Proyecto de adecuación de la fachada marítima de Saplaya sur (T.M. Alboraia, Valencia). Paseo marítimo alternativa I

[EN] As a result of the new development in the current commercial area, and the current state of degradation of the beach, a series of actions to help improve the general state of the area are planned. To do this, it aims to build a new boardwalk along the stretch of coast that study, which will replace the currently located. This action, which accompanies a series of improvements and adjustments such as beach regeneration, improving access, detours from the ditch, etc ... help you fulfill what is expected of a coastal or beach which is close in a residential area, in addition to solving the problems of erosion that has suffered this stretch of coastline, and provide new value to what is all this coastal zone.[ES] Como consecuencia de la nueva urbanización en la actual zona comercial, y del estado de degradación actual de la playa, se planean una serie de actuaciones que ayuden a mejorar el estado general de la zona. Para ello, se pretende construir un nuevo paseo marítimo a lo largo del tramo de costa que estudiamos, el cual sustituya al que actualmente se encuentra. Esta actuación, que acompaña a una serie de mejoras y adecuaciones como son la regeneración de la playa, mejora de accesos, desvíos de la acequia, etc¿ ayudarán a cumplir lo que se espera de una zona costera o playa que se encuentra próxima a una urbanización residencial, además de solucionar los problemas de erosión que ha venido sufriendo este tramo de costa, así como dotar de un nuevo valor a lo que es toda esa zona costera.[CA] Com a conseqüència de la nova urbanització en l'actual zona comercial, i de l'estat de degradació actual de la platja, es planegen una sèrie d'actuacions que ajuden a millorar l'estat general de la zona. Per a això, es pretén construir un nou passeig marítim al llarg del tram de costa que estudiem, el qual substituïsca el què hi ha actualment. Esta actuació, que acompanya a una sèrie de millores i adequacions com són la regeneració de la platja, millora d'accessos, desviacions de la séquia, etc... ajudaran a complir el que s'espera d'una zona costanera o platja que es troba pròxima a una urbanització residencial, a més de solucionar els problemes d'erosió que ha patit este tram de costa, així com dotar d'un nou valor al que és tota eixa zona costanera.Blasco Ramos, A. (2015). Proyecto de adecuación de la fachada marítima de Saplaya sur (T.M. Alboraia, Valencia). Paseo marítimo alternativa I. http://hdl.handle.net/10251/54528

La vuelta al mundo, de un novelista [Texto impreso]

Contiene: 1. Estados Unidos. Cuba.Panamá. Hawai. Japón. Corea. Manchuria. -- 2.China. Macao. Hong Kong. Filipinas. Java. Singapore. Birmania. Calcuta. -- 3. India. Ceilán. Sudán. Nubia. Egipto / [ilustración de la cubierta, Arturo Ballester

Libro-homenaje al inmortal novelista V. Blasco Ibáñez [Texto impreso]

Precede al tít.: In memoria

Improving network intrusion detection by means of domain-aware genetic programming

Proceeding of: International Conference on Availability, Reliability, and Security, 2010. ARES '10, 15-18 February 2010, Krakow, PolandOne of the central areas in network intrusion detection is how to build effective systems that are able to distinguish normal from intrusive traffic. In this paper we explore the use of Genetic Programming (GP) for such a purpose. Although GP has already been studied for this task, the inner features of network intrusion detection have been systematically ignored. To avoid the blind use of GP shown in previous research, we guide the search by means of a fitness function based on recent advances on IDS evaluation. For the experimental work we use a well-known dataset (i.e. KDD- 99) that has become a standard to compare research although its drawbacks. Results clearly show that an intelligent use of GP achieves systems that are comparable (and even better in realistic conditions) to top state-of-the-art proposals in terms of effectiveness, improving them in efficiency and simplicity.This work was partially supported by CDTI, Ministerio de Industria, Turismo y Comercio of Spain in collaboration with Telefónica I+D, Project SEGUR@ CENIT-2007 2004Publicad

Entrapped Transient Chloroform Solvates of Bilastine

The knowledge about the solid forms landscape of Bilastine (BL) has been extended. The crystal structures of two anhydrous forms have been determined, and the relative thermodynamic stability among the three known anhydrous polymorphs has been established. Moreover, three chloroform solvates with variable stoichiometry have been identified and characterized, showing that S3CHCl3-H2O and SCHCl3 can be classified as transient solvateswhich transforminto the newchloroform solvate SCHCl3-H2O when removed fromthemother liquor. The determination of their crystal structures from combined single crystal/synchrotron X-ray powder diffraction data has allowed the complete characterization of these solvates, being two of them heterosolvates (S3CHCl3-H2O and SCHCl3-H2O) and SCHCl3 a monosolvate. Moreover, the temperature dependent stability and interrelation pathways among the chloroform solvates and the anhydrous forms of BL have been studied

Assessing and forecasting the impacts of global change on Mediterranean rivers. The SCARCE Consolider project on Iberian basins

Introduction The Consolider-Ingenio 2010 project SCARCE, with the full title “Assessing and predicting effects on water quantity and quality in Iberian Rivers caused by global change” aims to examine and predict the relevance of global change on water availability, water quality, and ecosystem services in Mediterranean river basins of the Iberian Peninsula, as well as their socio-economic impacts. Starting in December 2009, it brought together a multidisciplinary team of 11 partner Spanish institutions, as well as the active involvement of water authorities, river basin managers, and other relevant agents as stakeholders. Methods The study areas are the Llobregat, Ebro, Jucar, and Guadalquivir river basins. These basins have been included in previous studies and projects, the majority of whom considered some of the aspects included in SCARCE but individually. Historical data will be used as a starting point of the project but also to obtain longer time series. The main added value of SCARCE project is the inclusion of scientific disciplines ranging from hydrology, geomorphology, ecology, chemistry, and ecotoxicology, to engineering, modeling, and economy, in an unprecedented effort in the Mediterranean area. The project performs data mining, field, and lab research as well as modeling and upscaling of the findings to apply them to the entire river basin. Results Scales ranging from the laboratory to river basins are addressed with the potential to help improve river basin management. The project emphasizes, thus, linking basic research and management practices in a single framework. In fact, one of the main objectives of SCARCE is to act as a bridge between the scientific and the management and to transform research results on management keys and tools for improving the River Basin Management Plans. Here, we outline the general structure of the project and the activities conducted within the ten Work Packages of SCARCE

Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study

The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60-72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months' follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunctio

Functional Analysis of the Phycomyces carRA Gene Encoding the Enzymes Phytoene Synthase and Lycopene Cyclase

Phycomyces carRA gene encodes a protein with two domains. Domain R is characterized by red carR mutants that accumulate lycopene. Domain A is characterized by white carA mutants that do not accumulate significant amounts of carotenoids. The carRA-encoded protein was identified as the lycopene cyclase and phytoene synthase enzyme by sequence homology with other proteins. However, no direct data showing the function of this protein have been reported so far. Different Mucor circinelloides mutants altered at the phytoene synthase, the lycopene cyclase or both activities were transformed with the Phycomyces carRA gene. Fully transcribed carRA mRNA molecules were detected by Northern assays in the transformants and the correct processing of the carRA messenger was verified by RT-PCR. These results showed that Phycomyces carRA gene was correctly expressed in Mucor. Carotenoids analysis in these transformants showed the presence of ß-carotene, absent in the untransformed strains, providing functional evidence that the Phycomyces carRA gene complements the M. circinelloides mutations. Co-transformation of the carRA cDNA in E. coli with different combinations of the carotenoid structural genes from Erwinia uredovora was also performed. Newly formed carotenoids were accumulated showing that the Phycomyces CarRA protein does contain lycopene cyclase and phytoene synthase activities. The heterologous expression of the carRA gene and the functional complementation of the mentioned activities are not very efficient in E. coli. However, the simultaneous presence of both carRA and carB gene products from Phycomyces increases the efficiency of these enzymes, presumably due to an interaction mechanism

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis