Data Sources as a Driver for Market‑Oriented Tourism Organizations: a Bibliometric Perspective

This paper presents a conceptual framework that accurately represents the current and future perspectives of data-driven companies in tourism by means of an analysis of the data sources used in the data-driven tourism research literature, as well as the research topics to which they are applied. For this purpose, a bibliometric analysis of data-driven tourism research is carried out. The framework of the study is all tourism-related publications whose research was based on data sources during the period 1982–2020. The results show some of the basic bibliometric performance indicators and the maps of science. The main themes of research interest are identified, and the conceptual evolution is obtained based on these maps. Three major thematic areas are identified: tourism research topics, information sources, and data analysis techniques. Based on these three thematic areas, the conceptual model of data architecture and processes of a data-driven organization in the tourism sector are obtained. An additional qualitative analysis of the three thematic areas is performedCRUE-CSIC agreement with Springer Natur

Mineral equilibria and thermodynamic uncertainties in the geothermometrical characterisation of carbonate geothermal systems of low temperature. The case of the Alhama-Jaraba system (Spain)

Geothermometrical characterisation of low-temperature, carbonate-evaporitic geothermal systems is usually hampered by the lack of appropriate mineral equilibria to successfully use most of the classical geothermometers and/or by the thermodynamic uncertainties affecting some of the most probable mineral equilibria in low temperature conditions. This situation is further hindered if the thermal waters are additionally affected by secondary processes (e.g., CO2 loss) during their ascent to surface. All these problems cluster together in the low-temperature Alhama-Jaraba thermal system, hosted in carbonate rocks, with spring temperatures about 30 °C and waters of Ca-Mg−HCO3/SO4 type. This system, one of the largest naturally flowing (600 L/s) low temperature thermal systems in Europe, is used in this paper as a suitable frame to assess the problems in the application of chemical geothermometrical techniques (classical geothermometers and geothermometrical modelling) and to provide a methodology that could be used in this type of geothermal system or in potential CO2 storage sites in similar aquifers. The results obtained have shown that the effects of the secondary processes can be avoided by selecting the samples unaffected by such processes and, therefore, representative of the conditions at depth, or by applying existing methodologies to reconstruct the original composition, as is usually done for medium to high temperature systems. The effective mineral equilibria at depth depend on the temperature, the residence time and the specific lithological/mineralogical characteristics of the system studied. In the present case, the mineral equilibria on which classical cation geothermometers are based have not been attained. The low proportion of evaporitic minerals in the hosting aquifer prevents the system from reaching anhydrite equilibrium, otherwise common in carbonate-evaporitic systems and necessary for the specific SO4-F geothermometer or the specially reliable quartz (or chalcedony) – anhydrite equilibrium in the geothermometrical modelling of these geothermal systems. Under these circumstances, the temperature estimation must rely on quartz (or chalcedony), clay minerals and, especially, calcite and dolomite. However, clay minerals and dolomite present important thermodynamic uncertainties related to possible variations in composition or crystallinity degree for clays and order/disorder degree for dolomite. To deal with these problems, a sensitivity analysis to the thermodynamic data for clay minerals has been carried out, comparing the results obtained when considering different solubility data. The uncertainties associated with dolomite have been addressed by reviewing the solubility data available for dolomites with different order degrees and performing specific calculations for the order degree of the dolomite in the aquifer. This approach can be used to find the most adequate dolomite thermodynamic data for the system under consideration, including medium-high temperature geothermal systems. Finally, the temperature estimation of the Alhama-Jaraba waters in the deep reservoir has been obtained from simultaneous equilibria of quartz, calcite, partially disordered dolomite and some aluminosilicate phases. The obtained value of 51 ± 14 °C is within the uncertainty range normally affecting this type of estimations and is coherent with independent estimations from geophysical data

Estudio geotermométrico de las aguas termales ricas en CO2 del acuífero de La Ermita del Saladillo (Murcia)

Las aguas del acuífero carbonatado de La Ermita del Saladillo representan una de las manifestaciones termales de aguas ricas en CO2 del sureste de la Península Ibérica. En este tipo de sistemas, la aplicación de las técnicas geotermométricas puede presentar problemas y por ello, en este trabajo se han verificado los resultados obtenidos mediante distintos geotermómetros en dos muestras de agua tomadas en este acuífero termal a partir de sondeos. Los geotermómetros catiónicos sobreestiman las temperaturas del reservorio ya que las aguas no parecen haber alcanzado los equilibrios en los que se basan esas técnicas. Sin embargo, los geotermómetros Ca-Mg y anhidrita – calcedonia, de uso en sistemas carbonatado – evaporíticos no carbónicos proporcionan resultados coherentes en las aguas estudiadas ricas en CO2. También el geotermómetro SiO2-calcedonia ha proporcionado resultados satisfactorios

About an Hispanic annular fibulae with ‘Hercules knot’ and other findings from La Monravana (Llíria, Valencia)

En el marco de la entrega al Museo de Prehistoria de Valencia de una fíbula anular hispánica decorada en su puente con un motivo de nudo hercúleo, recuperada en el poblado ibérico de La Monravana, se presenta una revisión del modelo que se fecha hacia el siglo IV a.C. con una distribución geográfica en las tierras del interior de la provincia de Valencia y el sur de Cuenca. Junto a la fíbula se conservaba un conjunto de fotografías que reproducen un variado repertorio cerámico supuestamente de la misma procedencia. Su estudio permite realizar una aproximación a las producciones de este tipo de materiales en el área edetana hacia finales del siglo III o inicios del II a.C.In the context of the cession to the Prehistory Museum of Valencia of a Hispanic annular fibulae decorated on the bridge with a Herculean knot, from the Iberian settlement of La Monravana, a review of these model is made. It is dated toward the fourth century BC and presents a geographical distribution in the inland of the province of Valencia and southern Cuenca. Together with the fibulae a set of photographs that reproduce a varied repertoire ceramic supposedly from the same source was kept. Their study allows an approach to the production of such materials in the Edetanian territory towards the end of the third century or early second century BC.Este trabajo se ha realizado dentro del marco del proyecto del Ministerio de Economía y Competitividad HAR2013-41447-P “El Bronce Final y la Edad del Hierro en el Sureste y el Levante de la Península Ibérica: procesos hacia la urbanización”

Application of different methods to formulate PEG-liposomes of oxaliplatin: Evaluation in vitro and in vivo

In this work the film method (FM), reverse-phase evaporation (REV) and the heating method (HM) were applied to prepare PEG-coated liposomes of oxaliplatin with natural neutral and cationic lipids, respectively. The formulations developed with the three methods, showed similar physicochemical characteristics, except in the loading of oxaliplatin, which was statistically lower (P<0.05) using the HM. The incorporation of a semi-synthetic lipid in the formulation developed by FM, provided liposomes with a particle size of 115 nm associated to the lowest polydispersity index and the highest drug loading, 35%, compared to the other two lipids, suggesting an increase of the membrane stability. That stability was also evaluated according to the presence of cholesterol, the impact of the temperature, and the application of different cryoprotectans during the lyophilization. The results indicated long-term stability of the developed formulation, because after its intravenous in-vivo administration to HT-29 tumor bearing mice was able to induce an inhibition of tumor growth statistically higher (P < 0.05) than the inhibition caused by the free drug. In conclusion, the FM was the simplest method in comparison with REV and HM to develop in vivo stable and efficient PEG-coated liposomes of oxaliplatin with a loading higher than those reported for REV

Travertines associated with the Alhama-Jaraba thermal waters (NE, Spain): Genesis and geochemistry

Freshwater carbonates are interesting archives in palaeoenvironmental reconstructions. However, more studies of those systems are needed to fully understand past environments. In this work the actively-forming travertines of the Alhama-Jaraba thermal system were studied for the first time in order to evaluate the relationship between the geochemical and mineralogical composition and the environmental conditions during their formation. With that aim, a combination of petrographical, mineralogical, geochemical and stable isotope analyses were carried out. These carbonates provide a natural laboratory for the study of the effect of different variables (natural and anthropogenic) on carbonate precipitation. The results showed that there is a close relationship between the mineralogy of the solid precipitates and the formation temperature, and only the samples formed from overheated waters (40–60 °C) show significant concentrations of aragonite. Aragonite-bearing samples show higher concentrations in Sr, Ba and U while calcitic solids are enriched in Mg. These differences could be attributed to mineralogy, temperature or different precipitation rates. The geochemical evaluation of the chemistry of both the solids and their parental waters suggests that differences in the rate of CO2-degassing and, in some cases, evaporation are the primary environmental controls on isotopic compositions. In addition, the results show that, if strong evaporation and CO2-degassing are involved, calcite precipitation occurs under conditions of isotopic disequilibrium with its parental water. The results of our study are useful to interpret old depositional environments and palaeotemperatures

Solid pseudopapillary tumor of the pancreas (SPPT). Still an unsolved enigma

Solid pseudo-papillary tumor (SPPT) is a rare cystic tumor of the pancreas (1-3% of exocrine tumors of the pancreas) which shows an “enigmatic” behavior on the clinical and molecular pattern. A retrospective analysis of the citological studies and resected specimens of pancreatic cystic tumors from May 1996 to February 2010 was carried out. Three cases of SPPT were found, which are the objective of this study. The diagnosis was established upon occasional finding in the abdominal CT, in spite of sizing between 3 and 6 cm of diameter. In the three cases the preoperative diagnosis was confirmed by citology and specific immunohistochemical staining. Cases 2 and 3 showed strong immunoreactivity for Beta-Catenina and E-Cadherina staining. Radical resection (R0) was carried out in the three cases. A young male –21 years of age (case 1)- who had duodenal infiltration and two lymph nodes metastases died of hepatic and peritoneal recurrence 20 months following surgery. The other two cases are free of disease. The current review of the literature reports roughly 800 cases since the first report in 1959, and shows the enigmatic character of this tumor regarding the cellular origin, molecular pathways, prognostic factors and clinical behavior

Heart transplantation using allografts from older donors: multicenter study results

33rd Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation, April 24–27, 2013, Montreal, Canada.[Abstract] Background. The lengthy waiting time for heart transplantation is associated with high mortality. To increase the number of donors, new strategies have emerged, including the use of hearts from donors ≥50 years old. However, this practice remains controversial. The aim of this study was to evaluate outcomes of patients receiving heart transplants from older donors. Methods. We retrospectively analyzed 2,102 consecutive heart transplants in 8 Spanish hospitals from 1998 to 2010. Acute and overall mortality were compared in patients with grafts from donors ≥50 years old versus grafts from younger donors. Results. There were 1,758 (84%) transplanted grafts from donors < 50 years old (Group I) and 344 (16%) from donors ≥50 years old (Group II). Group I had more male donors than Group II (71% vs 57%, p = 0.0001). The incidence of cardiovascular risk factors was higher in older donors. There were no differences in acute mortality or acute rejection episodes between the 2 groups. Global mortality was higher in Group II (rate ratio, 1.40; 95% confidence interval, 1.18–1.67; p = 0.001) than in Group I. After adjusting for donor cause of death, donor smoking history, recipient age, induction therapy, and cyclosporine therapy, the differences lost significance. Group II had a higher incidence of coronary allograft vasculopathy at 5 years (rate ratio, 1.67; 95% confidence interval, 1.22–2.27; p = 0.001). Conclusions. There were no differences in acute and overall mortality after adjusting for confounding factors. However, there was a midterm increased risk of coronary allograft vasculopathy with the use of older donors. Careful selection of recipients and close monitoring of coronary allograft vasculopathy are warranted in these patients.Instituto de Salud Carlos III; RD12/0042/00

Repeatability of in-vitro optical quality measurements of intraocular lenses with a deflectometry technique effect of the toricity

AIM: To evaluate the repeatability of an optical device for measuring the Zernike coefficients of toric intraocular lenses (IOLs) and assess whether its toricity has any impact in its repeatability. METHODS: An experienced technician used the NIMO TR1504 to measure the Zernike coefficients 30 times for an aperture of 4.50 mm for all lenses included. The IOLs included were divided into two group: toric and non-toric ones. The cylindrical powers of the toric lenses included in the present study were 1.00, 1.50, 2.25, 3.00 and 3.75 D. Finally, the repeatability of the NIMO TR1504 was described in terms of within subject standard deviation (Sw) and repeatability limit. RESULTS: The Sw was smaller than 0.011 µm for both lens groups and all Zernike coefficients, and the difference between both groups was smaller than 0.004 µm for all Zernike coefficients. Regarding the repeatability limit, this value was smaller than 0.025 µm for the toric lens group, and smaller than 0.031 µm for the non-toric lens one for all Zernike coefficients. Furthermore, the maximum difference between both lens groups was 0.010 µm. CONCLUSION: The repeatability of the NIMO TR1504 to measure the optical quality is high and independent of the lens toricity. These results reflect that this system is robust and could be used to measure the in-vitro optical quality of either toric or non-toric IOLs

Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design

The diagnosis of myeloid neoplasms (MN) has significantly evolved through the last few decades. Next Generation Sequencing (NGS) is gradually becoming an essential tool to help clinicians with disease management. To this end, most specialized genetic laboratories have implemented NGS panels targeting a number of different genes relevant to MN. The aim of the present study is to evaluate the performance of four different targeted NGS gene panels based on their technical features and clinical utility. A total of 32 patient bone marrow samples were accrued and sequenced with 3 commercially available panels and 1 custom panel. Variants were classified by two geneticists based on their clinical relevance in MN. There was a difference in panel¿s depth of coverage. We found 11 discordant clinically relevant variants between panels, with a trend to miss long insertions. Our data show that there is a high risk of finding different mutations depending on the panel of choice, due both to the panel design and the data analysis method. Of note, CEBPA, CALR and FLT3 genes, remains challenging the use of NGS for diagnosis of MN in compliance with current guidelines. Therefore, conventional molecular testing might need to be kept in place for the correct diagnosis of MN for now