Deliverable D32 Core indicators for the interconnection between short and long-distance transport networks ; projet 7FP CLOSER (Connecting LOng and Short-distance networks for Efficient Transport); September 2011

The CLOSER project has been set to analyse the interfaces and interconnections between long distance transport networks and local/regional transport networks of all modes. The project is funded within the Seventh Framework Programme of the European Commission, under the topic TPT-2008.0.0.13 “New mobility/organisational schemes: interconnection between short and long-distance transport networks”. The goal of WP3 of CLOSER is to establish a set of core indicators that reflect the most crucial issues connected to interfaces between short and long-distance transport networks, both for passenger and freight transport. This includes the creation of a structured representation of these interfaces, determination of core indicators, and the assessment of usability of the core indicators. CLOSER WP3 has produced two deliverables, of which the current document is the second. The first deliverable “Interconnections between short and long-distance transport networks: Structure of interface and existing indicators” (Andersen et al., 2010) contained a review of existing indicators related to interfaces between long and short-distance freight and passenger transport.The aim of this document is to structure the interconnections between short and longdistancetransport networks. This in particular includes:- Establishment of selection criteria to choose core indicators- Selection and validation of core indicators and new indicators- Set of typologies of interfacesThe document also presents the results of the WP3 workshop arranged in Lille on May 24, 2011

Case studies: results and synthesis projet 7FP CLOSER (Connecting LOng and Short-distance networks for Efficient Transport) Rapport de recherche Deliverable 5.2 project européen CLOSER.

The CLOSER project has been set to analyse the interfaces and interconnectionsbetween long distance transport networks and local/regional transport networks of allmodes. The project is funded within the Seventh Framework Programme of theEuropean Commission, under the topic TPT-2008.0.0.13 “New mobility/organisationalschemes: interconnection between short and long-distance transport networks”.The objective of WP5 of CLOSER is to accomplish in-depth case studies to deepenand validate the understanding of results obtained in Work packages 2, 3 and 4. Thiswill be achieved by:- Developing a joint assessment and evaluation framework for the case studies,incorporating knowledge that has been obtained in WP 2, WP 3 and WP 4- Carrying out the case studies- Synthesising the results of the case studies in order to give inputs for thedevelopment of recommendations in WP 6.The deliverable at hand summarises the seven case studies that have been conductedin the CLOSER project: Leipzig-Halle airport (Germany) Armentiéres station (France) Oslo bus terminal Vaterland (Norway) Port of Helsinki (Finland) Thessaloniki port (Greece) Constantza port (Romania) Vilnius Airport (Lithuania

Risque de contamination des filières de production des denrées alimentaires par des rejets accidentels de radionucléides (rédaction de fiches synthétiques à l'usage des décideurs)

LYON1-BU Santé (693882101) / SudocTOULOUSE-EN Vétérinaire (315552301) / SudocSudocFranceF

New Insights into the Epigenetic Activities of Natural Compounds

International audienceHistone deacetylases (HDACs) are a family of enzymes found in bacteria, fungi, plants, and animals that profoundly affect cellular function by catalyzing the removal of acetyl groups from -N-acetylated lysine residues of various protein substrates including histones, transcription factors, alpha-tubulin, and nuclear importers. Although the precise roles of HDAC isoforms in cellular function are not yet completely understood, inhibition of HDAC activity has emerged as a promising approach for reversing the aberrant epigenetic states associated with cancer and other chronic diseases. Potent new isoform-selective HDAC inhibitors would therefore help expand our understanding of the HDAC enzymes and represent attractive lead compounds for drug design, especially if combined with high-resolution structural analyses of such inhibitors to shed light on the three-dimensional pharmacophoric features necessary for the future design of more potent and selective compounds. Here we present structural and functional analyses of a series of beta-amino-acid-containing HDAC inhibitors inspired by cyclic tetrapeptide natural products. To survey a diverse ensemble of pharmacophoric configurations, we systematically varied the position of the beta-amino acid, amino acid chirality, functionalization of the Zn(2+)-coordinating amino acid side chain, and alkylation of the backbone amide nitrogen atoms around the macrocycle. In many cases, the compounds were a single conformation in solution and exhibited potent activities against a number of HDAC isoforms as well as effective antiproliferative and cytotoxic activities against human tumor cells. High-resolution NMR solution structures were determined for a selection of the inhibitors, providing a useful means of correlating detailed structural information with potency. The structure-based approach described here is expected to furnish valuable insights toward the future design of more selective HDAC inhibitors

MOBILITY4EU - D2.1 - Societal needs and requirements for future transportation and mobility as well as opportunities and challenges of current solutions

Mobility4EU is a Coordination and Support Action of the European Commission started in January 2016 and lasting for 3 years, until 31 December 2018. The project will deliver a vision for the European transport system in 2030 and an action plan including a roadmap to implement that vision. The work towards that vision and action plan is based on the identification and assessment of societal challenges that will influence future transport demand and supply and the compilation of a portfolio of promising cross-modal technical and organisational transport solutions. The entire process from studying trends and options for solutions, developing a vision and finally the action plan are organized within a structured participatory approach that focuses on user-centeredness and that aims to engage a broad stakeholder community into the consultation processes. A further goal is to build a European Transport Forum that continues the work beyond the project duration and works on complementing the action plan. The present document reports on the results of researching trends and societal drivers impacting mobility demands and transport in Europe until 2030

MOBILITY4EU - D2.1 - Societal needs and requirements for future transportation and mobility as well as opportunities and challenges of current solutions

Mobility4EU is a Coordination and Support Action of the European Commission started in January 2016 and lasting for 3 years, until 31 December 2018. The project will deliver a vision for the European transport system in 2030 and an action plan including a roadmap to implement that vision. The work towards that vision and action plan is based on the identification and assessment of societal challenges that will influence future transport demand and supply and the compilation of a portfolio of promising cross-modal technical and organisational transport solutions. The entire process from studying trends and options for solutions, developing a vision and finally the action plan are organized within a structured participatory approach that focuses on user-centeredness and that aims to engage a broad stakeholder community into the consultation processes. A further goal is to build a European Transport Forum that continues the work beyond the project duration and works on complementing the action plan. The present document reports on the results of researching trends and societal drivers impacting mobility demands and transport in Europe until 2030

High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn’s Disease

International audienceBackground & AimsLittle is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn’s disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn’s perianal disease followed up in the Cancers Et Surrisque Associé aux Maladies Inflammatoires Intestinales En France (CESAME) cohort.MethodsWe collected data from 19,486 patients with inflammatory bowel disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14.9% of participants had past or current anal and/or perianal Crohn’s disease. Subjects were followed up for a median time of 35 months (interquartile range, 29–40 mo). To identify risk factors for anal cancer in the total CESAME population, we performed a case-control study in which participants were matched for age and sex.ResultsAmong the total IBD population, 8 patients developed anal cancer and 14 patients developed rectal cancer. In the subgroup of 2911 patients with past or current anal and/or perianal Crohn’s lesions at cohort entry, 2 developed anal squamous-cell carcinoma, 3 developed perianal fistula–related adenocarcinoma, and 6 developed rectal cancer. The corresponding incidence rates were 0.26 per 1000 patient-years for anal squamous-cell carcinoma, 0.38 per 1000 patient-years for perianal fistula–related adenocarcinoma, and 0.77 per 1000 patient-years for rectal cancer. Among the 16,575 patients with ulcerative colitis or Crohn’s disease without anal or perianal lesions, the incidence rate of anal cancer was 0.08 per 1000 patient-years and of rectal cancer was 0.21 per 1000 patient-years. Among factors tested by univariate conditional regression (IBD subtype, disease duration, exposure to immune-suppressive therapy, presence of past or current anal and/or perianal lesions), the presence of past or current anal and/or perianal lesions at cohort entry was the only factor significantly associated with development of anal cancer (odds ratio, 11.2; 95% CI, 1.18-551.51; P = .03).ConclusionsIn an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn’s disease have a high risk of anal cancer, including perianal fistula–related cancer, and a high risk of rectal cancer

A highly virulent variant of HIV-1 circulating in the Netherlands

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence