Constraining Axion Dark Matter with Big Bang Nucleosynthesis

We show that Big Bang Nucleosynthesis (BBN) significantly constrains axion-like dark matter. The axion acts like an oscillating QCD $\theta$ angle that redshifts in the early universe, increasing the neutron-proton mass difference at neutron freeze-out. An axion-like particle that couples too strongly to QCD results in the underproduction of 4He during BBN and is thus excluded. The BBN bound overlaps with much of the parameter space that would be covered by proposed searches for time-varying neutron EDMs. The QCD axion does not couple strongly enough to affect BBN.Comment: 5 pages, 2 figures; v2 typos corrected, numerical values for quark masses update

People Analytics : Eine datenschutzrechtliche Betrachtung moderner Einsatzszenarien für automatisierte, datenbasierte Entscheidungen

Modernes Personalmanagement („People Analytics“) bedarf des Einsatzes komplexer Algorithmen und der Auswertung einer Vielzahl von Daten. Hierbei geraten Unternehmen schnell in den Konflikt mit den geltenden Datenschutzbestimmungen. Der Autor stellt die einschlägigen Vorschriften zum Daten-, Betriebsverfassungs- und Telekommunikationsrecht dar und zeigt anhand konkreter Fallbeispiele auf, welche Fallstricke zu beachten sind. Er entwirft rechtskonforme Lösungen für den Einsatz von automatisierten Entscheidungen, Big Data und IoT im Unternehmen. Für die Zielgruppe der Anwälte, Betriebsräte und Unternehmen wird zudem eine Musterbetriebsvereinbarung zu möglichen Einsatzszenarien entworfen

Mob Justice and ‘The Civilized Commodity’

Our theory of ‘the civilized commodity' examines ‘mob violence' affecting high-value commodities, including the vanilla boom of Madagascar. We illustrate producers' labor under fraught conditions of violence and contradictory claims of ‘street justice.' Specifically we ask, what counts as justice and to whom? We highlights broader arguments around ‘moral hyper-proximity' of producer-consumer relations, and the strategies of state and market actors to circulate ‘civilized' visions for systemic and future governance over commodity landscapes. State and market calls for ‘law and order,' however, obscure the structural inequities faced by smallholders in their ‘everyday’ production of commodities under periodic crisis

ENGINEERED CLOSTRIDIUM BOTULINUM TOXIN ADAPTED TO DELIVER MOLECULES INTO SELECTED CELLS

An engineered payload-delivery system includes a target cell binding unit, covlently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeri protein-based composition is capable of specifically delivering payload to neural cells

Ocular direct current stimulation affects retinal ganglion cells

Ocular current stimulation (oCS) with weak current intensities (a few mA) has shown positive effects on retinal nerve cells, which indicates that neurodegenerative ocular diseases could be treated with current stimulation of the eye. During oCS, a significant polarity-independent reduction in the characteristic P50 amplitude of a pattern-reversal electroretinogram was found, while no current stimulation effect was found for a full field electroretinogram (ffERG). The ffERG data indicated a trend for a polarity-dependent influence during oCS on the photopic negative response (PhNR) wave, which represents the sum activity of the retinal ganglion cells. Therefore, an ffERG with adjusted parameters for the standardized measurement of the PhNR wave was combined with simultaneous oCS to study the potential effects of direct oCS on cumulative ganglion cell activity. Compared with that measured before oCS, the PhNR amplitude in the cathodal group increased significantly during current stimulation, while in the anodal and sham groups, no effect was visible (α = 0.05, pcathodal = 0.006*). Furthermore, repeated-measures ANOVA revealed a significant difference in PhNR amplitude between the anodal and cathodal groups as well as between the cathodal and sham groups (p* ≤ 0.0167, pcathodal − anodal = 0.002*, pcathodal − sham = 0.011*)

The effects of an ocular direct electrical stimulation on pattern-reversal electroretinogram

Studies on transcranial current stimulation have shown that a direct current stimulation of the occipital cortex can influence the amplitude size of a visual evoked potential (VEP). The current direction (cathodal or anodal) determines whether the VEP amplitudes increase or decrease. The aim of this study was to design a new experimental setup that will enable a simultaneous ocular direct current stimulation and electroretinogram (ERG) recording which will broaden our understanding of current stimulation effects on the visual system. Furthermore, we examined whether a direct current stimulation on the eye has a similar effect on an ERG as on a VEP. The pattern-reversal ERG was measured with sintered Ag/AgCl skin-electrodes, positioned on the lower eyelid (active), the earlobe (reference), and the forehead (ground). Direct current was applied through a ring rubber electrode placed around the eye and a 5 cm 5 cm rubber electrode placed at the ipsilateral temple with a current strength of 500 mA and a duration time of 5 min. Fifty-seven healthy volunteers were divided into three groups depending on the current direction (cathodal, anodal, and sham stimulation, n = 19 each). One ERG measurement (ERG 1) was performed before and another (ERG 2) during the direct current stimulation. The difference between ERG 1 and ERG 2 measurements for the characteristic P50, N95 and N950 (N95 minimum measured from zero line) amplitudes were evaluated by both confidence interval analysis and t-test for related samples (a = 0.05, after Bonferroni correction p = 0.0055). The P50 amplitude was significantly decreased for ERG 2 measurement in the cathodal and anodal stimulation group (cathodal p = 0.001, anodal p = 0.000). No significant changes could be found in the N95 and N950 amplitudes as well as in the sham-stimulation group. Additionally, the latencies did not undergo any significant changes. In conclusion, the newly designed experimental setup enables simultaneous current stimulation and ERG recording. The current influenced P50 amplitude although not the N95 and N950 amplitudes. Furthermore, the amplitude size decreased for both current directions and did not lead to contrary effects as expected