missions. The topics covered include: (1) scientific instrumentation; (2) mission management, planning, and costing; (3) power and propulsion system; (4) structural subsystem; (5) command, control, and communication; and (6) attitude and articulation control

    Theoretical perspectives in purchasing and supply chain management: an analysis of the literature

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    The research presented in this paper is work-in-progress and aims to investigate to what extent purchasing and supply chain management (SCM), as a relatively new area of academic enquiry, is ready or able to join the select group of modern scientific disciplines. The analysis indicates that the discipline lacks coherence and exhibits significant and increasingly interdisciplinary breath and is some way off becoming a natural science. Furthermore, it is argued that SCM research has diverse agendas and therefore it is unlikely that one dominant paradigm will emerge.N/

    A Molecular Function Map of Ewing's Sarcoma

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    EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifically expressed in Ewing's sarcoma family tumors (ESFT) and is thought to initiate the development of the disease. Previous genomic profiling experiments have identified EWS-FLI1-regulated genes and genes that discriminate ESFT from other sarcomas, but so far a comprehensive analysis of EWS-FLI1-dependent molecular functions characterizing this aggressive cancer is lacking.In this study, a molecular function map of ESFT was constructed based on an integrative analysis of gene expression profiling experiments following EWS-FLI1 knockdown in a panel of five ESFT cell lines, and on gene expression data from the same platform of 59 primary ESFT. Out of 80 normal tissues tested, mesenchymal progenitor cells (MPC) were found to fit the hypothesis that EWS-FLI1 is the driving transcriptional force in ESFT best and were therefore used as the reference tissue for the construction of the molecular function map. The interrelations of molecular pathways were visualized by measuring the similarity among annotated gene functions by gene sharing. The molecular function map highlighted distinct clusters of activities for EWS-FLI1 regulated genes in ESFT and revealed a striking difference between EWS-FLI1 up- and down-regulated genes: EWS-FLI1 induced genes mainly belong to cell cycle regulation, proliferation, and response to DNA damage, while repressed genes were associated with differentiation and cell communication.This study revealed that EWS-FLI1 combines by distinct molecular mechanisms two important functions of cellular transformation in one protein, growth promotion and differentiation blockage. By taking MPC as a reference tissue, a significant EWS-FLI1 signature was discovered in ESFT that only partially overlapped with previously published EWS-FLI1-dependent gene expression patterns, identifying a series of novel targets for the chimeric protein in ESFT. Our results may guide target selection for future ESFT specific therapies

    Plant disease and insect advisory, vol. 01, no. 18

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    This publication, formally known as the Plant Disease and Insect Advisory newsletter by the Oklahoma Cooperative Extension Service, underwent a title transition. It is now recognized by the title Pest e-Alerts.Entomology and Plant Patholog
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