Picaduras y mordeduras de animales

Under the heading of this subject we deal with stings by arthropods, making reference to the differences that exist between the stings of wasps and bees, commenting on the composition of the poisons and the different local and general reactions that are caused by such stings. Also discussed are the stings/bites caused by scorpions, spiders, ticks, and marine animals, with the clinical picture they provoke and the treatment that must be administered. Finally, snakebites are considered, with reference to the most frequent types of ophidia to be found in Navarra, how to differentiate between the bites of snakes and vipers, the different clinical pictures they provoke and the treatment to be applie

Correlated responses on growth traits after two-stage selection for ovulation rate and litter size in rabbits

[EN] Rabbit commercial maternal lines are usually selected for litter size (LS) and paternal lines for growth rate (GR). Line OR_LS was selected by ovulation rate (OR) and LS to improve LS more efficiently. In this study, growth traits of line OR_LS were evaluated by estimating the correlated response on weaning weight (WW), slaughter weight (SW) and GR during fattening period as well as their variability (DWW, DSW and DGR, respectively). Data were analyzed using Bayesian inference methods. Heritability estimates were low for growth traits (0.09, 0.13 and 0.14 for WW, SW and GR, respectively) and negligible for growth traits variability (0.01, 0.004 and 0.01 for DWW, DSW and DGR, respectively). Moderate common litter effect ratio (c(2); 0.35, 0.28 and 0.27) and low maternal effect ratio (m(2); 0.11, 0.05 and 0.01) were obtained for WW, SW and GR, respectively. Both c(2) and m(2) were lower at slaughter than at weaning. In addition, low common litter effect and negligible maternal effect were observed for growth traits variability. Genetic correlations between LS and both growth traits and their variability were close to zero. Positive genetic correlations were observed between OR and growth traits (0.19, 0.38 and 0.36 for WW, SW and GR, respectively) as well as between OR and growth traits variability (0.35, 0.62 and 0.20 for DWW, DSW and DGR, respectively). Positive correlated responses in both periods were obtained for growth traits, WW, SW and GR (0.037, 0.156 and 0.110 kg, respectively). The correlated response found in growth traits might be due to the positive genetic correlations between OR and these traits. However, selection for OR and LS using independent culling levels did not modify the growth traits variability. Therefore, no negative consequences on growth traits can be expected in current commercial maternal lines.This study was supported by the Ministerio de Economia y Competitividad (AGL2014-55921-C2-1-P) and by funds from Generalitat Valenciana research programme (Prometeo 2009/125).Peiró Barber, RM.; Yehia-Badawy Elmoghazy, A.; Blasco Mateu, A.; Santacreu Jerez, MA. (2019). Correlated responses on growth traits after two-stage selection for ovulation rate and litter size in rabbits. Animal. 13(11):2457-2462. https://doi.org/10.1017/S1751731119001423S245724621311ZHANG, T., WANG, L., SHI, H., YAN, H., ZHANG, L., LIU, X., … WANG, L. (2016). Hritabilities and genetic and phenotypic correlations of litter uniformity and litter size in Large White sows. Journal of Integrative Agriculture, 15(4), 848-854. doi:10.1016/s2095-3119(15)61155-8Wolf, J., Žáková, E., & Groeneveld, E. (2008). Within-litter variation of birth weight in hyperprolific Czech Large White sows and its relation to litter size traits, stillborn piglets and losses until weaning. Livestock Science, 115(2-3), 195-205. doi:10.1016/j.livsci.2007.07.009Ruíz-Flores, A., & Johnson, R. K. (2001). Direct and correlated responses to two-stage selection for ovulation rate and number of fully formed pigs at birth in swine. Journal of Animal Science, 79(9), 2286. doi:10.2527/2001.7992286xRosendo, A., Canario, L., Druet, T., Gogué, J., & Bidanel, J. P. (2007). Correlated responses of pre- and postweaning growth and backfat thickness to six generations of selection for ovulation rate or prenatal survival in French Large White pigs. Journal of Animal Science, 85(12), 3209-3217. doi:10.2527/jas.2007-0106Mocé ML and Santacreu MA 2010. Genetic improvement of litter size in rabbits: a review. In Proceeding of the 9th World Congress on Genetics Applied to Livestock Production, 1–6 August 2010, Leipzig, Germany, communication 25.Mínguez, C., Sanchez, J. P., EL Nagar, A. G., Ragab, M., & Baselga, M. (2015). Growth traits of four maternal lines of rabbits founded on different criteria: comparisons at foundation and at last periods after selection. Journal of Animal Breeding and Genetics, 133(4), 303-315. doi:10.1111/jbg.12197Legarra A , Varona L and López de Maturana E 2008. Program TM. Retrieved on 28 September 2017 from http://snp.toulouse.inra.fr/~alegarra/Hsu, W. L., & Johnson, R. K. (2014). Analysis of 28 generations of selection for reproduction, growth, and carcass traits in swine. Journal of Animal Science, 92(11), 4806-4822. doi:10.2527/jas.2014-8125Drummond, H., Vazquez, E., Sanchez-Colon, S., Martinez-Gomez, M., & Hudson, R. (2000). Competition for Milk in the Domestic Rabbit: Survivors Benefit from Littermate Deaths. Ethology, 106(6), 511-526. doi:10.1046/j.1439-0310.2000.00554.xDrouilhet, L., Gilbert, H., Balmisse, E., Ruesche, J., Tircazes, A., Larzul, C., & Garreau, H. (2013). Genetic parameters for two selection criteria for feed efficiency in rabbits1. Journal of Animal Science, 91(7), 3121-3128. doi:10.2527/jas.2012-6176Damgaard, L. H., Rydhmer, L., Løvendahl, P., & Grandinson, K. (2003). Genetic parameters for within-litter variation in piglet birth weight and change in within-litter variation during suckling1. Journal of Animal Science, 81(3), 604-610. doi:10.2527/2003.813604xCunningham, P. J., England, M. E., Young, L. D., & Zimmerman, D. R. (1979). Selection for Ovulation Rate in Swine: Correlated Response in Litter Size and Weight. Journal of Animal Science, 48(3), 509-516. doi:10.2527/jas1979.483509xBidanel, J., Gruand, J., & Legault, C. (1996). Genetic variability of age and weight at puberty, ovulation rate and embryo survival in gilts and relations with production traits. Genetics Selection Evolution, 28(1), 103. doi:10.1186/1297-9686-28-1-103Badawy, A. Y., Peiró, R., Blasco, A., & Santacreu, M. A. (2018). Correlated responses on litter size traits and survival traits after two-stage selection for ovulation rate and litter size in rabbits. animal, 13(3), 453-459. doi:10.1017/s1751731118002033Argente, M. J., Santacreu, M. A., Climent, A., & Blasco, A. (1999). Phenotypic and genetic parameters of birth weight and weaning weight of rabbits born from unilaterally ovariectomized and intact does. Livestock Production Science, 57(2), 159-167. doi:10.1016/s0301-6226(98)00166-3Garcı́a, M. ., & Baselga, M. (2002). Estimation of correlated response on growth traits to selection in litter size of rabbits using a cryopreserved control population and genetic trends. Livestock Production Science, 78(2), 91-98. doi:10.1016/s0301-6226(02)00093-

Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

BACKGROUND: Despite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults. METHODS: This study enrolled 160 healthy subjects (92 women/68 men; 23±4 y; 22.0±2.9 kg/m2). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry. RESULTS: Total cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (≥611 nmol/[mL/min]) and of NSL (≥430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations. CONCLUSIONS: Ox-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance

Dietary patterns and difficulty conceiving: a nested case–control study

Objective: To investigate potential associations between dietary patterns (defined using factor analysis) and difficulty conceiving. Design: Case–control study nested in a Spanish cohort of university graduates (Seguimiento Universidad de Navarra [SUN] Project). Setting: Female university graduates all over Spain participating in the SUN Project. Patient(s): A total of 485 women, aged 20–45 years, reporting having presented with difficulty getting pregnant, and 1,669 age-matched controls who had at least one child. Intervention(s): None. Main Outcome Measure(s): Reported difficulty getting pregnant. Data were collected from baseline and follow-up questionnaires of the SUN Project. Results: Two dietary patterns were identified. They were labeled as “Mediterranean-type” and “Western-type” patterns. A lower risk of difficulty getting pregnant was apparent in the highest quartile of adherence to the Mediterranean-type pattern compared with the lowest quartile (odds ratio 0.56, 95% confidence interval 0.35–0.95). Greater adherence to the Western-type dietary pattern showed no association with this outcome. Conclusion: A greater adherence to the Mediterranean-type dietary pattern may enhance fertility. Further evidence about the relationship between this dietary pattern and fertility is needed to develop nutritional interventions for women desiring to get pregnant

Peutz-Jeghers syndrome and duodeno-jejunal adenocarcinoma-therapeutic implications

The Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous poliposis describred in 1921. Hemminki in 1997 described the presence of LKB-1 mutation tumor-suppressor gen.The patients with PJS develop a higher cumulative incidence of gastrointestinal, pancreas and extraintestinal tumors, being occasion of a renew interest on hamartomatous polyposis syndromes regarding the clinical care, cancer surveillance treatment and long term follow-up.We report the case of a 38 years old male, diagnosed of PJS who developed a multiple adenocarcinoma in duodenum and yeyunum. Surgically treated and with a long-term free disease survival of 11 years represents the sixth case reported in the spanish literature of PJS associated with a gastrointestinal tumor.A critical review, molecular alterations and the established criteria of tumor screening and surveillance are reviewed

Students' perception on learning methods in engineering disciplines

This article is (c) Emerald Group Publishing and permission has been granted for this version to appear here (please insert the web address here). Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited.[EN] Purpose - This study explores the preferences for learning methods among the students of seven engineering disciplines in a Spanish technical university. The purpose of this paper is to investigate the students' views and from them contribute to the knowledge of the effectiveness of learning methodologies. Design/methodology/approach - An online anonymous questionnaire survey was adopted to collect students' perceptions. Seven learning methods were compared in seven engineering degrees. The authors sampled 1660 students, and 426 completed responses were analysed. In addition to a descriptive analysis of the results, a multiple correspondence analysis (MCA) was performed using R data processing software. Findings - It was found that project-based learning and problem-based learning were perceived as the more effective ones. MCA identified response patterns between the preference and the efficiency of learning methods showing that students can be classified into two groups according to their preferred level of activeness in learning. Research limitations/implications - The study focusses on a single technical university and not all engineering degrees could be sampled. However, five different engineering fields were studied and no significant differences among them were found. Practical implications - The results add up to the known literature showing that students have different learning needs and consequently they perceive some methods as more effective. Instructors can use this information to strengthen their learning activities. Results also suggest that students can be classified into two groups in relation to their level of activeness in learning. This can also help to enhance general student motivation if two paths with different levels of activeness are planned. Originality/value - No previous studies have compared several learning methods in different engineering fields. Thus, this study contributes to fill this gap and contributes to the body of evidence around learning methodologies from the perspective of students.Vidal Rodriguez, B.; Fenollosa Ribera, ML.; Ribal, J.; Sanchis Kilders, P.; García-Rupérez, J.; Bes-Piá, M.; Blasco-Tamarit, E.... (2022). Students' perception on learning methods in engineering disciplines. Journal of Applied Research in Higher Education. 14(3):946-957. https://doi.org/10.1108/JARHE-01-2021-0041S94695714

Atopic dermatitis incidence and risk factors in young adults in Castellon (Spain): A prospective cohort study

Introduction: There are few atopic dermatitis (AD) incidence cohort studies in young adults, the etiology of this disease remains obscure, and AD risk factors in adults are not well understood. The objective of this study was to estimate AD ten-year incidence and prevalence in a cohort of adolescent aged 14–16 at inception in Castellon province in Valencia Region, Spain and describe related risk factors. Material and methods: From 2002 to 2012, a population-based prospective cohort study was carried out. Questionnaires from the International Study of Asthma and Allergies in Childhood (ISAAC) were used with an additional questionnaire for related factors completed by participants and their parents, respectively, in 2002. In 2012 the same questionnaires were completed by the participants’ through a telephone interview, and incidence and prevalence of AD were estimated. Directed acyclic graphs, Poisson regression and inverse probability weighted regression adjustment were used. Results: The participation rate was 79.5% (1435/1805) with AD lifetime prevalence of 34.9% and AD incidence of 13.5 per 1000 person years. Females presented higher prevalence and incidence than males. After adjustment significant risk factors were being female, history of asthma or allergic rhinitis, family history of AD, history of respiratory infections, history of bronchitis, history of pneumonia, history of sinusitis, and birthplace outside Castellon province. The highest AD population attributable risks were female, 30.3%, and history of respiratory infections 15.3%. Differences with AD childhood risk factors were found. Conclusions: AD incidence in our cohort was high and several risks factors were related to AD

Anti-proliferative effect of melissa officinalis on human colon cancer cell line

Melissa officinalis L. (Lamiaceae) is consumed as a traditional herbal tea in the Mediterranean region. The cytotoxic effect of the 50% ethanolic and aqueous extract, determined by the MTT and NR assays, was evaluated in vitro on Human Colon Cancer Cell Line (HCT-116), using Triton 10% as positive control. The 50 % ethanolic extract showed significant differences after 72 hours of treatment, reducing cell proliferation to values close to 40%, even the lowest dose tested (5 μg/ml). In the MTT assay, the same extract caused the lowest cell viability with 13% at a concentration of 1000 μg/ml after 72 h of treatment, being a value lower than triton 10%. The antioxidant activity was also confirmed evaluating the capacity of the extracts to scavenge ABTS and DPPH radicals, and IC50 values were highly correlated with the total phenolic and flavonoid content. Bioassay guided fractionation led to the isolation of an anti-proliferative compound, rosmarinic acid. Its structural elucidation was performed by HPLC/DAD/ESI/MS analysis. High dose of rosmarinic acid (1000 μg/ml) was clearly cytotoxic against HCT-116 cells, with a significant decrease in cell number since the earliest time point (24 h)

Propuesta de representación gráfica y tratamiento de datos anómalos de una báscula de autopesaje de corderos

En algunas ocasiones, es muy difícil saber qué estimación es la más correcta. Generalmente, los méto - dos robustos tienen más probabilidades de obtener la mejor estimación. Sin embargo, en ocasiones hay individuos que ni viendo los datos es posible decidir, debiendo descartar dichos datos.Financiado con fondos FEDER, a través de proyectos del Gobierno de Aragón FITE (TERGENOVID), PDR (PESOVI, GCP2021004600) y Grupo SAGAS (Ref. A14_20R

Effects of parity order and reproductive management on the efficiency of rabbit productive systems.

The aim of this work was to study the effect of parity order and reproductive management systems on rabbit production performance. A total of 73 rabbit does (I group) were submitted to a 35-day intensive rhythm [artificial insemination (AI) on day 4 post-partum (pp) and weaning at 25 days of lactation], and 108 rabbit does (SI group) were submitted to a 42-day semi-intensive rhythm (AI on day 11 pp and weaning at 35 days of lactation) during 9 months. Primiparous does had the lowest live body weight at parturition (P < 0.0001) and at 21 days of lactation (P < 0.0001). They also had lower milk production (P < 0.0001) than does with later parities. I group animals needed a higher number of AI than SI group to become pregnant (1.70 ± 0.03 vs. 1.39 ± 0.03; P < 0.0001: especially after the third). Prolificacy was not affected by the management system. Parturition interval (PI) was longer than expected in both groups [56.0 ± 1.4 and 50.9 ± 1.38 days in I and SI groups, respectively (P < 0.05)]. Mean productivity, estimated as number of weaned rabbits per female and year, was 12 kits higher in rabbit does of the SI group (P < 0.05). From the third parturition onward, an increase in live body weight of kits at different ages was observed. At 21 (P < 0.05) and 25 days of age (P < 0.01), kits from the I group rabbit does weighed more than those from the SI group; however, the latter showed a higher weight at 35 (P < 0.05) and 60 days of age (P < 0.05). Rabbit does with two or three parturitions had higher litter size at 21 and 25 days of age (P < 0.0001 and P < 0.001, respectively). Kit mortality between 21 and 25 days of age and between 35 and 60 days of age was not affected by treatments but was higher in the I group between 25 and 35 days (18.2 vs. 5.03% in the I and SI groups, respectively; P < 0.0001) and as age of does increased (P < 0.05). In light of these results, we could conclude that long term doe reproductive performance is negatively affected and litter viability decreased when using intensive compared to a semi-intensive reproductive management