1,316 research outputs found
Counting chiral primaries in N=1 d=4 superconformal field theories
I derive a procedure to count chiral primary states in N=1 superconformal
field theories in four dimensions. The chiral primaries are counted by putting
the N=1 field theory on S^3 X R. I also define an index that counts semi-short
multiplets of the superconformal theory. I construct N=1 supersymmetric
Lagrangians on S^3 X R for theories which are believed to flow to a conformal
fixed point in the IR. For ungauged theories I reduce the field theory to a
supersymmetric quantum mechanics, whereas for gauge theories I use chiral ring
arguments. I count chiral primaries for SU(2) SYM with three flavors and its
Seiberg dual. Those two results agree provided a new chiral ring relation
holds.Comment: 34 pages, significant revisio
Closed-form two-loop Euler-Heisenberg Lagrangian in a self-dual background
We show that the two-loop Euler-Heisenberg effective Lagrangian for scalar
QED in a constant Euclidean self-dual background has a simple explicit closed
form expression in terms of the digamma function. This result leads to a simple
analysis of the weak- and strong-field expansions, the two-loop scalar QED beta
function, and the analytic continuation properties of the effective Lagrangian
and its imaginary part.Comment: 8 pages, late
FLT3 mutations in Early T-Cell Precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults. To unravel the underlying pathomechanisms and the clinical course we assessed molecular alterations and clinical characteristics in a large cohort of ETP-ALL (n = 68) in comparison to non-ETP T-ALL adult patients. Interestingly, we found a high rate of FLT3-mutations in ETP-ALL samples (n = 24, 35%). Furthermore, FLT3 mutated ETP-ALL was characterized by a specific immunophenotype (CD2+/CD5-/CD13+/CD33-), a distinct gene expression pattern (aberrant expression of IGFBP7, WT1, GATA3) and mutational status (absence of NOTCH1 mutations and a low frequency, 21%, of clonal TCR rearrangements). The observed low GATA3 expression and high WT1 expression in combination with lack of NOTCH1 mutations and a low rate of TCR rearrangements point to a leukemic transformation at the pluripotent prothymocyte stage in FLT3 mutated ETP-ALL. The clinical outcome in ETP-ALL patients was poor, but encouraging in those patients with allogeneic stem cell transplantation (3-year OS: 74%). To further explore the efficacy of targeted therapies, we demonstrate that T-ALL cell lines transfected with FLT3 expression constructs were particularly sensitive to tyrosine kinase inhibitors. In conclusion, FLT3 mutated ETP-ALL defines a molecular distinct stem cell like leukemic subtype. These data warrant clinical studies with the implementation of FLT3 inhibitors in addition to early allogeneic stem cell transplantation for this high risk subgroup
Selberg Supertrace Formula for Super Riemann Surfaces III: Bordered Super Riemann Surfaces
This paper is the third in a sequel to develop a super-analogue of the
classical Selberg trace formula, the Selberg supertrace formula. It deals with
bordered super Riemann surfaces. The theory of bordered super Riemann surfaces
is outlined, and the corresponding Selberg supertrace formula is developed. The
analytic properties of the Selberg super zeta-functions on bordered super
Riemann surfaces are discussed, and super-determinants of Dirac-Laplace
operators on bordered super Riemann surfaces are calculated in terms of Selberg
super zeta-functions.Comment: 43 pages, amste
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